Ernst J Kuipers

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Diagnostic and therapeutic endoscopy
    E J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3000 CA Rotterdam, The Netherlands
    J Surg Oncol 92:203-9. 2005
  2. pmc Prevalence of autoimmune pancreatitis and other benign disorders in pancreatoduodenectomy for presumed malignancy of the pancreatic head
    M J van Heerde
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Dig Dis Sci 57:2458-65. 2012
  3. doi request reprint Colorectal cancer screening--optimizing current strategies and new directions
    Ernst J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Nat Rev Clin Oncol 10:130-42. 2013
  4. pmc Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management
    Dewkoemar Ramsoekh
    Department of Gastroenterology and Hepatology Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Hered Cancer Clin Pract 7:17. 2009
  5. pmc Update on the endoscopic management of peptic ulcer bleeding
    Ingrid Lisanne Holster
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Gastroenterol Rep 13:525-31. 2011
  6. pmc Preoperative biliary drainage for periampullary tumors causing obstructive jaundice; DRainage vs. (direct) OPeration (DROP-trial)
    Niels A van der Gaag
    Department of Surgery, Academic Medical Center Amsterdam, The Netherlands
    BMC Surg 7:3. 2007
  7. pmc Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial
    Thomas R de Wijkerslooth
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    BMC Gastroenterol 10:47. 2010
  8. ncbi request reprint Bacteria and mucosal inflammation of the gut: lessons from Helicobacter pylori
    Ernst J Kuipers
    Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Helicobacter 10:66-70. 2005
  9. ncbi request reprint Good bugs and bad bugs: indications and therapies for Helicobacter pylori eradication
    Ernst J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Opin Pharmacol 3:480-5. 2003
  10. pmc Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial
    E J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Gut 53:12-20. 2004

Collaborators

Detail Information

Publications207 found, 100 shown here

  1. ncbi request reprint Diagnostic and therapeutic endoscopy
    E J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3000 CA Rotterdam, The Netherlands
    J Surg Oncol 92:203-9. 2005
    ..This review discusses the new developments in flexible endoscopy for diagnosis and therapy of early and advanced and advanced esophageal adenocarcinoma...
  2. pmc Prevalence of autoimmune pancreatitis and other benign disorders in pancreatoduodenectomy for presumed malignancy of the pancreatic head
    M J van Heerde
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Dig Dis Sci 57:2458-65. 2012
    ..We aimed to determine the prevalence of benign disease and AIP in patients who underwent pancreatoduodenectomy (PD) over a 9-year period, and to explore if and how surgery could have been avoided...
  3. doi request reprint Colorectal cancer screening--optimizing current strategies and new directions
    Ernst J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Nat Rev Clin Oncol 10:130-42. 2013
    ..In this Review, we discuss a range of screening modalities and describe the factors to be considered to achieve a truly effective population CRC screening programme...
  4. pmc Cancer risk in MLH1, MSH2 and MSH6 mutation carriers; different risk profiles may influence clinical management
    Dewkoemar Ramsoekh
    Department of Gastroenterology and Hepatology Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Hered Cancer Clin Pract 7:17. 2009
    ..The risk is dependent of the affected mismatch repair gene. The aim of the present study was to calculate the cumulative risk of LS related cancers in proven MLH1, MSH2 and MSH6 mutation carriers...
  5. pmc Update on the endoscopic management of peptic ulcer bleeding
    Ingrid Lisanne Holster
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Gastroenterol Rep 13:525-31. 2011
    ..Helicobacter pylori should be tested for in all patients with peptic ulcer bleeding and eradicated if positive. These recommendations have been captured in a recent international guideline...
  6. pmc Preoperative biliary drainage for periampullary tumors causing obstructive jaundice; DRainage vs. (direct) OPeration (DROP-trial)
    Niels A van der Gaag
    Department of Surgery, Academic Medical Center Amsterdam, The Netherlands
    BMC Surg 7:3. 2007
    ....
  7. pmc Study protocol: population screening for colorectal cancer by colonoscopy or CT colonography: a randomized controlled trial
    Thomas R de Wijkerslooth
    Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands
    BMC Gastroenterol 10:47. 2010
    ....
  8. ncbi request reprint Bacteria and mucosal inflammation of the gut: lessons from Helicobacter pylori
    Ernst J Kuipers
    Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Helicobacter 10:66-70. 2005
    ..pylori serves as an excellent model for the understanding of the processes involved in bacterial colonization and host response including mediation of immunoregulation, and the mechanisms by which this response can lead to disease...
  9. ncbi request reprint Good bugs and bad bugs: indications and therapies for Helicobacter pylori eradication
    Ernst J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Opin Pharmacol 3:480-5. 2003
    ..The expansion of knowledge and the development of new therapeutic modalities are likely to lead to a further implementation of H. pylori-related methods in strategies for the prevention and treatment of upper gastrointestinal disorders...
  10. pmc Cure of Helicobacter pylori infection in patients with reflux oesophagitis treated with long term omeprazole reverses gastritis without exacerbation of reflux disease: results of a randomised controlled trial
    E J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Gut 53:12-20. 2004
    ..This prospective randomised study aimed to investigate whether H pylori eradication can influence gastritis and its sequelae during long term omeprazole therapy for gastro-oesophageal reflux disease (GORD)...
  11. pmc Proton pump inhibitors and gastric neoplasia
    E J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Gut 55:1217-21. 2006
    ..This makes long term PPI treatment a safe therapy for patients with acid peptic disorders. The potential side effects of such therapy are discussed here...
  12. ncbi request reprint In through the out door: serology for atrophic gastritis
    Ernst J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 15:877-9. 2003
    ..g. H. pylori antibodies and pepsinogen I, may balance this issue and provide adequate screening tools, although there is a clear need for further improvement and simplification of serological testing for atrophic gastritis...
  13. doi request reprint Clostridium difficile infection
    Ernst J Kuipers
    Departments of Gastroenterology and Hepatology, and Internal Medicine, Erasmus MC University Medical Center, 3000 CA Rotterdam, Netherlands
    Lancet 371:1486-8. 2008
  14. ncbi request reprint The aetiology and clinical relevance of gastric intestinal metaplasia
    E J Kuipers
    Dig Liver Dis 36:501-4. 2004
  15. ncbi request reprint Helicobacter pylori and nonmalignant diseases
    Ernst J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3000 CA Rotterdam, The Netherlands
    Helicobacter 9:29-34. 2004
    ..In patients using proton pump inhibitors for GERD, H. pylori eradication leads to a resolution of their corpus-predominant pangastritis, without impairing the efficacy of PPI therapy...
  16. ncbi request reprint Helicobacter pylori eradication for the prevention of gastric cancer
    Ernst J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Helicobacter 11:52-7. 2006
    ..pylori treatment in patients with non-atrophic gastritis. Trials with higher number of patients, with longer follow-up periods, and with more careful controlling of cancer type and underlying gastric mucosal conditions are needed...
  17. doi request reprint Safety and tolerability of high-dose intravenous esomeprazole for prevention of peptic ulcer rebleeding
    Ernst J Kuipers
    Department of Gastroenterology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Adv Ther 28:150-9. 2011
    ..gov identifier: NCT00251979). Mortality rates and detailed safety and tolerability results from this study are reported here...
  18. ncbi request reprint Proton pump inhibitors and Helicobacter pylori gastritis: friends or foes?
    Ernst J Kuipers
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Basic Clin Pharmacol Toxicol 99:187-94. 2006
    ..Such considerations prevent the persistent presence of active corpus-predominant gastritis in proton pump inhibitor-treated reflux patients without impairing the clinical efficacy of treatment...
  19. doi request reprint Aneuploidy and overexpression of Ki67 and p53 as markers for neoplastic progression in Barrett's esophagus: a case-control study
    Marjolein Sikkema
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Gastroenterol 104:2673-80. 2009
    ..The aim of this study was to determine the predictive value of p53, Ki67, and aneuploidy as markers of neoplastic progression in BE...
  20. doi request reprint The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis
    Lisette G Capelle
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Gastrointest Endosc 71:1150-8. 2010
    ..AG remains a difficult histopathologic diagnosis with low interobserver agreement, whereas intestinal metaplasia (IM) is associated with high interobserver agreement...
  21. doi request reprint Adherence to gastroprotection during cyclooxygenase 2 inhibitor treatment and the risk of upper gastrointestinal tract events: a population-based study
    Vera E Valkhoff
    Erasmus University Medical Centre, Rotterdam, The Netherlands
    Arthritis Rheum 64:2792-802. 2012
    ..We undertook this study to determine the association between GPA adherence and UGI tract events among patients receiving coxibs...
  22. doi request reprint Yield of routine molecular analyses in colorectal cancer patients ≤70 years to detect underlying Lynch syndrome
    Margot G F Van Lier
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    J Pathol 226:764-74. 2012
    ..Routine use of MSI testing may be considered in CRC patients up to the age of 70 years, with a central role for the pathologist in the selection of patients...
  23. doi request reprint Identification of molecular alterations in gastrointestinal carcinomas and dysplastic hamartomas in Peutz-Jeghers syndrome
    Susanne E Korsse
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    Carcinogenesis 34:1611-9. 2013
    ..Inactivation of transforming growth factor-β/bone morphogenetic protein signalling and complete loss of LKB1 might be involved in dysplastic transformation of gastrointestinal hamartomas specifically. ..
  24. doi request reprint Reasons for participation and nonparticipation in colorectal cancer screening: a randomized trial of colonoscopy and CT colonography
    Thomas R de Wijkerslooth
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Gastroenterol 107:1777-83. 2012
    ..We compared reported reasons for participation and nonparticipation in colorectal cancer (CRC) screening between colonoscopy and computed tomographic (CT) colonography in a randomized controlled trial...
  25. pmc Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma
    Anouk van de Winkel
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    BMC Gastroenterol 11:108. 2011
    ..This study aimed to investigate the expression and genetic variation of PXR in reflux esophagitis (RE), Barrett's esophagus (BE) and esophageal adenocarcinoma...
  26. pmc Iron-responsive regulation of the Helicobacter pylori iron-cofactored superoxide dismutase SodB is mediated by Fur
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Dijkzigt L 4, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Bacteriol 187:3687-92. 2005
    ..In conclusion, H. pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization, including superoxide stress defense...
  27. doi request reprint The use of clinical, histologic, and serologic parameters to predict the intragastric extent of intestinal metaplasia: a recommendation for routine practice
    Annemarie C de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastrointest Endosc 70:18-25. 2009
    ..Patients with extensive IM are at increased cancer risk; however, the intragastric extent of IM is usually unknown at the time of the initial diagnosis...
  28. pmc Iron-responsive repression of urease expression in Helicobacter hepaticus is mediated by the transcriptional regulator Fur
    Clara Belzer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3015 CE Rotterdam, The Netherlands
    Infect Immun 75:745-52. 2007
    ..This represents a novel type of urease regulation in ureolytic bacteria and extends the already diverse regulatory repertoire of the Fur protein...
  29. doi request reprint Serum levels of leptin as marker for patients at high risk of gastric cancer
    Lisette G Capelle
    Department of Gastroenterology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Helicobacter 14:596-604. 2009
    ..Serological screening for gastric cancer (GC) may reduce mortality. However, optimal serum markers for advanced gastric precursor lesions are lacking...
  30. pmc Biomarker-based prediction of inflammatory bowel disease-related colorectal cancer: a case-control study
    Monique M Gerrits
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Cell Oncol (Dordr) 34:107-17. 2011
    ..Screening accuracy may increase by using a biomarker-based surveillance strategy...
  31. doi request reprint Gastric cancer risk in patients with premalignant gastric lesions: a nationwide cohort study in the Netherlands
    Annemarie C de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 134:945-52. 2008
    ..Quantification of gastric cancer risk in patients with premalignant gastric lesions is unclear, however. Consequently, endoscopic surveillance is controversial, especially in Western populations...
  32. doi request reprint Increased suppressor of cytokine signaling-3 expression predicts mucosal relapse in ulcerative colitis
    Yi Li
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, Netherlands
    Inflamm Bowel Dis 19:132-40. 2013
    ....
  33. doi request reprint Increased risk of esophageal squamous cell carcinoma in patients with gastric atrophy: independent of the severity of atrophic changes
    Annemarie C de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 124:2135-8. 2009
    ..Therefore, a causal relationship seems unlikely. Confounding factors, such as smoking, may explain both associations...
  34. ncbi request reprint COX-2 CA-haplotype is a risk factor for the development of esophageal adenocarcinoma
    Leon M G Moons
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Gastroenterol 102:2373-9. 2007
    ..Neoplastic progression of BE towards EAC is associated with increased expression of COX-2. Increased COX-2 expression and enzyme activity is linked to the COX-2 CA haplotype, which consists of two gene polymorphisms in the COX-2 promoter...
  35. ncbi request reprint Quantitative assessment of gastric antrum atrophy shows restitution to normal histology after Helicobacter pylori eradication
    Nicole C T van Grieken
    Department of Gastroenterology, Free University Medical Center, Amsterdam, The Netherlands
    Digestion 69:27-33. 2004
    ..The aims of the present study were to evaluate the applicability of this method for the grading of antral atrophy and to study the effect of Helicobacter pylori eradication on the antral mucosa...
  36. ncbi request reprint The functional status of the Helicobacter pylori sabB adhesin gene as a putative marker for disease outcome
    Ramon de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Helicobacter 9:158-64. 2004
    ..We have evaluated the correlation between the expression status of these four genes and disease outcome of H. pylori infection in a Dutch patient population...
  37. doi request reprint Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett's oesophagus
    Florine Kastelein
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Gut 62:1676-83. 2013
    ..The aim of this study was therefore to evaluate the value of p53 immunohistochemistry for predicting neoplastic progression in patients with BO...
  38. doi request reprint Differences in proximal serrated polyp detection among endoscopists are associated with variability in withdrawal time
    Thomas R de Wijkerslooth
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gastrointest Endosc 77:617-23. 2013
    ..Insufficient detection of proximal serrated polyps (PSP) might explain the occurrence of a proportion of interval carcinomas in colonoscopy surveillance programs...
  39. ncbi request reprint Chromosomal and microsatellite instability of adenocarcinomas and dysplastic lesions (DALM) in ulcerative colitis
    Jolanda M van Dieren
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
    Diagn Mol Pathol 15:216-22. 2006
    ..Further, we found a low percentage of MSI. Thus, DALM/UCCs display profound chromosomal instability, but this is not associated with concurrent MSI...
  40. doi request reprint Myo9B is associated with an increased risk of Barrett's esophagus and esophageal adenocarcinoma
    Vivianda Menke
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Scand J Gastroenterol 47:1422-8. 2012
    ..Polymorphisms in the 3' region of myosin IXB (Myo9B) are associated with chronic inflammatory gastrointestinal disorders like celiac disease and ulcerative colitis, assuming that variation in Myo9B influences the intestinal permeability...
  41. pmc Cost-effectiveness of one versus two sample faecal immunochemical testing for colorectal cancer screening
    S Lucas Goede
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, Rotterdam 3000 CA, The Netherlands
    Gut 62:727-34. 2013
    ..This study aimed to evaluate if two-sample FIT screening is cost-effective compared with one-sample FIT...
  42. doi request reprint Random comparison of repeated faecal immunochemical testing at different intervals for population-based colorectal cancer screening
    Aafke H C van Roon
    Erasmus University Medical Centre, Department of Gastroenterology and Hepatology, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Gut 62:409-15. 2013
    ..However, data on the influence of the length of the screening interval on participation and diagnostic yield are lacking. Repeated FIT screening was therefore performed in a population-based trial comparing various repeat intervals...
  43. ncbi request reprint Burden of colonoscopy compared to non-cathartic CT-colonography in a colorectal cancer screening programme: randomised controlled trial
    Thomas R de Wijkerslooth
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Gut 61:1552-9. 2012
    ..CT-colonography has been suggested to be less burdensome for primary colorectal cancer (CRC) screening than colonoscopy. To compare the expected and perceived burden of both in a randomised trial...
  44. doi request reprint NcoI TNF-β gene polymorphism and TNF expression are associated with an increased risk of developing Barrett's esophagus and esophageal adenocarcinoma
    Vivianda Menke
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Scand J Gastroenterol 47:378-86. 2012
    ..The aim of the study was to determine the impact of TNF gene variation on the RE-BE-EAC cascade...
  45. doi request reprint Nonsteroidal anti-inflammatory drugs and statins have chemopreventative effects in patients with Barrett's esophagus
    Florine Kastelein
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 141:2000-8; quiz e13-4. 2011
    ..We investigated whether NSAID or statin use reduces the risk of neoplastic progression from Barrett's esophagus...
  46. doi request reprint Fecal occult blood testing when colonoscopy capacity is limited
    Janneke A Wilschut
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Natl Cancer Inst 103:1741-51. 2011
    ..Which of these options is most clinically effective and cost-effective has yet to be established...
  47. pmc The nickel-responsive regulator NikR controls activation and repression of gene transcription in Helicobacter pylori
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Infect Immun 73:7252-8. 2005
    ..In conclusion, the NikR protein is able to function both as a repressor and as an activator of gene transcription, depending on the position of the binding site...
  48. doi request reprint A new fully covered stent with antimigration properties for the palliation of malignant dysphagia: a prospective cohort study
    Madeleen J Uitdehaag
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Gastrointest Endosc 71:600-5. 2010
    ..Fully covered stents are designed to resist tissue ingrowth that is often seen with partially covered stents. An issue with fully covered stents is the risk of migration...
  49. doi request reprint Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): a multicenter randomized trial
    Suzanne M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Gastrointest Endosc 71:490-9. 2010
    ..Both gastrojejunostomy (GJJ) and stent placement are commonly used palliative treatments of obstructive symptoms caused by malignant gastric outlet obstruction (GOO)...
  50. doi request reprint Underutilization of microsatellite instability analysis in colorectal cancer patients at high risk for Lynch syndrome
    Margot G F Van Lier
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Scand J Gastroenterol 44:600-4. 2009
    ..The aim of this study was to evaluate whether MSI analysis was performed in colorectal cancer patients at risk for LS according to the revised Bethesda Guidelines...
  51. doi request reprint Migrant communities constitute a possible target population for primary prevention of Helicobacter pylori-related complications in low incidence countries
    Annemarie C de Vries
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Scand J Gastroenterol 43:403-9. 2008
    ..The aim of this study was to determine the prevalence of and risk factors for H. pylori infection and atrophic gastritis in a migrant community in The Netherlands...
  52. ncbi request reprint Ultrasound, computed tomography, or the combination for the detection of supraclavicular lymph nodes in patients with esophageal or gastric cardia cancer: a comparative study
    Evelyn P M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Surg Oncol 96:200-6. 2007
    ..Aim was to compare US, US plus fine-needle aspiration (US-FNA), CT, US + CT, and US-FNA + CT for the detection of these metastases in esophageal or gastric cardia cancer patients...
  53. doi request reprint The incidence of 30-day adverse events after colonoscopy among outpatients in the Netherlands
    Vincent de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Am J Gastroenterol 107:878-84. 2012
    ..It is generally accepted as a safe procedure and major adverse events occur at a low rate. However, few data are available on structured assessment of (minor) post-procedural adverse events...
  54. doi request reprint Functional single-nucleotide polymorphism of epidermal growth factor is associated with the development of Barrett's esophagus and esophageal adenocarcinoma
    Vivianda Menke
    Departments of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Hum Genet 57:26-32. 2012
    ..This indicates that reduced mucosal protection resulting from genetically decreased EGF expression enhances esophageal tumor development...
  55. doi request reprint Transient postprandial ischemia is associated with increased intestinal fatty acid binding protein in patients with chronic gastrointestinal ischemia
    Peter B F Mensink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 21:278-82. 2009
    ....
  56. ncbi request reprint CARD15 mutations in Dutch familial and sporadic inflammatory bowel disease and an overview of European studies
    Klaas van der Linde
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Eur J Gastroenterol Hepatol 19:449-59. 2007
    ..The aim of this study was to evaluate the prevalence of these gene variations in Dutch multiple inflammatory bowel disease-affected families, in sporadic inflammatory bowel disease patients and in healthy controls...
  57. pmc Effect of rising chemotherapy costs on the cost savings of colorectal cancer screening
    Iris Lansdorp-Vogelaar
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Natl Cancer Inst 101:1412-22. 2009
    ..We examined whether colorectal cancer screening would become cost saving with the widespread use of the newer, more expensive chemotherapies...
  58. doi request reprint A randomized comparison of electrocautery incision with Savary bougienage for relief of anastomotic gastroesophageal strictures
    Marjan L Hordijk
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Gastrointest Endosc 70:849-55. 2009
    ..Benign gastroesophageal anastomotic strictures are common and often refractory to treatment. Various endoscopic dilation techniques have been reported, but none of these methods has been proven to be superior...
  59. ncbi request reprint Transcriptional profiling of Helicobacter pylori Fur- and iron-regulated gene expression
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Dijkzigt L 455, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Microbiology 151:533-46. 2005
    ..pylori Fur is a versatile regulator involved in many pathways essential for gastric colonization. These findings further delineate the central role of Fur in regulating the unique capacity of H. pylori to colonize the human stomach...
  60. doi request reprint Predictors of survival in patients with malignant gastric outlet obstruction: a patient-oriented decision approach for palliative treatment
    Suzanne M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Dig Liver Dis 43:548-52. 2011
    ..Our objective was to investigate predictors of survival in patients with malignant GOO and to develop a model that could aid in the decision for either gastrojejunostomy or stentplacement...
  61. ncbi request reprint Palliative therapy
    Marjolein Y V Homs
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Surg Oncol 92:246-56. 2005
    ..For the future, a multimodality approach with stent placement or brachytherapy in combination with chemotherapy may be indicated...
  62. pmc Local immune regulation of mucosal inflammation by tacrolimus
    Jolanda M van Dieren
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Dig Dis Sci 55:2514-9. 2010
    ..Our in vivo studies aimed at evaluating whether local tacrolimus treatment in mice would bring about local immune suppression and to compare colonic and systemic tacrolimus levels after locally and systemically applied tacrolimus...
  63. doi request reprint Risk of malignant progression in patients with Barrett's oesophagus: a Dutch nationwide cohort study
    Pieter J F de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Gut 59:1030-6. 2010
    ..Reported incidence rates of oesophageal adenocarcinoma (OAC) in Barrett's oesophagus (BO) vary widely. As the effectiveness of BO surveillance is crucially dependent on this rate, its clarification is essential...
  64. pmc Acid-responsive gene induction of ammonia-producing enzymes in Helicobacter pylori is mediated via a metal-responsive repressor cascade
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Infect Immun 72:766-73. 2004
    ..5 in wild-type H. pylori. We hypothesize that H. pylori uses a repressor cascade to respond to low pH, with NikR initiating the response directly via the urease operon and indirectly via the members of the Fur regulon...
  65. doi request reprint Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial
    Thomas R de Wijkerslooth
    Department of Gastroenterology and Hepatology, Academic Medical Center, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Gut 61:1426-34. 2012
    ..Cap-assisted colonoscopy (CAC) was compared with CC for adenoma detection. Secondary outcomes were caecal intubation time, caecal intubation rate and the degree of discomfort of colonoscopy...
  66. doi request reprint Are fecal immunochemical test characteristics influenced by sample return time? A population-based colorectal cancer screening trial
    Aafke H C van Roon
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Am J Gastroenterol 107:99-107. 2012
    ..However, hemoglobin (Hb) degradation over time may influence FIT outcome. We therefore evaluated the effect of sample return time on FIT performance characteristics in a population-based CRC screening trial...
  67. doi request reprint Participation and yield of colonoscopy versus non-cathartic CT colonography in population-based screening for colorectal cancer: a randomised controlled trial
    Esther M Stoop
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, Netherlands
    Lancet Oncol 13:55-64. 2012
    ..Screening for colorectal cancer is widely recommended, but the preferred strategy remains unidentified. We aimed to compare participation and diagnostic yield between screening with colonoscopy and with non-cathartic CT colonography...
  68. doi request reprint Absence of ABCG2-mediated mucosal detoxification in patients with active inflammatory bowel disease is due to impeded protein folding
    J Jasper Deuring
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, 3015 CE Rotterdam, The Netherlands
    Biochem J 441:87-93. 2012
    ....
  69. pmc Stent versus gastrojejunostomy for the palliation of gastric outlet obstruction: a systematic review
    Suzanne M Jeurnink
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    BMC Gastroenterol 7:18. 2007
    ..Recently, stent placement has been introduced as an alternative treatment. We reviewed the available literature on stent placement and GJJ for gastric outlet obstruction, with regard to medical effects and costs...
  70. ncbi request reprint Effect of stent size on complications and recurrent dysphagia in patients with esophageal or gastric cardia cancer
    Els M L Verschuur
    Department of Gastroenterology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Gastrointest Endosc 65:592-601. 2007
    ..A major drawback of stents is the occurrence of recurrent dysphagia. Large-diameter stents were introduced for the prevention of migration but may be associated with more complications...
  71. ncbi request reprint CDX2 expression in columnar metaplasia of the remnant esophagus in patients who underwent esophagectomy
    Dorine Bax
    Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Gastroenterol 41:375-9. 2007
    ..A subset of these patients will develop columnar epithelium in the remnant esophagus, which can be of the gastric or intestinal type (Barrett esophagus)...
  72. ncbi request reprint Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells
    Thanyalak Tha-In
    Department of Gastroenterology and Hepatology, Erasmus Medical Center University Medical Center, 3015 CE Rotterdam, The Netherlands
    Blood 110:3253-62. 2007
    ..By influencing the interaction between DCs and NK cells, IVIgs modulate the ability of the innate immunity to trigger T-cell activation, a mechanism that can "cool down" the immune system at times of activation...
  73. ncbi request reprint The Helicobacter pylori plasticity region locus jhp0947-jhp0949 is associated with duodenal ulcer disease and interleukin-12 production in monocyte cells
    Ramon de Jonge
    Department of Gastroenterology and Hepatology, Room L 459, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 41:161-7. 2004
    ..027). Therefore, the jhp0947-jhp0949 locus may be a novel putative H. pylori marker for disease outcome independent of the cag PAI...
  74. pmc NikR mediates nickel-responsive transcriptional repression of the Helicobacter pylori outer membrane proteins FecA3 (HP1400) and FrpB4 (HP1512)
    Florian D Ernst
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Room L 455, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Infect Immun 74:6821-8. 2006
    ..pylori to the gastric lifestyle...
  75. doi request reprint Cost-effectiveness analysis of a quantitative immunochemical test for colorectal cancer screening
    Janneke A Wilschut
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Gastroenterology 141:1648-55.e1. 2011
    ..We aimed to identify the most cost-effective FIT cutoff level for referral to colonoscopy based on data from these trials and allowing for differences in screening ages...
  76. doi request reprint Migration of allosensitizing donor myeloid dendritic cells into recipients after liver transplantation
    Brenda M Bosma
    Department of Gastroenterology and Hepatology, University Medical Center, Rotterdam, The Netherlands
    Liver Transpl 16:12-22. 2010
    ....
  77. doi request reprint Risk of colorectal cancer in patients with Barrett's esophagus: A Dutch population-based study
    Pieter J F de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Am J Gastroenterol 105:77-83. 2010
    ..Population-based studies on the risk of CRC in BE are scarce. The aim of this study was to determine the risk of CRC in a nationwide cohort of patients with BE in the Netherlands with long-term follow-up...
  78. ncbi request reprint Genomic alterations in primary gastric adenocarcinomas correlate with clinicopathological characteristics and survival
    Marjan M Weiss
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    Cell Oncol 26:307-17. 2004
    ..With this recently developed technique chromosomal aberrations can be studied with high resolution and sensitivity...
  79. doi request reprint Liver grafts contain a unique subset of natural killer cells that are transferred into the recipient after liver transplantation
    Viviana Moroso
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Liver Transpl 16:895-908. 2010
    ..The unique properties of the transferred hepatic NK cells may enable them to play a role in regulating the immunological response of the recipient against the graft and therefore contribute to liver tolerogenicity...
  80. pmc Serum markers and intestinal mucosal injury in chronic gastrointestinal ischemia
    Désirée van Noord
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Dig Dis Sci 56:506-12. 2011
    ..Diagnosing chronic gastrointestinal ischemia (CGI) is a challenging problem in clinical practice. Serum markers for CGI would be of great diagnostic value as a non-invasive test method...
  81. ncbi request reprint Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trial
    Marjolein Y V Homs
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands
    Lancet 364:1497-504. 2004
    ..We undertook a randomised trial to compare the outcomes of brachytherapy and stent placement in patients with oesophageal cancer...
  82. pmc Narrow band imaging for the detection of gastric intestinal metaplasia and dysplasia during surveillance endoscopy
    Lisette G Capelle
    Department of Gastroenterology and Hepatology, ErasmusUniversity Medical Center, Room L 462, 3015 CE Rotterdam, The Netherlands
    Dig Dis Sci 55:3442-8. 2010
    ..Conclusions NBI increases the diagnostic yield for detection of advanced premalignant gastric lesions compared to routine WLE...
  83. ncbi request reprint Determination of amplicon boundaries at 20q13.2 in tissue samples of human gastric adenocarcinomas by high-resolution microarray comparative genomic hybridization
    Marjan M Weiss
    Department of Gastroenterology, VU University Medical Centre, Amsterdam, The Netherlands
    J Pathol 200:320-6. 2003
    ..In the present study, an amplicon at 20q13.2 has been narrowed down to 800 kb which is likely to harbour one or more putative oncogenes relevant to gastric carcinogenesis, for which ZNF217 and CYP24 are good candidates...
  84. doi request reprint Labeled versus unlabeled discrete choice experiments in health economics: an application to colorectal cancer screening
    Esther W de Bekker-Grob
    Department of Public Health, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Value Health 13:315-23. 2010
    ..We empirically compared the feasibility, respondents' trading behavior, and convergent validity between a labeled and an unlabeled DCE for colorectal cancer (CRC) screening programs in The Netherlands...
  85. ncbi request reprint New design esophageal stents for the palliation of dysphagia from esophageal or gastric cardia cancer: a randomized trial
    Els M L Verschuur
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Gastroenterol 103:304-12. 2008
    ..New stents have been designed to overcome this unwanted sequela of stent placement. In the present study, we investigated whether results of stent placement could be improved with newer stent designs...
  86. ncbi request reprint Aneuploidy and high expression of p53 and Ki67 is associated with neoplastic progression in Barrett esophagus
    Marjon Kerkhof
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Cancer Biomark 4:1-10. 2008
    ..Accumulation of p53 was seen several years before development of HGD/EAC, and may therefore be an early marker in BE at a stage when dysplasia is not yet detected. A prospective follow-up study is needed to confirm these findings...
  87. doi request reprint Esophageal stents for the palliation of malignant dysphagia and fistula recurrence after esophagectomy
    Nicoline C M Van Heel
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Gastrointest Endosc 72:249-54. 2010
    ..Despite advances in staging methods, surgical techniques, and adjuvant treatment, recurrent cancer after esophagectomy is a major cause of morbidity and mortality...
  88. ncbi request reprint UreA2B2: a second urease system in the gastric pathogen Helicobacter felis
    Raymond G J Pot
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    FEMS Immunol Med Microbiol 50:273-9. 2007
    ..Although the exact function of the UreA2B2 system is still unknown, it is conceivable that UreA2B2 may contribute to pathogenesis of H. felis infection through a yet unknown mechanism...
  89. doi request reprint Risk and epidemiological time trends of gastric cancer in Lynch syndrome carriers in the Netherlands
    Lisette G Capelle
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 138:487-92. 2010
    ..The aim of this study was to evaluate incidence trends and risk of developing gastric cancer among Lynch syndrome mutation carriers in a Western population...
  90. ncbi request reprint Modelling a population with Barrett's oesophagus from oesophageal adenocarcinoma incidence data
    Mark van Blankenstein
    Department of Gastroenterology and Hepatology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Scand J Gastroenterol 42:308-17. 2007
    ..The aim of this study was to create models estimating the BO population fitting each of these three hypotheses, in order to select the most plausible hypothesis and to gain insight into the Danish BO population...
  91. ncbi request reprint The influence of Helicobacter pylori on oesophageal acid exposure in GERD during acid suppressive therapy
    F T Peters
    Department of Gastroenterology and Hepatology, University Hospital, Groningen, The Netherlands
    Aliment Pharmacol Ther 13:921-6. 1999
    ..Helicobacter pylori exaggerates the effect of acid suppressive drugs on intragastric pH. It is unknown whether this is relevant for the treatment of GERD...
  92. ncbi request reprint The role of the Ferric Uptake Regulator (Fur) in regulation of Helicobacter pylori iron uptake
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
    Helicobacter 7:237-44. 2002
    ..Bacterial iron-responsive regulation is often mediated by Ferric Uptake Regulator (Fur) homologs, and in this study we have determined the role of H. pylori Fur in regulation of H. pylori iron uptake...
  93. ncbi request reprint A comparison of 3 types of covered metal stents for the palliation of patients with dysphagia caused by esophagogastric carcinoma: a prospective, randomized study
    P D Siersema
    Departments of Gastroenterology and Hepatology and Epidemiology and Biostatistics, University Hospital Rotterdam-Dijkzigt, Rotterdam, The Netherlands
    Gastrointest Endosc 54:145-53. 2001
    ..Although stent migration is reduced by increasing stent diameter, tumor overgrowth remains an intractable problem that requires a new approach...
  94. ncbi request reprint Colorectal neoplasia in veterans is associated with Barrett's esophagus but not with proton-pump inhibitor or aspirin/NSAID use
    Peter D Siersema
    Departments of Gastroenterology and Hepatology and Public Health, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Gastrointest Endosc 63:581-6. 2006
    ..It has been suggested that Barrett's esophagus (BE) is associated with an increased risk of developing colorectal neoplasia, but this has not been reported consistently...
  95. doi request reprint Sporadic duodenal adenoma and the association with colorectal neoplasia: a case-control study
    Dewkoemar Ramsoekh
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Am J Gastroenterol 103:1505-9. 2008
    ....
  96. ncbi request reprint Molecular evaluation of ablative therapy of Barrett's oesophagus
    Mariska Hage
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Pathol 205:57-64. 2005
    ..Persistent Barrett's oesophagus may still harbour molecular aberrations and must therefore be considered still to be at risk of progression to adenocarcinoma...
  97. pmc NikR mediates nickel-responsive transcriptional induction of urease expression in Helicobacter pylori
    Arnoud H M van Vliet
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
    Infect Immun 70:2846-52. 2002
    ..In conclusion, the H. pylori NikR protein and a 19-bp operator sequence in the ureA promoter are both essential for nickel-responsive induction of urease expression in H. pylori...
  98. ncbi request reprint Risk factors for the development of esophageal adenocarcinoma in Barrett's esophagus
    Pieter J F de Jonge
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Am J Gastroenterol 101:1421-9. 2006
    ..To identify risk factors for esophageal adenocarcinoma (EAC) in patients with Barrett's esophagus (BE)...
  99. pmc Trends in the incidence of adenocarcinoma of the oesophagus and cardia in the Netherlands 1989-2003
    M van Blankenstein
    Department of Gastroenterology and Hepatology, Erasmus MC, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Br J Cancer 96:1767-71. 2007
    ..Proposed underlying factors for the rise in ACO incidence appear to have little effect on AGC incidence. This and the secular decline in smoking among males may have led to the decline in AGC incidence...
  100. ncbi request reprint Colonization with cagA-positive Helicobacter pylori strains in intestinal metaplasia of the esophagus and the esophagogastric junction
    Pernilla Ackermark
    Department of Gastroenterology, St Antonius Hospital, Nieuwegein, The Netherlands
    Am J Gastroenterol 98:1719-24. 2003
    ..pylori virulence factor cagA in it has not been investigated. The aim of our study was to assess the relationship between H. pylori and cagA-positive H. pylori in particular and IM at an endoscopically normal EGJ and Barrett's esophagus...
  101. ncbi request reprint Barrett's adenocarcinomas resemble adenocarcinomas of the gastric cardia in terms of chromosomal copy number changes, but relate to squamous cell carcinomas of the distal oesophagus with respect to the presence of high-level amplifications
    Marjan M Weiss
    Department of Gastroenterology, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    J Pathol 199:157-65. 2003
    ..With respect to Barrett's cancer, the chromosomal aberrations more closely reflect the adenocarcinoma phenotype than the squamous origin of the epithelium...