Mariette H W Kappers

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Paraganglioma of the urinary bladder
    M H W Kappers
    Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands
    Neth J Med 66:163-5. 2008
  2. doi Sunitinib-induced hypothyroidism is due to induction of type 3 deiodinase activity and thyroidal capillary regression
    Mariette H W Kappers
    Division of Pharmacology, Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 96:3087-94. 2011
  3. doi The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system
    Mariette H W Kappers
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Hypertension 58:295-302. 2011
  4. doi Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels
    Mariette H W Kappers
    Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 56:675-81. 2010
  5. doi Sunitinib-induced systemic vasoconstriction in swine is endothelin mediated and does not involve nitric oxide or oxidative stress
    Mariette H W Kappers
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 59:151-7. 2012
  6. doi Hypertension during vascular endothelial growth factor inhibition: focus on nitric oxide, endothelin-1, and oxidative stress
    Stephanie Lankhorst
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Antioxid Redox Signal 20:135-45. 2014
  7. doi Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: preclinical study
    Stephanie Lankhorst
    From the Division of Pharmacology and Vascular Medicine, Department of Internal Medicine S L, M H W K, J H M v E, A H J D, A H v d M and Department of Medical Oncology, Erasmus MC Cancer Institute S S, R H J M, Erasmus Medical Center, Rotterdam, The Netherlands Department of Pathology, Reinier de Graaf Groep, Delft, The Netherlands F M M S Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands M H W K and Department of Pathology, Leiden University Medical Center, Leiden H J B
    Hypertension 64:1282-9. 2014
  8. doi Greater Sensitivity of Blood Pressure Than Renal Toxicity to Tyrosine Kinase Receptor Inhibition With Sunitinib
    Stephanie Lankhorst
    From the Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands S L, M H W K, F M M S, A H J D, A H v d M Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands H J B Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands M H W K Department of Pathology, Reinier de Graaf Gasthuis, Delft, The Netherlands F M M S Department of Pathology, Herlev University Hospital, Herlev, Denmark A H Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands M C C v G and Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands S S, R H JM
    Hypertension 66:543-9. 2015
  9. doi Mechanism of hypertension and proteinuria during angiogenesis inhibition: evolving role of endothelin-1
    Stephanie Lankhorst
    Department of Internal Medicine, Pharmacology and Vascular Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 31:444-54; discussion 454. 2013
  10. ncbi [New insights into the pathogenesis of pre-eclampsia: the role of angiogenesis-inhibiting factors]
    Koen Verdonk
    Erasmus Medisch Centrum, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A2946. 2011

Collaborators

Detail Information

Publications11

  1. ncbi Paraganglioma of the urinary bladder
    M H W Kappers
    Department of Internal Medicine, Ikazia Hospital, Rotterdam, The Netherlands
    Neth J Med 66:163-5. 2008
    ..Although the patient presented with classical signs and symptoms, these were only appreciated after histological examination of a transurethral resection specimen had elucidated the correct diagnosis...
  2. doi Sunitinib-induced hypothyroidism is due to induction of type 3 deiodinase activity and thyroidal capillary regression
    Mariette H W Kappers
    Division of Pharmacology, Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 96:3087-94. 2011
    ..Anticancer treatment with the tyrosine kinase inhibitor sunitinib causes thyroid dysfunction...
  3. doi The vascular endothelial growth factor receptor inhibitor sunitinib causes a preeclampsia-like syndrome with activation of the endothelin system
    Mariette H W Kappers
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Hypertension 58:295-302. 2011
    ....
  4. doi Hypertension induced by the tyrosine kinase inhibitor sunitinib is associated with increased circulating endothelin-1 levels
    Mariette H W Kappers
    Division of Pharmacology, Vascular and Metabolic Diseases, Department of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 56:675-81. 2010
    ..In conclusion, sunitinib induces a reversible rise in BP in patients and in rats associated with activation of the endothelin-1 system, suppression of the renin-angiotensin system, and generalized microvascular dysfunction...
  5. doi Sunitinib-induced systemic vasoconstriction in swine is endothelin mediated and does not involve nitric oxide or oxidative stress
    Mariette H W Kappers
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 59:151-7. 2012
    ..The sunitinib-mediated systemic hypertension is principally attributed to an increased vasoconstrictor influence of endothelin, with no apparent contributions of a loss of NO bioavailability or increased oxidative stress...
  6. doi Hypertension during vascular endothelial growth factor inhibition: focus on nitric oxide, endothelin-1, and oxidative stress
    Stephanie Lankhorst
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Antioxid Redox Signal 20:135-45. 2014
    ..A common side effect of angiogenesis inhibition is the development of sometimes severe hypertension, which simultaneously appears to be predictive for a favorable antitumor response...
  7. doi Treatment of hypertension and renal injury induced by the angiogenesis inhibitor sunitinib: preclinical study
    Stephanie Lankhorst
    From the Division of Pharmacology and Vascular Medicine, Department of Internal Medicine S L, M H W K, J H M v E, A H J D, A H v d M and Department of Medical Oncology, Erasmus MC Cancer Institute S S, R H J M, Erasmus Medical Center, Rotterdam, The Netherlands Department of Pathology, Reinier de Graaf Groep, Delft, The Netherlands F M M S Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands M H W K and Department of Pathology, Leiden University Medical Center, Leiden H J B
    Hypertension 64:1282-9. 2014
    ..Moreover, the variable response of hypertension and renal injury to different antihypertensive agents suggests that these side effects are, at least in part, unrelated. ..
  8. doi Greater Sensitivity of Blood Pressure Than Renal Toxicity to Tyrosine Kinase Receptor Inhibition With Sunitinib
    Stephanie Lankhorst
    From the Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands S L, M H W K, F M M S, A H J D, A H v d M Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands H J B Department of Internal Medicine, Amphia Hospital, Breda, The Netherlands M H W K Department of Pathology, Reinier de Graaf Gasthuis, Delft, The Netherlands F M M S Department of Pathology, Herlev University Hospital, Herlev, Denmark A H Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands M C C v G and Department of Medical Oncology, Erasmus MC Cancer Institute, Erasmus Medical Center, Rotterdam, the Netherlands S S, R H JM
    Hypertension 66:543-9. 2015
    ....
  9. doi Mechanism of hypertension and proteinuria during angiogenesis inhibition: evolving role of endothelin-1
    Stephanie Lankhorst
    Department of Internal Medicine, Pharmacology and Vascular Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 31:444-54; discussion 454. 2013
    ....
  10. ncbi [New insights into the pathogenesis of pre-eclampsia: the role of angiogenesis-inhibiting factors]
    Koen Verdonk
    Erasmus Medisch Centrum, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 155:A2946. 2011
    ..Whether elevations in the plasma concentrations of sFlt and sEng, combined with a decrease in placental growth factor concentrations, can be utilised as a predictor for pre-eclampsia is currently under investigation...
  11. doi Light-induced vs. bradykinin-induced relaxation of coronary arteries: do S-nitrosothiols act as endothelium-derived hyperpolarizing factors?
    Wendy W Batenburg
    Department of Internal Medicine, Division of Pharmacology, Vascular and Metabolic Diseases, Erasmus Medical Center, Rotterdam 3015 GE, The Netherlands
    J Hypertens 27:1631-40. 2009
    ..Here we compared the mechanism of light-induced and bradykinin-induced PCA relaxation...