S W Lamberts

Summary

Affiliation: Erasmus Medisch Centrum
Country: The Netherlands

Publications

  1. ncbi request reprint The somatopause: to treat or not to treat?
    S W Lamberts
    Department of Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands
    Horm Res 53:42-3. 2000
  2. ncbi request reprint The endocrinology of aging
    S W Lamberts
    Department of Medicine, Erasmus University, Rotterdam, Netherlands
    Science 278:419-24. 1997
  3. ncbi request reprint [Vulnerability of scientific research in university medical centers]
    S W J Lamberts
    Erasmus Medisch Centrum, afd Inwendige Geneeskunde, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 146:52-5. 2002
  4. ncbi request reprint Glucocorticoid receptors and Cushing's disease
    S W J Lamberts
    Department of Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Mol Cell Endocrinol 197:69-72. 2002
  5. ncbi request reprint Somatostatin analogs in the diagnosis and treatment of cancer
    Steven W J Lamberts
    Dept Medicine, Erasmus Medical Centre, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Trends Endocrinol Metab 13:451-7. 2002
  6. ncbi request reprint Somatostatin receptor expression in multiple endocrine neoplasia and in von Hippel-Lindau disease
    S W Lamberts
    Department of Medicine, Erasmus University Rotterdam, The Netherlands
    J Intern Med 243:569-71. 1998
  7. ncbi request reprint [Interculturalisation of medical education in the Netherlands]
    S W J Lamberts
    Erasmus Medisch Centrum, afd Inwendige Geneeskunde, Dr Molewaterplein 40, 3015 GD Rotterdam
    Ned Tijdschr Geneeskd 147:789-92. 2003
  8. ncbi request reprint Luteinizing hormone and different genetic variants, as indicators of frailty in healthy elderly men
    A van den Beld
    Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
    J Clin Endocrinol Metab 84:1334-9. 1999
  9. ncbi request reprint Neuroendocrine tumor markers
    S W Lamberts
    Department of Medicine, University Hospital Dijkzigt, Erasmus University, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Front Neuroendocrinol 22:309-39. 2001
  10. ncbi request reprint Dissociation between the effects of somatostatin (SS) and octapeptide SS-analogs on hormone release in a small subgroup of pituitary- and islet cell tumors
    L J Hofland
    Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 82:3011-8. 1997

Collaborators

Detail Information

Publications117 found, 100 shown here

  1. ncbi request reprint The somatopause: to treat or not to treat?
    S W Lamberts
    Department of Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands
    Horm Res 53:42-3. 2000
    ..No definitive answers can presently be given regarding the safety of long-term GH therapy in otherwise healthy individuals during the somatopause...
  2. ncbi request reprint The endocrinology of aging
    S W Lamberts
    Department of Medicine, Erasmus University, Rotterdam, Netherlands
    Science 278:419-24. 1997
    ....
  3. ncbi request reprint [Vulnerability of scientific research in university medical centers]
    S W J Lamberts
    Erasmus Medisch Centrum, afd Inwendige Geneeskunde, Postbus 1738, 3000 DR Rotterdam
    Ned Tijdschr Geneeskd 146:52-5. 2002
    ..Managers wanted a 'top-down' approach and researchers a 'bottom-up' approach...
  4. ncbi request reprint Glucocorticoid receptors and Cushing's disease
    S W J Lamberts
    Department of Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Mol Cell Endocrinol 197:69-72. 2002
    ....
  5. ncbi request reprint Somatostatin analogs in the diagnosis and treatment of cancer
    Steven W J Lamberts
    Dept Medicine, Erasmus Medical Centre, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Trends Endocrinol Metab 13:451-7. 2002
    ..Knowledge about the differential anti-tumor effects of the sst subtypes on tumor cells might have clinical significance after the development of new subtype-specific somatostatin analogs...
  6. ncbi request reprint Somatostatin receptor expression in multiple endocrine neoplasia and in von Hippel-Lindau disease
    S W Lamberts
    Department of Medicine, Erasmus University Rotterdam, The Netherlands
    J Intern Med 243:569-71. 1998
    ..The presence and role of somatostatin receptors on the tumours which occur in multiple endocrine neoplasia and von Hippel-Lindau disease are discussed...
  7. ncbi request reprint [Interculturalisation of medical education in the Netherlands]
    S W J Lamberts
    Erasmus Medisch Centrum, afd Inwendige Geneeskunde, Dr Molewaterplein 40, 3015 GD Rotterdam
    Ned Tijdschr Geneeskd 147:789-92. 2003
    ....
  8. ncbi request reprint Luteinizing hormone and different genetic variants, as indicators of frailty in healthy elderly men
    A van den Beld
    Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
    J Clin Endocrinol Metab 84:1334-9. 1999
    ..A difference in biological response between the two LH forms is suggested, as a difference exists in the relation between LH and fat mass, respectively, and leptin in the heterozygote LH variant subjects vs. the wild-type LH subjects...
  9. ncbi request reprint Neuroendocrine tumor markers
    S W Lamberts
    Department of Medicine, University Hospital Dijkzigt, Erasmus University, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Front Neuroendocrinol 22:309-39. 2001
    ..Other markers, such as chromogranin A, neuron-specific enolase, and alpha-subunit, as well as peptide receptor visualization, are of increasing importance in the diagnosis and follow-up of neuroendocrine and non-neuroendocrine tumors...
  10. ncbi request reprint Dissociation between the effects of somatostatin (SS) and octapeptide SS-analogs on hormone release in a small subgroup of pituitary- and islet cell tumors
    L J Hofland
    Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 82:3011-8. 1997
    ..However, in the majority of NFAs and prolactinomas, DA-agonists were equally or more effective than SS in the suppression of tumoral secretion products...
  11. ncbi request reprint Immunohistochemical detection of somatostatin receptor subtypes sst1 and sst2A in human somatostatin receptor positive tumors
    L J Hofland
    Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
    J Clin Endocrinol Metab 84:775-80. 1999
    ....
  12. ncbi request reprint Insulin and cognitive function in an elderly population. The Rotterdam Study
    R P Stolk
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Diabetes Care 20:792-5. 1997
    ..To examine the association between insulin and cognitive function in the population-based Rotterdam Study...
  13. ncbi request reprint Interferon-alpha-2a is a potent inhibitor of hormone secretion by cultured human pituitary adenomas
    L J Hofland
    Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 84:3336-43. 1999
    ....
  14. ncbi request reprint Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants
    P de Lange
    Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands
    Mol Endocrinol 11:1156-64. 1997
    ..Our findings indicate that different point mutations in the GR can affect separate pathways of gene regulation in a differential fashion, which can explain the various phenotypes observed...
  15. ncbi request reprint Decreased ligand affinity rather than glucocorticoid receptor down-regulation in patients with endogenous Cushing's syndrome
    N A Huizenga
    Department of Internal Medicine III, Dijkzigt University Hospital Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur J Endocrinol 142:472-6. 2000
    ..The mechanisms of action of GCs are mediated by the intracellular glucocorticoid receptor (GR). Over the years, many studies have been performed concerning the regulation of GR expression by GC concentrations...
  16. ncbi request reprint A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo
    N A Huizenga
    Department of Internal Medicine III, Dijkzigt University Hospital, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 83:144-51. 1998
    ..Life-long exposure to the mutated allele may be accompanied by an increased BMI and a lowered BMD in the lumbar spine but does not affect blood pressure...
  17. ncbi request reprint Prognostic value of p53, bcl-2, and c-erbB-2 protein expression in phaeochromocytomas
    R R de Krijger
    Department of Pathology, Erasmus University and University Hospital, Rotterdam, The Netherlands
    J Pathol 188:51-5. 1999
    ..In conclusion, p53, bcl-2, and c-erbB-2 all appear to be involved in the pathogenesis of a proportion of phaeochromocytomas. Immunoreactivity to p53 and bcl-2 proteins may help to predict the clinical behaviour of phaeochromocytomas...
  18. ncbi request reprint Proliferative index in phaeochromocytomas: does it predict the occurrence of metastases?
    E van der Harst
    Department of Surgery, Erasmus University Hospital, Rotterdam, The Netherlands
    J Pathol 191:175-80. 2000
    ..The predictive value of S100 immunostaining, tumour size, and extra-adrenal location of the tumour was also confirmed...
  19. ncbi request reprint Pharmacotherapy or surgery as primary treatment for acromegaly?
    D Ferone
    Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands
    Drugs Aging 17:81-92. 2000
    ..Moreover, a multidisciplinary team of well trained specialists is needed in order to guarantee the most optimal quality of life and life expectancy for patients with acromegaly...
  20. ncbi request reprint Long-term treatment with the dopamine agonist quinagolide of patients with clinically non-functioning pituitary adenoma
    F R Nobels
    Department of Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands
    Eur J Endocrinol 143:615-21. 2000
    ....
  21. ncbi request reprint Natural variants of the beta isoform of the human glucocorticoid receptor do not alter sensitivity to glucocorticoids
    P de Lange
    Department of Internal Medicine III, Erasmus University Hospital, Rotterdam, The Netherlands
    Mol Cell Endocrinol 153:163-8. 1999
    ....
  22. ncbi request reprint Neuropeptides and their receptors in the immune system
    P M van Hagen
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    Ann Med 31:15-22. 1999
    ....
  23. ncbi request reprint Antiprogestins and iatrogenic glucocorticoid resistance
    J W Koper
    Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
    Life Sci 60:617-24. 1997
    ..This may make them more suitable than RU 38486 for application in long-term antiprogestin treatment...
  24. ncbi request reprint Gonadotropin release by clinically nonfunctioning and gonadotroph pituitary adenomas in vivo and in vitro: relation to sex and effects of thyrotropin-releasing hormone, gonadotropin-releasing hormone, and bromocriptine
    D J Kwekkeboom
    Department of Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 68:1128-35. 1989
    ....
  25. ncbi request reprint Immunohistochemical localization of somatostatin receptor sst2A in human rheumatoid synovium
    A M ten Bokum
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    J Rheumatol 26:532-5. 1999
    ..To identify the somatostatin receptor-expressing cells in rheumatoid synovium using a recently developed antiserum directed against the somatostatin receptor subtype 2A (sst2A)...
  26. ncbi request reprint Neuroendocrine aspects of immunolymphoproliferative diseases
    D Ferone
    Department of Internal Medicine, Erasmus University, Rotterdam, The Netherlands
    Ann Oncol 12:S125-30. 2001
    ..These concepts increase the possibility of a wider antitumor treatment with ligands for neuroepeptide receptors than in established 'classic' neuroendocrine tumors...
  27. ncbi request reprint 111In-octreotide scintigraphy in oncology
    E P Krenning
    Department of Nuclear Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands
    Digestion 54:84-7. 1993
    ..abstract truncated at 250 words)..
  28. pmc Somatostatin analogue treatment of neuroendocrine tumours
    W W de Herder
    Department of Internal Medicine III, University Hospital, Rotterdam, Netherlands
    Postgrad Med J 72:403-8. 1996
    ..Long-term therapy with somatostatin analogues of catecholamine-secreting (malignant) paragangliomas and phaeochromocytomas has not shown clinical benefits...
  29. ncbi request reprint The definition of true recurrence of pituitary-dependent Cushing's syndrome after transsphenoidal operation
    S W Lamberts
    Department of Medicine and Clinical Endocrinology, Erasmus University, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 26:707-12. 1987
    ....
  30. ncbi request reprint Measures of bioavailable serum testosterone and estradiol and their relationships with muscle strength, bone density, and body composition in elderly men
    A W van den Beld
    Department of Internal Medicine III, Erasmus University Rotterdam, The Netherlands
    J Clin Endocrinol Metab 85:3276-82. 2000
    ..Non-SHBG-bound E2 seems to be the best parameter of serum bioactive E2 in describing its positive relation with BMD...
  31. ncbi request reprint Control of tumor size and disease activity during cotreatment with octreotide and the growth hormone receptor antagonist pegvisomant in an acromegalic patient
    A J van der Lely
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 86:478-81. 2001
    ..The patient described did benefit from cotreatment with pegvisomant and octreotide, including decreased GH levels, normalization of serum insulin-like growth factor I concentrations, and improvement of visual field defects...
  32. ncbi request reprint Immunohistochemical localization of somatostatin receptor sst2A in sarcoid granulomas
    A M ten Bokum
    Department of Immunology, Erasmus University Rotterdam, The Netherlands
    Eur J Clin Invest 29:630-6. 1999
    ..In this study we used a polyclonal antiserum directed against the sst2A receptor to identify more accurately the sst2A-expressing cells in sarcoidosis and other granulomatous diseases...
  33. ncbi request reprint Somatostatin induces migration of acute myeloid leukemia cells via activation of somatostatin receptor subtype 2
    S P Oomen
    Institute of Hematology, Dr Daniel den Hoed Cancer Center, Erasmus University, Rotterdam, The Netherlands
    Leukemia 15:621-7. 2001
    ....
  34. ncbi request reprint Internalization-defective mutants of somatostatin receptor subtype 2 exert normal signaling functions in hematopoietic cells
    S P Oomen
    Institute of Hematology, Erasmus University Rotterdam, The Netherlands
    FEBS Lett 503:163-7. 2001
    ....
  35. ncbi request reprint The male climacterium: clinical signs and symptoms of a changing endocrine environment
    A W van den Beld
    Department of Internal Medicine III, Erasmus University Hospital, Rotterdam, The Netherlands
    Prostate Suppl 10:2-8. 2000
    ..In conclusion, these findings are in agreement with other studies, which suggest that the maintenance of a good physical functional ability and quality of life is related to serum T, E2, and DHEA(S) concentrations...
  36. ncbi request reprint Functional role of somatostatin receptors in neuroendocrine and immune cells
    L J Hofland
    Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands
    Ann Med 31:23-7. 1999
    ..The recent development of novel SS-R subtype-selective SS analogues will be helpful in unravelling the functional roles of the individual SS-R subtypes in SS-R-expressing human neuroendocrine and immune cells...
  37. ncbi request reprint Weak estrogenic activity of phenol red in the culture medium: its role in the study of the regulation of prolactin release in vitro
    L J Hofland
    Department of Medicine, Erasmus University, Rotterdam, The Netherlands
    Mol Cell Endocrinol 54:43-50. 1987
    ....
  38. ncbi request reprint Differences in secretion characteristics in Cushing's disease with and without radiologically evident pituitary tumors
    S W Lamberts
    Department of Medicine III, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands
    J Endocrinol Invest 3:257-62. 1980
    ..The increase in the size of a pituitary (micro-) adenoma in patients with Cushing's disease is accompanied by a more severe hypercortisolism and an increased responsiveness of the pituitary-adrenal axis to the manipulations mentioned...
  39. ncbi request reprint Somatostatin modulates G-CSF-induced but not interleukin-3-induced proliferative responses in myeloid 32D cells via activation of somatostatin receptor subtype 2
    S P Oomen
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Hematol J 2:322-9. 2001
    ..While 0.1-1 x 10(-9) M of somatostatin, or its synthetic stable analog octreotide, can inhibit G-CSF-induced proliferation of AML cells, little or no effects are seen on GM-CSF- or IL-3-induced responses...
  40. ncbi request reprint Acute effect of pegvisomant on cardiovascular risk markers in healthy men: implications for the pathogenesis of atherosclerosis in GH deficiency
    A F Muller
    Department of Internal Medicine, Erasmus University Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 86:5165-71. 2001
    ..These data suggest that the secondary metabolic changes, e.g. abdominal obesity or inflammatory factors, that develop as a result of long-standing GHD are of primary importance in the pathogenesis of atherosclerosis in patients with GHD...
  41. ncbi request reprint Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance
    J W Koper
    Department of Internal Medicine III, Erasmus University Rotterdam, Dijkzigt University Hospital, The Netherlands
    Hum Genet 99:663-8. 1997
    ..Although relative resistance to glucocorticoids seems to be rather frequent in otherwise healthy persons, it is not usually associated with mutations or polymorphisms in the glucocorticoid receptor gene...
  42. pmc Treatment of patients with metastatic pancreatic and gastrointestinal tumours with the somatostatin analogue Sandostatin: a phase II study including endocrine effects
    J G Klijn
    Division of Endocrine Oncology Biochemistry and Endocrinology, Dr Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Br J Cancer 62:627-30. 1990
    ..However, the overall survival remained disappointing, emphasising the need for better treatment regimens...
  43. ncbi request reprint A risk-benefit assessment of octreotide in the treatment of acromegaly
    A J van der Lely
    Department of Internal Medicine, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands
    Drug Saf 17:317-24. 1997
    ..Desensitisation to the beneficial effects of octreotide therapy is highly unusual. A long-acting formulation of octreotide is being studied, and should be available by the end of 1997...
  44. ncbi request reprint Somatostatin receptor scintigraphy useful in stage I-II Hodgkin's disease: more extended disease identified
    P J Lugtenburg
    Department of Haematology, Erasmus University and University Hospital Rotterdam, Daniel den Hoed Cancer Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Br J Haematol 112:936-44. 2001
    ..Our data would support the validity of SS-R scanning as a powerful imaging technique for the staging of patients with HD...
  45. ncbi request reprint Hereditary glucocorticoid resistance
    S W Lamberts
    Department of Medicine, University Hospital Dijkzigt, Rotterdam, The Netherlands
    Ann Endocrinol (Paris) 62:164-7. 2001
    ....
  46. pmc Feasibility, endocrine and anti-tumour effects of a triple endocrine therapy with tamoxifen, a somatostatin analogue and an antiprolactin in post-menopausal metastatic breast cancer: a randomized study with long-term follow-up
    M Bontenbal
    Division of Endocrine Oncology Department of Medical Oncology, Dr Daniel den Hoed Kliniek, Rotterdam, The Netherlands
    Br J Cancer 77:115-22. 1998
    ..Large phase III trials using depot formulations (to increase the feasibility) of somatostatin analogues are warranted to demonstrate the potential extra beneficial anti-tumour effects of such combination therapy...
  47. ncbi request reprint Chromogranin A: its clinical value as marker of neuroendocrine tumours
    F R Nobels
    University Hospital Dijkzigt, Rotterdam, The Netherlands
    Eur J Clin Invest 28:431-40. 1998
    ..Its role as an important general neuroendocrine marker may be extended in the future by the development of immunoscintigraphy of membrane-bound CgA, allowing in vivo visualization of neuroendocrine neoplasms...
  48. ncbi request reprint Use of human GH in elderly patients with accidental hip fracture
    A J van der Lely
    Erasmus University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur J Endocrinol 143:585-92. 2000
    ..To investigate whether early intervention with recombinant human growth hormone (hGH) after hip fracture improves functional recovery and long-term outcome...
  49. ncbi request reprint Rat prostatic weight regression in reaction to ketoconazole, cyproterone acetate, and RU 23908 as adjuncts to a depot formulation of gonadotropin-releasing hormone analogue
    S W Lamberts
    Department of Medicine, Erasmus University, Rotterdam, The Netherlands
    Cancer Res 48:6063-8. 1988
    ..The addition of RU 23908 did not change the LHRH agonist-induced changes in adrenocortical activity.(ABSTRACT TRUNCATED AT 400 WORDS)..
  50. ncbi request reprint The effect of the long-acting somatostatin analogue SMS 201-995 on ACTH secretion in Nelson's syndrome and Cushing's disease
    S W Lamberts
    Department of Medicine, Erasmus University, Rotterdam, The Netherlands
    Acta Endocrinol (Copenh) 120:760-6. 1989
    ..This effect could be shown best if cortisol replacement was temporarily withheld. SMS 201-995 did not affect plasma ACTH and cortisol levels in three patients with untreated Cushing's disease...
  51. ncbi request reprint Effects of fasting and pegvisomant on the GH-releasing hormone and GH-releasing peptide-6 stimulated growth hormone secretion
    A F Muller
    Department of Internal Medicine, Erasmus University Medical Centre Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 55:461-7. 2001
    ..Pegvisomant is a mutated GH molecule which prevents functional dimerization and subsequent activation of the growth hormone receptor. Pegvisomant and fasting both lead to GH resistance...
  52. ncbi request reprint Systemic ghrelin levels in subjects with growth hormone deficiency are not modified by one year of growth hormone replacement therapy
    J A Janssen
    Department of Internal Medicine, University of Turin, Italy
    Eur J Endocrinol 145:711-6. 2001
    ..Moreover, no data on the feedback of GH on systemic ghrelin concentrations are available. It has recently been suggested that ghrelin may induce obesity...
  53. ncbi request reprint Somatostatin receptor subtype expression in human tumors
    L J Hofland
    Department of Internal Medicine, Erasmus University Medical Centre Rotterdam, The Netherlands
    Ann Oncol 12:S31-6. 2001
    ..Therefore, the characterisation of SSR subtypes in human tumors may have important clinical consequences...
  54. ncbi request reprint RET is expressed but not mutated in extra-adrenal paragangliomas
    R R de Krijger
    Department of Pathology, Erasmus University and University Hospital, Rotterdam, The Netherlands
    J Pathol 191:264-8. 2000
    ..Although paragangliomas exhibit RET protein expression, these data indicate that oncogenic RET proto-oncogene mutations do not appear to be generally important in the formation of sporadic paragangliomas...
  55. ncbi request reprint In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells
    D Ferone
    Department of Internal Medicine III, Erasmus University, Rotterdam, The Netherlands
    Endocrinology 140:373-80. 1999
    ..These data suggest a paracrine/autocrine role of SS and its receptors in the regulation of cell growth in thymic microenvironment...
  56. ncbi request reprint A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction
    N Vaessen
    Department of Epidemiology and Biostatistics, the Center for Biomedical Genetics, Rotterdam, The Netherlands
    Diabetes 50:637-42. 2001
    ..4 (95% CI 1.1-11.3). Our study suggests that a genetically determined exposure to relatively low IGF-I levels is associated with an increased risk for type 2 diabetes and myocardial infarction...
  57. ncbi request reprint [Unused knowledge? A useful result of research from the funded Investigative Medicine program]
    R van der Sande
    Erasmus Medisch Centrum, afd Interne Geneeskunde, Rotterdam
    Ned Tijdschr Geneeskd 147:2390-3. 2003
    ..In almost all cases, the formulation of governance policies concerning the financing and distribution of medical services and interventions required considerably more time...
  58. ncbi request reprint Sporadic endocrine tumours and their relationship to the hereditary endocrine neoplasia syndromes
    J W Koper
    Department of Internal Medicine, Erasmus University Rotterdam, School of Medicine, The Netherlands
    Eur J Clin Invest 30:493-500. 2000
    ..In this review we want to give a brief summary of the present status with regard to some of the questions mentioned above, in relation to the endocrine tumour syndromes caused by the vhl, ret and menin genes...
  59. ncbi request reprint Validation of somatostatin receptor scintigraphy in the localization of neuroendocrine tumors
    S W Lamberts
    Department of Medicine, Erasmus University, Rotterdam, The Netherlands
    Acta Oncol 32:167-70. 1993
    ..This scintigraphic method might help in patient selection for clinical trials with somatostatin analogs in the treatment of neuroendocrine cancers...
  60. ncbi request reprint Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells
    Joost van der Hoek
    Dept of Internal Medicine, Section Endocrinology, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 289:E278-87. 2005
    ..In conclusion, our data support the concept that the sst5 receptor might be a target for new therapeutic agents to treat Cushing's disease...
  61. ncbi request reprint Differential regulation of synthetic glucocorticoids on gene expression levels of glucocorticoid-induced leucine zipper and interleukin-2
    Pauline Smit
    Department of Internal Medicine, Room Ee 585, Erasmus Medical Center, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:2994-3000. 2005
    ....
  62. ncbi request reprint Somatostatin analogs as radiodiagnostic tools
    Wouter W de Herder
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam
    Rev Endocr Metab Disord 6:23-7. 2005
  63. ncbi request reprint The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5
    Leo J Hofland
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Centre, GD Rotterdam, The Netherlands
    Eur J Endocrinol 152:645-54. 2005
    ..We compared the in vitro effects of the sst(2)-preferring SS analogue octreotide (OCT) and the multi-ligand SOM230 on ACTH release by human and mouse corticotroph tumour cells...
  64. ncbi request reprint Novel subtype specific and universal somatostatin analogues: clinical potential and pitfalls
    Joost van der Hoek
    Department of Internal Medicine, Section Endocrinology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Curr Pharm Des 11:1573-92. 2005
    ..Finally, acknowledged side effects and possible pitfalls of the use of SS-analogues are discussed...
  65. ncbi request reprint Cabergoline plus lanreotide for ectopic Cushing's syndrome
    Rosario Pivonello
    N Engl J Med 352:2457-8. 2005
  66. doi request reprint Correlation of in vitro and in vivo somatotropic adenoma responsiveness to somatostatin analogs and dopamine agonists with immunohistochemical evaluation of somatostatin and dopamine receptors and electron microscopy
    Diego Ferone
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:1412-7. 2008
    ..In nine cases, GH and PRL content was further studied by immunoelectron microscopy...
  67. ncbi request reprint Expression of the human glucocorticoid receptor splice variants alpha, beta, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism
    Antje Hagendorf
    Department of Internal Medicine, Section of Endocrinology, Room Ee 585, Erasmus Medical Center, P O B 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:6237-43. 2005
    ..The effects of cortisol are mediated by the alpha-isoform of the glucocorticoid receptor (GR). GR-alpha levels and activity are modulated by alternative splicing of the common pre-mRNA into mRNAs for the GR-beta and GR-P isoforms...
  68. ncbi request reprint The role of somatostatin analogs in Cushing's disease
    Joost van der Hoek
    Department of Internal Medicine, Section Endocrinology, Erasmus MC, 3015 Rotterdam, The Netherlands
    Pituitary 7:257-64. 2004
    ....
  69. ncbi request reprint Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells
    Sandra Blaj Moore
    University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0343, and Erasmus MC, Rotterdam, The Netherlands
    J Med Chem 48:6643-52. 2005
    ....
  70. ncbi request reprint Strategies for the characterization of disorders in cortisol sensitivity
    Henk Russcher
    Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Dr Molewaterplein 40, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:694-701. 2006
    ..The clinical presentation of abnormalities in glucocorticoid (GC) sensitivity is diverse, and therefore it is difficult to diagnose this condition...
  71. ncbi request reprint Glucocorticoid receptor polymorphism affects transrepression but not transactivation
    Erica L T Van Den Akker
    Erasmus Medical Center, Department of Internal Medicine, Room Ee 585, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:2800-3. 2006
    ..Their beneficial effects are thought to be mediated by GC transrepression on gene expression. However, their use is limited by serious adverse effects, presumably mediated by GC transactivation of gene expression...
  72. ncbi request reprint Glucocorticoid resistance syndrome: A diagnostic and therapeutic approach
    Elisabeth F C van Rossum
    University Medical Center, Department of Internal Medicine Room D400, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Best Pract Res Clin Endocrinol Metab 20:611-26. 2006
    ..Diagnosis of generalized GC resistance can be difficult. This review highlights the diagnostic process and therapeutic options for treating patients with this disease...
  73. ncbi request reprint Preclinical and clinical experiences with the role of somatostatin receptors in the treatment of pituitary adenomas
    Joost van der Hoek
    Department of Internal Medicine, Section Endocrinology, Room Ee30b, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Eur J Endocrinol 156:S45-51. 2007
    ..In the present review, the functional role of sst in all types of pituitary adenomas, based on recent preclinical and clinical studies, is being discussed...
  74. ncbi request reprint Characterization of a promoter polymorphism in the glucocorticoid receptor gene and its relationship to three other polymorphisms
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasumus Medical Center, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 61:573-81. 2004
    ..We investigated the exact sequence alteration of a TthIIII polymorphism in the GR gene, whether it is associated with glucocorticoid sensitivity, and its relationship to 3 polymorphisms of the GR gene (N363S, BclI, ER22/23EK)...
  75. ncbi request reprint Crucial role for somatostatin receptor subtype 2 in determining the uptake of [111In-DTPA-D-Phe1]octreotide in somatostatin receptor-positive organs
    Leo J Hofland
    Department of Internal Medicine Room Bd240, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Nucl Med 44:1315-21. 2003
    ....
  76. ncbi request reprint Somatostatin receptors in malignant lymphomas: targets for radiotherapy?
    Virgil A S H Dalm
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nucl Med 45:8-16. 2004
    ..Therefore, we investigated in vitro the characteristics of lymphoma tissues and lymphoid cell lines to evaluate whether lymphomas can be targets for radiotherapy...
  77. ncbi request reprint Somatostatin analog therapy in treatment of gastrointestinal disorders and tumors
    Wouter W de Herder
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Endocrine 20:285-90. 2003
    ..Radiotherapy with octapeptide somatostatin analogs coupled to radionuclides such as indium-111, yttrium-90, and lutetium- 177 is currently being studied in phase I-III trials...
  78. ncbi request reprint Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes
    Diego Ferone
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 283:E1056-66. 2002
    ....
  79. ncbi request reprint The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro
    Leo J Hofland
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:1577-85. 2004
    ..Second, compared with OCT, SOM230 is more potent in inhibiting PRL release by mixed GH/PRL-secreting adenoma and prolactinoma cells...
  80. ncbi request reprint Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells
    Virgil A S H Dalm
    Dept of Internal Medicine, Rm Bd 240, Erasmus MC, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 285:E344-53. 2003
    ....
  81. ncbi request reprint Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells
    Sigrid P M A Oomen
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Exp Hematol 30:116-25. 2002
    ..Despite the broad use of SST and its analogs in clinical practice, the spectrum of activities of SST is incompletely defined. Here, we examined the role of SST and its receptors in hematopoiesis...
  82. ncbi request reprint Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro
    Richard A Feelders
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:230-7. 2003
    ..Despite the regulatory potential of LH and 5-HT4 receptor agonists on cortisol production in our patients, their adrenals seemed to be still sensitive to ACTH, both in vivo and in vitro...
  83. ncbi request reprint Somatostatin and somatostatin analogues: diagnostic and therapeutic uses
    Wouter W de Herder
    Division of Endocrinology, Department of Internal Medicine, University Hospital, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Curr Opin Oncol 14:53-7. 2002
    ..Radiolabeled octapeptide analogues can also be used for radiotherapy of sst 2 - and sst 5 -positive advanced or metastatic neuroendocrine tumors...
  84. ncbi request reprint An insulin-like growth factor-I promoter polymorphism is associated with increased mortality in subjects with myocardial infarction in an elderly Caucasian population
    Mojgan Yazdanpanah
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Cardiol 97:1274-6. 2006
    ..10 to 2.10, p = 0.02). The risk of death increased with the number of variant alleles. Our study suggests that genetically determined low IGF-I activity is an important determinant of mortality in subjects with MI...
  85. ncbi request reprint Polymorphisms of the glucocorticoid receptor gene and major depression
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Biol Psychiatry 59:681-8. 2006
    ..The N363S and BclI polymorphisms have been associated with hypersensitivity to glucocorticoids, whereas the ER22/23EK polymorphism is related to glucocorticoid resistance...
  86. ncbi request reprint Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth
    Peter M van Koetsveld
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:4537-43. 2006
    ..Despite efforts to develop new therapeutic regimens for metastatic ACC, surgery remains the mainstay of treatment. Interferons are known to exert tumor-suppressive effects in several types of human cancer...
  87. ncbi request reprint Dopamine receptor expression and function in corticotroph ectopic tumors
    Rosario Pivonello
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:65-9. 2007
    ..Dopamine receptor (DR) expression and dopamine agonist (DA) effectiveness have never been demonstrated in neuroendocrine tumors associated with ectopic ACTH syndrome (EAS)...
  88. pmc Ethnic differences in internal medicine referrals and diagnosis in the Netherlands
    Loes C Lanting
    Erasmus MC, Department of Public Health, Rotterdam, The Netherlands
    BMC Public Health 8:287. 2008
    ..The aim of this study is to examine ethnic differences in the use of internal medicine outpatient care, specifically to examine ethnic differences in the reason for referral and diagnosis...
  89. ncbi request reprint Prediction of treatment response by HPA-axis and glucocorticoid receptor polymorphisms in major depression
    Jantien P Brouwer
    Department of Endocrinology, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, Netherlands
    Psychoneuroendocrinology 31:1154-63. 2006
    ..We investigated whether treatment response is predicted by hypothalamus-pituitary-adrenal (HPA) axis parameters, or by genetic polymorphisms in the glucocorticoid receptor (GR), that regulates its feedback...
  90. ncbi request reprint Lack of Association of the 11beta-hydroxysteroid dehydrogenase type 1 gene 83,557insA and hexose-6-phosphate dehydrogenase gene R453Q polymorphisms with body composition, adrenal androgen production, blood pressure, glucose metabolism, and dementia
    Pauline Smit
    Department of Internal Medicine, Room Ee530C, Erasmus Medical Center, Dr Molewaterplein 40, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:359-62. 2007
    ....
  91. ncbi request reprint IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes
    Mojgan Yazdanpanah
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 155:751-6. 2006
    ....
  92. ncbi request reprint A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 51:3128-34. 2002
    ..Our data suggest that carriers of the 22/23EK allele are relatively more resistant to the effects of GCs with respect to the sensitivity of the adrenal feedback mechanism than noncarriers, resulting in a better metabolic health profile...
  93. ncbi request reprint Glucocorticoid receptor variant and risk of dementia and white matter lesions
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neurobiol Aging 29:716-23. 2008
    ..A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities...
  94. ncbi request reprint Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene
    Henk Russcher
    Department of Internal Medicine, Erasmus MC, University Medical Center Dr Molewaterplein 40, Rotterdam, The Netherlands
    J Mol Endocrinol 38:91-8. 2007
    ..This indicates that regulation of GR splice variants could partly occur through selective use of the multiple promoters, and that this is another way to sensitize cells and tissues to the different activities of the GR isoforms...
  95. ncbi request reprint Novel insights in dopamine receptor physiology
    Rosario Pivonello
    Departments of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini, 5, 80131 Naples, Italy
    Eur J Endocrinol 156:S13-21. 2007
    ..In addition, the recent findings on the relationship between dopamine receptors and neuroendocrine tumors are summarized...
  96. ncbi request reprint Change in albuminuria is predictive of cardiovascular outcome in normotensive patients with type 2 diabetes and microalbuminuria
    Adrienne A M Zandbergen
    Department of Internal Medicine, Erasmus University Medical Centre, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Diabetes Care 30:3119-21. 2007
  97. ncbi request reprint Glucocorticoid receptor gene and risk of cardiovascular disease
    Erica L T Van Den Akker
    Department of Internal Medicine, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arch Intern Med 168:33-9. 2008
    ..Our aim was to determine the contribution of genetic glucocorticoid receptor variants, with different cortisol sensitivities, to the risk of cardiovascular disease...
  98. ncbi request reprint Association between an IGF-I gene polymorphism and body fatness: differences between generations
    Paul G Voorhoeve
    Department of Pediatric Endocrinology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Eur J Endocrinol 154:379-88. 2006
    ..In this study, we investigated whether this polymorphism is associated with body composition in young healthy subjects in two cohorts of different generations...
  99. ncbi request reprint Relations between body composition, functional and hormonal parameters and quality of life in healthy postmenopausal women
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands Department of Internal Medicine, Erasmus University Medical Center Rotterdam, The Netherlands
    Maturitas 55:82-92. 2006
    ..To investigate whether body composition, functional status and serum hormone levels are associated with quality of life in healthy postmenopausal women...
  100. ncbi request reprint IFN-beta is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro
    Giovanni Vitale
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer Res 66:554-62. 2006
    ..Further studies are required to establish whether IFN-beta has comparable potent tumor growth inhibitory effects in vivo...
  101. ncbi request reprint Dopamine receptor expression and function in corticotroph pituitary tumors
    Rosario Pivonello
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:2452-62. 2004
    ..The effectiveness of cabergoline in normalizing cortisol secretion in 40% of cases supports its therapeutic use in the management of Cushing's disease...