Ralph W J Leunissen

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Fat mass accumulation during childhood determines insulin sensitivity in early adulthood
    R W J Leunissen
    Department of Paediatrics, Division of Endocrinology, Erasmus Medical Centre Sophia, Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:445-51. 2008
  2. doi request reprint Growth patterns during childhood and the relationship with acylation-stimulating protein
    R W J Leunissen
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 72:775-80. 2010
  3. doi request reprint Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood
    Ralph W J Leunissen
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    JAMA 301:2234-42. 2009
  4. doi request reprint Fat mass and apolipoprotein E genotype influence serum lipoprotein levels in early adulthood, whereas birth size does not
    R W J Leunissen
    Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Room number Sb 2670, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:4307-14. 2008
  5. doi request reprint Influence of birth size on body composition in early adulthood: the programming factors for growth and metabolism (PROGRAM)-study
    R W J Leunissen
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 70:245-51. 2009
  6. doi request reprint Influence of birth size and body composition on bone mineral density in early adulthood: the PROGRAM study
    R W J Leunissen
    Department of Paediatrics, Subdivision of Endocrinology, Erasmus MC, Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 69:386-92. 2008
  7. doi request reprint Prematurity is not associated with reduced insulin sensitivity in adulthood
    Ruben H Willemsen
    Department of Pediatrics, Division of Endocrinology, Erasmus Medical Centre Sophia, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:1695-700. 2009
  8. doi request reprint Influence of preterm birth and birth size on gonadal function in young men
    Gerthe F Kerkhof
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:4243-50. 2009
  9. doi request reprint Does preterm birth influence cardiovascular risk in early adulthood?
    Gerthe F Kerkhof
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pediatr 161:390-396.e1. 2012
  10. doi request reprint Health profile of young adults born preterm: negative effects of rapid weight gain in early life
    Gerthe F Kerkhof
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:4498-506. 2012

Detail Information

Publications17

  1. ncbi request reprint Fat mass accumulation during childhood determines insulin sensitivity in early adulthood
    R W J Leunissen
    Department of Paediatrics, Division of Endocrinology, Erasmus Medical Centre Sophia, Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:445-51. 2008
    ..We evaluated the contribution of birth and adult size, body composition, and waist-to-hip ratio to DMII risk factors in young adulthood...
  2. doi request reprint Growth patterns during childhood and the relationship with acylation-stimulating protein
    R W J Leunissen
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 72:775-80. 2010
    ..As postnatal catch-up growth has been associated with dyslipidaemia in later life, we investigated the association between ASP and birth size, adult size and different growth patterns during childhood...
  3. doi request reprint Timing and tempo of first-year rapid growth in relation to cardiovascular and metabolic risk profile in early adulthood
    Ralph W J Leunissen
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    JAMA 301:2234-42. 2009
    ..Growth during infancy appears to be an important determinant of cardiovascular disease and type 2 diabetes later in life...
  4. doi request reprint Fat mass and apolipoprotein E genotype influence serum lipoprotein levels in early adulthood, whereas birth size does not
    R W J Leunissen
    Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Room number Sb 2670, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:4307-14. 2008
    ..We hypothesized that birth size does not have any influence on serum lipid levels but fat accumulation during childhood has...
  5. doi request reprint Influence of birth size on body composition in early adulthood: the programming factors for growth and metabolism (PROGRAM)-study
    R W J Leunissen
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 70:245-51. 2009
    ..We hypothesized that birth size has no influence on adult body composition, whereas weight gain during childhood has...
  6. doi request reprint Influence of birth size and body composition on bone mineral density in early adulthood: the PROGRAM study
    R W J Leunissen
    Department of Paediatrics, Subdivision of Endocrinology, Erasmus MC, Sophia Children s Hospital, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 69:386-92. 2008
    ..Our objective was to investigate whether birth size, lean body mass (LBM) and fat mass (FM) are determinants of BMD of the total body (BMD(TB)) and the lumbar spine (BMD(LS))...
  7. doi request reprint Prematurity is not associated with reduced insulin sensitivity in adulthood
    Ruben H Willemsen
    Department of Pediatrics, Division of Endocrinology, Erasmus Medical Centre Sophia, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:1695-700. 2009
    ..It is, however, still unknown whether this reduced insulin sensitivity persists into adulthood...
  8. doi request reprint Influence of preterm birth and birth size on gonadal function in young men
    Gerthe F Kerkhof
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:4243-50. 2009
    ..We hypothesized that alterations concerning gonadal function in young men are not due to preterm birth or being born SGA, but are due to other (environmental) factors...
  9. doi request reprint Does preterm birth influence cardiovascular risk in early adulthood?
    Gerthe F Kerkhof
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Pediatr 161:390-396.e1. 2012
    ..To investigate the effect of preterm birth on risk factors for cardiovascular disease (CVD), independent of birth size...
  10. doi request reprint Health profile of young adults born preterm: negative effects of rapid weight gain in early life
    Gerthe F Kerkhof
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:4498-506. 2012
    ..We aimed to investigate the association of weight gain during different periods, and weight trajectories in early life after preterm birth, with determinants of CVD and DM2 in early adulthood...
  11. doi request reprint Preterm birth does not affect bone mineral density in young adults
    Petra E Breukhoven
    Subdivision of Endocrinology, Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Room number SB 2603, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Eur J Endocrinol 164:133-8. 2011
    ..The objective of our study was to assess the long-term effects of preterm birth on BMD of the total body (BMD(TB)), lumbar spine (BMD(LS)) and bone mineral apparent density of the LS (BMAD(LS))...
  12. doi request reprint Serum insulin-like growth factor-binding protein-2 levels and metabolic and cardiovascular risk factors in young adults and children born small for gestational age
    Sandra W K de Kort
    Erasmus MC Sophia, Room SB 2603, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 95:864-71. 2010
    ..In short SGA children, IGFBP-2 SDS did not correlate with any of the cardiovascular risk factors. Conclusion: In young adults who were born SGA, serum IGFBP-2 levels associate with cardiovascular risk markers...
  13. pmc Early origins of the metabolic syndrome: role of small size at birth, early postnatal weight gain, and adult IGF-I
    Gerthe F Kerkhof
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus Medical Center Sophia Children s Hospital, 3015 GJ Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:2637-43. 2012
    ..The relationship between low birth weight and increased risk for metabolic syndrome (MetS) in later life has been frequently described, but mechanisms underlying this association remain unknown...
  14. doi request reprint Pathways leading to atherosclerosis: a structural equation modeling approach in young adults
    Gerthe F Kerkhof
    Department of Pediatrics, Subdivision of Endocrinology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Hypertension 57:255-60. 2011
    ..We present a model involving several pathways, showing that fat mass has an influence on risk factors for atherosclerosis, already at 21 years of age...
  15. doi request reprint Cardiovascular and metabolic risk profile and acylation-stimulating protein levels in children with Prader-Willi syndrome and effects of growth hormone treatment
    Roderick F A de Lind van Wijngaarden
    Dutch Growth Research Foundation, 3016 AH Rotterdam, The Netherlands
    J Clin Endocrinol Metab 95:1758-66. 2010
    ..Acylation-stimulating protein (ASP) stimulates glucose uptake and triglyceride storage in adipose tissue...
  16. doi request reprint Influence of preterm birth and small birth size on serum anti-Müllerian hormone levels in young adult women
    G F Kerkhof
    Division of Endocrinology, Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Endocrinol 163:937-44. 2010
    ..Recent findings in young men showed no effect of preterm and SGA birth on testis function. We hypothesised that follicle pool size in young adult women is also not affected by preterm and SGA birth...
  17. doi request reprint Glucocorticoid receptor gene haplotypes are not associated with birth anthropometry, blood pressure, glucose and insulin concentrations, and body composition in subjects born small for gestational age
    L Manenschijn
    Subdivision of Endocrinology, Department of Internal Medicine, Erasmus Medical Center and Sophia Children s Hospital, Rotterdam, The Netherlands
    Eur J Endocrinol 163:911-8. 2010
    ....