Harmjan Kuipers

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus University MC, Rotterdam, The Netherlands
    J Immunol 171:3645-54. 2003
  2. ncbi Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Leukoc Biol 76:1028-38. 2004
  3. ncbi Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Immunol 36:2472-82. 2006
  4. ncbi Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs
    Mirjam Kool
    Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
    J Leukoc Biol 90:1177-90. 2011
  5. ncbi Inducible costimulator blockade prolongs airway luminal patency in a mouse model of obliterative bronchiolitis
    Alex Kleinjan
    Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Transplantation 86:1436-44. 2008
  6. ncbi The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Curr Opin Immunol 16:702-8. 2004
  7. ncbi Modification of dendritic cell function as a tool to prevent and treat allergic asthma
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 23:4577-88. 2005
  8. ncbi A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma
    Leonie S van Rijt
    Department of Pulmonary and Critical Care Medicine, Erasmus University Medical Center Room Ee22 57a, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Immunol Methods 288:111-21. 2004
  9. ncbi GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
    Pierre Yves Mantel
    Swiss Institute of Allergy and Asthma Research Davos SIAF, Davos Platz, Switzerland
    PLoS Biol 5:e329. 2007
  10. ncbi Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: sustained viral suppression and normalization of T cell subsets
    Wayne B Dyer
    Australian Red Cross Blood Service, Sydney, NSW 2000, Australia
    AIDS Res Hum Retroviruses 18:999-1010. 2002

Collaborators

Detail Information

Publications10

  1. ncbi Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus University MC, Rotterdam, The Netherlands
    J Immunol 171:3645-54. 2003
    ..These results suggest that LPS reduces sensitization to inhaled Ag by reducing DC-driven Th2 development, but that IL-12 is not necessary for this effect...
  2. ncbi Dendritic cells retrovirally overexpressing IL-12 induce strong Th1 responses to inhaled antigen in the lung but fail to revert established Th2 sensitization
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Leukoc Biol 76:1028-38. 2004
    ..Enhancing IL-12 production in DCs should be seen as a primary prevention strategy for atopic disorders. Enhancing IL-12 production in DCs is less likely to be of benefit in already Th2-sensitized individuals...
  3. ncbi Contribution of the PD-1 ligands/PD-1 signaling pathway to dendritic cell-mediated CD4+ T cell activation
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Immunol 36:2472-82. 2006
    ..This study suggests a relatively minor contribution of PD-1 ligands in DC-driven CD4+ T cell activation and provides evidence for reverse signaling by PD-L1 and PD-L2 into DC, resulting in a suppressive DC phenotype...
  4. ncbi Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs
    Mirjam Kool
    Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
    J Leukoc Biol 90:1177-90. 2011
    ..Thus, timing of TLR ligation and facilitated antigen uptake dictate the potential of pDCs to present endogenous or exogenous antigen by influencing endosomal traffic and antigen-processing machinery...
  5. ncbi Inducible costimulator blockade prolongs airway luminal patency in a mouse model of obliterative bronchiolitis
    Alex Kleinjan
    Department of Pulmonary Medicine, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Transplantation 86:1436-44. 2008
    ..We studied the presence and activation status of DCs in transplanted tracheas in a mouse model of OB and studied the effect on graft luminal patency of blocking the costimulatory B7RP-1/inducible costimulator (ICOS) pathway...
  6. ncbi The interplay of dendritic cells, Th2 cells and regulatory T cells in asthma
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Curr Opin Immunol 16:702-8. 2004
    ..A picture is emerging wherein the balance of pathogenic Th2 cells and regulatory T cells is tuned by dendritic cells not only at the initiation but also at the effector stage of the allergic immune response...
  7. ncbi Modification of dendritic cell function as a tool to prevent and treat allergic asthma
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 23:4577-88. 2005
    ..In this review, we explore the different possibilities to exploit dendritic cell vaccines in order to prevent the development of (or inhibit established) atopic asthma...
  8. ncbi A rapid flow cytometric method for determining the cellular composition of bronchoalveolar lavage fluid cells in mouse models of asthma
    Leonie S van Rijt
    Department of Pulmonary and Critical Care Medicine, Erasmus University Medical Center Room Ee22 57a, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Immunol Methods 288:111-21. 2004
    ..Flow cytometric determination of the cellular composition of BAL fluid in mouse models of asthma is a rapid and easy method that can replace differential cell counts based on morphology...
  9. ncbi GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
    Pierre Yves Mantel
    Swiss Institute of Allergy and Asthma Research Davos SIAF, Davos Platz, Switzerland
    PLoS Biol 5:e329. 2007
    ....
  10. ncbi Correlates of antiviral immune restoration in acute and chronic HIV type 1 infection: sustained viral suppression and normalization of T cell subsets
    Wayne B Dyer
    Australian Red Cross Blood Service, Sydney, NSW 2000, Australia
    AIDS Res Hum Retroviruses 18:999-1010. 2002
    ..This study uniquely demonstrates that dual-PI regimens are superior in achieving these levels of virological control and immune restoration in both chronic and acute infection, compared with single-PI or non-PI regimens...