Wendy E Kaman
Affiliation: Erasmus MC
Country: The Netherlands
- Bacterial proteases: targets for diagnostics and therapyW E Kaman
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
Eur J Clin Microbiol Infect Dis 33:1081-7. 2014..Current and future bacterial protease targets are described and their limitations outlined...
- Evaluation of a D-amino-acid-containing fluorescence resonance energy transfer peptide library for profiling prokaryotic proteasesWendy E Kaman
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands
Anal Biochem 441:38-43. 2013..Overall, the specific characteristic of our substrate peptide library makes it a rapid tool to high-throughput screen for novel substrates to detect bacterial proteolytic activity...
- Peptide-based fluorescence resonance energy transfer protease substrates for the detection and diagnosis of Bacillus speciesWendy E Kaman
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
Anal Chem 83:2511-7. 2011..anthracis spores and diagnosis of anthrax infection is at hand. We are the first who present fluorogenic substrates for detection of bacterial proteolytic enzymes that can be directly applied in situ by the use of D-oriented amino acids...
- A comprehensive study on the role of the Yersinia pestis virulence markers in an animal model of pneumonic plagueW E Kaman
TNO Defence, Security and Safety, 2280 AA, Rijswijk, The Netherlands
Folia Microbiol (Praha) 56:95-102. 2011..We can conclude that all known virulence genes are required for the establishment of pneumonic plague in mammalian animal models, the role of HmsF being of particular importance in disease progression...
- Highly specific protease-based approach for detection of porphyromonas gingivalis in diagnosis of periodontitisWendy E Kaman
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
J Clin Microbiol 50:104-12. 2012..We envisage that these substrates may improve the specificity of the current enzyme-based diagnosis of periodontitis associated with P. gingivalis...
- Evaluation of a FRET-peptide substrate to predict virulence in Pseudomonas aeruginosaWendy E Kaman
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands Department of Oral Biochemistry, Academic Centre for Dentistry Amsterdam, University of Amsterdam and VU University Amsterdam, Amsterdam, The Netherlands
PLoS ONE 8:e81428. 2013..In conclusion, we designed and evaluated a 3xGly substrate possibly useful as a simple tool to predict virulence and AZM susceptibility. ..
- Activation of Toll-like receptors and dendritic cells by a broad range of bacterial moleculesLinda C L Boele
TNO Defence, Security and Safety, Business Unit Biological and Chemical Protection, Detection and Identification, PO Box 45, 2280AA Rijswijk, The Netherlands
Cell Immunol 255:17-25. 2009..Taken together, this study provides insight into qualitative differences and general effects of pathogen-derived molecules on dendritic cells...
- Perceptions of point-of-care infectious disease testing among European medical personnel, point-of-care test kit manufacturers, and the general publicWendy E Kaman
Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Center, Rotterdam, The Netherlands
Patient Prefer Adherence 7:559-77. 2013..To determine the current requirements and perceived barriers to the introduction of POC diagnostics in the field of medical microbiology (MM)-POC a prospective online survey (TEMPOtest-QC) was established...
- The bradykinin B2 receptor in the early immune response against Listeria infectionWendy E Kaman
TNO Defence, Security and Safety, Business Unit Biological and Chemical Protection, 2280 AA, Rijswijk, The Netherlands
Med Microbiol Immunol 198:39-46. 2009..Thus, we show that bradykinin and the B(2)R play a role in early innate immune functions during bacterial infection...