Vincent Wv Jaddoe

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc The Generation R Study Biobank: a resource for epidemiological studies in children and their parents
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 22:917-23. 2007
  2. pmc Breast-feeding modifies the association of PPARgamma2 polymorphism Pro12Ala with growth in early life: the Generation R Study
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:992-8. 2009
  3. pmc Heritability estimates of body size in fetal life and early childhood
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 7:e39901. 2012
  4. pmc A common genetic variant at 15q25 modifies the associations of maternal smoking during pregnancy with fetal growth: the generation R study
    Elisabeth T M Leermakers
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 7:e34584. 2012
  5. pmc First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands
    BMJ 348:g14. 2014
  6. ncbi request reprint Childhood cardiometabolic outcomes of maternal obesity during pregnancy: the Generation R Study
    Romy Gaillard
    The Generation R Study Group Na29 15, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 63:683-91. 2014
  7. pmc Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort
    Agnes M M Sonnenschein-van der Voort
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:91. 2012
  8. pmc Differences in problem behaviour among ethnic minority and majority preschoolers in the Netherlands and the role of family functioning and parenting factors as mediators: the Generation R Study
    Ilse J E Flink
    The Generation R Study Group, Erasmus University Medical Centre, Rotterdam, The Netherlands
    BMC Public Health 12:1092. 2012
  9. doi request reprint The Generation R Study: design and cohort update 2012
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 27:739-56. 2012
  10. pmc Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study
    H Rob Taal
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Pediatr Nephrol 26:1275-83. 2011

Collaborators

Detail Information

Publications97

  1. pmc The Generation R Study Biobank: a resource for epidemiological studies in children and their parents
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 22:917-23. 2007
    ....
  2. pmc Breast-feeding modifies the association of PPARgamma2 polymorphism Pro12Ala with growth in early life: the Generation R Study
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:992-8. 2009
    ..We examined whether the PPARgamma2 Ala12 allele influences growth in early life and whether this association is modified by breast-feeding...
  3. pmc Heritability estimates of body size in fetal life and early childhood
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 7:e39901. 2012
    ..The objective was to estimate the heritability for height and weight during fetal life and early childhood in two independent studies, one including parent and singleton offsprings and one of mono- and dizygotic twins...
  4. pmc A common genetic variant at 15q25 modifies the associations of maternal smoking during pregnancy with fetal growth: the generation R study
    Elisabeth T M Leermakers
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 7:e34584. 2012
    ..We examined whether a common genetic variant at chromosome 15q25 (rs1051730), which is known to be involved in nicotine metabolism, modifies the associations of maternal smoking with fetal growth characteristics...
  5. pmc First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands
    BMJ 348:g14. 2014
    ..To examine whether first trimester fetal growth restriction correlates with cardiovascular outcomes in childhood...
  6. ncbi request reprint Childhood cardiometabolic outcomes of maternal obesity during pregnancy: the Generation R Study
    Romy Gaillard
    The Generation R Study Group Na29 15, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 63:683-91. 2014
    ..These findings suggest that maternal prepregnancy BMI may influence the cardiometabolic health of offspring through direct intrauterine mechanisms. ..
  7. pmc Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort
    Agnes M M Sonnenschein-van der Voort
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:91. 2012
    ..We examined the associations of exposure to ambient particulate matter (PM10) and nitrogen dioxide (NO2) with the risk of wheezing in preschool children, and assessed whether these associations were modified by tobacco smoke exposure...
  8. pmc Differences in problem behaviour among ethnic minority and majority preschoolers in the Netherlands and the role of family functioning and parenting factors as mediators: the Generation R Study
    Ilse J E Flink
    The Generation R Study Group, Erasmus University Medical Centre, Rotterdam, The Netherlands
    BMC Public Health 12:1092. 2012
    ..This study aimed to further unravel the differences in problem behaviour among ethnic minority and native preschoolers by examining the mediating role of family functioning and parenting factors...
  9. doi request reprint The Generation R Study: design and cohort update 2012
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 27:739-56. 2012
    ..Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  10. pmc Maternal smoking during pregnancy and kidney volume in the offspring: the Generation R Study
    H Rob Taal
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Pediatr Nephrol 26:1275-83. 2011
    ..Further studies are needed to assess the underlying mechanisms and whether these differences in fetal kidney volume have postnatal consequences for kidney function and blood pressure...
  11. pmc Individually customised fetal weight charts derived from ultrasound measurements: the Generation R Study
    Romy Gaillard
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 26:919-26. 2011
    ..These charts might be useful for use in epidemiological studies and in clinical practice...
  12. pmc Cardiovascular and metabolic influences of fetal smoke exposure
    Hanneke Bakker
    The Generation R Study Group Room Ae 012, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Epidemiol 26:763-70. 2011
    ..We also discuss potential biological mechanisms, and challenges for future epidemiological studies...
  13. pmc Maternal smoking during pregnancy and subcutaneous fat mass in early childhood. The Generation R Study
    Büşra Durmuş
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000, CA, Rotterdam, The Netherlands
    Eur J Epidemiol 26:295-304. 2011
    ..Follow-up studies are needed in children at older ages and to identify associations of maternal smoking during pregnancy with other measures of body composition...
  14. pmc Residential traffic exposure and pregnancy-related outcomes: a prospective birth cohort study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 8:59. 2009
    ..The considerable traffic-related intra-urban spatial variation needs to be considered in exposure assessment. Residential proximity to traffic is a proxy for traffic-related exposures that takes into account within-city contrasts...
  15. pmc Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 10:67. 2009
    ..The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy...
  16. pmc Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study
    Miranda J J Geelhoed
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:39. 2010
    ..We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal and early postnatal life...
  17. ncbi request reprint The Generation R Study: Design and cohort profile
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 21:475-84. 2006
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  18. ncbi request reprint Assessment of maternal smoking status during pregnancy and the associations with neonatal outcomes
    Rachel Bakker
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Nicotine Tob Res 13:1250-6. 2011
    ....
  19. doi request reprint The Generation R Study: design and cohort update until the age of 4 years
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 23:801-11. 2008
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  20. ncbi request reprint Hypotheses on the fetal origins of adult diseases: contributions of epidemiological studies
    Vincent W V Jaddoe
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 21:91-102. 2006
    ..This knowledge is needed to develop strategies for identifying groups at risk and prevention focused on early life...
  21. ncbi request reprint Moderate alcohol consumption during pregnancy and the risk of low birth weight and preterm birth. The generation R study
    Vincent W V Jaddoe
    Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    Ann Epidemiol 17:834-40. 2007
    ..To examine the associations of alcohol consumption in different periods of pregnancy with the risks of low birth weight and preterm birth...
  22. pmc The Generation R Study: design and cohort update 2010
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:823-41. 2010
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  23. ncbi request reprint Active and passive maternal smoking during pregnancy and the risks of low birthweight and preterm birth: the Generation R Study
    Vincent W V Jaddoe
    The Generation R Study Group, and Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Paediatr Perinat Epidemiol 22:162-71. 2008
    ..Smoking in early pregnancy only, seems not to affect fetal growth adversely. Health care strategies for pregnant women should be aimed at quitting smoking completely rather than reducing the number of cigarettes...
  24. ncbi request reprint Maternal smoking and fetal growth characteristics in different periods of pregnancy: the generation R study
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Epidemiol 165:1207-15. 2007
    ..The larger effect on femur length suggests that smoking during pregnancy affects primarily peripheral tissues...
  25. ncbi request reprint Maternal smoking in pregnancy is associated with cholesterol development in the offspring: A 27-years follow-up study
    Vincent W V Jaddoe
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Atherosclerosis 196:42-8. 2008
    ..To examine the associations of maternal smoking in pregnancy with development of cholesterol levels from childhood to adulthood...
  26. ncbi request reprint [Diagnostic image (388). A boy with blue ears]
    V W V Jaddoe
    Reinier de Graaf Gasthuis, afd Kindergeneeskunde, Delft
    Ned Tijdschr Geneeskd 152:1972. 2008
    ..An 8-year-old boy was presented with painful blue ears due to infection with Mycoplasma pneumoniae. The changes disappeared spontaneously...
  27. pmc Children's eating behavior, feeding practices of parents and weight problems in early childhood: results from the population-based Generation R Study
    Pauline W Jansen
    The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Behav Nutr Phys Act 9:130. 2012
    ....
  28. doi request reprint Risk factors and outcomes associated with first-trimester fetal growth restriction
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 303:527-34. 2010
    ..Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known...
  29. doi request reprint Maternal folate status in early pregnancy and child emotional and behavioral problems: the Generation R Study
    Jolien Steenweg-de Graaff
    Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Clin Nutr 95:1413-21. 2012
    ..Maternal prenatal folate status has been linked to neurodevelopmental disorders, but the association with child emotional and behavioral problems is unclear...
  30. doi request reprint Low socioeconomic status is a risk factor for preeclampsia: the Generation R Study
    Lindsay M Silva
    The Generation R Study Group, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Hypertens 26:1200-8. 2008
    ..To examine whether maternal socioeconomic status, as indicated by maternal educational level, is associated with preeclampsia, and if so, to what extent known risk factors for preeclampsia mediate the effect of educational level...
  31. doi request reprint Maternal smoking and blood pressure in different trimesters of pregnancy: the Generation R study
    Rachel Bakker
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 28:2210-8. 2010
    ....
  32. ncbi request reprint Maternal folic acid supplement use in early pregnancy and child behavioural problems: The Generation R Study
    Sabine J Roza
    The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Br J Nutr 103:445-52. 2010
    ..Folic acid supplementation in early pregnancy, aimed to prevent neural tube defects, may also reduce mental health problems in children...
  33. ncbi request reprint Fetal programming of infant neuromotor development: the generation R study
    Tamara van Batenburg-Eddes
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3000 CA, The Netherlands
    Pediatr Res 67:132-7. 2010
    ..These results suggest that differences in infant neuromotor development, a marker of behavioral and cognitive problems, are at least partly caused by processes occurring early in fetal life...
  34. pmc Predicting asthma in preschool children with asthma symptoms: study rationale and design
    Esther Hafkamp-de Groen
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    BMC Pulm Med 12:65. 2012
    ....
  35. pmc Air pollution exposure estimation using dispersion modelling and continuous monitoring data in a prospective birth cohort study in The Netherlands
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:9. 2012
    ..The Generation R Study provides unique possibilities to examine effects of short- and long-term air pollution exposure on various maternal and childhood outcomes and to identify potential critical windows of exposure...
  36. doi request reprint Socioeconomic inequalities in infant temperament: the generation R study
    Pauline W Jansen
    The Generation R Study Group, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 44:87-95. 2009
    ..Furthermore, they generally did not examine explanatory mechanisms underlying the association between SES and temperament. We investigated the association between SES and temperament in infancy...
  37. pmc Toward an operative diagnosis of fussy/picky eating: a latent profile approach in a population-based cohort
    Anne Tharner
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Behav Nutr Phys Act 11:14. 2014
    ..Definitions and assessment methods of fussy/picky eating are heterogeneous and remain unclear.We aimed to identify an eating behavior profile reflecting fussy/picky eating in children and to describe characteristics of fussy eaters...
  38. doi request reprint Maternal smoking during pregnancy and child behaviour problems: the Generation R Study
    Sabine J Roza
    The Generation R Study Group, Erasmus Medical Center Rotterdam, The Netherlands
    Int J Epidemiol 38:680-9. 2009
    ..It is unclear whether this is a causal association, or can be explained by other smoking-related vulnerability factors for child behavioural problems...
  39. doi request reprint Fetal growth from mid- to late pregnancy is associated with infant development: the Generation R Study
    Jens Henrichs
    Institute of Psychology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Dev Med Child Neurol 52:644-51. 2010
    ....
  40. ncbi request reprint A variant of the IGF-I gene is associated with blood pressure but not with left heart dimensions at the age of 2 years: the Generation R Study
    Vera A A van Houten
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 159:209-16. 2008
    ..The objective of this study was to examine whether this variant of the IGF-I gene is associated with blood pressure and left heart dimensions in early childhood...
  41. ncbi request reprint Maternal caffeine intake from coffee and tea, fetal growth, and the risks of adverse birth outcomes: the Generation R Study
    Rachel Bakker
    Departments of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
    Am J Clin Nutr 91:1691-8. 2010
    ..Caffeine is a widely used and accepted pharmacologically active substance. The effect of caffeine intake during pregnancy on fetal growth and development is still unclear...
  42. ncbi request reprint Demographic, emotional and social determinants of cannabis use in early pregnancy: the Generation R study
    Hanan El Marroun
    Generation R Study Group, Erasmus Medical Center Rotterdam, The Netherlands
    Drug Alcohol Depend 98:218-26. 2008
    ..To ascertain demographic, emotional and social determinants of cannabis use in early pregnancy...
  43. doi request reprint Maternal smoking in prenatal and early postnatal life and the risk of respiratory tract infections in infancy. The Generation R study
    Liesbeth Duijts
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 23:547-55. 2008
    ..To assess the associations of maternal smoking during pregnancy and in the postnatal period with respiratory tract infections in young infants...
  44. ncbi request reprint Fetal and postnatal growth and blood pressure at the age of 2 years. The Generation R Study
    Vera A A van Houten
    The Generation R Study Group, Erasmus Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    J Hypertens 27:1152-7. 2009
    ..To examine which fetal and postnatal growth characteristics are associated with blood pressure (BP) in children at the age of 2 years...
  45. ncbi request reprint The role of early life factors in the development of ethnic differences in growth and overweight in preschool children: a prospective birth cohort
    Lenie van Rossem
    The Generation R Study Group, Erasmus MC University Medical Centre Rotterdam, Dr, Molewaterplein 50, Rotterdam 3015 GE, The Netherlands
    BMC Public Health 14:722. 2014
    ..Furthermore, we assessed body mass index (BMI) z-score development from birth to age 4 years to study ethnic-specific differences in BMI z-score trajectory...
  46. pmc Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial
    Esther Hafkamp-de Groen
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    BMC Public Health 10:555. 2010
    ..Early detection and counselling is expected to reduce the prevalence of asthma symptoms and improve health-related quality of life at age 6 years...
  47. pmc Early influences on cardiovascular and renal development
    J J Miranda Geelhoed
    Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 25:677-92. 2010
    ..This review is focused on specific adverse fetal exposures, cardiovascular adaptations and perspectives for new studies...
  48. pmc Natural antibodies against several pneumococcal virulence proteins in children during the pre-pneumococcal-vaccine era: the generation R study
    Ankie Lebon
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    Infect Immun 79:1680-7. 2011
    ..Certain antibodies against pneumococcal virulence proteins, some of which are induced by colonization, are associated with a decreased number of RTIs in children. This should be taken into account in future pneumococcal vaccine studies...
  49. doi request reprint Mother's educational level and fetal growth: the genesis of health inequalities
    Lindsay M Silva
    The Generation R Study Group, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Int J Epidemiol 39:1250-61. 2010
    ....
  50. doi request reprint Does disturbed sleeping precede symptoms of anxiety or depression in toddlers? The generation R study
    Pauline W Jansen
    Erasmus Medical Center University Medical Center Rotterdam, Department of Child and Adolescent Psychiatry, P O Box 2060, 3000 CB Rotterdam, The Netherlands
    Psychosom Med 73:242-9. 2011
    ..To examine whether sleep problems in infancy and early toddlerhood precede symptoms of anxiety or depression at 3 years...
  51. doi request reprint Air pollution, blood pressure, and the risk of hypertensive complications during pregnancy: the generation R study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 57:406-12. 2011
    ..72 [95% CI 1.12 to 2.63] per 10-μg/m(3) increase). In conclusion, our results suggest that air pollution may affect maternal cardiovascular health during pregnancy. The effects might be small but relevant on a population level...
  52. pmc Individual accumulation of heterogeneous risks explains perinatal inequalities within deprived neighbourhoods
    Sarah Timmermans
    The Generation R Study Group, Erasmus MC Rotterdam, POB 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Epidemiol 26:165-80. 2011
    ..To conclude, women from a socioeconomically deprived neighbourhood are at an increased risk for adverse pregnancy outcomes. Differences regarding possibly avoidable risk factors imply that preventive strategies may prove effective...
  53. pmc The inverse correlation between Staphylococcus aureus and Streptococcus pneumoniae colonization in infants is not explained by differences in serum antibody levels in the Generation R Study
    Ankie Lebon
    The Generation R Study Group, Erasmus Medical Center Erasmus MC, Rotterdam, Netherlands
    Clin Vaccine Immunol 18:180-3. 2011
    ..In the first year of life, no association between maternal IgG levels and colonization was seen. In addition, no association between the IgG and IgA levels in the child versus colonization status was seen...
  54. doi request reprint Fetal growth retardation and risk of febrile seizures
    Annemarie M Visser
    Generation R Study Group, Erasmus University Medical Center, Department of Neurology, PO Box 2040, 3000 CA Rotterdam, Netherlands
    Pediatrics 126:e919-25. 2010
    ..The goal was to examine the associations between fetal growth characteristics in different trimesters of pregnancy and the occurrence of febrile seizures in early childhood...
  55. ncbi request reprint The Generation R study: a candidate gene study and genome-wide association study (GWAS) on health-related quality of life (HRQOL) of mothers and young children
    Hein Raat
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Qual Life Res 19:1439-46. 2010
    ..The aim of this paper is to describe the Generation R study as a template that enables candidate gene study and genome-wide association study regarding health-related quality of life (HRQOL) of mothers and their young children...
  56. doi request reprint A comparison of parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview: The Generation R study
    Ashna D Mohangoo
    The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam 3000 CA, The Netherlands
    Pediatr Pulmonol 45:500-7. 2010
    ..The aim of this study was to compare parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview...
  57. ncbi request reprint Associations of light and moderate maternal alcohol consumption with fetal growth characteristics in different periods of pregnancy: the Generation R Study
    Rachel Bakker
    The Generation R Study Group, Erasmus Medical Centre, Rotterdam, The Netherlands
    Int J Epidemiol 39:777-89. 2010
    ..Therefore, we examined the associations of light-to-moderate maternal alcohol consumption with various fetal growth characteristics measured in different periods of pregnancy...
  58. doi request reprint No midpregnancy fall in diastolic blood pressure in women with a low educational level: the Generation R Study
    Lindsay M Silva
    The Generation R Study Group, Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hypertension 52:645-51. 2008
    ..This might partly explain these women's susceptibility to preeclampsia...
  59. doi request reprint Cardiac structures track during the first 2 years of life and are associated with fetal growth and hemodynamics: the Generation R Study
    J J Miranda Geelhoed
    Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Am Heart J 158:71-7. 2009
    ..The aim of this study is to examine whether cardiac size and function track in early childhood and are associated with fetal and early postnatal growth and blood flow characteristics...
  60. doi request reprint Are starting and continuing breastfeeding related to educational background? The generation R study
    Lenie van Rossem
    Generation R Study Group, Department of Public Health, Erasmus MC University Medical Centre Rotterdam, Rotterdam, Netherlands
    Pediatrics 123:e1017-27. 2009
    ..To assess the effect of a woman's educational level on starting and continuing breastfeeding and to assess the role of sociodemographic, lifestyle-related, psychosocial, and birth characteristics in this association...
  61. doi request reprint Interactions between TCF7L2 genotype and growth hormone-induced changes in glucose homeostasis in small for gestational age children
    Sandra W K de Kort
    Department of Paediatrics, Division of Endocrinology, Erasmus MC Sophia, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 72:47-52. 2010
    ..Therefore, GH-treated SGA children are an ideal group to investigate whether the TCF7L2 rs7903146 genotype is associated with changes in glucose homeostasis...
  62. ncbi request reprint Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study
    Sarah Timmermans
    The Generation R Study Group, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Br J Nutr 102:777-85. 2009
    ..28, 0.69 and OR 0.40, 95 % CI 0.22, 0.72). In conclusion, periconception folic acid supplementation is associated with increased fetal growth resulting in higher placental and birth weight, and decreased risks of low birth weight and SGA...
  63. doi request reprint Fetal and postnatal growth and body composition at 6 months of age
    Lamise Ay
    The Generation R Study Group AE006, Department of Pediatrics, Erasmus Medical Center, P O Box 2040, Rotterdam 3000 CA, The Netherlands
    J Clin Endocrinol Metab 94:2023-30. 2009
    ....
  64. ncbi request reprint Smoking during pregnancy in ethnic populations: the Generation R study
    Ernst Jan W M Troe
    The Generation R Study Group, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    Nicotine Tob Res 10:1373-84. 2008
    ..Smoking rates and correlates of smoking during pregnancy varied by ethnic background. These observations should be considered when designing maternal smoking prevention and intervention strategies...
  65. ncbi request reprint Maternal anthropometrics in pregnancy are associated with left ventricular mass in infancy. The generation R study
    J J Miranda Geelhoed
    The Generation R Study Group, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Pediatr Res 63:62-6. 2008
    ..Further studies are needed to identify the underlying causal mechanisms and the long-term consequences...
  66. doi request reprint Determinants of folic acid use in early pregnancy in a multi-ethnic urban population in The Netherlands: the Generation R study
    Sarah Timmermans
    Department of Obstetrics and Gynecology, Division of Obstetrics and Prenatal Medicine, Erasmus MC Rotterdam, The Netherlands
    Prev Med 47:427-32. 2008
    ..Recommendations on folic acid use to prevent neural tube defects have been launched in several countries. Adequate folic acid use seems to be low. This study assesses the prevalence of folic acid use and identifies its determinants...
  67. ncbi request reprint Role of Staphylococcus aureus nasal colonization in atopic dermatitis in infants: the Generation R Study
    Ankie Lebon
    Department of Pediatrics, Erasmus Medical Center Sophia Children s Hospital, University Medical Center, PO Box 2060, 3000 CB Rotterdam, The Netherlands
    Arch Pediatr Adolesc Med 163:745-9. 2009
    ..To study the association between Staphylococcus aureus nasal colonization and atopic dermatitis (AD) in infancy...
  68. doi request reprint Growth in foetal life and infancy is associated with abdominal adiposity at the age of 2 years: the generation R study
    Büşra Durmuş
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 72:633-40. 2010
    ..We examined the associations of foetal and postnatal growth characteristics with abdominal fat mass at the age of 2 years...
  69. doi request reprint Explaining educational inequalities in birthweight: the Generation R Study
    Pauline W Jansen
    The Generation R Study Group, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Paediatr Perinat Epidemiol 23:216-28. 2009
    ..In order to tackle inequalities in birthweight, it is important that interventions are accessible for pregnant women in lower socio-economic strata...
  70. doi request reprint Intrauterine cannabis exposure affects fetal growth trajectories: the Generation R Study
    Hanan El Marroun
    Department of Child and Adolescent Psychiatry and the Generation R Study Group, Rotterdam, The Netherlands
    J Am Acad Child Adolesc Psychiatry 48:1173-81. 2009
    ..This study examined the relation between maternal cannabis use and fetal growth until birth in a population-based sample...
  71. ncbi request reprint Growth, development and health from early fetal life until young adulthood: the Generation R Study
    Albert Hofman
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Sophia Children s Hospital, Rotterdam, The Netherlands
    Paediatr Perinat Epidemiol 18:61-72. 2004
    ..The study entered its pilot phase to test the logistics in December 2001. Full participant recruitment and complete data collection started in 2002...
  72. ncbi request reprint Variation in the IGF1 gene and growth in foetal life and infancy. The Generation R Study
    J J Miranda Geelhoed
    The Generation R Study Group, Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 68:382-9. 2008
    ..The objective of this study was to examine whether variants of the IGF1 gene are associated with growth patterns from foetal life until infancy...
  73. ncbi request reprint Socioeconomic status is not inversely associated with overweight in preschool children
    Lenie van Rossem
    Generation R Study Group, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    J Pediatr 157:929-935.e1. 2010
    ..To assess whether socioeconomic inequalities were already present in preschool children...
  74. ncbi request reprint Employment status and the risk of pregnancy complications: the Generation R Study
    Pauline W Jansen
    The Generation R Study Group, Erasmus MC University Medical Centre Rotterdam, PO Box 2040 Room Ae 029, 3000 CA Rotterdam, The Netherlands
    Occup Environ Med 67:387-94. 2010
    ..This study explored the relationships of employment status, type of unemployment and number of weekly working hours, with a wide range of pregnancy outcomes...
  75. doi request reprint Foetal and postnatal growth and bone mass at 6 months: the Generation R Study
    Lamise Ay
    The Generation R Study Group, Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 74:181-90. 2011
    ..To examine whether parental, foetal and postnatal characteristics and growth patterns in foetal life and infancy are associated with bone mass at 6 months, as bone acquisition seems to be associated with genetic and environmental factors...
  76. doi request reprint Colonization of healthy children by Moraxella catarrhalis is characterized by genotype heterogeneity, virulence gene diversity and co-colonization with Haemophilus influenzae
    Suzanne J C Verhaegh
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    Microbiology 157:169-78. 2011
    ..catarrhalis isolates, may be a result of immune evasion by this pathogen. Finally, the factors facilitating M. catarrhalis and H. influenzae co-colonization need to be further investigated...
  77. doi request reprint Glucocorticoid receptor-9beta polymorphism is associated with systolic blood pressure and heart growth during early childhood. The Generation R Study
    J J Miranda Geelhoed
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Early Hum Dev 87:97-102. 2011
    ..glucocorticoid receptor-9β polymorphism (rs6198) is associated with the susceptibility for cardiovascular disease...
  78. pmc Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior
    Fleur P Velders
    Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Neuropsychopharmacology 37:2541-9. 2012
    ..05). These findings emphasize the potential effect of prenatal gene-environment interaction, and give insight in possible mechanisms accounting for children's individual vulnerability to develop emotional and behavioral problems...
  79. ncbi request reprint Effects of maternal smoking in pregnancy on prenatal brain development. The Generation R Study
    Sabine J Roza
    The Generation R Study Group, Erasmus MC University Medical Centre Rotterdam, The Netherlands
    Eur J Neurosci 25:611-7. 2007
    ..Further research should focus on the causal pathway from prenatal cigarette exposure via brain development to behavioural and cognitive functions...
  80. doi request reprint Intra- and interobserver reproducibility study of early fetal growth parameters
    Bero O Verburg
    The Generation R Study Group, Erasmus Medical Center, Sophia Children s Hospital, Rotterdam, The Netherlands
    Prenat Diagn 28:323-31. 2008
    ..To assess the intra- and interobserver reproducibility of fetal biometry measurements by transabdominal ultrasound in early pregnancy...
  81. ncbi request reprint Perinatal stress influences lymphocyte subset counts in neonates. The generation R study
    Liesbeth Duijts
    The Generation R Study Group, Erasmus Medical Center, 3000 CB Rotterdam, The Netherlands
    Pediatr Res 63:292-8. 2008
    ..We conclude that, in the general population, lymphocyte subset counts in neonates increase with increasing stress- and hypoxia-related perinatal factors...
  82. doi request reprint Fetal hemodynamic adaptive changes related to intrauterine growth: the Generation R Study
    Bero O Verburg
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Sophia Children s Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Circulation 117:649-59. 2008
    ..The aim of the present study was to evaluate whether reduced fetal growth is associated with fetal circulatory changes and cardiac dysfunction...
  83. ncbi request reprint A prospective study on intrauterine cannabis exposure and fetal blood flow
    Hanan El Marroun
    Erasmus Medical Center, The Netherlands
    Early Hum Dev 86:231-6. 2010
    ..Cannabis is commonly used among pregnant women. It is unclear whether cannabis exposure causes hemodynamic modifications in the fetus, like tobacco does...
  84. doi request reprint Insulin VNTR and IGF-1 promoter region polymorphisms are not associated with body composition in early childhood: the generation R study
    Janneke A J B M Maas
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Horm Res Paediatr 73:120-7. 2010
    ....
  85. doi request reprint Prolonged and exclusive breastfeeding reduces the risk of infectious diseases in infancy
    Liesbeth Duijts
    Generation R Study Group, Rotterdam, Netherlands
    Pediatrics 126:e18-25. 2010
    ..To examine the associations of duration of exclusive breastfeeding with infections in the upper respiratory (URTI), lower respiratory (LRTI), and gastrointestinal tracts (GI) in infancy...
  86. doi request reprint Tracking and determinants of kidney size from fetal life until the age of 2 years: the Generation R Study
    J J Miranda Geelhoed
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Kidney Dis 53:248-58. 2009
    ..The aims of this study are to examine whether kidney size tracks from fetal life to childhood and whether maternal and fetal characteristics are associated with kidney size at the age of 2 years...
  87. doi request reprint Effect of birth weight and postnatal weight gain on body composition in early infancy: The Generation R Study
    Susanne Holzhauer
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Early Hum Dev 85:285-90. 2009
    ..The influence of rapid weight gain on body composition in early infancy is still unknown and the critical periods of weight gain for later disease are debated...
  88. ncbi request reprint Kidney growth curves in healthy children from the third trimester of pregnancy until the age of two years. The Generation R Study
    J J Miranda Geelhoed
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Pediatr Nephrol 25:289-98. 2010
    ..Left kidney size tended to be smaller than right kidney size, except for kidney length. The reference curves can be used for assessing kidney structures by ultrasound in foetal life and early childhood...
  89. ncbi request reprint Insulin gene variable number of tandem repeats is not associated with weight from fetal life until infancy: the Generation R Study
    Dennis O Mook-Kanamori
    The Generation R Study Group, Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 157:741-8. 2007
    ..The aim of this study was to examine whether the insulin gene variable number of tandem repeats (INS VNTR) is associated with growth patterns in fetal life and infancy...
  90. ncbi request reprint Maternal first-trimester diet and childhood bone mass: the Generation R Study
    Denise H M Heppe
    Generation R Study Group and the Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Clin Nutr 98:224-32. 2013
    ..Maternal diet during pregnancy has been suggested to influence bone health in later life...
  91. doi request reprint Hemodynamic adaptations in different trimesters among nulliparous and multiparous pregnant women; the Generation R study
    Akashi Andrew Rurangirwa
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Hypertens 25:892-9. 2012
    ..Therefore, we examined the associations of parity with blood pressure and hemodynamic placental function during pregnancy and risks of gestational hypertensive disorders...
  92. doi request reprint Growth, obesity, and cardiac structures in early childhood: the Generation R Study
    Layla L de Jonge
    Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Hypertension 57:934-40. 2011
    ..Overweight and obese children show cardiac adaptations already at the age of 2 years. Further studies are needed to assess whether these structural adaptations influence the risk of cardiovascular disease in later life...
  93. pmc Urinary metabolite concentrations of organophosphorous pesticides, bisphenol A, and phthalates among pregnant women in Rotterdam, the Netherlands: the Generation R study
    Xibiao Ye
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, MD A3 05, PO Box 12233, Research Triangle Park, NC 27709, USA
    Environ Res 108:260-7. 2008
    ..The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation...
  94. doi request reprint Intrauterine growth and infant temperamental difficulties: the Generation R Study
    Sabine J Roza
    Department of Child and Adolescent Psychiatry, Rotterdam, The Netherlands
    J Am Acad Child Adolesc Psychiatry 47:264-72. 2008
    ..To determine whether intrauterine growth trajectories are associated with temperamental difficulties in infancy...
  95. doi request reprint What is spared by fetal brain-sparing? Fetal circulatory redistribution and behavioral problems in the general population
    Sabine J Roza
    Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Epidemiol 168:1145-52. 2008
    ..This suggests that "brain-sparing" does not completely spare the brain and indicates underlying pathology with consequences for later behavior...
  96. pmc Dynamics and determinants of Staphylococcus aureus carriage in infancy: the Generation R Study
    Ankie Lebon
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Microbiol 46:3517-21. 2008
    ..1% at the age of 1.5 months to 12.9% at 14 months. Persistent carriage, defined as continuous carriage of the same S. aureus strain at the three sampling moments, was rarely detected in early infancy...
  97. ncbi request reprint Foetal growth determines cerebral ventricular volume in infants The Generation R Study
    Sabine J Roza
    The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Neuroimage 39:1491-8. 2008
    ..Moreover, the naturally occurring enlargement of ventricles during infancy should be considered in interpreting reports on increased ventricular volumes in several neuropsychiatric disorders...