Esther Korpershoek

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Trp53 inactivation leads to earlier phaeochromocytoma formation in pten knockout mice
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, CA Rotterdam, The Netherlands
    Endocr Relat Cancer 19:731-40. 2012
  2. pmc Murine models and cell lines for the investigation of pheochromocytoma: applications for future therapies?
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Room Ae304, P O Box 2040, 3000, CA, Rotterdam, The Netherlands
    Endocr Pathol 23:43-54. 2012
  3. doi request reprint Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
    Endocr Relat Cancer 17:653-62. 2010
  4. doi request reprint SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas
    Esther Korpershoek
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 96:E1472-6. 2011
  5. doi request reprint Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Pathol 217:597-604. 2009
  6. doi request reprint Parasympathetic paragangliomas are part of the Von Hippel-Lindau syndrome
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:4367-71. 2009
  7. ncbi request reprint An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, Netherlands
    Lancet Oncol 10:764-71. 2009
  8. doi request reprint Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Room Ae304, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 95:1274-8. 2010
  9. ncbi request reprint Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, JNI room 222, PO Box 2040, 3000 CR Rotterdam, The Netherlands
    Endocr Relat Cancer 14:453-62. 2007
  10. doi request reprint SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors
    Lindsey Oudijk
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Mod Pathol 26:456-63. 2013

Detail Information

Publications18

  1. doi request reprint Trp53 inactivation leads to earlier phaeochromocytoma formation in pten knockout mice
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, CA Rotterdam, The Netherlands
    Endocr Relat Cancer 19:731-40. 2012
    ..Therefore, the present model appears to be a suitable model that might allow the preclinical study of new therapeutics for these tumours...
  2. pmc Murine models and cell lines for the investigation of pheochromocytoma: applications for future therapies?
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Room Ae304, P O Box 2040, 3000, CA, Rotterdam, The Netherlands
    Endocr Pathol 23:43-54. 2012
    ..These studies also indicate that some mouse models and both mouse PCC cell lines are suitable for testing new therapies for metastatic PCC...
  3. doi request reprint Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
    Endocr Relat Cancer 17:653-62. 2010
    ..We demonstrate that malignant PCC and sPGL have more intra-tumoral molecular heterogeneity than benign tumors, which suggests that benign and malignant PCC and sPGL have a different pathogenesis...
  4. doi request reprint SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas
    Esther Korpershoek
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 96:E1472-6. 2011
    ..A recent report described a patient with an abdominal paraganglioma, immunohistochemically negative for SDHA, and identified a causal germline mutation in SDHA...
  5. doi request reprint Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Pathol 217:597-604. 2009
    ..The mouse model should allow further studies into the pathogenesis of human malignant PCCs and into therapeutic strategies for these tumours...
  6. doi request reprint Parasympathetic paragangliomas are part of the Von Hippel-Lindau syndrome
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:4367-71. 2009
    ..However, in parasympathetic paragangliomas occurring in VHL disease, biallelic inactivation of the VHL gene has not been demonstrated to date...
  7. ncbi request reprint An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, Netherlands
    Lancet Oncol 10:764-71. 2009
    ..We investigated whether SDHB immunohistochemistry could effectively discriminate between SDH-related and non-SDH-related phaeochromocytomas and paragangliomas in large retrospective and prospective tumour series...
  8. doi request reprint Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Room Ae304, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 95:1274-8. 2010
    ..Conclusion: IDH mutations are very rare in paragangliomas and pheochromocytomas and do not appear to play an important role in oncogenic HIF activation known to be present in these tumors...
  9. ncbi request reprint Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, JNI room 222, PO Box 2040, 3000 CR Rotterdam, The Netherlands
    Endocr Relat Cancer 14:453-62. 2007
    ..We suggest that sequential mutation analysis should be directed first at RET, followed by VHL and SDHD for patients with bilateral adrenal PCC at diagnosis, and at SDHB and SDHD for patients with sPGL...
  10. doi request reprint SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors
    Lindsey Oudijk
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Mod Pathol 26:456-63. 2013
    ..Identifying GISTs with deficient SDH activity warrants additional genetic testing, evaluation and follow-up for inherited disorders and paragangliomas...
  11. doi request reprint Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas
    Bart Jeroen Petri
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Mod Pathol 21:407-13. 2008
    ..We conclude that, although there is frequent loss of the p53 locus on 17p, the p53 gene does not appear to play a major role in pheochromocytoma tumorigenesis...
  12. doi request reprint Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis
    Thomas G Papathomas
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 170:1-12. 2014
    ..Absence of SDHB expression in tumors derived from tissues susceptible to SDH deficiency is not fully elucidated...
  13. doi request reprint Array-comparative genomic hybridization in sporadic benign pheochromocytomas
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Endocr Relat Cancer 16:505-13. 2009
    ..In addition, genes on 21q and 22q might play a more important role in PCC pathogenesis than had been assumed thus far...
  14. pmc SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mod Pathol 24:147-51. 2011
    ..In case of negative SDHB staining in GISTs, Carney-Stratakis syndrome or Carney triad should be considered and appropriate clinical surveillance should be instituted...
  15. ncbi request reprint New developments in the detection of the clinical behavior of pheochromocytomas and paragangliomas
    Ronald R de Krijger
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Endocr Pathol 17:137-41. 2006
    ..In this article, recent attempts at marker detection, such as those mentioned above, as well as emerging knowledge on the molecular abnormalities in benign and malignant PCC and PGL will be presented...
  16. ncbi request reprint The occurrence of SDHB gene mutations in pheochromocytoma
    Francien H van Nederveen
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Room Be 232, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Ann N Y Acad Sci 1073:177-82. 2006
    ..Also, a link has been established between malignant behavior and inactivating mutations of SDHB. In this article we review the published SDHB gene mutations, as well as the location and behavior of the resulting PCCs...
  17. ncbi request reprint Frequent genetic changes in childhood pheochromocytomas
    Ronald R de Krijger
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Ann N Y Acad Sci 1073:166-76. 2006
    ..From our findings we conclude that (a) a large proportion (40%) of pediatric PCC patients is diagnosed in the context of inherited cancer syndromes, and (b) candidate gene analysis appears to be indicated to detect germline mutations...
  18. pmc Expression of GAD67 and novel GAD67 splice variants during human fetal pancreas development: GAD67 expression in the fetal pancreas
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Room 222, Erasmus MC University Medical Centre Rotterdam, P O Box 2040, Dr Molenwaterplein 50, 3000 CA Rotterdam, The Netherlands
    Endocr Pathol 18:31-6. 2007
    ..We speculate that the expression of these GAD67 splice variants might be related to human fetal pancreas development...