Edwin J O Kompanje

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Medical research in emergency research in the European Union member states: tensions between theory and practice
    Erwin J O Kompanje
    Department of Intensive Care Medicine, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 40:496-503. 2014
  2. doi request reprint 'Real men wear kilts'. The anecdotal evidence that wearing a Scottish kilt has influence on reproductive potential: how much is true?
    E J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Centre, The Netherlands
    Scott Med J 58:e1-5. 2013
  3. ncbi request reprint A national multicenter trial on family presence during brain death determination: the FABRA study
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center, P O Box 2040, CA 3000 Rotterdam, The Netherlands
    Neurocrit Care 17:301-8. 2012
  4. pmc Remarkable changes in the choice of timing to discuss organ donation with the relatives of a patient: a study in 228 organ donations in 20 years
    Yorick J de Groot
    Department of Intensive Care, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Crit Care 15:R235. 2011
  5. pmc Donor conversion rates depend on the assessment tools used in the evaluation of potential organ donors
    Yorick J de Groot
    Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Intensive Care Med 37:665-70. 2011
  6. pmc Imminent brain death: point of departure for potential heart-beating organ donor recognition
    Yorick J de Groot
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 36:1488-94. 2010
  7. pmc The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843
    E J O Kompanje
    Intensive Care Med 33:1967-71. 2007
  8. pmc Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial results
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Center, CA, Rotterdam, The Netherlands
    Intensive Care Med 36:1962-5. 2010
  9. pmc Deferred consent in emergency intensive care research: what if the patient dies early? Use the data or not?
    T C Jansen
    Department of Intensive Care, Erasmus MC University Medical Center, P O Box 2040, 3000, CA Rotterdam, The Netherlands
    Intensive Care Med 33:894-900. 2007
  10. doi request reprint Is organ donation from brain dead donors reaching an inescapable and desirable nadir?
    Erwin J O Kompanje
    Department of Intensive Care Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Transplantation 91:1177-80. 2011

Detail Information

Publications51

  1. ncbi request reprint Medical research in emergency research in the European Union member states: tensions between theory and practice
    Erwin J O Kompanje
    Department of Intensive Care Medicine, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 40:496-503. 2014
    ..As the regulation shall be binding in its entirety in all member states, emergency research in acute situations is still not possible as it should be...
  2. doi request reprint 'Real men wear kilts'. The anecdotal evidence that wearing a Scottish kilt has influence on reproductive potential: how much is true?
    E J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Centre, The Netherlands
    Scott Med J 58:e1-5. 2013
    ..Thus, it seems plausible that men should wear skirts and avoid trousers, at least during the period during which they plan to conceive children...
  3. ncbi request reprint A national multicenter trial on family presence during brain death determination: the FABRA study
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center, P O Box 2040, CA 3000 Rotterdam, The Netherlands
    Neurocrit Care 17:301-8. 2012
    ....
  4. pmc Remarkable changes in the choice of timing to discuss organ donation with the relatives of a patient: a study in 228 organ donations in 20 years
    Yorick J de Groot
    Department of Intensive Care, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Crit Care 15:R235. 2011
    ..Second, we investigated how thorough the process of brain death determination was over time by studying the number of medical specialists involved. And we studied the possible influence of the Donor Register on the consent rate...
  5. pmc Donor conversion rates depend on the assessment tools used in the evaluation of potential organ donors
    Yorick J de Groot
    Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Intensive Care Med 37:665-70. 2011
    ..Our aim was to determine which assessment tool can be used for a realistic estimation of a POD pool and how they compare to each other with regard to DCR...
  6. pmc Imminent brain death: point of departure for potential heart-beating organ donor recognition
    Yorick J de Groot
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 36:1488-94. 2010
    ..Although the term is increasingly being used in recent literature, it is seldom defined in detail. We searched for criteria for determination of imminent brain death, which can be seen as a precursor for organ donation...
  7. pmc The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814-1869) in January 1843
    E J O Kompanje
    Intensive Care Med 33:1967-71. 2007
  8. pmc Inability to obtain deferred consent due to early death in emergency research: effect on validity of clinical trial results
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Center, CA, Rotterdam, The Netherlands
    Intensive Care Med 36:1962-5. 2010
    ..To illustrate the impact on the validity of trial results due to excluding patients from a randomized controlled trial for whom no deferred consent could be obtained after randomization because study procedures had already been finished...
  9. pmc Deferred consent in emergency intensive care research: what if the patient dies early? Use the data or not?
    T C Jansen
    Department of Intensive Care, Erasmus MC University Medical Center, P O Box 2040, 3000, CA Rotterdam, The Netherlands
    Intensive Care Med 33:894-900. 2007
  10. doi request reprint Is organ donation from brain dead donors reaching an inescapable and desirable nadir?
    Erwin J O Kompanje
    Department of Intensive Care Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Transplantation 91:1177-80. 2011
    ..In this article, we offer arguments for this statement and discuss alternatives to maintain a necessary level of donor organs for transplantation...
  11. ncbi request reprint Ethical implications of time frames in a randomized controlled trial in acute severe traumatic brain injury
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands, and Ospedale Policlinico IRCCS, Milan, Italy
    Prog Brain Res 161:243-50. 2007
    ..To analyze factors determining the time between injury and study drug administration (SDA) in a randomized controlled trial (RCT) of acute severe traumatic brain injury (TBI) and to discuss the ethical implications...
  12. ncbi request reprint [Communication with the relatives of a patient presumed brain dead]
    Erwin J O Kompanje
    Erasmus MC Universitair Medisch Centrum, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A3404. 2011
    ..This is illustrated by three cases...
  13. pmc Anticipation of distress after discontinuation of mechanical ventilation in the ICU at the end of life
    E J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 34:1593-9. 2008
    ..Post-extubation stridor can give rise to the relatives' perception that the patient is choking and suffering. Existing protocols lack adequate anticipatory preparation to respond to all distressing symptoms...
  14. ncbi request reprint Euthanasia in intensive care: a 56-year-old man with a pontine hemorrhage resulting in a locked-in syndrome
    Edwin J O Kompanje
    Departments of Intensive Care and Medical Ethics, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Crit Care Med 35:2428-30. 2007
    ..To describe a case of deliberate termination of life (euthanasia) in intensive care...
  15. pmc 'No Time to be Lost!' Ethical considerations on consent for inclusion in emergency pharmacological research in severe traumatic brain injury in the European Union
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, P O Box 2040, Rotterdam, 3000 CA, The Netherlands
    Sci Eng Ethics 13:371-81. 2007
    ..Making progress in knowledge of treatment in acute neurological and other intensive care conditions is only possible if national regulations and legislations allow waiver of consent or deferred consent for clinical trials...
  16. ncbi request reprint Cephalopagus conjoined twins in a leopard cat (Prionailurus bengalensis)
    Erwin J O Kompanje
    Natural History Museum Rotterdam, PO Box 23452, 3001 KL Rotterdam, The Netherlands
    J Wildl Dis 44:177-80. 2008
    ..A review of known cases of conjoined twinning in wild mammals is given...
  17. ncbi request reprint 'The devil lay upon her and held her down'. Hypnagogic hallucinations and sleep paralysis described by the Dutch physician Isbrand van Diemerbroeck (1609-1674) in 1664
    E J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Sleep Res 17:464-7. 2008
    ....
  18. ncbi request reprint [Deferred consent for inclusion of patients unable to give their consent in studies in the field of emergency medicine]
    E J O Kompanje
    Erasmus MC Centrum, afd Intensive Care Volwassenen, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 152:2057-61. 2008
    ..Relatives do not have the authority to give consent for the use of medical data after the patient has died. Data can be used anonymously in the final analysis of the trial. We propose a flowchart for this procedure...
  19. doi request reprint Historical sources of basilar artery occlusion
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurology 76:1520-3. 2011
    ..Around 1880, the clinical symptoms of BAO were obviously well-known to the experienced clinician. In this article we offer a chronological description of historical sources...
  20. ncbi request reprint "Flatus profuse present in the muscles": subcutaneous emphysema of the lower abdominal wall and thighs, described in 1593 by fabricius hildanus
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Surg Infect (Larchmt) 10:349-51. 2009
    ..Between 1598 and 1641, 600 medical and surgical observations made by the famous German surgeon Guilhelmius Fabricius Hildanus (1560-1634) were published in his Observationum et curationum chirurgicarum centuriae I-VI...
  21. ncbi request reprint [Clinical trials on medical products for human use in the case of acutely incapacitated patients within the fields of neurology and neurosurgery; implications of the new European legislation]
    E J Kompanje
    afd Neurochirurgie, Erasmus Medisch Centrum, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 147:1585-9. 2003
    ....
  22. ncbi request reprint [Questionable basis for 'hopeless and unbearable suffering' as the criterion for the active termination of life in newborns with spina bifida]
    E J O Kompanje
    Erasmus MC, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 149:2067-9. 2005
    ..and on what basis should a given situation be regarded as an 'emergency situation'?; (b) what qualifies as a very severe form of spina bifida?; (c) what kind of care should be provided after the decision to withhold active care?..
  23. ncbi request reprint "The death rattle" in the intensive care unit after withdrawal of mechanical ventilation in neurological patients
    Erwin J O Kompanje
    Department of Intensive Care and Department of Neurosurgery, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurocrit Care 3:107-10. 2005
    ..The distressing experience and negative influence in the bereavement process indicates an ethical demand to treat this symptom from the perspective of others merely than that of the patient...
  24. ncbi request reprint Ethical considerations on consent procedures for emergency research in severe and moderate traumatic brain injury
    E J O Kompanje
    Department of Neurosurgery, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Acta Neurochir (Wien) 147:633-9; discussion 639-40. 2005
    ..Nevertheless, we consider that randomising patients with TBI into carefully evaluated trial protocols without prior consent may be considered ethically justified...
  25. ncbi request reprint The first successful separation of conjoined twins in 1689: some additions and corrections
    Erwin J O Kompanje
    Department of Neurological Surgery, Erasmus Medical Center Rotterdam, The Netherlands
    Twin Res 7:537-41. 2004
    ..Fatio copied the engraved plate in his book from Konig's engraving. These two sources should be cited as the first publications on the successful separation of Elisabet and Catherina, and not Fatio's book from 1752...
  26. ncbi request reprint 'Death rattle' after withdrawal of mechanical ventilation: practical and ethical considerations
    Erwin J O Kompanje
    Department of Intensive Care and Department of Medical Ethics, Erasmus MC University Medical Center, Room V 208, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Intensive Crit Care Nurs 22:214-9. 2006
    ..In practice, injectable scopolamine is the reference drug for symptomatic treatment of death rattle...
  27. ncbi request reprint A remarkable case in the history of obstetrical surgery: a laparotomy performed by the Dutch surgeon Abraham Cyprianus in 1694
    Erwin J O Kompanje
    Erasmus Medical Center Rotterdam, Department of Neurological Surgery, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur J Obstet Gynecol Reprod Biol 118:119-23. 2005
    ..This particular case is reviewed in this article...
  28. ncbi request reprint ['The rumbling of shaking brains'; the treatment of traumatic skull and brain injury in the Netherlands in the 17th century: 7 case reports from Observationes medicae by Nicolaes Tulp]
    E J Kompanje
    Erasmus Medisch Centrum, afd Neurochirurgie, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 148:677-82. 2004
    ..It may be further concluded from the descriptions that Tulp adhered to a large extent to the medical views concerning the blood circulation as described by Galenus (129-199 AD)...
  29. ncbi request reprint Features described and illustrated in 1684 suggesting Meckel-Gruber syndrome
    Erwin J O Kompanje
    Department of Neurosurgery, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Pediatr Dev Pathol 6:595-8. 2003
    ..This may represent the oldest description and illustration of the syndrome, of which the first detailed description is attributed to Johann Friedrich der Jüngere in 1822...
  30. ncbi request reprint Painful sexual intercourse caused by a disproportionately long penis: an historical note on a remarkable treatment devised by Guilhelmius Fabricius Hildanus (1560-1634)
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center, P O Box 2040, 3000, CA Rotterdam, The Netherlands
    Arch Sex Behav 35:603-5. 2006
    ..Four hundred years later, Hildanus' forgotten penis shortening device deserves a resurrection in today's medical practice. This remarkable and almost forgotten case report is described and discussed...
  31. ncbi request reprint Care for the dying in intensive care in The Netherlands
    Erwin J O Kompanje
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, Rotterdam, CA, The Netherlands
    Intensive Care Med 32:2067-9. 2006
  32. ncbi request reprint Why opioids and sedatives may prolong life rather than hasten death after ventilator withdrawal in critically ill patients
    Jan Bakker
    Department of Intensive Care, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Am J Hosp Palliat Care 25:152-4. 2008
    ....
  33. pmc What to do when a competent ICU patient does not want to live anymore but is dependent on life-sustaining treatment? Experience from The Netherlands
    Ben van der Hoven
    Department of Intensive Care, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 36:2145-8. 2010
    ..We conclude that the doctrine of the double effect is not applicable in this situation, and mentioning it criminalised the practice unnecessarily and wrongfully...
  34. ncbi request reprint A case of malingering by proxy described in 1593
    Erwin J O Kompanje
    Erasmus MC University Medical Center Rotterdam, Department of Intensive Care, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Child Abuse Negl 31:1013-7. 2007
  35. doi request reprint Deferred proxy consent in emergency critical care research: ethically valid and practically feasible
    Tim C Jansen
    Department of Intensive Care, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Crit Care Med 37:S65-8. 2009
    ..In addition, we recommend using the study data if study procedures are finished before proxies can be informed and consent be sought, provided sufficient privacy measures have been applied...
  36. ncbi request reprint Organ donations and unused potential donations in traumatic brain injury, subarachnoid haemorrhage and intracerebral haemorrhage
    Erwin J O Kompanje
    Department of Neurosurgery, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Intensive Care Med 32:217-22. 2006
    ..1 million inhabitants)...
  37. doi request reprint Importance of screening logs in clinical trials for severe traumatic brain injury
    François J A Slieker
    Department of Neurosurgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurosurgery 62:1321-8; discussion 1328-9. 2008
    ..We aimed to investigate the benefits of collecting screening logs in two randomized clinical trials conducted in TBI...
  38. pmc Comment on "Attitudes of European physicians, nurses, patients, and families regarding end-of-life decisions: the ETHICATT study" by Sprung et al
    Astrid M Vrakking
    Intensive Care Med 33:747; author reply 748. 2007
  39. ncbi request reprint 'Treat first, ask later?' Emergency research in acute neurology and neurotraumatology in the European Union
    Erwin J O Kompanje
    Intensive Care Med 30:168-9. 2004
  40. doi request reprint The crystal ball in end-of-life care
    Erwin J O Kompanje
    Crit Care Med 36:2482; author reply 2483-4. 2008
  41. ncbi request reprint End-of-life practices in European intensive care units
    Erwin J O Kompanje
    JAMA 290:2938-9; author reply 2939-40. 2003
  42. ncbi request reprint Morphine is not a sedative and does not shorten life
    Erwin J O Kompanje
    Arch Intern Med 166:2047; author reply 2047-8. 2006
  43. ncbi request reprint The European Clinical Trials Directive revisited: the VISEAR recommendations
    Kathleen Liddell
    Faculty of Law, University of Cambridge and Cambridge Genetics Knowledge Park, UK
    Resuscitation 69:9-14. 2006
  44. ncbi request reprint Recommendations in relation to the EU clinical trials directive and medical research involving incapacitated adults
    Kathleen Liddell
    Faculty of Law, University of Cambridge and Cambridge Genetics Knowledge Park, UK
    Wien Klin Wochenschr 118:183-91. 2006
  45. ncbi request reprint An historical homage from Denmark: the aqueduct of Sylvius
    Erwin J O Kompanje
    Neurosurg Rev 28:77-8. 2005
  46. ncbi request reprint Very rare congenital malformations: responsibilities of scientists. The case of rachipagus conjoined twins
    Erwin J O Kompanje
    Fetal Diagn Ther 21:319-20. 2006
  47. pmc Differences in completion of screening logs between Europe and the United States in an emergency phase III trial resulting from HIPAA requirements
    Andrew I R Maas
    Ann Surg 241:382-3. 2005
  48. doi request reprint A case of strawberry induced migraine aura without headache described in 1627
    Erwin J O Kompanje
    Headache 48:974-5. 2008
  49. ncbi request reprint Is the Glasgow Coma Scale score protected health information?The effect of new United States regulations (HIPAA) on completion of screening logs in emergency research trials
    Erwin J O Kompanje
    Intensive Care Med 32:313-4. 2006
  50. doi request reprint Request for complementary medicine after brain death
    Erwin J O Kompanje
    JAMA 300:1517; author reply 1517-8. 2008