A Cecile Jw Janssens

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Towards predictive genetic testing of complex diseases
    A Cecile J W Janssens
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 21:869-70. 2006
  2. ncbi A genome-wide screen for depression in two independent Dutch populations
    Suzanne Schol-Gelok
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Biol Psychiatry 68:187-96. 2010
  3. ncbi The role of disease characteristics in the ethical debate on personal genome testing
    Eline M Bunnik
    Dept of Medical Ethics and Philosophy of Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam 3015 GE, The Netherlands
    BMC Med Genomics 5:4. 2012
  4. ncbi Does genetic testing really improve the prediction of future type 2 diabetes?
    A Cecile J W Janssens
    PLoS Med 3:e114; author reply e127. 2006
  5. ncbi Genome-based prediction of common diseases: methodological considerations for future research
    A Cecile Jw Janssens
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Genome Med 1:20. 2009
  6. ncbi PredictABEL: an R package for the assessment of risk prediction models
    Suman Kundu
    Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 26:261-4. 2011
  7. ncbi HFE gene mutations increase the risk of coronary heart disease in women
    M Carolina Pardo Silva
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands
    Eur J Epidemiol 25:643-9. 2010
  8. ncbi A methodological perspective on genetic risk prediction studies in type 2 diabetes: recommendations for future research
    Sara M Willems
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Diab Rep 11:511-8. 2011
  9. ncbi Using family history information to promote healthy lifestyles and prevent diseases; a discussion of the evidence
    Liesbeth Claassen
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    BMC Public Health 10:248. 2010
  10. ncbi Personal genome testing: test characteristics to clarify the discourse on ethical, legal and societal issues
    Eline M Bunnik
    Department of Medical Ethics and Philosophy of Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Med Ethics 12:11. 2011

Detail Information

Publications59

  1. ncbi Towards predictive genetic testing of complex diseases
    A Cecile J W Janssens
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 21:869-70. 2006
  2. ncbi A genome-wide screen for depression in two independent Dutch populations
    Suzanne Schol-Gelok
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Biol Psychiatry 68:187-96. 2010
    ..Depression has a strong genetic component but candidate gene studies conducted to date have not shown consistent associations...
  3. ncbi The role of disease characteristics in the ethical debate on personal genome testing
    Eline M Bunnik
    Dept of Medical Ethics and Philosophy of Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, Rotterdam 3015 GE, The Netherlands
    BMC Med Genomics 5:4. 2012
    ..Insight into morally relevant differences between diseases will assist researchers, healthcare professionals, policy-makers and other stakeholders in the ethical evaluation of personal genome tests...
  4. ncbi Does genetic testing really improve the prediction of future type 2 diabetes?
    A Cecile J W Janssens
    PLoS Med 3:e114; author reply e127. 2006
  5. ncbi Genome-based prediction of common diseases: methodological considerations for future research
    A Cecile Jw Janssens
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    Genome Med 1:20. 2009
    ..Careful consideration of these issues will contribute to the knowledge base that is needed to identify useful genome-based applications for implementation in clinical and public health practice...
  6. ncbi PredictABEL: an R package for the assessment of risk prediction models
    Suman Kundu
    Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 26:261-4. 2011
    ..PredictABEL is freely available at the websites of GenABEL ( http://www.genabel.org ) and CRAN ( http://cran.r-project.org/)...
  7. ncbi HFE gene mutations increase the risk of coronary heart disease in women
    M Carolina Pardo Silva
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands
    Eur J Epidemiol 25:643-9. 2010
    ..8, 95% CI 1.1-2.8) and current smokers (HR = 3.1, 95% CI 1.4-7.1), but not in former smokers (HR = 1.3, 95% CI 0.7-2.4). HFE mutations are associated with increased risk of incident CHD in women...
  8. ncbi A methodological perspective on genetic risk prediction studies in type 2 diabetes: recommendations for future research
    Sara M Willems
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Diab Rep 11:511-8. 2011
    ..Of all genetic risk prediction studies to date, only a few were conducted in populations that might be relevant for targeting preventive interventions...
  9. ncbi Using family history information to promote healthy lifestyles and prevent diseases; a discussion of the evidence
    Liesbeth Claassen
    Department of Public and Occupational Health, EMGO Institute for Health and Care Research, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
    BMC Public Health 10:248. 2010
    ....
  10. ncbi Personal genome testing: test characteristics to clarify the discourse on ethical, legal and societal issues
    Eline M Bunnik
    Department of Medical Ethics and Philosophy of Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Med Ethics 12:11. 2011
    ..This paper presents a systematic approach to the ELSI-evaluation of personal genome testing for multifactorial diseases along the lines of its test characteristics...
  11. ncbi Strengthening the reporting of Genetic RIsk Prediction Studies (GRIPS): explanation and elaboration
    A Cecile J W Janssens
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Epidemiol 64:e1-e22. 2011
    ....
  12. ncbi Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration
    A Cecile J W Janssens
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Hum Genet 19:18 p preceding 494. 2011
    ....
  13. ncbi Strengthening the reporting of genetic risk prediction studies: the GRIPS statement
    A Cecile J W Janssens
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Hum Genet 19:833-6. 2011
    ..A detailed Explanation and Elaboration document is published on the EJHG website...
  14. ncbi A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions
    A Cecile J W Janssens
    Department of Public Health, Erasmus MC University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:593-9. 2008
    ..There is insufficient scientific evidence to conclude that genomic profiles are useful in measuring genetic risk for common diseases or in developing personalized diet and lifestyle recommendations for disease prevention...
  15. ncbi An empirical comparison of meta-analyses of published gene-disease associations versus consortium analyses
    A Cecile J W Janssens
    Department of Public Health, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Genet Med 11:153-62. 2009
    ..It is not clear how the results obtained by consortia compare with those derived from meta-analyses of published studies...
  16. ncbi Genome-based prediction of common diseases: advances and prospects
    A Cecile J W Janssens
    Department of Public Health, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hum Mol Genet 17:R166-73. 2008
    ....
  17. ncbi Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration
    A Cecile J W Janssens
    Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 26:313-37. 2011
    ....
  18. ncbi The impact of genotype frequencies on the clinical validity of genomic profiling for predicting common chronic diseases
    A Cecile J W Janssens
    Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    Genet Med 9:528-35. 2007
    ..We investigated the impact of genotype frequencies on the clinical discriminative accuracy for the simultaneous testing of 40 independent susceptibility genetic variants...
  19. ncbi Strengthening the reporting of genetic risk prediction studies: the GRIPS statement
    A Cecile J W Janssens
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 26:255-9. 2011
    ..A detailed Explanation and Elaboration document is published...
  20. ncbi An epidemiological perspective on the future of direct-to-consumer personal genome testing
    A Cecile Jw Janssens
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands
    Investig Genet 1:10. 2010
    ..Personal genome testing will have minimal benefits for individual consumers unless major breakthroughs are made in the near future...
  21. ncbi Predictive genetic testing for the identification of high-risk groups: a simulation study on the impact of predictive ability
    Raluca Mihaescu
    Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Genome Med 3:51. 2011
    ..We investigated the performance of this risk stratification strategy by examining epidemiological parameters that impact the predictive ability of risk models...
  22. ncbi A new logistic regression approach for the evaluation of diagnostic test results
    A Cecile J W Janssens
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus MC, Netherlands
    Med Decis Making 25:168-77. 2005
    ....
  23. ncbi Predictive testing for complex diseases using multiple genes: fact or fiction?
    A Cecile J W Janssens
    Erasmus MC, University Medical Center Rotterdam, The Netherlands
    Genet Med 8:395-400. 2006
    ..There is ongoing debate about whether testing low-risk genes at multiple loci will be useful in clinical care and public health. We investigated the usefulness of multiple genetic testing using simulated data...
  24. ncbi Strengthening the reporting of genetic risk prediction studies: the GRIPS statement
    A Cecile J W Janssens
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Clin Invest 41:1004-9. 2011
    ..A detailed Explanation and Elaboration document is published as an accompanying article [1]...
  25. ncbi Prediction of anxiety and distress following diagnosis of multiple sclerosis: a two-year longitudinal study
    A C J W Janssens
    Department of Public Health, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Mult Scler 12:794-801. 2006
    ..To investigate the course of anxiety, depression and disease-related distress of patients with multiple sclerosis (MS) and their partners in the first years after diagnosis...
  26. ncbi Strengthening the reporting of genetic risk prediction studies (GRIPS): explanation and elaboration
    A Cecile J W Janssens
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Clin Invest 41:1010-35. 2011
    ....
  27. ncbi Accuracy of self-reported family history is strongly influenced by the accuracy of self-reported personal health status of relatives
    A Cecile J W Janssens
    Department of Public Health, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Epidemiol 65:82-9. 2012
    ....
  28. ncbi Value of genetic profiling for the prediction of coronary heart disease
    Jeroen B van der Net
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 50 60, Rotterdam, The Netherlands
    Am Heart J 158:105-10. 2009
    ..This may improve CHD risk prediction. The aim of the present simulation study was to investigate to what degree CHD risk can be predicted by testing multiple genetic variants (genetic profiling)...
  29. ncbi Evaluation of risk prediction updates from commercial genome-wide scans
    Raluca Mihaescu
    Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Genet Med 11:588-94. 2009
    ..Commercial internet-based companies offer genome-wide scans to predict the risk of common diseases and personalize nutrition and lifestyle recommendations. These risk estimates are updated with every new gene discovery...
  30. ncbi Health-related quality of life in patients with musculoskeletal complaints in a general acupuncture practice: an observational study
    Ineke van den Berg
    Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Acupunct Med 28:130-5. 2010
    ..Although acupuncture is a frequently used therapy for musculoskeletal complaints, little is known about the effect on health-related quality of life (HRQoL)...
  31. ncbi Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
    ..001) and coronary heart disease incidence (P = 0.04). The genetic risk score improves the screening of high-risk groups of dyslipidemia over classical risk factors...
  32. ncbi Predicting human height by Victorian and genomic methods
    Yurii S Aulchenko
    Department of Epidemiology and Biostatistics and Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 17:1070-5. 2009
    ....
  33. ncbi Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene
    Manfred Kayser
    Department of Forensic Molecular Biology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Am J Hum Genet 82:411-23. 2008
    ..Testing markers in the HERC2-OCA2 region may be useful in forensic applications to predict eye color phenotypes of unknown persons of European genetic origin...
  34. ncbi Genetic architecture of open angle glaucoma and related determinants
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Med Genet 48:190-6. 2011
    ..We evaluated whether the same genes that determine VCDR and IOP also predict OAG...
  35. ncbi Value of the HLA-DRB1 shared epitope for predicting radiographic damage in rheumatoid arthritis depends on the individual patient risk profile
    A Cecile J W Janssens
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Rheumatol 33:2383-9. 2006
    ..To investigate the influence of individual patient risk profiles on the value of the HLA-DRB1 shared epitope (SE) as a predictor of severe erosive damage in rheumatoid arthritis (RA)...
  36. ncbi Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
    ..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
  37. ncbi Translational research in genomics of Alzheimer's disease: a review of current practice and future perspectives
    Raluca Mihaescu
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Alzheimers Dis 20:967-80. 2010
    ..Most research on genome-based applications in AD is still in the first phase of the translational research framework, which means that further research is still needed before their implementation can be considered...
  38. ncbi Cox proportional hazards models have more statistical power than logistic regression models in cross-sectional genetic association studies
    Jeroen B van der Net
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Eur J Hum Genet 16:1111-6. 2008
    ..5. In conclusion, Cox proportional hazards models can increase statistical power in cross-sectional genetic association studies, especially in the range of effect estimates that are expected for genetic associations in common diseases...
  39. ncbi Usefulness of genetic polymorphisms and conventional risk factors to predict coronary heart disease in patients with familial hypercholesterolemia
    Jeroen B van der Net
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Cardiol 103:375-80. 2009
    ..To improve genome-based prediction of CHD, larger numbers of genetic variants need to be identified that either on their own or in gene-gene interaction have substantial effects on CHD risk...
  40. ncbi Angiotensinogen M235T polymorphism and symptoms of depression in a population-based study and a family-based study
    Sandra Lopez-Leon
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Psychiatr Genet 18:162-6. 2008
    ..The aim of this paper is to examine the association between the AGT M235T polymorphism and symptoms of depression in two independent populations; a population-based study, and a family-based study...
  41. ncbi Shared genetic factors in the co-occurrence of symptoms of depression and cardiovascular risk factors
    Sandra Lopez-Leon
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Affect Disord 122:247-52. 2010
    ..We aim to investigate the extent to which shared genetic and shared environmental factors play a role in the co-occurrence of symptoms of depression and cardiovascular risk factors...
  42. ncbi A study of the SORL1 gene in Alzheimer's disease and cognitive function
    Fan Liu
    Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    J Alzheimers Dis 18:51-64. 2009
    ..In conclusion, our data do not support the hypothesis that genetic variants in SORL1 are related to the risk of AD...
  43. ncbi Patients with Barrett's esophagus perceive their risk of developing esophageal adenocarcinoma as low
    Michelle E Kruijshaar
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Gastrointest Endosc 65:26-30. 2007
    ..The risk of developing esophageal adenocarcinoma (EAC) for patients with Barrett's esophagus (BE) is approximately 0.5% per year...
  44. ncbi Genome-based prediction of breast cancer risk in the general population: a modeling study based on meta-analyses of genetic associations
    Moniek van Zitteren
    Department of Epidemiology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Cancer Epidemiol Biomarkers Prev 20:9-22. 2011
    ..This review and modeling study aimed to investigate the current and potential predictive performance of genetic risk models...
  45. ncbi Role of shared genetic and environmental factors in symptoms of depression and body composition
    Wing Chi Choy
    Department of Epidemiology and Biostatistics, Genetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam, The Netherlands
    Psychiatr Genet 19:32-8. 2009
    ..Both obesity and lean mass have been correlated with symptoms of depression...
  46. ncbi Genetic factors influence the clustering of depression among individuals with lower socioeconomic status
    Sandra Lopez-Leon
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics and Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 4:e5069. 2009
    ..To investigate the extent to which shared genetic factors can explain the clustering of depression among individuals with lower socioeconomic status, and to examine if neuroticism or intelligence are involved in these pathways...
  47. ncbi Cholesteryl ester transfer protein gene and coronary heart disease mortality: the Rotterdam study
    M Carolina Pardo Silva
    J Am Geriatr Soc 55:1483-4. 2007
  48. ncbi Predictive value of multiple genetic testing for age-related macular degeneration
    Dominiek D G Despriet
    Arch Ophthalmol 125:1270-1. 2007
  49. ncbi Apolipoprotein E gene is related to mortality only in normal weight individuals: the Rotterdam Study
    M Carolina Pardo Silva
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Epidemiol 23:135-42. 2008
    ..To investigate the relationship between the apolipoprotein E (APOE) gene and the risk of mortality in normal weight, overweight and obese individuals...
  50. ncbi Perception of prognostic risk in patients with multiple sclerosis: the relationship with anxiety, depression, and disease-related distress
    A Cecile J W Janssens
    Erasmus MC, Department of Neurology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Epidemiol 57:180-6. 2004
    ..These findings underscore the importance of informing patients with chronic disorders about the short-term prognosis of important long-term consequences of disease...
  51. ncbi Five genetic variants associated with prostate cancer
    A Cecile J W Janssens
    N Engl J Med 358:2739; author reply 2741. 2008
  52. ncbi Revisiting the clinical validity of multiplex genetic testing in complex diseases
    A Cecile J W Janssens
    Am J Hum Genet 74:585-8; author reply 588-9. 2004
  53. ncbi Most published research findings are false-but a little replication goes a long way
    Ramal Moonesinghe
    National Office of Public Health Genomics, Coordinating Center for Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
    PLoS Med 4:e28. 2007
  54. ncbi Prenatal exposure to the 1944-45 Dutch 'hunger winter' and addiction later in life
    Ernst J Franzek
    Bouman Mental Health Care Rotterdam, The Netherlands
    Addiction 103:433-8. 2008
    ..We studied the relationship between prenatal exposure to famine during the Dutch hunger winter of 1944-45 and addiction later in life...
  55. ncbi Impact of presymptomatic genetic testing for hereditary ataxia and neuromuscular disorders: where is the evidence?
    A Cecile J W Janssens
    Arch Neurol 62:164; author reply 164. 2005
  56. ncbi Divorce and unemployment in multiple sclerosis: recalculation of the data of Morales-Gonzáles J M, Benito-Leon J, Rivera-Navarro J and Mitchell A J
    A Cecile J W Janssens
    Mult Scler 10:716; author reply 717. 2004
  57. ncbi Adaptation is favorable for most patients with multiple sclerosis
    A Cecile J W Janssens
    Arch Neurol 61:1807; author reply 1808. 2004
  58. ncbi 'It might happen or it might not': how patients with multiple sclerosis explain their perception of prognostic risk
    Hennie R Boeije
    Department of Methodology and Statistics, Utrecht University, Netherlands
    Soc Sci Med 59:861-8. 2004
    ..Comparison of quantitative and qualitative assessments indicated good construct validity for perception of the absolute risk and seriousness of wheelchair dependence...
  59. ncbi Predictive genetic testing for type 2 diabetes
    A Cecile J W Janssens
    BMJ 333:509-10. 2006