T Kuiken

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Phocine distemper outbreak, The Netherlands, 2002
    Jolianne M Rijks
    Dutch Wildlife Health Center, Rotterdam, The Netherlands
    Emerg Infect Dis 11:1945-8. 2005
  2. pmc Wild ducks as long-distance vectors of highly pathogenic avian influenza virus (H5N1)
    Juthatip Keawcharoen
    Erasmus Medical Center, Rotterdam, The Netherlands
    Emerg Infect Dis 14:600-7. 2008
  3. pmc Infected or not: are PCR-positive oropharyngeal swabs indicative of low pathogenic influenza A virus infection in the respiratory tract of Mallard Anas platyrhynchos?
    Michelle Wille
    Department of Viroscience, Erasmus Medical Centre, Dr, Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vet Res 45:53. 2014
  4. pmc Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses
    Leslie A Reperant
    Princeton University, Princeton, New Jersey, USA
    Emerg Infect Dis 14:1835-41. 2008
  5. pmc Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-alpha induction
    Debby van Riel
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    PLoS Pathog 7:e1002099. 2011
  6. pmc Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets
    Judith M A van den Brand
    Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    PLoS ONE 7:e42343. 2012
  7. pmc Highly pathogenic avian influenza virus H5N1 infection in a long-distance migrant shorebird under migratory and non-migratory states
    Leslie A Reperant
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 6:e27814. 2011
  8. pmc Is low pathogenic avian influenza virus virulent for wild waterbirds?
    Thijs Kuiken
    Department of Viroscience, Erasmus University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Proc Biol Sci 280:20130990. 2013
  9. pmc Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species
    Taiana Costa
    Departament de Sanitat i Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Vet Res 43:28. 2012
  10. ncbi request reprint Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis)
    T Kuiken
    Institute of Virology, National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Vet Pathol 40:304-10. 2003

Detail Information

Publications82

  1. pmc Phocine distemper outbreak, The Netherlands, 2002
    Jolianne M Rijks
    Dutch Wildlife Health Center, Rotterdam, The Netherlands
    Emerg Infect Dis 11:1945-8. 2005
    ..Stranding pattern varied with age, sex, state of decomposition, wind, and location. Cumulative proportion of deaths (54%) was comparable to that in the first reported epidemic in 1988...
  2. pmc Wild ducks as long-distance vectors of highly pathogenic avian influenza virus (H5N1)
    Juthatip Keawcharoen
    Erasmus Medical Center, Rotterdam, The Netherlands
    Emerg Infect Dis 14:600-7. 2008
    ....
  3. pmc Infected or not: are PCR-positive oropharyngeal swabs indicative of low pathogenic influenza A virus infection in the respiratory tract of Mallard Anas platyrhynchos?
    Michelle Wille
    Department of Viroscience, Erasmus Medical Centre, Dr, Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vet Res 45:53. 2014
    ..None had detectable virus antigen in the respiratory tract, suggesting it was not infected. An alternative explanation is that the oropharynx was contaminated with virus through feeding in surface water or through preening...
  4. pmc Highly pathogenic avian influenza virus (H5N1) infection in red foxes fed infected bird carcasses
    Leslie A Reperant
    Princeton University, Princeton, New Jersey, USA
    Emerg Infect Dis 14:1835-41. 2008
    ..This study demonstrates that red foxes fed bird carcasses infected with HPAI virus (H5N1) can excrete virus while remaining free of severe disease, thereby potentially playing a role in virus dispersal...
  5. pmc Highly pathogenic avian influenza virus H5N1 infects alveolar macrophages without virus production or excessive TNF-alpha induction
    Debby van Riel
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    PLoS Pathog 7:e1002099. 2011
    ..Furthermore, the interaction between HPAIV H5N1 and AM could contribute to the pathogenicity of this virus in humans, due to the relative high percentage of infected cells rather than virus production or an excessive TNF-alpha induction...
  6. pmc Comparison of temporal and spatial dynamics of seasonal H3N2, pandemic H1N1 and highly pathogenic avian influenza H5N1 virus infections in ferrets
    Judith M A van den Brand
    Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    PLoS ONE 7:e42343. 2012
    ..This study shows that seasonal, pandemic, and zoonotic influenza viruses differ strongly in the spatial and temporal dynamics of infection in the respiratory tract and extra-respiratory tissues of ferrets...
  7. pmc Highly pathogenic avian influenza virus H5N1 infection in a long-distance migrant shorebird under migratory and non-migratory states
    Leslie A Reperant
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 6:e27814. 2011
    ..Therefore, assuming no effect of sub-clinical infection on the likelihood of migratory take-off, this may favor the spread of HPAIV H5N1 by migratory birds over long distances...
  8. pmc Is low pathogenic avian influenza virus virulent for wild waterbirds?
    Thijs Kuiken
    Department of Viroscience, Erasmus University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Proc Biol Sci 280:20130990. 2013
    ..Based on this correlation, together with the demonstrated LPAIV tropism for the intestinal tract, I hypothesize that LPAIV reduces digestive tract function, and suggest how future studies could be directed to test this hypothesis...
  9. pmc Distribution patterns of influenza virus receptors and viral attachment patterns in the respiratory and intestinal tracts of seven avian species
    Taiana Costa
    Departament de Sanitat i Anatomia Animals, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Vet Res 43:28. 2012
    ..The differential expression and distribution of α-2,3 and α-2,6 receptors among various avian species might reflect a potentially decisive factor in the emergence of new viral strains...
  10. ncbi request reprint Pathology of human influenza A (H5N1) virus infection in cynomolgus macaques (Macaca fascicularis)
    T Kuiken
    Institute of Virology, National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    Vet Pathol 40:304-10. 2003
    ....
  11. ncbi request reprint Host species barriers to influenza virus infections
    Thijs Kuiken
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:394-7. 2006
    ....
  12. ncbi request reprint The 2000 canine distemper epidemic in Caspian seals (Phoca caspica): pathology and analysis of contributory factors
    T Kuiken
    Department of Virology, Erasmus Medical Center, PO Box 1738, Rotterdam, 3000 DR, The Netherlands
    Vet Pathol 43:321-38. 2006
    ..Several infectious and parasitic organisms, including poxvirus, Atopobacter phocae, Eimeria- and Sarcocystis-like organisms, and Halarachne sp. were identified in Caspian seals for the first time...
  13. ncbi request reprint Avian H5N1 influenza in cats
    Thijs Kuiken
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 306:241. 2004
    ..These results show that domestic cats are at risk of disease or death from H5N1 virus, can be infected by horizontal transmission, and may play a role in the epidemiology of this virus...
  14. pmc Pathology of human influenza revisited
    Thijs Kuiken
    Department of Virology, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 26:D59-66. 2008
    ..Further understanding and comparison of the pathology of human and avian influenza virus infections only can be achieved by directed and careful pathological analysis of additional influenza cases...
  15. pmc Experimental human metapneumovirus infection of cynomolgus macaques (Macaca fascicularis) results in virus replication in ciliated epithelial cells and pneumocytes with associated lesions throughout the respiratory tract
    Thijs Kuiken
    Departments of Virology and Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Pathol 164:1893-900. 2004
    ..This study demonstrates that hMPV is a respiratory pathogen and indicates that viral replication is short-lived, polarized to the apical surface, and occurs primarily in ciliated respiratory epithelial cells...
  16. pmc Marked endotheliotropism of highly pathogenic avian influenza virus H5N1 following intestinal inoculation in cats
    Leslie A Reperant
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey, USA
    J Virol 86:1158-65. 2012
    ..The marked endotheliotropism of the virus following intestinal inoculation indicates that the pathogenesis of systemic influenza virus infection in mammals may differ according to the portal of entry...
  17. ncbi request reprint Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome
    Thijs Kuiken
    Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR, Rotterdam, Netherlands
    Lancet 362:263-70. 2003
    ..We did clinical and experimental studies to assess the role of this virus in the cause of SARS...
  18. ncbi request reprint Comparative pathology of select agent influenza a virus infections
    T Kuiken
    Erasmus MC, Department of Virology, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Vet Pathol 47:893-914. 2010
    ..Such animal models may be applied for the development of more effective antiviral drugs and vaccines to protect humans from the threat of these virus infections...
  19. ncbi request reprint Emerging viral infections in a rapidly changing world
    Thijs Kuiken
    Department of Virology, Erasmus Medical Center, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Curr Opin Biotechnol 14:641-6. 2003
    ..Addressing these factors might help to decrease the rate of emergence of infectious diseases and allow the transition to a more sustainable society...
  20. ncbi request reprint Preclinical evaluation of a modified vaccinia virus Ankara (MVA)-based vaccine against influenza A/H5N1 viruses
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Vaccine 27:6296-9. 2009
    ..Therefore MVA-HA-VN/04 is a promising vaccine candidate for the induction of protective immunity against highly pathogenic avian influenza A/H5N1 viruses...
  21. pmc A single immunization with CoVaccine HT-adjuvanted H5N1 influenza virus vaccine induces protective cellular and humoral immune responses in ferrets
    R Bodewes
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, PO Box 2040, 3000 CA Rotterdam, Netherlands
    J Virol 84:7943-52. 2010
    ..1 of H5N1 influenza viruses. Thus, the use of the novel adjuvant CoVaccine HT with cell culture-derived inactivated influenza A/H5N1 virus antigen is a promising and dose-sparing vaccine approach warranting further clinical evaluation...
  22. pmc Vaccination against seasonal influenza A/H3N2 virus reduces the induction of heterosubtypic immunity against influenza A/H5N1 virus infection in ferrets
    R Bodewes
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, P O Box 2040, 3000 CA Rotterdam, Netherlands
    J Virol 85:2695-702. 2011
    ..The implications of these findings are discussed in the context of vaccination strategies and vaccine development aiming at the induction of immunity to pandemic influenza...
  23. doi request reprint Quantitative analysis of the 2002 phocine distemper epidemic in the Netherlands
    J M Rijks
    Department of Virology, Erasmus Medical Centre, Postbus 2040, 3000 CA Rotterdam, The Netherlands
    Vet Pathol 45:516-30. 2008
    ..These results illustrate how quantitative analysis of pathology data from such epidemics can improve understanding of the causative disease...
  24. doi request reprint Recombinant modified vaccinia virus Ankara expressing the hemagglutinin gene confers protection against homologous and heterologous H5N1 influenza virus infections in macaques
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 199:405-13. 2009
    ....
  25. ncbi request reprint Public health. Pathogen surveillance in animals
    T Kuiken
    Department of Virology, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    Science 309:1680-1. 2005
  26. doi request reprint Pathology of experimental SARS coronavirus infection in cats and ferrets
    J M A van den Brand
    Department of Virology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vet Pathol 45:551-62. 2008
    ....
  27. ncbi request reprint Pathology and virus distribution in chickens naturally infected with highly pathogenic avian influenza A virus (H7N7) During the 2003 outbreak in The Netherlands
    D van Riel
    Erasmus MC, Department of Virology, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Vet Pathol 46:971-6. 2009
    ..This might explain, at least partly, the tropism of the virus and the associated severity of lesions in this tissue...
  28. ncbi request reprint H5N1 Virus Attachment to Lower Respiratory Tract
    Debby van Riel
    Department of Virology, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    Science 312:399. 2006
    ..These findings may explain, at least in part, the localization and severity of H5N1 viral pneumonia in humans. They also identify the cat and the ferret as suitable experimental animals based on this criterion...
  29. doi request reprint Pandemic 2009 H1N1 influenza virus causes diffuse alveolar damage in cynomolgus macaques
    S Herfst
    Department of Virology, Erasmus Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Vet Pathol 47:1040-7. 2010
    ..Its higher pathogenicity compared with a seasonal H1N1 virus may be explained in part by higher replication in the lower respiratory tract...
  30. ncbi request reprint Neurological signs in juvenile harbour seals (Phoca vitulina) with fatal phocine distemper
    J D W Philippa
    Department of Virology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Vet Rec 164:327-31. 2009
    ..When first examined, 11 of the pups had a positive serum IgG titre, and four had a positive serum IgM titre. High levels of PDV-specific serum IgG antibodies were not correlated with an absence of clinical signs or longer survival...
  31. pmc The aetiology of SARS: Koch's postulates fulfilled
    A D M E Osterhaus
    Institute of Virology, Erasmus University Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Philos Trans R Soc Lond B Biol Sci 359:1081-2. 2004
    ....
  32. pmc Pathogenesis of influenza A (H5N1) virus infection in a primate model
    G F Rimmelzwaan
    Institute of Virology, National Influenza Center, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Virol 75:6687-91. 2001
    ..Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus...
  33. ncbi request reprint A newly discovered human pneumovirus isolated from young children with respiratory tract disease
    B G van den Hoogen
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Med 7:719-24. 2001
    ..Serological studies showed that by the age of five years, virtually all children in the Netherlands have been exposed to human metapneumovirus and that the virus has been circulating in humans for at least 50 years...
  34. doi request reprint Identification and characterization of a novel adenovirus in the cloacal bursa of gulls
    R Bodewes
    Department of Viroscience, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Virology 440:84-8. 2013
    ..The present study demonstrates that birds of the Laridae family are infected by family-specific adenoviruses that differ from known adenoviruses in other bird species...
  35. doi request reprint Modification of the ferret model for pneumonia from seasonal human influenza A virus infection
    J M A van den Brand
    Department of Virology, Erasmus Medical Centre, Rotterdam, Netherlands
    Vet Pathol 49:562-8. 2012
    ..In conclusion, the above H1N1 and H3N2 strains cause severe pneumonia in ferrets by use of the modified experimental procedures and provide a good model for pneumonia caused by seasonal influenza A virus infection in humans...
  36. ncbi request reprint Confirmation and phylogenetic analysis of rabbit hemorrhagic disease virus in free-living rabbits from the Netherlands
    M W G van de Bildt
    Dutch Wildlife Health Centre, Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Wildl Dis 42:808-12. 2006
    ....
  37. ncbi request reprint Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques
    K J Stittelaar
    Institute of Virology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
    Vaccine 19:3700-9. 2001
    ..These data suggest that MVA can safely be used as a basis for recombinant human vaccines, and that it is also safe for use in immunocompromised individuals...
  38. ncbi request reprint A primate model to study the pathogenesis of influenza A (H5N1) virus infection
    G F Rimmelzwaan
    Institute of Virology, National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Avian Dis 47:931-3. 2003
    ..The data indicate that ARDS and multiple organ dysfunction syndrome (MODS), observed in both humans and monkeys infected with this virus, are caused by diffuse alveolar damage from virus replication in the lungs alone...
  39. ncbi request reprint Primary influenza A virus infection induces cross-protective immunity against a lethal infection with a heterosubtypic virus strain in mice
    J H C M Kreijtz
    Department of Virology, Erasmus Medical Centre, P O Box 1738, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Vaccine 25:612-20. 2007
    ..The implications of these observations are discussed in the light of the current pandemic threat and development of vaccines that aim at the induction of virus-specific CTL...
  40. ncbi request reprint Virology: SARS virus infection of cats and ferrets
    Byron E E Martina
    Institute of Virology, Erasmus Medical Centre, 3015 GE Rotterdam, The Netherlands
    Nature 425:915. 2003
  41. doi request reprint Pathogenesis of influenza virus infections: the good, the bad and the ugly
    T Kuiken
    Erasmus Medical Center, Department of Virology, Rotterdam, The Netherlands
    Curr Opin Virol 2:276-86. 2012
    ..By interdisciplinary efforts to better understand the intricate interaction between virus, tissue, and immune response, we may be able to find new ways to improve the outcome of influenza virus infections...
  42. ncbi request reprint The molecular basis of the pathogenicity of the Dutch highly pathogenic human influenza A H7N7 viruses
    Vincent J Munster
    Department of Virology and National Influenza Center, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 196:258-65. 2007
    ..We conclude that the influenza virus HA and PB2 genes should be the prime targets for molecular surveillance during outbreaks of zoonotic HPAI viruses...
  43. ncbi request reprint The pathology and pathogenesis of experimental severe acute respiratory syndrome and influenza in animal models
    J M A van den Brand
    Department of Viroscience, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Comp Pathol 151:83-112. 2014
    ..The design of appropriate animal models requires an accurate pathological description of human cases, as well as a good understanding of the effect of experimental variables on disease outcome. ..
  44. ncbi request reprint Obliterative endophlebitis in mute swans (Cygnus olor) caused by Trichobilharzia sp. (Digenea: Schistosomatidae) infection
    G H van Bolhuis
    Dutch Wildlife Health Center, Department of Virology, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Vet Pathol 41:658-65. 2004
    ..The vascular lesions associated with Trichobilharzia sp. infection may have contributed to the emaciation and death of those mute swans by obstruction of venous return in the intestinal and portal veins...
  45. doi request reprint Heterozygosity and lungworm burden in harbour seals (Phoca vitulina)
    J M Rijks
    Department of Virology, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Heredity (Edinb) 100:587-93. 2008
    ..Taken as a whole, our results support the notion that homozygosity increases susceptibility to parasitic infection and suggest that parasites can be effective in removing inbred individuals from the population...
  46. ncbi request reprint Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses
    Ron Am Fouchier
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Opin Infect Dis 18:141-6. 2005
    ..Here we review the recent literature on these respiratory viruses...
  47. ncbi request reprint Pathogenesis and transmission of swine-origin 2009 A(H1N1) influenza virus in ferrets
    Vincent J Munster
    National Influenza Center and Department of Virology, Erasmus Medical Center, 3015GE Rotterdam, The Netherlands
    Science 325:481-3. 2009
    ..These data suggest that the 2009 A(H1N1) influenza virus has the ability to persist in the human population, potentially with more severe clinical consequences...
  48. ncbi request reprint Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques
    Bart L Haagmans
    Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR, Rotterdam, Netherlands
    Nat Med 10:290-3. 2004
    ..Postexposure treatment with pegylated IFN-alpha yielded intermediate results. We therefore suggest that pegylated IFN-alpha protects type 1 pneumocytes from SCV infection, and should be considered a candidate drug for SARS therapy...
  49. pmc Exacerbated innate host response to SARS-CoV in aged non-human primates
    Saskia L Smits
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Pathog 6:e1000756. 2010
    ..Thus, ALI in SARS-CoV-infected aged macaques developed as a result of an exacerbated innate host response. The anti-inflammatory action of type I IFN reveals a potential intervention strategy for virus-induced ALI...
  50. pmc Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome
    Ron A M Fouchier
    Department of Virology and National Influenza Center, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 101:1356-61. 2004
    ..Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans...
  51. ncbi request reprint Aetiology: Koch's postulates fulfilled for SARS virus
    Ron A M Fouchier
    Department of Virology, Erasmus Medical Centre, 3015 GE Rotterdam, The Netherlands
    Nature 423:240. 2003
  52. ncbi request reprint Recombinant modified vaccinia virus Ankara-based vaccine induces protective immunity in mice against infection with influenza virus H5N1
    Joost H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Infect Dis 195:1598-606. 2007
    ..Our data suggest that recombinant MVA expressing the HA of influenza virus A/Vietnam/1194/04 is a promising alternative vaccine candidate that could be used for the induction of protective immunity against various H5N1 influenza strains...
  53. pmc Modified vaccinia virus Ankara protects macaques against respiratory challenge with monkeypox virus
    Koert J Stittelaar
    Department of Virology, Erasmus MC, Building Hoboken, Room Ee 17 26, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Virol 79:7845-51. 2005
    ..The MVA-based smallpox vaccine protected macaques against a lethal respiratory challenge with monkeypox virus and is therefore an important candidate for the protection of humans against smallpox...
  54. ncbi request reprint Attachment of infectious influenza A viruses of various subtypes to live mammalian and avian cells as measured by flow cytometry
    Guus F Rimmelzwaan
    Department of Virology, Postgraduate School Molecular Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Virus Res 129:175-81. 2007
    ..Virus attachment was not always predictive for efficient infection of the cells...
  55. ncbi request reprint Measles vaccination of macaques by dry powder inhalation
    Rik L De Swart
    Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Rotterdam, The Netherlands
    Vaccine 25:1183-90. 2007
    ..These studies provide proof of principle that dry powder inhalation is a possible route for measles vaccination, but suggest that either the vaccine formulation or the method of delivery need to be improved for a better immune response...
  56. pmc Human and avian influenza viruses target different cells in the lower respiratory tract of humans and other mammals
    Debby van Riel
    Department of Virology, Erasmus MC, P O Box 2040, 3015 CA, Rotterdam, The Netherlands
    Am J Pathol 171:1215-23. 2007
    ..The PVA in human respiratory tract most closely mirrored that in ferrets and pigs for human influenza viruses and that in ferrets, pigs, and cats for avian influenza viruses...
  57. ncbi request reprint Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection
    Rik L De Swart
    Department of Virology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Vaccine 25:8518-28. 2007
    ..This study indicates that formalin-inactivated hMPV vaccines have the same propensity to predispose for immune-mediated disease as inactivated RSV and MV vaccines...
  58. ncbi request reprint Aerosol measles vaccination in macaques: preclinical studies of immune responses and safety
    Rik L De Swart
    Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Vaccine 24:6424-36. 2006
    ..No evidence for a safety hazard associated with the route of vaccination was detected. The results of this study support further clinical evaluation of aerosol vaccination for measles...
  59. ncbi request reprint Avian influenza viruses in mammals
    L A Reperant
    Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544, USA
    Rev Sci Tech 28:137-59. 2009
    ..Until now, highly pathogenic avian influenza viruses H5N1 have not acquired this ability, but there are concerns that they may adapt to mammalian species and, thus, could spark an influenza pandemic in humans...
  60. ncbi request reprint Escherichia coli septicemia associated with lack of maternally acquired immunity in a bottlenose dolphin calf
    C E Van Elk
    Department of Virology, Erasmus Medical Center, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Vet Pathol 44:88-92. 2007
    ..The observed failure to nurse may have resulted from brain injury due to perinatal asphyxia. Evidence for perinatal asphyxia was the diffuse presence of a moderate amount of meconium in the lungs...
  61. ncbi request reprint Fatal enterocolitis in harbour seals (Phoca vitulina) caused by infection with Eimeria phocae
    G H van Bolhuis
    Dutch Wildlife Health Centre, Department of Virology, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Vet Rec 160:297-300. 2007
    ..A retrospective microscopical examination of intestinal tissues from 113 harbour seals that had died between 1999 and 2004 revealed one seal that was positive for E phocae...
  62. pmc Immunization of macaques with formalin-inactivated respiratory syncytial virus (RSV) induces interleukin-13-associated hypersensitivity to subsequent RSV infection
    Rik L De Swart
    Institute of Virology, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    J Virol 76:11561-9. 2002
    ..We hypothesize that an IL-13-associated asthma-like mechanism resulted in airway hyperreactivity in these animals. This nonhuman primate model will be an important tool to assess the safety of nonreplicating candidate RSV vaccines...
  63. ncbi request reprint In vitro and in vivo replication of seal gammaherpesviruses in cells of multiple species
    Byron E Martina
    Erasmus Medical Centre, Institute of Virology, P O Box 1738, 3000 DR Rotterdam, Netherlands
    Microbes Infect 9:40-6. 2007
    ..The development of myoepitheliomas and spleen hyperplasia upon cyclosporin A treatment in some of the PhHV-2-infected animals warrants further investigation of the oncogenic and zoonotic potential of this virus...
  64. ncbi request reprint Highly pathogenic avian influenza (H7N7): vaccination of zoo birds and transmission to non-poultry species
    Joost D W Philippa
    Institute of Virology, Erasmus, MC, Dr Molenwaterplein 50, Rotterdam, The Netherlands
    Vaccine 23:5743-50. 2005
    ....
  65. ncbi request reprint Feline friend or potential foe?
    Thijs Kuiken
    Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Nature 440:741-2. 2006
  66. doi request reprint Severity of pneumonia due to new H1N1 influenza virus in ferrets is intermediate between that due to seasonal H1N1 virus and highly pathogenic avian influenza H5N1 virus
    Judith M A van den Brand
    Department of Virology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Infect Dis 201:993-9. 2010
    ..Three influenza pandemics of the previous century caused variable mortality, which largely depended on the development of severe pneumonia. However, the ability of the new H1N1 virus to cause pneumonia is poorly understood...
  67. pmc Virulence-associated substitution D222G in the hemagglutinin of 2009 pandemic influenza A(H1N1) virus affects receptor binding
    Salin Chutinimitkul
    Department of Virology, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands
    J Virol 84:11802-13. 2010
    ..Altered receptor specificity of the virus with D222G thus affected interaction with cells of the human lower respiratory tract, possibly explaining the observed association with enhanced disease in humans...
  68. doi request reprint Evaluation of a modified vaccinia virus Ankara (MVA)-based candidate pandemic influenza A/H1N1 vaccine in the ferret model
    Joost H C M Kreijtz
    Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Gen Virol 91:2745-52. 2010
    ..In contrast, two immunizations induced robust antibody responses and protected ferrets from developing severe disease, confirming that MVA is an attractive influenza vaccine production platform...
  69. ncbi request reprint Antibodies to selected pathogens in free-ranging terrestrial carnivores and marine mammals in Canada
    J D W Philippa
    Institute of Virology, Erasmus University, Rotterdam, The Netherlands
    Vet Rec 155:135-40. 2004
    ....
  70. pmc Influenza A virus (H5N1) infection in cats causes systemic disease with potential novel routes of virus spread within and between hosts
    Guus F Rimmelzwaan
    Department of Virology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Am J Pathol 168:176-83; quiz 364. 2006
    ..This study in cats demonstrates that H5N1 virus infection causes systemic disease and spreads by potentially novel routes within and between mammalian hosts...
  71. pmc In vitro assessment of attachment pattern and replication efficiency of H5N1 influenza A viruses with altered receptor specificity
    Salin Chutinimitkul
    Department of Virology and National Influenza Center, Erasmus MC, P O Box 2040, 3000CA Rotterdam, Netherlands
    J Virol 84:6825-33. 2010
    ....
  72. pmc Seasonal and pandemic human influenza viruses attach better to human upper respiratory tract epithelium than avian influenza viruses
    Debby van Riel
    Erasmus Medical Center, Department of Virology, CA Rotterdam, The Netherlands
    Am J Pathol 176:1614-8. 2010
    ..These results suggest that the ability of an influenza virus to attach to human upper respiratory tract is a critical factor for efficient transmission in the human population...
  73. ncbi request reprint Serologic survey for selected viral pathogens in free-ranging endangered European mink (Mustela lutreola) and other mustelids from south-western France
    Joost Philippa
    Department of Virology, Erasmus MC, 3000 CA, Rotterdam, The Netherlands
    J Wildl Dis 44:791-801. 2008
    ..The high antibody prevalence to potentially lethal CDV suggests that this pathogen could have significant effects on the free-ranging populations and has implications for the conservation efforts for the endangered European mink...
  74. ncbi request reprint Global task force for influenza
    Ron Fouchier
    National Influenza Centre and Department of Virology, Erasmus Medical Centre Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Nature 435:419-20. 2005
  75. doi request reprint Identification and characterization of deer astroviruses
    Saskia L Smits
    ViroClinics BioSciences BV, Erasmus Medical Center, CA Rotterdam, The Netherlands
    J Gen Virol 91:2719-22. 2010
    ..Phylogenetic analyses on amplified sequences showed that these viruses were most closely related to each other, were a novel species in the genus Mamastrovirus and may represent two different serotypes...
  76. pmc Molecular determinants of adaptation of highly pathogenic avian influenza H7N7 viruses to efficient replication in the human host
    Emmie de Wit
    National Influenza Center and Department of Virology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Virol 84:1597-606. 2010
    ....
  77. ncbi request reprint Another phocine distemper outbreak in Europe
    Trine Jensen
    Seal Rehabilitation and Research Center, Hoofdstraat 94a, NL 9968 AG Pieterburen, Netherlands
    Science 297:209. 2002
  78. ncbi request reprint Immunogenicity and efficacy of recombinant subunit vaccines against phocid herpesvirus type 1
    Byron E E Martina
    Seal Rehabilitation and Research Centre, Pieterburen, 9968 AG, Pieterburen, The Netherlands
    Vaccine 21:2433-40. 2003
    ....
  79. ncbi request reprint Human monoclonal antibody as prophylaxis for SARS coronavirus infection in ferrets
    Jan Ter Meulen
    Crucell Holland BV, Leiden, Netherlands
    Lancet 363:2139-41. 2004
    ..The data generated in this animal model show that administration of a human monoclonal antibody might offer a feasible and effective prophylaxis for the control of human SARS coronavirus infection...
  80. pmc Avian influenza H5N1 in tigers and leopards
    Juthatip Keawcharoen
    Chulalongkorn University, Bangkok, Thailand
    Emerg Infect Dis 10:2189-91. 2004
    ..This finding extends the host range of influenza virus and has implications for influenza virus epidemiology and wildlife conservation...
  81. pmc Distemper outbreak and its effect on African wild dog conservation
    Marco W G van de Bildt
    Seal Rehabilitation and Research Centre, Pieterburen, The Netherlands
    Emerg Infect Dis 8:211-3. 2002
    ..This report emphasizes the importance of adequate protection against infectious diseases for the successful outcome of captive breeding programs of endangered species...