R Krams

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity
    Rob Krams
    Cardiology, Erasmus Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Eur Heart J 26:2200-5. 2005
  2. ncbi request reprint Effect of vessel curvature on Doppler derived velocity profiles and fluid flow
    R Krams
    Department of Biomedical Engineering, Erasmus MC, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Ultrasound Med Biol 31:663-71. 2005
  3. doi request reprint Predicting patient-specific expansion of abdominal aortic aneurysms
    F Helderman
    Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands
    Eur J Vasc Endovasc Surg 40:47-53. 2010
  4. ncbi request reprint Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system
    R Krams
    Laboratory Hemodynamics, Thoraxcenter, Erasmus University Rotterdam, The Netherlands
    Ultrasound Med Biol 25:803-10. 1999
  5. ncbi request reprint Quantification of plaque volume, shear stress on the endothelium, and mechanical properties of the arterial wall with intravascular ultrasound imaging
    N Bom
    Erasmus University Rotterdam, The Netherlands
    Z Kardiol 89:105-11. 2000
  6. doi request reprint A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness
    F Helderman
    Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands
    Med Biol Eng Comput 46:1121-7. 2008
  7. ncbi request reprint High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization
    Attila Thury
    Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center Rotterdam, The Netherlands
    Am Heart J 144:136-43. 2002
  8. ncbi request reprint Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients
    Robert W Nette
    Erasmus MC, Department of Internal Medicine, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Nephrol Dial Transplant 21:1305-11. 2006
  9. ncbi request reprint Three-dimensional palpography of human coronary arteries. Ex vivo validation and in-patient evaluation
    Johannes A Schaar
    Erasmus University, Rotterdam, The Netherlands
    Herz 30:125-33. 2005
  10. ncbi request reprint Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress
    Caroline Cheng
    Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Circulation 113:2744-53. 2006

Collaborators

Detail Information

Publications33

  1. ncbi request reprint In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity
    Rob Krams
    Cardiology, Erasmus Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Eur Heart J 26:2200-5. 2005
    ..As macrophages are a major source of MMPs, we examined whether regional temperature changes are related to local MMP activity and macrophage accumulation...
  2. ncbi request reprint Effect of vessel curvature on Doppler derived velocity profiles and fluid flow
    R Krams
    Department of Biomedical Engineering, Erasmus MC, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Ultrasound Med Biol 31:663-71. 2005
    ....
  3. doi request reprint Predicting patient-specific expansion of abdominal aortic aneurysms
    F Helderman
    Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands
    Eur J Vasc Endovasc Surg 40:47-53. 2010
    ..We describe a hybrid method that combines finite element modelling and statistical methods to predict patient-specific aneurysm expansion...
  4. ncbi request reprint Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system
    R Krams
    Laboratory Hemodynamics, Thoraxcenter, Erasmus University Rotterdam, The Netherlands
    Ultrasound Med Biol 25:803-10. 1999
    ..During hyperemic flow conditions, flow measurements might be accompanied by large axial pressure drops because the catheter, itself, might act as a significant stenosis...
  5. ncbi request reprint Quantification of plaque volume, shear stress on the endothelium, and mechanical properties of the arterial wall with intravascular ultrasound imaging
    N Bom
    Erasmus University Rotterdam, The Netherlands
    Z Kardiol 89:105-11. 2000
    ..From this, shear stress values close to the arterial wall can be calculated. Under the assumption that low values for local shear stress are areas prone to restenosis, predictions of endangered areas can be made...
  6. doi request reprint A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness
    F Helderman
    Department of Cardiology, Erasmus MC, Rotterdam, The Netherlands
    Med Biol Eng Comput 46:1121-7. 2008
    ..Furthermore, it revealed that location of peak wall stress changed over time. The assumptions of this model are discussed in detail in this manuscript, and the implications are related to literature findings...
  7. ncbi request reprint High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization
    Attila Thury
    Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center Rotterdam, The Netherlands
    Am Heart J 144:136-43. 2002
    ..Vascular wall shear stress (WSS) has been implied in the pathogenesis of atherosclerosis and vascular remodeling. Our aim was to calculate WSS after balloon angioplasty and evaluate its predictive value for long-term outcome...
  8. ncbi request reprint Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients
    Robert W Nette
    Erasmus MC, Department of Internal Medicine, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Nephrol Dial Transplant 21:1305-11. 2006
    ..Hypotension during haemodialysis results from an inadequate cardiovascular response to ultrafiltration-induced hypovolaemia. It has been suggested that plasma volume could be increased as a result of systemic vasoconstriction...
  9. ncbi request reprint Three-dimensional palpography of human coronary arteries. Ex vivo validation and in-patient evaluation
    Johannes A Schaar
    Erasmus University, Rotterdam, The Netherlands
    Herz 30:125-33. 2005
    ..At present, techniques with sufficient sensitivity and specificity to identify these unstable plaques are not clinically available. This paper describes a new technique to identify these plaques...
  10. ncbi request reprint Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress
    Caroline Cheng
    Department of Cardiology, Thoraxcenter, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Circulation 113:2744-53. 2006
    ..However, the effect of shear stress on plaque vulnerability is unknown because the lack of an appropriate in vivo model precludes cause-effect studies...
  11. ncbi request reprint Intravascular ultrasound tissue harmonic imaging in vivo
    Martijn E Frijlink
    Biomedical Engineering, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    IEEE Trans Ultrason Ferroelectr Freq Control 53:1844-52. 2006
    ..The harmonic acquisitions also showed the potential of THI to reduce image artifacts compared to fundamental imaging...
  12. ncbi request reprint Harmonic intravascular ultrasound imaging with a dual-frequency catheter
    Martijn E Frijlink
    Biomedical Engineering, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Ultrasound Med Biol 32:1649-54. 2006
    ..Finally, in vivo experiments were conducted and showed image improvement in H40 acquisitions with respect to the conventional IVUS catheter...
  13. ncbi request reprint Large variations in absolute wall shear stress levels within one species and between species
    Caroline Cheng
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Atherosclerosis 195:225-35. 2007
    ..These data support an "r(2) law" rather than Murray's r(3) law for the larger vessels in the arterial tree...
  14. ncbi request reprint Gelatinolytic activity in atherosclerotic plaques is highly localized and is associated with both macrophages and smooth muscle cells in vivo
    Dolf Segers
    Thoraxcenter, Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circulation 115:609-16. 2007
    ..Recent studies provided evidence for a predominant upstream location of plaque inflammation. The present study introduces a novel technique that evaluates the underlying mechanism of this spatial organization...
  15. ncbi request reprint Rapamycin modulates the eNOS vs. shear stress relationship
    Caroline Cheng
    Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    Cardiovasc Res 78:123-9. 2008
    ..We evaluated in this study whether rapamycin affects endothelial nitric oxide synthase (eNOS) responsiveness to shear stress under normo- and hypercholesteraemic conditions to explain these findings...
  16. doi request reprint Increased endothelial mitogen-activated protein kinase phosphatase-1 expression suppresses proinflammatory activation at sites that are resistant to atherosclerosis
    Mustafa Zakkar
    British Heart Foundation Cardiovascular Sciences Unit, National Heart and Lung Institute, Imperial College London, London, United Kingdom
    Circ Res 103:726-32. 2008
    ..We conclude that MKP-1 induction is required for the antiinflammatory effects of shear stress. Thus, our findings reveal a novel molecular mechanism contributing to the spatial distribution of vascular inflammation and atherosclerosis...
  17. ncbi request reprint Myocardial contractility does not determine the haemodynamic response during dialysis
    Eric H Y Ie
    Department of Medicine, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Nephrol Dial Transplant 20:2465-71. 2005
    ....
  18. ncbi request reprint Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique
    Caroline Cheng
    Department of Cardiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Blood 106:3691-8. 2005
    ..This model provides the opportunity to study the relationship between shear stress alterations, gene expression, and atherosclerosis...
  19. ncbi request reprint Shear stress, vascular remodeling and neointimal formation
    Jolanda J Wentzel
    Department of Cardiology, Thoraxcentre EE2322, Erasmus Medical Centre Rotterdam, Erasmus University Rotterdam, P O Box 1738, 3000 DR Rotterdam, Netherlands
    J Biomech 36:681-8. 2003
    ..Attempts to locally increase shear stress by a newly developed flow divider indicate that shear stress reduce in-stent neointimal formation by 50%...
  20. ncbi request reprint Augmentation of wall shear stress inhibits neointimal hyperplasia after stent implantation: inhibition through reduction of inflammation?
    Stephane G Carlier
    Thoraxcentre, Erasmus Medical Center Rotterdam, Netherlands
    Circulation 107:2741-6. 2003
    ..We studied the causal relationship between WSS and NH formation in stents by locally increasing WSS with a flow divider (Anti-Restenotic Diffuser, Endoart SA) placed in the center of the stent...
  21. ncbi request reprint Extension of increased atherosclerotic wall thickness into high shear stress regions is associated with loss of compensatory remodeling
    Jolanda J Wentzel
    Department of Cardiology, Hemodynamics Laboratory, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    Circulation 108:17-23. 2003
    ..Prolonged plaque accumulation at low SS predilection locations explains an inverse relation between wall thickness (WT) and SS. No data exist on WT-SS relations when lumen narrowing and loss of compensatory remodeling commence...
  22. pmc Functional expression of endothelial nitric oxide synthase fused to green fluorescent protein in transgenic mice
    Rien van Haperen
    Departments of Cell Biology and Genetics, Experimental Cardiology, Thoraxcenter, Erasmus Laboratory Animal Science Center EDC, and Vascular Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Pathol 163:1677-86. 2003
    ....
  23. ncbi request reprint The effect of reduced blood-flow on the coronary wall temperature. Are significant lesions suitable for intravascular thermography?
    Leonidas Diamantopoulos
    Cardiology Dept, University Gasthuisberg, Leuven, Belgium
    Eur Heart J 24:1788-95. 2003
    ..The purpose of this study was to investigate the relation between acute coronary flow reduction and arterial wall temperature...
  24. ncbi request reprint Intravascular thermography: Immediate functional and morphological vascular findings
    Stefan Verheye
    Cardiovascular Translational Research Institute, Antwerp, Belgium
    Eur Heart J 25:158-65. 2004
    ..To investigate safety, feasibility, and injurious effect on endothelial cells of a thermography catheter as well as effect of flow on measured temperature in non-obstructive arteries...
  25. ncbi request reprint Diastolic coronary vascular reserve: a new index to detect changes in the coronary microcirculation in hypertrophic cardiomyopathy
    Rob Krams
    Department of Cardiology, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    J Am Coll Cardiol 43:670-7. 2004
    ..The present study introduces a modification of the diastolic coronary conductance concept that maintains its sensitive properties to detect changes in the coronary microcirculation in human hypertrophy...
  26. ncbi request reprint Letter regarding article by Korshunov and Berk, "Strain-dependent vascular remodeling: the 'Glagov phenomenon' is genetically determined"
    Jolanda J Wentzel
    Circulation 111:e119; author reply e119. 2005
  27. ncbi request reprint Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries
    Jolanda J Wentzel
    Hemodynamics Laboratory, Department of Cardiology, P O Box 1738, Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands
    J Biomech 38:1551-5. 2005
    ..70+/-0.46 mm/Pa. These data suggest that using a geometry guided way of data averaging may reveal history related effects of SS, which in part explains localization of atherosclerotic plaques...
  28. ncbi request reprint Images in cardiovascular medicine. Focal in-stent restenosis near step-up: roles of low and oscillating shear stress?
    Attila Thury
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Circulation 105:e185-7. 2002
  29. ncbi request reprint Inflammation and atherosclerosis: mechanisms underlying vulnerable plaque
    Rob Krams
    Thoraxcentre Room Ee2369, Erasmus MC Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Interv Cardiol 16:107-13. 2003
  30. ncbi request reprint Effect of shear stress on vascular inflammation and plaque development
    Frank Helderman
    Department of Physics, Free University of Amsterdam, The Netherlands
    Curr Opin Lipidol 18:527-33. 2007
    ..This review describes evidence that shear stress acts through modulation of inflammation and by that process affects atherogenesis and plaque composition...
  31. ncbi request reprint Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis
    Kim Van der Heiden
    Department of Anatomy and Embryology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Atherosclerosis 196:542-50. 2008
    ..Experimentally induced flow disturbance leads to induction of primary cilia, and subsequently to atherogenesis, which suggests a role for primary cilia in endothelial activation and dysfunction...
  32. pmc Shear stress-induced changes in atherosclerotic plaque composition are modulated by chemokines
    Caroline Cheng
    Department of Cardiology, Thoraxcenter, Rotterdam, The Netherlands
    J Clin Invest 117:616-26. 2007
    ..We conclude that LSS or OSS triggers expression of chemokines involved in atherogenesis. Fractalkine upregulation is critically important for the composition of LSS-induced atherosclerotic lesions...
  33. ncbi request reprint Calcium sensitizer EMD 57033, but not the beta1-adrenoreceptor agonist dobutamine, increases mechanical efficiency in stunned myocardium
    Serge A I P Trines
    Department of Cardiology, Thoraxcenter, Erasmus Medical Center Rotterdam, The Netherlands
    J Cardiovasc Pharmacol 39:61-72. 2002
    ..Consequently, mechanical efficiency increased linearly with contractility during EMD 57033 infusion but remained constant during infusion of dobutamine...