Manfred Kayser

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Model-based prediction of human hair color using DNA variants
    Wojciech Branicki
    Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31 033, Krakow, Poland
    Hum Genet 129:443-54. 2011
  2. ncbi Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans
    Paula Kersbergen
    Department of Human Biological Traces R and D, Netherlands Forensic Institute, PO Box 24044, 2490 AA The Hague, The Netherlands
    BMC Genet 10:69. 2009
  3. ncbi DNA-based prediction of human externally visible characteristics in forensics: motivations, scientific challenges, and ethical considerations
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 3:154-61. 2009
  4. ncbi Multiplex genotyping system for efficient inference of matrilineal genetic ancestry with continental resolution
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Investig Genet 2:6. 2011
  5. ncbi Improving human forensics through advances in genetics, genomics and molecular biology
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Nat Rev Genet 12:179-92. 2011
  6. ncbi Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 23:2234-44. 2006
  7. ncbi Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:194-8. 2008
  8. ncbi Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
  9. ncbi The impact of the Austronesian expansion: evidence from mtDNA and Y chromosome diversity in the Admiralty Islands of Melanesia
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Biol Evol 25:1362-74. 2008
  10. ncbi The human genetic history of Oceania: near and remote views of dispersal
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Biol 20:R194-201. 2010

Detail Information

Publications74

  1. ncbi Model-based prediction of human hair color using DNA variants
    Wojciech Branicki
    Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31 033, Krakow, Poland
    Hum Genet 129:443-54. 2011
    ....
  2. ncbi Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans
    Paula Kersbergen
    Department of Human Biological Traces R and D, Netherlands Forensic Institute, PO Box 24044, 2490 AA The Hague, The Netherlands
    BMC Genet 10:69. 2009
    ....
  3. ncbi DNA-based prediction of human externally visible characteristics in forensics: motivations, scientific challenges, and ethical considerations
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 3:154-61. 2009
    ..To gain the attention of legislative bodies, we invite the forensic community to participate in a public discourse of these issues...
  4. ncbi Multiplex genotyping system for efficient inference of matrilineal genetic ancestry with continental resolution
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Investig Genet 2:6. 2011
    ..abstract:..
  5. ncbi Improving human forensics through advances in genetics, genomics and molecular biology
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Nat Rev Genet 12:179-92. 2011
    ..Such advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future...
  6. ncbi Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 23:2234-44. 2006
    ..We also demonstrate that Fiji played a pivotal role in the history of Polynesia: humans probably first migrated to Fiji, and subsequent settlement of Polynesia probably came from Fiji...
  7. ncbi Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:194-8. 2008
    ....
  8. ncbi Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
  9. ncbi The impact of the Austronesian expansion: evidence from mtDNA and Y chromosome diversity in the Admiralty Islands of Melanesia
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Biol Evol 25:1362-74. 2008
    ..These results significantly advance our understanding of the impact of the Austronesian expansion and human history in the Pacific region...
  10. ncbi The human genetic history of Oceania: near and remote views of dispersal
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Biol 20:R194-201. 2010
    ....
  11. ncbi Relating two deep-rooted pedigrees from Central Germany by high-resolution Y-STR haplotyping
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Forensic Sci Int Genet 1:125-8. 2007
    ..This shortcoming makes a strong case for more comprehensive haplotype databases, including more samples and larger numbers of loci...
  12. ncbi Significant genetic differentiation between Poland and Germany follows present-day political borders, as revealed by Y-chromosome analysis
    Manfred Kayser
    Department of Forensic Molecular Biology, Medical Genetic Cluster, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands
    Hum Genet 117:428-43. 2005
    ....
  13. ncbi A comprehensive survey of human Y-chromosomal microsatellites
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 74:1183-97. 2004
    ..As a result of this work, a large number of new, highly polymorphic Y-chromosomal microsatellites are now available for population-genetic, evolutionary, genealogical, and forensic investigations...
  14. ncbi Improving global and regional resolution of male lineage differentiation by simple single-copy Y-chromosomal short tandem repeat polymorphisms
    Mark Vermeulen
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Forensic Sci Int Genet 3:205-13. 2009
    ....
  15. ncbi A new future of forensic Y-chromosome analysis: rapidly mutating Y-STRs for differentiating male relatives and paternal lineages
    Kaye N Ballantyne
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Forensic Sci Int Genet 6:208-18. 2012
    ..7% and 8%, respectively, with Yfiler. Thus, by introducing RM Y-STRs to the forensic genetic community we provide important solutions to several of the current limitations of Y chromosome analysis in forensic genetics...
  16. ncbi Apparent intrachromosomal exchange on the human Y chromosome explained by population history
    Ralf Kittler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany
    Eur J Hum Genet 11:304-14. 2003
    ..Thus, we demonstrate here that allele frequency distributions at duplicate loci that are suggestive of intrachromosomal recombination can be explained solely by population history...
  17. ncbi Y chromosome STR haplotypes and the genetic structure of U.S. populations of African, European, and Hispanic ancestry
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 13:624-34. 2003
    ....
  18. ncbi The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
    Forensic Sci Int Genet 7:98-115. 2013
    ....
  19. ncbi MtDNA SNP multiplexes for efficient inference of matrilineal genetic ancestry within Oceania
    Kaye N Ballantyne
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 6:425-36. 2012
    ....
  20. ncbi Bridging near and remote Oceania: mtDNA and NRY variation in the Solomon Islands
    Frederick Delfin
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 29:545-64. 2012
    ..Our results fill an important lacuna in human genetic studies of Oceania and aid in understanding the colonization and genetic history of this region...
  21. ncbi Mutability of Y-chromosomal microsatellites: rates, characteristics, molecular bases, and forensic implications
    Kaye N Ballantyne
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, The Netherlands
    Am J Hum Genet 87:341-53. 2010
    ..This finding is expected to revolutionize Y-chromosomal applications in forensic biology, from previous male lineage differentiation toward future male individual identification...
  22. ncbi Reduced Y-chromosome, but not mitochondrial DNA, diversity in human populations from West New Guinea
    Manfred Kayser
    Department for Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:281-302. 2003
    ..Our data further provide evidence for primarily female-mediated gene flow within the highlands of New Guinea but primarily male-mediated gene flow between highland and lowland/coastal regions...
  23. ncbi A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population
    Fan Liu
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Hum Genet 81:17-31. 2007
    ..For this region, our analysis identified the NMNAT3 and CLSTN2 genes. Our findings confirm linkage to chromosome 11q25. We were unable to confirm SORL1; instead, our analysis points to the OPCML and HNT genes...
  24. ncbi Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians
    Sean Myles
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Eur J Hum Genet 15:584-9. 2007
    ..703, P=0.007) and we therefore suggest that this allele may play a role in the large difference in type II diabetes prevalence between Polynesians and neighboring populations...
  25. ncbi Genome-wide data substantiate Holocene gene flow from India to Australia
    Irina Pugach
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 110:1803-8. 2013
    ..This is also approximately when changes in tool technology, food processing, and the dingo appear in the Australian archaeological record, suggesting that these may be related to the migration from India...
  26. ncbi DNA-based eye colour prediction across Europe with the IrisPlex system
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 6:330-40. 2012
    ....
  27. ncbi Detecting low frequent loss-of-function alleles in genome wide association studies with red hair color as example
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e28145. 2011
    ..11×10⁻¹⁴² vs. P for rs258322 = 1.33×10⁻⁶⁶). The CDH test will contribute towards finding rare LOF variants in GWAS and sequencing studies...
  28. ncbi Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis
    Ilse A Hoppenbrouwers
    Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
    J Hum Genet 54:676-80. 2009
    ..Several of these risk genes, including CD58 and CLEC16A, are shared by different autoimmune diseases. Fine mapping studies will be needed to determine the functional contributions to distinct autoimmune phenotypes...
  29. ncbi Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans
    Leonie C Jacobs
    Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Genet 132:147-58. 2013
    ..The variants identified in this study may also contribute to the risk of skin cancer. Our findings are also important for predicting skin color in forensic investigations...
  30. ncbi A genome-wide association study identifies five loci influencing facial morphology in Europeans
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Genet 8:e1002932. 2012
    ....
  31. ncbi HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter
    Mijke Visser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Genome Res 22:446-55. 2012
    ..This concept is highly relevant for future studies aiming to unveil the functional basis of genetically determined phenotypes, including diseases...
  32. ncbi IrisPlex: a sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence of ancestry information
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 5:170-80. 2011
    ....
  33. ncbi Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Am J Hum Genet 78:680-90. 2006
    ....
  34. ncbi Comprehensive mutation analysis of 17 Y-chromosomal short tandem repeat polymorphisms included in the AmpFlSTR Yfiler PCR amplification kit
    Miriam Goedbloed
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam The Netherlands
    Int J Legal Med 123:471-82. 2009
    ....
  35. ncbi Dating the age of admixture via wavelet transform analysis of genome-wide data
    Irina Pugach
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D 04103, Germany
    Genome Biol 12:R19. 2011
    ..The wavelet transform method offers better resolution than existing methods for dating admixture, and can be applied to either SNP or sequence data from humans or other species...
  36. ncbi Genetic admixture history of Eastern Indonesia as revealed by Y-chromosome and mitochondrial DNA analysis
    Stefano Mona
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Biol Evol 26:1865-77. 2009
    ....
  37. ncbi Evaluating self-declared ancestry of U.S. Americans with autosomal, Y-chromosomal and mitochondrial DNA
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Mutat 31:E1875-93. 2010
    ..S. African Americans or U.S. European Americans, relative to their assumed parental populations from Africa or Europe. This provides genetic support for the importance of skin color in the complex process of ancestry identification...
  38. ncbi Y-chromosome analysis confirms highly sex-biased dispersal and suggests a low male effective population size in bonobos (Pan paniscus)
    Jonas Eriksson
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany
    Mol Ecol 15:939-49. 2006
    ..40,000-45,000). For humans the difference is merely a factor of two, suggesting a more stable demographic history in bonobos in comparison to humans...
  39. ncbi A multiplex SNP assay for the dissection of human Y-chromosome haplogroup O representing the major paternal lineage in East and Southeast Asia
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Hum Genet 57:65-9. 2012
    ....
  40. ncbi MicroRNA markers for forensic body fluid identification obtained from microarray screening and quantitative RT-PCR confirmation
    Dmitry Zubakov
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 124:217-26. 2010
    ..Additional work remains necessary in search for suitable miRNA markers for other forensically relevant body fluids...
  41. ncbi New markers for old stains: stable mRNA markers for blood and saliva identification from up to 16-year-old stains
    Dmitry Zubakov
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Int J Legal Med 123:71-4. 2009
    ..Moreover, our findings imply that forensic RNA testing can be reliable and robust if degraded samples are considered in the marker ascertainment procedure, with promising expectations beyond tissue identification purposes...
  42. ncbi Development of Y-chromosomal microsatellite markers for nonhuman primates
    Axel Erler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany
    Mol Ecol 13:2921-30. 2004
    ....
  43. ncbi Online Y-chromosomal short tandem repeat haplotype reference database (YHRD) for U.S. populations
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    J Forensic Sci 47:513-9. 2002
    ....
  44. ncbi Molecular evolution of Pediculus humanus and the origin of clothing
    Ralf Kittler
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103 Leipzig, Germany
    Curr Biol 13:1414-7. 2003
    ..These results suggest that clothing was a surprisingly recent innovation in human evolution...
  45. ncbi Predicting human height by Victorian and genomic methods
    Yurii S Aulchenko
    Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 17:1070-5. 2009
    ....
  46. ncbi Digital quantification of human eye color highlights genetic association of three new loci
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000934. 2010
    ..A model for predicting quantitative eye colors explained over 50% of trait variance in the Rotterdam Study. Over all our data exemplify that fine phenotyping is a useful strategy for finding genes involved in human complex traits...
  47. ncbi A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation
    Karol Estrada
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Mol Genet 18:3516-24. 2009
    ..1 x 10(-7)). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height...
  48. ncbi Correlation between genetic and geographic structure in Europe
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Curr Biol 18:1241-8. 2008
    ..By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry...
  49. ncbi Forensic pregnancy diagnostics with placental mRNA markers
    Jeanot Gauvin
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 124:13-7. 2010
    ....
  50. ncbi mRNA-based skin identification for forensic applications
    Mijke Visser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Int J Legal Med 125:253-63. 2011
    ....
  51. ncbi Unexpected island effects at an extreme: reduced Y chromosome and mitochondrial DNA diversity in Nias
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Biol Evol 28:1349-61. 2011
    ..Our work underlines the importance of human genetic diversity studies not only for a better understanding of human population history but also because of the potential relevance for genetic disease-mapping studies...
  52. ncbi Developmental validation of the IrisPlex system: determination of blue and brown iris colour for forensic intelligence
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, Zuid Holland, The Netherlands
    Forensic Sci Int Genet 5:464-71. 2011
    ....
  53. ncbi Diurnal rhythms in blood cell populations and the effect of acute sleep deprivation in healthy young men
    Katrin Ackermann
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Sleep 35:933-40. 2012
    ....
  54. ncbi Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing
    Johanna Maria de Gruijter
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands
    Investig Genet 2:24. 2011
    ..abstract:..
  55. ncbi An efficient multiplex genotyping approach for detecting the major worldwide human Y-chromosome haplogroups
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 125:879-85. 2011
    ..These Y-SNP assays thus form a valuable tool for researchers in the fields of forensic genetics and genetic anthropology to infer a man's patrilineal bio-geographic ancestry from DNA...
  56. ncbi Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, The Netherlands
    Hum Mutat 30:E386-94. 2009
    ..This complete mtDNA tree includes previously published as well as newly identified haplogroups, is easily navigable, will be continuously and regularly updated in the future, and is online available at http://www.phylotree.org...
  57. ncbi A genome scan to detect candidate regions influenced by local natural selection in human populations
    Manfred Kayser
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 20:893-900. 2003
    ..Our results demonstrate that genome scans are a promising means of identifying candidate regions that have been subjected to local selection...
  58. ncbi Evaluation of saliva as a source of human DNA for population and association studies
    Dominique Quinque
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D-04103, Leipzig, Germany
    Anal Biochem 353:272-7. 2006
    ..Thus, saliva can be considered a reliable source of DNA for a wide variety of genetic studies...
  59. ncbi Stable RNA markers for identification of blood and saliva stains revealed from whole genome expression analysis of time-wise degraded samples
    Dmitry Zubakov
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 Rotterdam, The Netherlands
    Int J Legal Med 122:135-42. 2008
    ..We propose the use of these 14 stable mRNA markers for identification of blood and saliva stains in future forensic practice...
  60. ncbi Estimating trace deposition time with circadian biomarkers: a prospective and versatile tool for crime scene reconstruction
    Katrin Ackermann
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Int J Legal Med 124:387-95. 2010
    ....
  61. ncbi Postnatal parental smoking: an important risk factor for SIDS
    Germaine Liebrechts-Akkerman
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Pediatr 170:1281-91. 2011
    ..4 [1.2, 4.8]). CONCLUSION: Postnatal parental smoking is currently a major environmental risk factor for SIDS in the Netherlands together with the long-established risk of prone sleeping...
  62. ncbi A whole genome amplification method to generate long fragments from low quantities of genomic DNA
    Ralf Kittler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D-04103 Leipzig, Germany
    Anal Biochem 300:237-44. 2002
    ..LL-DOP-PCR provides significantly better coverage for microsatellites and unique sequences in comparison to a conventional DOP-PCR method...
  63. ncbi Microsatellite length differences between humans and chimpanzees at autosomal Loci are not found at equivalent haploid Y chromosomal Loci
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Genetics 173:2179-86. 2006
    ..Such a pattern is consistent with predictions from the heterozygote instability model and is not expected under models of microsatellite evolution that do not include interchromosomal events such as the enzyme evolution model...
  64. ncbi Microbial DNA fingerprinting of human fingerprints: dynamic colonization of fingertip microflora challenges human host inferences for forensic purposes
    Sebastian Tims
    Department of Medical Microbiology and Infectious Diseases, Unit Research and Development, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 124:477-81. 2010
    ..Overall, our results suggest that human fingerprint microflora is too dynamic to allow for forensic marker developments for retrieving human information...
  65. ncbi Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development
    Catherine Robin
    Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Cell Stem Cell 5:385-95. 2009
    ..Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development...
  66. ncbi Sex and gender issues in competitive sports: investigation of a historical case leads to a new viewpoint
    Kaye N Ballantyne
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Br J Sports Med 46:614-7. 2012
    ....
  67. ncbi Asian online Y-STR Haplotype Reference Database
    Ruediger Lessig
    Institute of Legal Medicine, University of Leipzig, Johannisallee 28, D-04103 Leipzig, Germany
    Leg Med (Tokyo) 5:S160-3. 2003
    ..All databases are maintained and curated at the Institute of Legal Medicine, Humboldt-University, Berlin and will soon be fused to a global repository including populations from all continents...
  68. ncbi Homogeneity and distinctiveness of Polish paternal lineages revealed by Y chromosome microsatellite haplotype analysis
    Rafal Ploski
    Human Molecular Genetics Lab, Department of Forensic Medicine, Warsaw Medical Academy, Poland
    Hum Genet 110:592-600. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/10.1007/s00439-002-0728-0...
  69. ncbi Patterns of Y-chromosome diversity intersect with the Trans-New Guinea hypothesis
    Stefano Mona
    Department of Genetics and Microbiology, University of Bari, Bari, Italy
    Mol Biol Evol 24:2546-55. 2007
    ....
  70. ncbi Evaluation of haplotype discrimination capacity of 35 Y-chromosomal short tandem repeat loci
    Heike Rodig
    Biotype AG, Moritzburger Weg 67, 01109 Dresden, Germany
    Forensic Sci Int 174:182-8. 2008
    ..Complete resolution of the pooled population was achieved by the additional genotyping of two further loci, DYS446 or DYS505 and DYF406S1 or DYS522...
  71. ncbi A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe
    Siiri Rootsi
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Eur J Hum Genet 15:204-11. 2007
    ..These phylogeographic patterns provide evidence consistent with male-mediated counter-clockwise late Pleistocene-Holocene migratory trajectories toward Northwestern Europe from an ancestral East Asian source of Paleolithic heritage...
  72. ncbi The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
    ..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria...
  73. ncbi Y-chromosomal evidence for a strong reduction in male population size of Yakuts
    Brigitte Pakendorf
    Institute of Human Biology, University of Hamburg, Germany
    Hum Genet 110:198-200. 2002
  74. ncbi Signature of recent historical events in the European Y-chromosomal STR haplotype distribution
    Lutz Roewer
    Institute of Legal Medicine, Humboldt-University, Berlin, Germany
    Hum Genet 116:279-91. 2005
    ..We conclude that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history...