Vincent Wv Jaddoe

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..Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...

..Further studies are needed to assess the underlying mechanisms and whether these differences in fetal kidney volume have postnatal consequences for kidney function and blood pressure...

..These charts might be useful for use in epidemiological studies and in clinical practice...

..We also discuss potential biological mechanisms, and challenges for future epidemiological studies...

..Follow-up studies are needed in children at older ages and to identify associations of maternal smoking during pregnancy with other measures of body composition...

..The considerable traffic-related intra-urban spatial variation needs to be considered in exposure assessment. Residential proximity to traffic is a proxy for traffic-related exposures that takes into account within-city contrasts...

..The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy...

..We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal and early postnatal life...

..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...

..Smoking in early pregnancy only, seems not to affect fetal growth adversely. Health care strategies for pregnant women should be aimed at quitting smoking completely rather than reducing the number of cigarettes...

..An 8-year-old boy was presented with painful blue ears due to infection with Mycoplasma pneumoniae. The changes disappeared spontaneously...

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..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...

..This knowledge is needed to develop strategies for identifying groups at risk and prevention focused on early life...

..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...

..To examine the associations of alcohol consumption in different periods of pregnancy with the risks of low birth weight and preterm birth...

..To examine the associations of maternal smoking in pregnancy with development of cholesterol levels from childhood to adulthood...

..The larger effect on femur length suggests that smoking during pregnancy affects primarily peripheral tissues...

..Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known...

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..These results suggest that differences in infant neuromotor development, a marker of behavioral and cognitive problems, are at least partly caused by processes occurring early in fetal life...

..Folic acid supplementation in early pregnancy, aimed to prevent neural tube defects, may also reduce mental health problems in children...

..The Generation R Study provides unique possibilities to examine effects of short- and long-term air pollution exposure on various maternal and childhood outcomes and to identify potential critical windows of exposure...

..Maternal prenatal folate status has been linked to neurodevelopmental disorders, but the association with child emotional and behavioral problems is unclear...

..Furthermore, they generally did not examine explanatory mechanisms underlying the association between SES and temperament. We investigated the association between SES and temperament in infancy...

..To examine whether maternal socioeconomic status, as indicated by maternal educational level, is associated with preeclampsia, and if so, to what extent known risk factors for preeclampsia mediate the effect of educational level...

..Caffeine is a widely used and accepted pharmacologically active substance. The effect of caffeine intake during pregnancy on fetal growth and development is still unclear...

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..We examined whether the PPARgamma2 Ala12 allele influences growth in early life and whether this association is modified by breast-feeding...

..To examine which fetal and postnatal growth characteristics are associated with blood pressure (BP) in children at the age of 2 years...

..To ascertain demographic, emotional and social determinants of cannabis use in early pregnancy...

..To assess the associations of maternal smoking during pregnancy and in the postnatal period with respiratory tract infections in young infants...

..The objective of this study was to examine whether this variant of the IGF-I gene is associated with blood pressure and left heart dimensions in early childhood...

..It is unclear whether this is a causal association, or can be explained by other smoking-related vulnerability factors for child behavioural problems...

..This study aimed to further unravel the differences in problem behaviour among ethnic minority and native preschoolers by examining the mediating role of family functioning and parenting factors...

..We examined the associations of exposure to ambient particulate matter (PM10) and nitrogen dioxide (NO2) with the risk of wheezing in preschool children, and assessed whether these associations were modified by tobacco smoke exposure...

..Early detection and counselling is expected to reduce the prevalence of asthma symptoms and improve health-related quality of life at age 6 years...

..The aim of this study was to compare parent-reported wheezing or shortness of breath among infants as assessed by questionnaire and physician-interview...

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..To assess whether socioeconomic inequalities were already present in preschool children...

..Therefore, we examined the associations of light-to-moderate maternal alcohol consumption with various fetal growth characteristics measured in different periods of pregnancy...

..The goal was to examine the associations between fetal growth characteristics in different trimesters of pregnancy and the occurrence of febrile seizures in early childhood...

..This review is focused on specific adverse fetal exposures, cardiovascular adaptations and perspectives for new studies...

..Growth in infancy was assessed at birth (weight) and at the ages of 6 weeks, 6 months and 14 months (head circumference, length, weight). The IGF1 promoter region genotype was determined in 738 children...

..In the first year of life, no association between maternal IgG levels and colonization was seen. In addition, no association between the IgG and IgA levels in the child versus colonization status was seen...

..To conclude, women from a socioeconomically deprived neighbourhood are at an increased risk for adverse pregnancy outcomes. Differences regarding possibly avoidable risk factors imply that preventive strategies may prove effective...

..72 [95% CI 1.12 to 2.63] per 10-μg/m(3) increase). In conclusion, our results suggest that air pollution may affect maternal cardiovascular health during pregnancy. The effects might be small but relevant on a population level...

..To examine whether sleep problems in infancy and early toddlerhood precede symptoms of anxiety or depression at 3 years...

..Certain antibodies against pneumococcal virulence proteins, some of which are induced by colonization, are associated with a decreased number of RTIs in children. This should be taken into account in future pneumococcal vaccine studies...

..The aim of this paper is to describe the Generation R study as a template that enables candidate gene study and genome-wide association study regarding health-related quality of life (HRQOL) of mothers and their young children...

..The aim of this study is to examine whether cardiac size and function track in early childhood and are associated with fetal and early postnatal growth and blood flow characteristics...

..To assess the effect of a woman's educational level on starting and continuing breastfeeding and to assess the role of sociodemographic, lifestyle-related, psychosocial, and birth characteristics in this association...

..28, 0.69 and OR 0.40, 95 % CI 0.22, 0.72). In conclusion, periconception folic acid supplementation is associated with increased fetal growth resulting in higher placental and birth weight, and decreased risks of low birth weight and SGA...

..Further studies are needed to identify the underlying causal mechanisms and the long-term consequences...

..To study the association between Staphylococcus aureus nasal colonization and atopic dermatitis (AD) in infancy...

..We examined the associations of foetal and postnatal growth characteristics with abdominal fat mass at the age of 2 years...

..This might partly explain these women's susceptibility to preeclampsia...

..In order to tackle inequalities in birthweight, it is important that interventions are accessible for pregnant women in lower socio-economic strata...

..Smoking rates and correlates of smoking during pregnancy varied by ethnic background. These observations should be considered when designing maternal smoking prevention and intervention strategies...

..Therefore, GH-treated SGA children are an ideal group to investigate whether the TCF7L2 rs7903146 genotype is associated with changes in glucose homeostasis...

..This study examined the relation between maternal cannabis use and fetal growth until birth in a population-based sample...

..Recommendations on folic acid use to prevent neural tube defects have been launched in several countries. Adequate folic acid use seems to be low. This study assesses the prevalence of folic acid use and identifies its determinants...

..The study entered its pilot phase to test the logistics in December 2001. Full participant recruitment and complete data collection started in 2002...

..This study explored the relationships of employment status, type of unemployment and number of weekly working hours, with a wide range of pregnancy outcomes...

..catarrhalis isolates, may be a result of immune evasion by this pathogen. Finally, the factors facilitating M. catarrhalis and H. influenzae co-colonization need to be further investigated...

..To examine whether parental, foetal and postnatal characteristics and growth patterns in foetal life and infancy are associated with bone mass at 6 months, as bone acquisition seems to be associated with genetic and environmental factors...

..glucocorticoid receptor-9β polymorphism (rs6198) is associated with the susceptibility for cardiovascular disease...

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..05). These findings emphasize the potential effect of prenatal gene-environment interaction, and give insight in possible mechanisms accounting for children's individual vulnerability to develop emotional and behavioral problems...

..The aim of the present study was to evaluate whether reduced fetal growth is associated with fetal circulatory changes and cardiac dysfunction...

..The influence of rapid weight gain on body composition in early infancy is still unknown and the critical periods of weight gain for later disease are debated...

..Further research should focus on the causal pathway from prenatal cigarette exposure via brain development to behavioural and cognitive functions...

..The aims of this study are to examine whether kidney size tracks from fetal life to childhood and whether maternal and fetal characteristics are associated with kidney size at the age of 2 years...

..Cannabis is commonly used among pregnant women. It is unclear whether cannabis exposure causes hemodynamic modifications in the fetus, like tobacco does...

..We conclude that, in the general population, lymphocyte subset counts in neonates increase with increasing stress- and hypoxia-related perinatal factors...

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..To assess the intra- and interobserver reproducibility of fetal biometry measurements by transabdominal ultrasound in early pregnancy...

..To examine the associations of duration of exclusive breastfeeding with infections in the upper respiratory (URTI), lower respiratory (LRTI), and gastrointestinal tracts (GI) in infancy...

..Left kidney size tended to be smaller than right kidney size, except for kidney length. The reference curves can be used for assessing kidney structures by ultrasound in foetal life and early childhood...

..The aim of this study was to examine whether the insulin gene variable number of tandem repeats (INS VNTR) is associated with growth patterns in fetal life and infancy...

..Therefore, we examined the associations of parity with blood pressure and hemodynamic placental function during pregnancy and risks of gestational hypertensive disorders...

..Overweight and obese children show cardiac adaptations already at the age of 2 years. Further studies are needed to assess whether these structural adaptations influence the risk of cardiovascular disease in later life...

..The data indicate that the Generation R study population provides a wide distribution of selected environmental exposures. Reasons for the relatively high levels and possible health effects need investigation...

..1% at the age of 1.5 months to 12.9% at 14 months. Persistent carriage, defined as continuous carriage of the same S. aureus strain at the three sampling moments, was rarely detected in early infancy...

..This suggests that "brain-sparing" does not completely spare the brain and indicates underlying pathology with consequences for later behavior...

..Moreover, the naturally occurring enlargement of ventricles during infancy should be considered in interpreting reports on increased ventricular volumes in several neuropsychiatric disorders...

..To determine whether intrauterine growth trajectories are associated with temperamental difficulties in infancy...