Manfred Kayser

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Bona fide colour: DNA prediction of human eye and hair colour from ancient and contemporary skeletal remains
    Jolanta Draus-Barini
    Institute of Forensic Research, Section of Forensic Genetics, Krakow, Poland
    Investig Genet 4:3. 2013
  2. pmc First all-in-one diagnostic tool for DNA intelligence: genome-wide inference of biogeographic ancestry, appearance, relatedness, and sex with the Identitas v1 Forensic Chip
    Brendan Keating
    The University of Pennsylvania, Office 1016, Abramson Building, 3615 Civic Center Bvld, Philadelphia, PA 19104 4399, USA
    Int J Legal Med 127:559-72. 2013
  3. pmc Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies
    Sara Raimondi
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ramusio 1, Milan, 20141, Italy
    BMC Med Res Methodol 12:116. 2012
  4. pmc Model-based prediction of human hair color using DNA variants
    Wojciech Branicki
    Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31 033, Krakow, Poland
    Hum Genet 129:443-54. 2011
  5. pmc Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans
    Paula Kersbergen
    Department of Human Biological Traces R and D, Netherlands Forensic Institute, PO Box 24044, 2490 AA The Hague, The Netherlands
    BMC Genet 10:69. 2009
  6. pmc Multiplex genotyping system for efficient inference of matrilineal genetic ancestry with continental resolution
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Investig Genet 2:6. 2011
  7. ncbi request reprint Significant genetic differentiation between Poland and Germany follows present-day political borders, as revealed by Y-chromosome analysis
    Manfred Kayser
    Department of Forensic Molecular Biology, Medical Genetic Cluster, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands
    Hum Genet 117:428-43. 2005
  8. doi request reprint DNA-based prediction of human externally visible characteristics in forensics: motivations, scientific challenges, and ethical considerations
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 3:154-61. 2009
  9. pmc A comprehensive survey of human Y-chromosomal microsatellites
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 74:1183-97. 2004
  10. doi request reprint The human genetic history of Oceania: near and remote views of dispersal
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Biol 20:R194-201. 2010

Detail Information

Publications79

  1. pmc Bona fide colour: DNA prediction of human eye and hair colour from ancient and contemporary skeletal remains
    Jolanta Draus-Barini
    Institute of Forensic Research, Section of Forensic Genetics, Krakow, Poland
    Investig Genet 4:3. 2013
    ..abstract:..
  2. pmc First all-in-one diagnostic tool for DNA intelligence: genome-wide inference of biogeographic ancestry, appearance, relatedness, and sex with the Identitas v1 Forensic Chip
    Brendan Keating
    The University of Pennsylvania, Office 1016, Abramson Building, 3615 Civic Center Bvld, Philadelphia, PA 19104 4399, USA
    Int J Legal Med 127:559-72. 2013
    ..Our results demonstrate that the Identitas v1 Forensic Chip holds great promise for a wide range of applications including criminal investigations, missing person investigations, and for national security purposes...
  3. pmc Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies
    Sara Raimondi
    Division of Epidemiology and Biostatistics, European Institute of Oncology, Via Ramusio 1, Milan, 20141, Italy
    BMC Med Res Methodol 12:116. 2012
    ..Pooled-analysis of epidemiological studies has many advantages over meta-analysis, and preliminary results may be obtained faster and with lower costs than with prospective consortia...
  4. pmc Model-based prediction of human hair color using DNA variants
    Wojciech Branicki
    Section of Forensic Genetics, Institute of Forensic Research, Westerplatte 9, 31 033, Krakow, Poland
    Hum Genet 129:443-54. 2011
    ....
  5. pmc Developing a set of ancestry-sensitive DNA markers reflecting continental origins of humans
    Paula Kersbergen
    Department of Human Biological Traces R and D, Netherlands Forensic Institute, PO Box 24044, 2490 AA The Hague, The Netherlands
    BMC Genet 10:69. 2009
    ..The identification and use of Ancestry-Sensitive Markers (ASMs), i.e. genetic polymorphisms facilitating the genetic reconstruction of geographical origins of individuals, is far from straightforward...
  6. pmc Multiplex genotyping system for efficient inference of matrilineal genetic ancestry with continental resolution
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Investig Genet 2:6. 2011
    ..abstract:..
  7. ncbi request reprint Significant genetic differentiation between Poland and Germany follows present-day political borders, as revealed by Y-chromosome analysis
    Manfred Kayser
    Department of Forensic Molecular Biology, Medical Genetic Cluster, Erasmus University Medical Center Rotterdam, PO Box 1738, 3000, DR Rotterdam, The Netherlands
    Hum Genet 117:428-43. 2005
    ....
  8. doi request reprint DNA-based prediction of human externally visible characteristics in forensics: motivations, scientific challenges, and ethical considerations
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 3:154-61. 2009
    ..To gain the attention of legislative bodies, we invite the forensic community to participate in a public discourse of these issues...
  9. pmc A comprehensive survey of human Y-chromosomal microsatellites
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 74:1183-97. 2004
    ..As a result of this work, a large number of new, highly polymorphic Y-chromosomal microsatellites are now available for population-genetic, evolutionary, genealogical, and forensic investigations...
  10. doi request reprint The human genetic history of Oceania: near and remote views of dispersal
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Biol 20:R194-201. 2010
    ....
  11. doi request reprint Improving human forensics through advances in genetics, genomics and molecular biology
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Nat Rev Genet 12:179-92. 2011
    ..Such advances in genetics, genomics and molecular biology are likely to improve human forensic case work in the near future...
  12. ncbi request reprint Melanesian and Asian origins of Polynesians: mtDNA and Y chromosome gradients across the Pacific
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 23:2234-44. 2006
    ..We also demonstrate that Fiji played a pivotal role in the history of Polynesia: humans probably first migrated to Fiji, and subsequent settlement of Polynesia probably came from Fiji...
  13. doi request reprint Relating two deep-rooted pedigrees from Central Germany by high-resolution Y-STR haplotyping
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Forensic Sci Int Genet 1:125-8. 2007
    ..This shortcoming makes a strong case for more comprehensive haplotype databases, including more samples and larger numbers of loci...
  14. pmc Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
  15. doi request reprint The impact of the Austronesian expansion: evidence from mtDNA and Y chromosome diversity in the Admiralty Islands of Melanesia
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Biol Evol 25:1362-74. 2008
    ..These results significantly advance our understanding of the impact of the Austronesian expansion and human history in the Pacific region...
  16. pmc Genome-wide analysis indicates more Asian than Melanesian ancestry of Polynesians
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:194-8. 2008
    ....
  17. pmc Improving global and regional resolution of male lineage differentiation by simple single-copy Y-chromosomal short tandem repeat polymorphisms
    Mark Vermeulen
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Forensic Sci Int Genet 3:205-13. 2009
    ....
  18. doi request reprint A new future of forensic Y-chromosome analysis: rapidly mutating Y-STRs for differentiating male relatives and paternal lineages
    Kaye N Ballantyne
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Forensic Sci Int Genet 6:208-18. 2012
    ..7% and 8%, respectively, with Yfiler. Thus, by introducing RM Y-STRs to the forensic genetic community we provide important solutions to several of the current limitations of Y chromosome analysis in forensic genetics...
  19. ncbi request reprint Apparent intrachromosomal exchange on the human Y chromosome explained by population history
    Ralf Kittler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Eur J Hum Genet 11:304-14. 2003
    ..Thus, we demonstrate here that allele frequency distributions at duplicate loci that are suggestive of intrachromosomal recombination can be explained solely by population history...
  20. pmc Y chromosome STR haplotypes and the genetic structure of U.S. populations of African, European, and Hispanic ancestry
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Genome Res 13:624-34. 2003
    ....
  21. doi request reprint The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, The Netherlands
    Forensic Sci Int Genet 7:98-115. 2013
    ....
  22. doi request reprint MtDNA SNP multiplexes for efficient inference of matrilineal genetic ancestry within Oceania
    Kaye N Ballantyne
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 6:425-36. 2012
    ....
  23. doi request reprint Bridging near and remote Oceania: mtDNA and NRY variation in the Solomon Islands
    Frederick Delfin
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 29:545-64. 2012
    ..Our results fill an important lacuna in human genetic studies of Oceania and aid in understanding the colonization and genetic history of this region...
  24. pmc Mutability of Y-chromosomal microsatellites: rates, characteristics, molecular bases, and forensic implications
    Kaye N Ballantyne
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, The Netherlands
    Am J Hum Genet 87:341-53. 2010
    ..This finding is expected to revolutionize Y-chromosomal applications in forensic biology, from previous male lineage differentiation toward future male individual identification...
  25. ncbi request reprint Identification of a candidate genetic variant for the high prevalence of type II diabetes in Polynesians
    Sean Myles
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Eur J Hum Genet 15:584-9. 2007
    ..703, P=0.007) and we therefore suggest that this allele may play a role in the large difference in type II diabetes prevalence between Polynesians and neighboring populations...
  26. pmc A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population
    Fan Liu
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Hum Genet 81:17-31. 2007
    ..For this region, our analysis identified the NMNAT3 and CLSTN2 genes. Our findings confirm linkage to chromosome 11q25. We were unable to confirm SORL1; instead, our analysis points to the OPCML and HNT genes...
  27. pmc Reduced Y-chromosome, but not mitochondrial DNA, diversity in human populations from West New Guinea
    Manfred Kayser
    Department for Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Am J Hum Genet 72:281-302. 2003
    ..Our data further provide evidence for primarily female-mediated gene flow within the highlands of New Guinea but primarily male-mediated gene flow between highland and lowland/coastal regions...
  28. pmc Genome-wide data substantiate Holocene gene flow from India to Australia
    Irina Pugach
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D 04103 Leipzig, Germany
    Proc Natl Acad Sci U S A 110:1803-8. 2013
    ..This is also approximately when changes in tool technology, food processing, and the dingo appear in the Australian archaeological record, suggesting that these may be related to the migration from India...
  29. doi request reprint DNA-based eye colour prediction across Europe with the IrisPlex system
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 6:330-40. 2012
    ....
  30. pmc Detecting low frequent loss-of-function alleles in genome wide association studies with red hair color as example
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e28145. 2011
    ..11×10⁻¹⁴² vs. P for rs258322 = 1.33×10⁻⁶⁶). The CDH test will contribute towards finding rare LOF variants in GWAS and sequencing studies...
  31. doi request reprint Replication of CD58 and CLEC16A as genome-wide significant risk genes for multiple sclerosis
    Ilse A Hoppenbrouwers
    Department of Neurology, MS Centre ErasMS, Erasmus MC, Rotterdam, The Netherlands
    J Hum Genet 54:676-80. 2009
    ..Several of these risk genes, including CD58 and CLEC16A, are shared by different autoimmune diseases. Fine mapping studies will be needed to determine the functional contributions to distinct autoimmune phenotypes...
  32. pmc Predicting human height by Victorian and genomic methods
    Yurii S Aulchenko
    Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 17:1070-5. 2009
    ....
  33. doi request reprint Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans
    Leonie C Jacobs
    Department of Dermatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Genet 132:147-58. 2013
    ..The variants identified in this study may also contribute to the risk of skin cancer. Our findings are also important for predicting skin color in forensic investigations...
  34. pmc A genome-wide association study identifies five loci influencing facial morphology in Europeans
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Genet 8:e1002932. 2012
    ....
  35. pmc HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter
    Mijke Visser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Genome Res 22:446-55. 2012
    ..This concept is highly relevant for future studies aiming to unveil the functional basis of genetically determined phenotypes, including diseases...
  36. doi request reprint IrisPlex: a sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence of ancestry information
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Forensic Sci Int Genet 5:170-80. 2011
    ....
  37. pmc Comprehensive mutation analysis of 17 Y-chromosomal short tandem repeat polymorphisms included in the AmpFlSTR Yfiler PCR amplification kit
    Miriam Goedbloed
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam The Netherlands
    Int J Legal Med 123:471-82. 2009
    ....
  38. pmc Proportioning whole-genome single-nucleotide-polymorphism diversity for the identification of geographic population structure and genetic ancestry
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Am J Hum Genet 78:680-90. 2006
    ....
  39. pmc Dating the age of admixture via wavelet transform analysis of genome-wide data
    Irina Pugach
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, Leipzig, D 04103, Germany
    Genome Biol 12:R19. 2011
    ..The wavelet transform method offers better resolution than existing methods for dating admixture, and can be applied to either SNP or sequence data from humans or other species...
  40. ncbi request reprint Y-chromosome analysis confirms highly sex-biased dispersal and suggests a low male effective population size in bonobos (Pan paniscus)
    Jonas Eriksson
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Mol Ecol 15:939-49. 2006
    ..40,000-45,000). For humans the difference is merely a factor of two, suggesting a more stable demographic history in bonobos in comparison to humans...
  41. doi request reprint Genetic admixture history of Eastern Indonesia as revealed by Y-chromosome and mitochondrial DNA analysis
    Stefano Mona
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Biol Evol 26:1865-77. 2009
    ....
  42. pmc Evaluating self-declared ancestry of U.S. Americans with autosomal, Y-chromosomal and mitochondrial DNA
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Mutat 31:E1875-93. 2010
    ..S. African Americans or U.S. European Americans, relative to their assumed parental populations from Africa or Europe. This provides genetic support for the importance of skin color in the complex process of ancestry identification...
  43. doi request reprint A multiplex SNP assay for the dissection of human Y-chromosome haplogroup O representing the major paternal lineage in East and Southeast Asia
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Hum Genet 57:65-9. 2012
    ....
  44. pmc MicroRNA markers for forensic body fluid identification obtained from microarray screening and quantitative RT-PCR confirmation
    Dmitry Zubakov
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 124:217-26. 2010
    ..Additional work remains necessary in search for suitable miRNA markers for other forensically relevant body fluids...
  45. doi request reprint New markers for old stains: stable mRNA markers for blood and saliva identification from up to 16-year-old stains
    Dmitry Zubakov
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Int J Legal Med 123:71-4. 2009
    ..Moreover, our findings imply that forensic RNA testing can be reliable and robust if degraded samples are considered in the marker ascertainment procedure, with promising expectations beyond tissue identification purposes...
  46. ncbi request reprint Development of Y-chromosomal microsatellite markers for nonhuman primates
    Axel Erler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Mol Ecol 13:2921-30. 2004
    ....
  47. ncbi request reprint Online Y-chromosomal short tandem repeat haplotype reference database (YHRD) for U.S. populations
    Manfred Kayser
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    J Forensic Sci 47:513-9. 2002
    ....
  48. pmc Digital quantification of human eye color highlights genetic association of three new loci
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000934. 2010
    ..A model for predicting quantitative eye colors explained over 50% of trait variance in the Rotterdam Study. Over all our data exemplify that fine phenotyping is a useful strategy for finding genes involved in human complex traits...
  49. doi request reprint Correlation between genetic and geographic structure in Europe
    Oscar Lao
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Curr Biol 18:1241-8. 2008
    ..By including the widely used CEPH from Utah (CEU) samples into our analysis, we could show that these individuals represent northern and western Europeans reasonably well, thereby confirming their assumed regional ancestry...
  50. ncbi request reprint Molecular evolution of Pediculus humanus and the origin of clothing
    Ralf Kittler
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103 Leipzig, Germany
    Curr Biol 13:1414-7. 2003
    ..These results suggest that clothing was a surprisingly recent innovation in human evolution...
  51. pmc A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation
    Karol Estrada
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Mol Genet 18:3516-24. 2009
    ..1 x 10(-7)). Taken together, these results suggest that variation in the C-type natriuretic peptide signaling pathway, involving the NPPC and NPR3 genes, plays an important role in determining human body height...
  52. pmc Forensic pregnancy diagnostics with placental mRNA markers
    Jeanot Gauvin
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 124:13-7. 2010
    ....
  53. pmc mRNA-based skin identification for forensic applications
    Mijke Visser
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Int J Legal Med 125:253-63. 2011
    ....
  54. doi request reprint Developmental validation of the IrisPlex system: determination of blue and brown iris colour for forensic intelligence
    Susan Walsh
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, Zuid Holland, The Netherlands
    Forensic Sci Int Genet 5:464-71. 2011
    ....
  55. doi request reprint Unexpected island effects at an extreme: reduced Y chromosome and mitochondrial DNA diversity in Nias
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mol Biol Evol 28:1349-61. 2011
    ..Our work underlines the importance of human genetic diversity studies not only for a better understanding of human population history but also because of the potential relevance for genetic disease-mapping studies...
  56. doi request reprint Effect of sleep deprivation on rhythms of clock gene expression and melatonin in humans
    Katrin Ackermann
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Chronobiol Int 30:901-9. 2013
    ..g., PER1-3, REV-ERBα) remained unaffected. These data suggest that the core clock mechanism in peripheral oscillators is compromised during acute sleep deprivation...
  57. doi request reprint Therapy failure resulting from superinfection by a drug-resistant HIV variant
    Marieke Pingen
    Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Antivir Ther 17:1621-5. 2012
    ..HIV-1-infected patients can be superinfected with additional HIV-1 variants. Therapy failure can be the consequence of an infection with a resistant strain...
  58. pmc Diurnal rhythms in blood cell populations and the effect of acute sleep deprivation in healthy young men
    Katrin Ackermann
    Department of Forensic Molecular Biology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Sleep 35:933-40. 2012
    ....
  59. pmc Contrasting signals of positive selection in genes involved in human skin-color variation from tests based on SNP scans and resequencing
    Johanna Maria de Gruijter
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center, PO Box 2040, Rotterdam, 3000 CA, The Netherlands
    Investig Genet 2:24. 2011
    ..abstract:..
  60. pmc An efficient multiplex genotyping approach for detecting the major worldwide human Y-chromosome haplogroups
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 125:879-85. 2011
    ..These Y-SNP assays thus form a valuable tool for researchers in the fields of forensic genetics and genetic anthropology to infer a man's patrilineal bio-geographic ancestry from DNA...
  61. ncbi request reprint A genome scan to detect candidate regions influenced by local natural selection in human populations
    Manfred Kayser
    Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany
    Mol Biol Evol 20:893-900. 2003
    ..Our results demonstrate that genome scans are a promising means of identifying candidate regions that have been subjected to local selection...
  62. doi request reprint Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation
    Mannis van Oven
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, The Netherlands
    Hum Mutat 30:E386-94. 2009
    ..This complete mtDNA tree includes previously published as well as newly identified haplogroups, is easily navigable, will be continuously and regularly updated in the future, and is online available at http://www.phylotree.org...
  63. pmc Stable RNA markers for identification of blood and saliva stains revealed from whole genome expression analysis of time-wise degraded samples
    Dmitry Zubakov
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, P O Box 2040, 3000 Rotterdam, The Netherlands
    Int J Legal Med 122:135-42. 2008
    ..We propose the use of these 14 stable mRNA markers for identification of blood and saliva stains in future forensic practice...
  64. ncbi request reprint Evaluation of saliva as a source of human DNA for population and association studies
    Dominique Quinque
    Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, D 04103, Leipzig, Germany
    Anal Biochem 353:272-7. 2006
    ..Thus, saliva can be considered a reliable source of DNA for a wide variety of genetic studies...
  65. pmc Estimating trace deposition time with circadian biomarkers: a prospective and versatile tool for crime scene reconstruction
    Katrin Ackermann
    Department of Forensic Molecular Biology, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Int J Legal Med 124:387-95. 2010
    ....
  66. pmc Postnatal parental smoking: an important risk factor for SIDS
    Germaine Liebrechts-Akkerman
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Pediatr 170:1281-91. 2011
    ..7 [1.0, 6.4]; paternal = 2.4 [1.3, 4.5] ) as was prone sleeping (OR put prone to sleep = 21.5 [10.6, 43.5]; turned prone during sleep = 100 [46, 219]). Premature birth was also significantly associated with SIDS (OR = 2.4 [1.2, 4.8])...
  67. ncbi request reprint A whole genome amplification method to generate long fragments from low quantities of genomic DNA
    Ralf Kittler
    Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, Inselstrasse 22, D 04103 Leipzig, Germany
    Anal Biochem 300:237-44. 2002
    ..LL-DOP-PCR provides significantly better coverage for microsatellites and unique sequences in comparison to a conventional DOP-PCR method...
  68. pmc Microsatellite length differences between humans and chimpanzees at autosomal Loci are not found at equivalent haploid Y chromosomal Loci
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Genetics 173:2179-86. 2006
    ..Such a pattern is consistent with predictions from the heterozygote instability model and is not expected under models of microsatellite evolution that do not include interchromosomal events such as the enzyme evolution model...
  69. pmc Microbial DNA fingerprinting of human fingerprints: dynamic colonization of fingertip microflora challenges human host inferences for forensic purposes
    Sebastian Tims
    Department of Medical Microbiology and Infectious Diseases, Unit Research and Development, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Legal Med 124:477-81. 2010
    ..Overall, our results suggest that human fingerprint microflora is too dynamic to allow for forensic marker developments for retrieving human information...
  70. pmc Human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development
    Catherine Robin
    Erasmus MC Stem Cell Institute, Department of Cell Biology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Cell Stem Cell 5:385-95. 2009
    ..Immunostaining of placenta sections during development localizes hematopoietic cells in close contact with pericytes/perivascular cells. Thus, the human placenta is a potent hematopoietic niche throughout development...
  71. pmc Sex and gender issues in competitive sports: investigation of a historical case leads to a new viewpoint
    Kaye N Ballantyne
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Br J Sports Med 46:614-7. 2012
    ....
  72. ncbi request reprint Evaluation of haplotype discrimination capacity of 35 Y-chromosomal short tandem repeat loci
    Heike Rodig
    Biotype AG, Moritzburger Weg 67, 01109 Dresden, Germany
    Forensic Sci Int 174:182-8. 2008
    ..Complete resolution of the pooled population was achieved by the additional genotyping of two further loci, DYS446 or DYS505 and DYF406S1 or DYS522...
  73. ncbi request reprint Homogeneity and distinctiveness of Polish paternal lineages revealed by Y chromosome microsatellite haplotype analysis
    Rafal Ploski
    Human Molecular Genetics Lab, Department of Forensic Medicine, Warsaw Medical Academy, Poland
    Hum Genet 110:592-600. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/10.1007/s00439-002-0728-0...
  74. pmc The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
    ..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria...
  75. ncbi request reprint A counter-clockwise northern route of the Y-chromosome haplogroup N from Southeast Asia towards Europe
    Siiri Rootsi
    Department of Evolutionary Biology, University of Tartu and Estonian Biocentre, Tartu, Estonia
    Eur J Hum Genet 15:204-11. 2007
    ..These phylogeographic patterns provide evidence consistent with male-mediated counter-clockwise late Pleistocene-Holocene migratory trajectories toward Northwestern Europe from an ancestral East Asian source of Paleolithic heritage...
  76. ncbi request reprint Asian online Y-STR Haplotype Reference Database
    Ruediger Lessig
    Institute of Legal Medicine, University of Leipzig, Johannisallee 28, D 04103 Leipzig, Germany
    Leg Med (Tokyo) 5:S160-3. 2003
    ..All databases are maintained and curated at the Institute of Legal Medicine, Humboldt-University, Berlin and will soon be fused to a global repository including populations from all continents...
  77. ncbi request reprint Patterns of Y-chromosome diversity intersect with the Trans-New Guinea hypothesis
    Stefano Mona
    Department of Genetics and Microbiology, University of Bari, Bari, Italy
    Mol Biol Evol 24:2546-55. 2007
    ....
  78. ncbi request reprint Y-chromosomal evidence for a strong reduction in male population size of Yakuts
    Brigitte Pakendorf
    Institute of Human Biology, University of Hamburg, Germany
    Hum Genet 110:198-200. 2002
  79. ncbi request reprint Signature of recent historical events in the European Y-chromosomal STR haplotype distribution
    Lutz Roewer
    Institute of Legal Medicine, Humboldt University, Berlin, Germany
    Hum Genet 116:279-91. 2005
    ..We conclude that Y-STRs may be capable of resolving male genealogies to an unparalleled degree and could therefore provide a useful means to study local population structure and recent demographic history...