L H J Looijenga

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. Rijlaarsdam M, van der Zwan Y, Dorssers L, Looijenga L. DMRforPairs: identifying differentially methylated regions between unique samples using array based methylation profiles. BMC Bioinformatics. 2014;15:141 pubmed publisher
    ..To our knowledge, DMRforPairs is the first tool to identify and visualize relevant and significant differentially methylated regions between unique samples. ..
  2. van Agthoven T, Eijkenboom W, Looijenga L. microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients. Cell Oncol (Dordr). 2017;40:379-388 pubmed publisher
    ..The ampTSmiR test is more sensitive than the conventional TGCC protein biomarkers for the detection of residual disease and relapse, excluding mature teratoma. ..
  3. Eckert D, Biermann K, Nettersheim D, Gillis A, Steger K, Jack H, et al. Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. BMC Dev Biol. 2008;8:106 pubmed publisher
    ..This imposes epigenetic modifications leading to transcriptional repression in mouse PGCs enabling them to escape the somatic differentiation program during migration, while expressing markers of pluripotency...
  4. request reprint
    Looijenga L, de Leeuw H, van Oorschot M, van Gurp R, Stoop H, Gillis A, et al. Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors. Cancer Res. 2003;63:7674-8 pubmed
    ..These patients may undergo tailored treatment to prevent the development of bilateral disease, with retention of testicular hormonal function. ..
  5. request reprint
    Looijenga L, Gillis A, Stoop H, Hersmus R, Oosterhuis J. Relevance of microRNAs in normal and malignant development, including human testicular germ cell tumours. Int J Androl. 2007;30:304-14; discussion 314-5 pubmed
    ..Specific sets of differentiating miRNA were found to characterize the various differentiation lineages within the GCTs, which simulate normal embryonic development. ..
  6. request reprint
    Looijenga L, Hersmus R, Oosterhuis J, Cools M, Drop S, Wolffenbuttel K. Tumor risk in disorders of sex development (DSD). Best Pract Res Clin Endocrinol Metab. 2007;21:480-95 pubmed
    ....
  7. request reprint
    Looijenga L, Gillis A, Stoop H, Hersmus R, Oosterhuis J. Chromosomes and expression in human testicular germ-cell tumors: insight into their cell of origin and pathogenesis. Ann N Y Acad Sci. 2007;1120:187-214 pubmed
    ..The conclusion is that TGCTs are embryonic cancers found in adults. ..
  8. Looijenga L. Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights. J Pathol. 2009;218:146-62 pubmed publisher
    ..The availability of representative cell lines, both for seminoma and for embryonal carcinoma, allows mechanistic studies into the initiation and progression of this disease. ..
  9. Looijenga L, Hersmus R, de Leeuw B, Stoop H, Cools M, Oosterhuis J, et al. Gonadal tumours and DSD. Best Pract Res Clin Endocrinol Metab. 2010;24:291-310 pubmed publisher
    ....
  10. Looijenga L. Spermatocytic seminoma: toward further understanding of pathogenesis. J Pathol. 2011;224:431-3 pubmed publisher
    ..However, this does not exclude an earlier cell of origin, possibly explaining the unique properties of this type of human germ cell tumour, with various counterparts in animals...

Detail Information

Publications11

  1. Rijlaarsdam M, van der Zwan Y, Dorssers L, Looijenga L. DMRforPairs: identifying differentially methylated regions between unique samples using array based methylation profiles. BMC Bioinformatics. 2014;15:141 pubmed publisher
    ..To our knowledge, DMRforPairs is the first tool to identify and visualize relevant and significant differentially methylated regions between unique samples. ..
  2. van Agthoven T, Eijkenboom W, Looijenga L. microRNA-371a-3p as informative biomarker for the follow-up of testicular germ cell cancer patients. Cell Oncol (Dordr). 2017;40:379-388 pubmed publisher
    ..The ampTSmiR test is more sensitive than the conventional TGCC protein biomarkers for the detection of residual disease and relapse, excluding mature teratoma. ..
  3. Eckert D, Biermann K, Nettersheim D, Gillis A, Steger K, Jack H, et al. Expression of BLIMP1/PRMT5 and concurrent histone H2A/H4 arginine 3 dimethylation in fetal germ cells, CIS/IGCNU and germ cell tumors. BMC Dev Biol. 2008;8:106 pubmed publisher
    ..This imposes epigenetic modifications leading to transcriptional repression in mouse PGCs enabling them to escape the somatic differentiation program during migration, while expressing markers of pluripotency...
  4. request reprint
    Looijenga L, de Leeuw H, van Oorschot M, van Gurp R, Stoop H, Gillis A, et al. Stem cell factor receptor (c-KIT) codon 816 mutations predict development of bilateral testicular germ-cell tumors. Cancer Res. 2003;63:7674-8 pubmed
    ..These patients may undergo tailored treatment to prevent the development of bilateral disease, with retention of testicular hormonal function. ..
  5. request reprint
    Looijenga L, Gillis A, Stoop H, Hersmus R, Oosterhuis J. Relevance of microRNAs in normal and malignant development, including human testicular germ cell tumours. Int J Androl. 2007;30:304-14; discussion 314-5 pubmed
    ..Specific sets of differentiating miRNA were found to characterize the various differentiation lineages within the GCTs, which simulate normal embryonic development. ..
  6. request reprint
    Looijenga L, Hersmus R, Oosterhuis J, Cools M, Drop S, Wolffenbuttel K. Tumor risk in disorders of sex development (DSD). Best Pract Res Clin Endocrinol Metab. 2007;21:480-95 pubmed
    ....
  7. request reprint
    Looijenga L, Gillis A, Stoop H, Hersmus R, Oosterhuis J. Chromosomes and expression in human testicular germ-cell tumors: insight into their cell of origin and pathogenesis. Ann N Y Acad Sci. 2007;1120:187-214 pubmed
    ..The conclusion is that TGCTs are embryonic cancers found in adults. ..
  8. Looijenga L. Human testicular (non)seminomatous germ cell tumours: the clinical implications of recent pathobiological insights. J Pathol. 2009;218:146-62 pubmed publisher
    ..The availability of representative cell lines, both for seminoma and for embryonal carcinoma, allows mechanistic studies into the initiation and progression of this disease. ..
  9. Looijenga L, Hersmus R, de Leeuw B, Stoop H, Cools M, Oosterhuis J, et al. Gonadal tumours and DSD. Best Pract Res Clin Endocrinol Metab. 2010;24:291-310 pubmed publisher
    ....
  10. Looijenga L. Spermatocytic seminoma: toward further understanding of pathogenesis. J Pathol. 2011;224:431-3 pubmed publisher
    ..However, this does not exclude an earlier cell of origin, possibly explaining the unique properties of this type of human germ cell tumour, with various counterparts in animals...
  11. Looijenga L, van Agthoven T, Biermann K. Development of malignant germ cells - the genvironmental hypothesis. Int J Dev Biol. 2013;57:241-53 pubmed publisher
    ..These insights will allow a better definition of individuals at risk of developing a germ cell malignancy, and allow a better selection of scientific approaches to elucidate the corresponding pathogenesis...