Harmjan Kuipers

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus University MC, Rotterdam, The Netherlands
    J Immunol 171:3645-54. 2003
  2. ncbi request reprint Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Leukoc Biol 76:1028-38. 2004
  3. ncbi request reprint Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Immunol 36:2472-82. 2006
  4. doi request reprint Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs
    Mirjam Kool
    Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
    J Leukoc Biol 90:1177-90. 2011
  5. doi request reprint Inducible costimulator blockade prolongs airway luminal patency in a mouse model of obliterative bronchiolitis
    Alex Kleinjan
    Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Transplantation 86:1436-44. 2008
  6. ncbi request reprint The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Curr Opin Immunol 16:702-8. 2004
  7. ncbi request reprint Modification of dendritic cell function as a tool to prevent and treat allergic asthma
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 23:4577-88. 2005
  8. ncbi request reprint A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma
    Leonie S van Rijt
    Department of Pulmonary and Critical Care Medicine, Erasmus University Medical Center Room Ee22 57a, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Immunol Methods 288:111-21. 2004
  9. pmc GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
    Pierre Yves Mantel
    Swiss Institute of Allergy and Asthma Research Davos SIAF, Davos Platz, Switzerland
    PLoS Biol 5:e329. 2007
  10. ncbi request reprint Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: sustained viral suppression and normalization of T cell subsets
    Wayne B Dyer
    Australian Red Cross Blood Service, Sydney, NSW 2000, Australia
    AIDS Res Hum Retroviruses 18:999-1010. 2002

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus University MC, Rotterdam, The Netherlands
    J Immunol 171:3645-54. 2003
    ..These results suggest that LPS reduces sensitization to inhaled Ag by reducing DC-driven Th2 development, but that IL-12 is not necessary for this effect...
  2. ncbi request reprint Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Leukoc Biol 76:1028-38. 2004
    ..Enhancing IL-12 production in DCs should be seen as a primary prevention strategy for atopic disorders. Enhancing IL-12 production in DCs is less likely to be of benefit in already Th2-sensitized individuals...
  3. ncbi request reprint Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Immunol 36:2472-82. 2006
    ..This study suggests a relatively minor contribution of PD-1 ligands in DC-driven CD4+ T cell activation and provides evidence for reverse signaling by PD-L1 and PD-L2 into DC, resulting in a suppressive DC phenotype...
  4. doi request reprint Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs
    Mirjam Kool
    Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
    J Leukoc Biol 90:1177-90. 2011
    ..Thus, timing of TLR ligation and facilitated antigen uptake dictate the potential of pDCs to present endogenous or exogenous antigen by influencing endosomal traffic and antigen-processing machinery...
  5. doi request reprint Inducible costimulator blockade prolongs airway luminal patency in a mouse model of obliterative bronchiolitis
    Alex Kleinjan
    Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Transplantation 86:1436-44. 2008
    ..We studied the presence and activation status of DCs in transplanted tracheas in a mouse model of OB and studied the effect on graft luminal patency of blocking the costimulatory B7RP-1/inducible costimulator (ICOS) pathway...
  6. ncbi request reprint The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Curr Opin Immunol 16:702-8. 2004
    ..A picture is emerging wherein the balance of pathogenic Th2 cells and regulatory T cells is tuned by dendritic cells not only at the initiation but also at the effector stage of the allergic immune response...
  7. ncbi request reprint Modification of dendritic cell function as a tool to prevent and treat allergic asthma
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 23:4577-88. 2005
    ..In this review, we explore the different possibilities to exploit dendritic cell vaccines in order to prevent the development of (or inhibit established) atopic asthma...
  8. ncbi request reprint A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma
    Leonie S van Rijt
    Department of Pulmonary and Critical Care Medicine, Erasmus University Medical Center Room Ee22 57a, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Immunol Methods 288:111-21. 2004
    ..Flow cytometric determination of the cellular composition of BAL fluid in mouse models of asthma is a rapid and easy method that can replace differential cell counts based on morphology...
  9. pmc GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
    Pierre Yves Mantel
    Swiss Institute of Allergy and Asthma Research Davos SIAF, Davos Platz, Switzerland
    PLoS Biol 5:e329. 2007
    ....
  10. ncbi request reprint Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: sustained viral suppression and normalization of T cell subsets
    Wayne B Dyer
    Australian Red Cross Blood Service, Sydney, NSW 2000, Australia
    AIDS Res Hum Retroviruses 18:999-1010. 2002
    ..This study uniquely demonstrates that dual-PI regimens are superior in achieving these levels of virological control and immune restoration in both chronic and acute infection, compared with single-PI or non-PI regimens...