T Kuiken


Affiliation: Erasmus MC
Country: The Netherlands


  1. Short K, Kroeze E, Fouchier R, Kuiken T. Pathogenesis of influenza-induced acute respiratory distress syndrome. Lancet Infect Dis. 2014;14:57-69 pubmed publisher
    ..This model for influenza-induced ARDS differs from the classic model, which is centred on endothelial damage, and provides a rationale for therapeutic intervention to moderate host response in influenza-induced ARDS. ..
  2. Verhagen J, Höfle U, van Amerongen G, van de Bildt M, Majoor F, Fouchier R, et al. Long-Term Effect of Serial Infections with H13 and H16 Low-Pathogenic Avian Influenza Viruses in Black-Headed Gulls. J Virol. 2015;89:11507-22 pubmed publisher
  3. van den Brand J, Verhagen J, Veldhuis Kroeze E, van de Bildt M, Bodewes R, Herfst S, et al. Wild ducks excrete highly pathogenic avian influenza virus H5N8 (2014-2015) without clinical or pathological evidence of disease. Emerg Microbes Infect. 2018;7:67 pubmed publisher
    ..The implications of the switch in species-specific virus excretion and decreased disease severity may be that the HPAI H5 virus more easily spreads in the wild-waterbird population. ..
  4. van den Brand J, Krone O, Wolf P, van de Bildt M, van Amerongen G, Osterhaus A, et al. Host-specific exposure and fatal neurologic disease in wild raptors from highly pathogenic avian influenza virus H5N1 during the 2006 outbreak in Germany. Vet Res. 2015;46:24 pubmed publisher
  5. Kuiken T, Fouchier R, Rimmelzwaan G, van den Brand J, van Riel D, Osterhaus A. Pigs, poultry, and pandemic influenza: how zoonotic pathogens threaten human health. Adv Exp Med Biol. 2011;719:59-66 pubmed publisher
  6. Short K, Kasper J, van der Aa S, Andeweg A, Zaaraoui Boutahar F, Goeijenbier M, et al. Influenza virus damages the alveolar barrier by disrupting epithelial cell tight junctions. Eur Respir J. 2016;47:954-66 pubmed publisher
    ..Taken together, these data suggest that maintaining epithelial cell integrity is key in reducing pulmonary oedema during IAV infection. ..
  7. van Elk C, van de Bildt M, van Run P, de Jong A, Getu S, Verjans G, et al. Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses. Vet Res. 2016;47:28 pubmed publisher
    ..In conclusion, harbor porpoises may be infected with at least three different herpesviruses, one of which can cause clinically severe neurological disease. ..
  8. Reperant L, Brown I, Haenen O, de Jong M, Osterhaus A, Papa A, et al. Companion Animals as a Source of Viruses for Human Beings and Food Production Animals. J Comp Pathol. 2016;155:S41-53 pubmed publisher
    ..The current list of viruses provides an objective basis for more in-depth analysis of the risk of companion animals as sources of viruses for human and food production animal health. ..
  9. Richard M, Knauf S, Lawrence P, Mather A, Munster V, Müller M, et al. Factors determining human-to-human transmissibility of zoonotic pathogens via contact. Curr Opin Virol. 2017;22:7-12 pubmed publisher
    ..The identification of such factors will lead to a better understanding of the requirements for human-to-human spread of pathogens, as well as improving risk assessment of newly emerging pathogens. ..

More Information


  1. request reprint
    Kuiken T, Kennedy S, Barrett T, van de Bildt M, Borgsteede F, Brew S, et al. The 2000 canine distemper epidemic in Caspian seals (Phoca caspica): pathology and analysis of contributory factors. Vet Pathol. 2006;43:321-38 pubmed
    ..Several infectious and parasitic organisms, including poxvirus, Atopobacter phocae, Eimeria- and Sarcocystis-like organisms, and Halarachne sp. were identified in Caspian seals for the first time...
  2. Kuiken T, Taubenberger J. Pathology of human influenza revisited. Vaccine. 2008;26 Suppl 4:D59-66 pubmed
    ..Further understanding and comparison of the pathology of human and avian influenza virus infections only can be achieved by directed and careful pathological analysis of additional influenza cases...
  3. Kuiken T. Is low pathogenic avian influenza virus virulent for wild waterbirds?. Proc Biol Sci. 2013;280:20130990 pubmed publisher
    ..Based on this correlation, together with the demonstrated LPAIV tropism for the intestinal tract, I hypothesize that LPAIV reduces digestive tract function, and suggest how future studies could be directed to test this hypothesis...
  4. van Riel D, Leijten L, de Graaf M, Siegers J, Short K, Spronken M, et al. Novel avian-origin influenza A (H7N9) virus attaches to epithelium in both upper and lower respiratory tract of humans. Am J Pathol. 2013;183:1137-1143 pubmed publisher
    ..With the caveat that virus attachment is only the first step in the virus replication cycle, these results suggest that the emerging H7N9 virus has the potential both to transmit efficiently among humans and to cause severe pneumonia. ..
  5. Begeman L, Geurtsvankessel C, Finke S, Freuling C, Koopmans M, Muller T, et al. Comparative pathogenesis of rabies in bats and carnivores, and implications for spillover to humans. Lancet Infect Dis. 2018;18:e147-e159 pubmed publisher
  6. Kuiken T, Buijs P, van Run P, van Amerongen G, Koopmans M, van den Hoogen B. Pigeon paramyxovirus type 1 from a fatal human case induces pneumonia in experimentally infected cynomolgus macaques (Macaca fascicularis). Vet Res. 2017;48:80 pubmed publisher
    ..The results of this study demonstrate that PPMV-1 is a primary respiratory pathogen in cynomolgus macaques, and support the conclusion that PPMV-1 may cause fatal respiratory disease in immunocompromised human patients. ..