George G J M Kuiper

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor
    George G J M Kuiper
    Department of Internal Medicine, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Endocrinology 143:1190-8. 2002
  2. ncbi request reprint Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs
    Frank W J S Wassen
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 145:4251-63. 2004
  3. ncbi request reprint Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference
    George G J M Kuiper
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Endocrinology 144:2505-13. 2003
  4. ncbi request reprint Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase
    George G J M Kuiper
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Endocrinology 144:5411-21. 2003
  5. ncbi request reprint Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism
    Edith C H Friesema
    Department of Internal Medicine, Erasmus MC, Room Ee502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Mol Endocrinol 20:2761-72. 2006
  6. ncbi request reprint Biochemical mechanisms of thyroid hormone deiodination
    George G J M Kuiper
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Thyroid 15:787-98. 2005
  7. ncbi request reprint An ascidian homolog of vertebrate iodothyronine deiodinases
    Caroline A Shepherdley
    Department of Internal Medicine, Erasmus Medical Center, 3000 Rotterdam, The Netherlands
    Endocrinology 145:1255-68. 2004
  8. ncbi request reprint Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil
    George G J M Kuiper
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 147:3519-29. 2006
  9. ncbi request reprint Expression of recombinant membrane-bound type I iodothyronine deiodinase in yeast
    George G J M Kuiper
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Mol Endocrinol 34:865-78. 2005
  10. ncbi request reprint A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters
    Robin P Peeters
    Department of Internal Medicine, Rm Ee 502, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 289:E75-81. 2005

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Substitution of cysteine for a conserved alanine residue in the catalytic center of type II iodothyronine deiodinase alters interaction with reducing cofactor
    George G J M Kuiper
    Department of Internal Medicine, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Endocrinology 143:1190-8. 2002
    ....
  2. ncbi request reprint Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs
    Frank W J S Wassen
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 145:4251-63. 2004
    ..The expression of D2 activity in thyroid and skeletal muscle is of particular interest for studies on the importance of this enzyme in (hypothyroid) humans...
  3. ncbi request reprint Substitution of cysteine for selenocysteine in the catalytic center of type III iodothyronine deiodinase reduces catalytic efficiency and alters substrate preference
    George G J M Kuiper
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Endocrinology 144:2505-13. 2003
    ..In conclusion, the SeC residue in the catalytic center of D3 is essential for efficient inner-ring deiodination of T(3) and in particular T(4) at physiological substrate concentrations...
  4. ncbi request reprint Molecular basis for the substrate selectivity of cat type I iodothyronine deiodinase
    George G J M Kuiper
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Endocrinology 144:5411-21. 2003
    ..Our findings suggest great flexibility of the active site in D1 that adapts to its various substrates. The active site of wild-type cat D1 is less flexible than the active site of rat/human D1 and favors sulfated iodothyronines...
  5. ncbi request reprint Thyroid hormone transport by the human monocarboxylate transporter 8 and its rate-limiting role in intracellular metabolism
    Edith C H Friesema
    Department of Internal Medicine, Erasmus MC, Room Ee502, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Mol Endocrinol 20:2761-72. 2006
    ..hMCT8 also facilitated affinity labeling of cotransfected D1 by bromoacetyl-T(3). Our findings indicate that hMCT8 mediates plasma membrane transport of iodothyronines, thus increasing their intracellular availability...
  6. ncbi request reprint Biochemical mechanisms of thyroid hormone deiodination
    George G J M Kuiper
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Thyroid 15:787-98. 2005
    ..These have resulted in the emerging view that the biological activity of thyroid hormone is regulated locally by tissue-specific regulation of the different deiodinases...
  7. ncbi request reprint An ascidian homolog of vertebrate iodothyronine deiodinases
    Caroline A Shepherdley
    Department of Internal Medicine, Erasmus Medical Center, 3000 Rotterdam, The Netherlands
    Endocrinology 145:1255-68. 2004
    ..This raises the hypothesis that, in protochordates, the prohormone T(4) is activated by enzymatic outer-ring deiodination to T(3)...
  8. ncbi request reprint Characterization of recombinant Xenopus laevis type I iodothyronine deiodinase: substitution of a proline residue in the catalytic center by serine (Pro132Ser) restores sensitivity to 6-propyl-2-thiouracil
    George G J M Kuiper
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocrinology 147:3519-29. 2006
    ..These results indicate the existence of a 6-PTU-insensitive D1 enzyme in X. laevis tissues, but its role during tadpole metamorphosis remains to be defined...
  9. ncbi request reprint Expression of recombinant membrane-bound type I iodothyronine deiodinase in yeast
    George G J M Kuiper
    Department of Internal Medicine, Room Ee 502, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Mol Endocrinol 34:865-78. 2005
    ..Overall, our studies indicate that yeast cells provide a useful system for the expression of relatively high levels of D1 protein which could be used for further structure-function analysis...
  10. ncbi request reprint A new polymorphism in the type II deiodinase gene is associated with circulating thyroid hormone parameters
    Robin P Peeters
    Department of Internal Medicine, Rm Ee 502, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 289:E75-81. 2005
    ..We hypothesize that this might be explained by the decline in skeletal muscle size during aging, resulting in a relative decrease in the contribution of D2 to serum T(3) production...
  11. ncbi request reprint Regulation of type III iodothyronine deiodinase expression in human cell lines
    Monique H A Kester
    Department of Internal Medicine, Erasmus Medical Center, Room Ee 502, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Endocrinology 147:5845-54. 2006
    ....
  12. ncbi request reprint Induction of thyroid hormone-degrading deiodinase in cardiac hypertrophy and failure
    Frank W J S Wassen
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Endocrinology 143:2812-5. 2002
    ..The induction of a cardiac TR-degrading deiodinase maybe expected to result in reduced cellular levels of T3 and thereby contribute to a local hypothyroid state in the hypertrophic and, particularly, in the failing ventricle...
  13. ncbi request reprint Polymorphisms in thyroid hormone pathway genes are associated with plasma TSH and iodothyronine levels in healthy subjects
    Robin P Peeters
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, 3000 DR The Netherlands
    J Clin Endocrinol Metab 88:2880-8. 2003
    ..We have analyzed eight SNPs in five thyroid hormone pathway genes and found significant associations of three SNPs in two genes (D1, TSHR) with plasma TSH or iodothyronine levels in a normal population...
  14. ncbi request reprint Deiodinase activity is present in Xenopus laevis during early embryogenesis
    Ghislaine Morvan Dubois
    Department of Regulations, Development, and Molecular Diversity, Museum national d histoire naturelle, 75231 Paris Cedex 05, France
    Endocrinology 147:4941-9. 2006
    ..These findings suggest that thyroid hormone signaling is a key component of early neuronal development in vertebrates...
  15. ncbi request reprint Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation
    Edith C H Friesema
    Department of Internal Medicine, Erasmus MC, Rotterdam, Netherlands
    Lancet 364:1435-7. 2004
    ..We suggest that this novel syndrome of X-linked psychomotor retardation is due to a defect in T3 entry into neurons through MCT8, resulting in impaired T3 action and metabolism...