B C Jacobs

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome
    Bart C Jacobs
    Department of Neurology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neuroimmunol 194:181-90. 2008
  2. ncbi request reprint Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding
    Bart C Jacobs
    Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Brain 126:2220-34. 2003
  3. ncbi request reprint A case of Guillain-Barré syndrome following a family outbreak of Campylobacter jejuni enteritis
    C W Ang
    Department of Neurology, Erasmus University Rotterdam, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    J Neuroimmunol 111:229-33. 2000
  4. doi request reprint Pain in Guillain-Barre syndrome: a long-term follow-up study
    L Ruts
    Erasmus MC, University Medical Center, Department of Neurology, Room BA 450, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Neurology 75:1439-47. 2010
  5. ncbi request reprint Rapidly progressive, predominantly motor Guillain-Barré syndrome with anti-GalNAc-GD1a antibodies
    C W Ang
    Department of Neurology, Erasmus University Medical Centre Rotterdam, The Netherlands
    Neurology 53:2122-7. 1999
  6. doi request reprint Multifocal motor neuropathy: association of anti-GM1 IgM antibodies with clinical features
    E A Cats
    Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neurology 75:1961-7. 2010
  7. doi request reprint Distinguishing acute-onset CIDP from fluctuating Guillain-Barre syndrome: a prospective study
    L Ruts
    Erasmus MC, University Medical Center, Department of Neurology, CA Rotterdam, The Netherlands
    Neurology 74:1680-6. 2010
  8. pmc Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits
    C W Ang
    Department of Neurology, Erasmus University, Rotterdam, The Netherlands
    Infect Immun 69:2462-9. 2001
  9. doi request reprint Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy
    M L Kuijf
    Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Neurology 73:688-95. 2009
  10. doi request reprint Correlates of outcome and response to IVIg in 88 patients with multifocal motor neuropathy
    E A Cats
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht100, 3584 CX Utrecht, The Netherlands
    Neurology 75:818-25. 2010

Collaborators

Detail Information

Publications58

  1. doi request reprint Subclass IgG to motor gangliosides related to infection and clinical course in Guillain-Barré syndrome
    Bart C Jacobs
    Department of Neurology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neuroimmunol 194:181-90. 2008
    ..These findings support a model in which C. jejuni and H. influenzae infections induce two distinct patterns of cross-reactive antibodies with different clinical outcome...
  2. ncbi request reprint Immunoglobulins inhibit pathophysiological effects of anti-GQ1b-positive sera at motor nerve terminals through inhibition of antibody binding
    Bart C Jacobs
    Department of Neurology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Brain 126:2220-34. 2003
    ....
  3. ncbi request reprint A case of Guillain-Barré syndrome following a family outbreak of Campylobacter jejuni enteritis
    C W Ang
    Department of Neurology, Erasmus University Rotterdam, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    J Neuroimmunol 111:229-33. 2000
    ..Ganglioside mimicry alone is necessary but not sufficient for the induction of anti-ganglioside antibodies. Other susceptibility factors are required to induce an anti-neural immune response...
  4. doi request reprint Pain in Guillain-Barre syndrome: a long-term follow-up study
    L Ruts
    Erasmus MC, University Medical Center, Department of Neurology, Room BA 450, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Neurology 75:1439-47. 2010
    ..Pain in Guillain-Barré syndrome (GBS) may be pronounced and is often overlooked...
  5. ncbi request reprint Rapidly progressive, predominantly motor Guillain-Barré syndrome with anti-GalNAc-GD1a antibodies
    C W Ang
    Department of Neurology, Erasmus University Medical Centre Rotterdam, The Netherlands
    Neurology 53:2122-7. 1999
    ..To investigate the presence of anti-GalNAc-GD1a antibodies in patients with Guillain-Barré syndrome (GBS) and to determine the relation of anti-ganglioside antibodies with clinical features...
  6. doi request reprint Multifocal motor neuropathy: association of anti-GM1 IgM antibodies with clinical features
    E A Cats
    Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Neurology 75:1961-7. 2010
    ..To determine the prevalence and specificity of antibodies against single gangliosides and ganglioside complexes in serum from 88 patients with multifocal motor neuropathy (MMN) and to study the association with clinical features...
  7. doi request reprint Distinguishing acute-onset CIDP from fluctuating Guillain-Barre syndrome: a prospective study
    L Ruts
    Erasmus MC, University Medical Center, Department of Neurology, CA Rotterdam, The Netherlands
    Neurology 74:1680-6. 2010
    ..The aim of the study was to provide criteria that can help to distinguish between GBS-TRF and A-CIDP in the early phase of disease...
  8. pmc Guillain-Barré syndrome- and Miller Fisher syndrome-associated Campylobacter jejuni lipopolysaccharides induce anti-GM1 and anti-GQ1b Antibodies in rabbits
    C W Ang
    Department of Neurology, Erasmus University, Rotterdam, The Netherlands
    Infect Immun 69:2462-9. 2001
    ..jejuni LPS results in antiganglioside antibodies. These results provide strong support for molecular mimicry as a mechanism in the induction of antiganglioside antibodies following infections...
  9. doi request reprint Detection of anti-MAG antibodies in polyneuropathy associated with IgM monoclonal gammopathy
    M L Kuijf
    Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Neurology 73:688-95. 2009
    ..In this study, the diagnostic accuracy of a new and more practical ELISA to detect these antibodies was validated...
  10. doi request reprint Correlates of outcome and response to IVIg in 88 patients with multifocal motor neuropathy
    E A Cats
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht100, 3584 CX Utrecht, The Netherlands
    Neurology 75:818-25. 2010
    ..Identification and examination of all patients with multifocal motor neuropathy (MMN) in the Netherlands to document the clinical spectrum and response to IV immunoglobulin (IVIg) and to determine correlates of outcome...
  11. ncbi request reprint Differential immune response to gangliosides in Guillain-Barré syndrome patients from Japan and The Netherlands
    C W Ang
    Department of Neurology, Erasmus University Medical Centre Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    J Neuroimmunol 121:83-7. 2001
    ..Our findings indicate that geographical determined factors, dependent on either the host or the triggering infectious agent, determine the isotype distribution and fine specificity of anti-ganglioside antibodies in GBS patients...
  12. ncbi request reprint Gastroenteritis-associated Guillain-Barré syndrome on the Caribbean island Curaçao
    R van Koningsveld
    Department of Neurology, Erasmus University Medical Center Rotterdam, The Netherlands
    Neurology 56:1467-72. 2001
    ..The number of patients with Guillain-Barré syndrome (GBS) who have been observed in Curaçao, the Netherlands Antilles, may be increasing...
  13. ncbi request reprint Cross-reactive anti-galactocerebroside antibodies and Mycoplasma pneumoniae infections in Guillain-Barré syndrome
    C W Ang
    Department of Medical Microbiology and Infectious Diseases, Erasmus Medical Centre, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    J Neuroimmunol 130:179-83. 2002
    ..Anti-GalC antibodies cross-reacted with MP antigen. In conclusion, anti-GalC antibodies in GBS patients may be induced by molecular mimicry with MP...
  14. pmc Molecular characterization of Campylobacter jejuni from patients with Guillain-Barré and Miller Fisher syndromes
    H P Endtz
    Departments of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Microbiol 38:2297-301. 2000
    ..Therefore, further characterization of GBS- or MFS-related C. jejuni should target the genes involved in the synthesis of LPS and the incorporation of sialic acid...
  15. doi request reprint TLR4-mediated sensing of Campylobacter jejuni by dendritic cells is determined by sialylation
    Mark L Kuijf
    Department of Neurology, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    J Immunol 185:748-55. 2010
    ..jejuni LOS enhances human DC activation and subsequent B cell proliferation, which may contribute to the development of cross-reactive anti-ganglioside Abs found in GBS patients following C. jejuni infection...
  16. pmc Structure of Campylobacter jejuni lipopolysaccharides determines antiganglioside specificity and clinical features of Guillain-Barré and Miller Fisher patients
    C W Ang
    Department of Neurology, Erasmus University Academic Hospital Dijkzigt Rotterdam, Rotterdam, The Netherlands
    Infect Immun 70:1202-8. 2002
    ..This study provides additional evidence for the hypothesis that the LPS fraction determines the antiganglioside specificity and clinical features in post-Campylobacter neuropathy patients...
  17. doi request reprint Siglec-7 specifically recognizes Campylobacter jejuni strains associated with oculomotor weakness in Guillain-Barré syndrome and Miller Fisher syndrome
    A P Heikema
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Clin Microbiol Infect 19:E106-12. 2013
    ..Lipo-oligosaccharide-specific binding of C. jejuni to Siglec-7 may be an initiating event in immune recognition and presentation, and lead to anti-GQ1b antibody production and the development of ocular weakness in GBS or MFS...
  18. ncbi request reprint HLA class II alleles are not a general susceptibility factor in Guillain-Barré syndrome
    K Geleijns
    Department of Neurology, Erasmus Medical Center, PO Box 1738, Rm Ee 2230, 3000 DR Rotterdam, The Netherlands
    Neurology 64:44-9. 2005
    ..To assess whether human leukocyte antigen (HLA)-DRB1 and HLA-DQB1 alleles confer susceptibility to Guillain-Barre syndrome (GBS) or are related to specific clinical or serologic subgroups of GBS...
  19. pmc Early recognition of poor prognosis in Guillain-Barre syndrome
    C Walgaard
    Department of Neurology, Erasmus MC, University Medical Centre, 3000 CA Rotterdam, The Netherlands
    Neurology 76:968-75. 2011
    ..We developed a clinical prognostic model for early prediction of outcome in GBS, applicable for clinical practice and future therapeutic trials...
  20. ncbi request reprint Antiganglioside antibodies in polyneuropathy associated with monoclonal gammopathy
    M Eurelings
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Neurology 57:1909-12. 2001
    ..Antiganglioside antibodies were significantly associated with demyelinating neuropathy and with IgM monoclonal gammopathy. Anti-GD1b and anti-GQ1b antibodies were significantly associated with predominantly sensory ataxic neuropathy...
  21. doi request reprint Susceptibility to Guillain-Barré syndrome is not associated with CD1A and CD1E gene polymorphisms
    Mark L Kuijf
    Department of Neurology, Erasmus MC, s Gravendijkwal 230, 3015CE, Rotterdam, The Netherlands
    J Neuroimmunol 205:110-2. 2008
    ..Based on this study, CD1 polymorphisms are not a susceptibility or disease modifying factor in GBS...
  22. doi request reprint A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain-Barré syndrome
    R Louwen
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center Rotterdam, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 32:207-26. 2013
    ..jejuni isolates. Our findings indicate a novel link between viral defence, virulence and GBS in a pathogenic bacterium...
  23. doi request reprint Recurrent Guillain-Barré syndrome
    K Kuitwaard
    Erasmus MC, Department of Neurology, s Gravendijkwal 230, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 80:56-9. 2009
    ..Guillain-Barré syndrome (GBS) is generally considered to be monophasic, but recurrences do occur in a presently undefined subgroup of patients...
  24. doi request reprint From stroboscope to dream machine: a history of flicker-induced hallucinations
    B C ter Meulen
    Department of Neurology and Neurophysiology, Haga Teaching Hospital, The Hague, The Netherlands
    Eur Neurol 62:316-20. 2009
    ..This article traces back the history of flicker-induced hallucinations from the early use of stroboscopes in neurophysiology to the dream machine...
  25. doi request reprint Mannose-binding lectin polymorphisms are not associated with rheumatoid arthritis--confirmation in two large cohorts
    F E van de Geijn
    Department of Rheumatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Rheumatology (Oxford) 47:1168-71. 2008
    ..This might be due to underpowerment of previous research work and the fact that no confirmation cohorts were used. Therefore a different approach is warranted...
  26. doi request reprint IVIG treatment and prognosis in Guillain-Barré syndrome
    Pieter A van Doorn
    Department of Neurology, Erasmus MC, University Medical Center Rotterdam, Room BA 450, s Gravendijkwal 230, Rotterdam, The Netherlands
    J Clin Immunol 30:S74-8. 2010
    ..These clinical factors were combined in a clinical prognostic scoring scale, the Erasmus GBS Outcome Scale (EGOS)...
  27. pmc Determination of pain and response to methylprednisolone in Guillain-Barré syndrome
    Liselotte Ruts
    Dept of Neurology, Erasmus MC, Room number Ee 2230, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    J Neurol 254:1318-22. 2007
    ..Pain can be a serious problem in patients with Guillain-Barré syndrome (GBS). Different pain symptoms and the effect of methylprednisolone on pain are evaluated...
  28. doi request reprint Clinical features, pathogenesis, and treatment of Guillain-Barré syndrome
    Pieter A van Doorn
    Department of Neurology, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet Neurol 7:939-50. 2008
    ..Advances in prognostic modelling have resulted in the development of a new and simple prognostic outcome scale that might also help to guide new treatment options, particularly in patients with GBS who have a poor prognosis...
  29. doi request reprint Guillain-Barré syndrome subtypes related to Campylobacter infection
    Judith Drenthen
    Department of Clinical Neurophysiology, Erasmus MC, University Medical Centre Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 82:300-5. 2011
    ..In The Netherlands C jejuni is the predominant type of preceding infection yet AMAN is rare. This may indicate that not all Dutch GBS patients with C jejuni infections have AMAN...
  30. ncbi request reprint Origin of ganglioside complex antibodies in Guillain-Barré syndrome
    Mark L Kuijf
    Department of Neurology, Erasmus MC, s Gravendijkwal 230, Rotterdam, The Netherlands
    J Neuroimmunol 188:69-73. 2007
    ..jejuni strain. Previous mass spectrometry studies on these LOS showed the presence of oligosaccharides with a similar structure, further supporting the hypothesis that in these patients LOS induced the ganglioside complex antibodies...
  31. ncbi request reprint Functional polymorphisms in LPS receptors CD14 and TLR4 are not associated with disease susceptibility or Campylobacter jejuni infection in Guillain-Barré patients
    Karin Geleijns
    Department of Immunology, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Neuroimmunol 150:132-8. 2004
    ..Comparison of the genotypes of 242 GBS patients and 210 healthy subjects showed that polymorphisms in CD14 and TLR4 did not confer disease susceptibility and were not associated with C. jejuni infection...
  32. ncbi request reprint Genetic polymorphisms of macrophage-mediators in Guillain-Barré syndrome
    Karin Geleijns
    Department of Neurology, Erasmus MC, s Gravendijkwal 230, Rotterdam, The Netherlands
    J Neuroimmunol 190:127-30. 2007
    ..The MMP9 C(-1562)T and TNFA C(-863)A SNP were associated with severe weakness and poor outcome, indicating that these SNP may be one of the factors predisposing to a severe form of GBS...
  33. doi request reprint Pharmacokinetics of intravenous immunoglobulin and outcome in Guillain-Barré syndrome
    Krista Kuitwaard
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 66:597-603. 2009
    ..IVIg clearance may depend on disease severity and vary between individuals, implying that this dose is suboptimal for some patients. In this study, we determined whether the pharmacokinetics of IVIg is related to outcome in GBS...
  34. ncbi request reprint Co-infection with two different Campylobacter jejuni strains in a patient with the Guillain-Barré syndrome
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Microbes Infect 8:248-53. 2006
    ..jejuni strain from a GBS patient has been demonstrated. This finding suggests that molecular mimicry with non-sialylated structures may also be involved in the pathogenesis of GBS...
  35. pmc Structural characterization of Campylobacter jejuni lipooligosaccharide outer cores associated with Guillain-Barre and Miller Fisher syndromes
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Infect Immun 75:1245-54. 2007
    ..jejuni-related GBS. However, our findings suggest that in some cases, other mechanisms may play a role. Further examination of the disease etiology in these patients is mandatory...
  36. ncbi request reprint Fas polymorphisms are associated with the presence of anti-ganglioside antibodies in Guillain-Barre syndrome
    Karin Geleijns
    Department of Neurology, Erasmus MC, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    J Neuroimmunol 161:183-9. 2005
    ....
  37. ncbi request reprint The Guillain-Barré syndrome: a true case of molecular mimicry
    C Wim Ang
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Trends Immunol 25:61-6. 2004
    ..Based on recent evidence, we argue that GBS should be considered as an excellent paradigm and an attractive model for elucidation of both host and microbial aspects of molecular mimicry...
  38. pmc The crucial role of Campylobacter jejuni genes in anti-ganglioside antibody induction in Guillain-Barre syndrome
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Clin Invest 114:1659-65. 2004
    ..We demonstrate, for the first time, to our knowledge, that specific bacterial genes are crucial for the induction of anti-ganglioside antibodies...
  39. ncbi request reprint Diagnostic value of anti-GM1 ganglioside serology and validation of the INCAT-ELISA
    Mark L Kuijf
    Department of Neurology, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    J Neurol Sci 239:37-44. 2005
    ..High IgM titers were associated with GBS and multifocal motor neuropathy. Low IgM titers had no additional diagnostic value. The INCAT-ELISA is a reliable test with additional diagnostic value in specific clinical situations...
  40. pmc PCR-restriction fragment length polymorphism analysis of Campylobacter jejuni genes involved in lipooligosaccharide biosynthesis identifies putative molecular markers for Guillain-Barré syndrome
    Peggy C R Godschalk
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
    J Clin Microbiol 45:2316-20. 2007
    ..PCR-restriction fragment length polymorphism analysis of C. jejuni genes involved in the biosynthesis of LOS demonstrated that specific genes were associated with the expression of ganglioside mimics and the development of neuropathy...
  41. pmc Amantadine for treatment of fatigue in Guillain-Barre syndrome: a randomised, double blind, placebo controlled, crossover trial
    M P J Garssen
    Department of Neurology, Erasmus Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:61-5. 2006
    ..In this trial, the effect of amantadine on severe fatigue related to GBS was studied...
  42. doi request reprint Neuromuscular synaptic function in mice lacking major subsets of gangliosides
    F M P Zitman
    Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands
    Neuroscience 156:885-97. 2008
    ..Rather, presynaptic gangliosides appear to play a modulating role in temperature- and use-dependent fine-tuning of transmitter output...
  43. ncbi request reprint Mannose-binding lectin contributes to the severity of Guillain-Barré syndrome
    Karin Geleijns
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 177:4211-7. 2006
    ..These results support the hypothesis that complement activation mediated by MBL contributes to the extent of nerve damage in GBS, which is codetermined by the MBL2 haplotype...
  44. doi request reprint Effect of glucocorticoid receptor gene polymorphisms in Guillain-Barré syndrome
    Marieke J H J Dekker
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Peripher Nerv Syst 14:75-83. 2009
    ..In conclusion, GR haplotypes are not a susceptibility factor for GBS. However, haplotypes carrying the minor allele of the BclI polymorphism were related to the phenotype and outcome of GBS...
  45. ncbi request reprint A clinical prognostic scoring system for Guillain-Barré syndrome
    Rinske van Koningsveld
    Department of Neurology, Erasmus MC, Rotterdam, Netherlands
    Lancet Neurol 6:589-94. 2007
    ..We aimed to develop and validate a scoring system based on clinical characteristics in the acute phase of GBS to predict outcome at 6 months...
  46. ncbi request reprint The occurrence of Guillain-Barre syndrome within families
    K Geleijns
    Department of Neurology, Room Ee 2230, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurology 63:1747-50. 2004
    ..The authors observed an earlier onset of GBS in successive generations. The occurrence of GBS within families suggests a role for genetic factors in the pathogenesis of GBS...
  47. doi request reprint Prediction of respiratory insufficiency in Guillain-Barré syndrome
    Christa Walgaard
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ann Neurol 67:781-7. 2010
    ..We aimed to develop a simple but accurate model to predict the chance of respiratory insufficiency in the acute stage of the disease based on clinical characteristics available at hospital admission...
  48. doi request reprint Recognizing Guillain-Barre syndrome in preschool children
    J Roodbol
    Department of Pediatric Neurology, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    Neurology 76:807-10. 2011
    ..To determine whether recognition of Guillain-Barré syndrome (GBS) is delayed in preschool children, what causes this delay, and if the clinical presentation differs from older children...
  49. ncbi request reprint Screening for anti-ganglioside antibodies in hypocretin-deficient human narcolepsy
    Sebastiaan Overeem
    Department of Neurology, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands
    Neurosci Lett 341:13-6. 2003
    ..However, as an autoimmune attack may be selective and/or transient, future studies are needed to ultimately refute or confirm the autoimmune hypothesis...
  50. ncbi request reprint Immunoglobulin gene analysis in polyneuropathy associated with IgM monoclonal gammopathy
    Marijke Eurelings
    Department of Neurology, The Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Neuroimmunol 175:152-9. 2006
    ..Polyneuropathy associated with monoclonal gammopathy may be caused by an immune response to bacterial antigens, which recruit somatically mutated autoreactive B cells...
  51. ncbi request reprint Severity of Guillain-Barré syndrome is associated with Fc gamma Receptor III polymorphisms
    Nina M van Sorge
    Department of Neurology G03 228, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Neuroimmunol 162:157-64. 2005
    ..Results suggest that Fc gammaRIII genotypes may represent mild disease-modifying factors in GBS...
  52. ncbi request reprint Detection and prevalence of alpha-latrotoxin-like effects of serum from patients with Guillain-Barré syndrome
    Bart C Jacobs
    Departments of Neurology and Immunology, Erasmus Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Muscle Nerve 25:549-58. 2002
    ..The twitching assay is an efficient test for detection of this effect, and allows for screening of large numbers of samples and modifying drugs...
  53. ncbi request reprint Dysfunction at the motor end-plate and axon membrane in Guillain-Barré syndrome: a single-fiber EMG study
    Frank Spaans
    Department of Clinical Neurophysiology, University Hospital, Postbox 5800, 6202 AZ Maastricht, The Netherlands
    Muscle Nerve 27:426-34. 2003
    ..The results of this study show that both a disorder of neuromuscular transmission and an axolemmal dysfunction play a role in the pathophysiology of GBS...
  54. doi request reprint GM3, GM2 and GM1 mimics designed for biosensing: chemoenzymatic synthesis, target affinities and 900 MHz NMR analysis
    Aliaksei V Pukin
    Laboratory of Organic Chemistry, Wageningen University, Dreijenplein 8, 6703 HB, Wageningen, The Netherlands
    Carbohydr Res 343:636-50. 2008
    ..TOCSY and DQF-COSY experiments in combination with 13C-1H correlation measurements (HSQC, HMBC) were carried out for primary structural characterization, and a complete assignment of all 1H and 13C chemical shifts is presented...
  55. doi request reprint Eculizumab prevents anti-ganglioside antibody-mediated neuropathy in a murine model
    Susan K Halstead
    University of Glasgow, Division of Clinical Neurosciences, Glasgow Biomedical Research Centre, Glasgow, UK
    Brain 131:1197-208. 2008
    ....
  56. ncbi request reprint Anti-GM1 IgG antibodies induce leukocyte effector functions via Fcgamma receptors
    Nina M van Sorge
    Department of Neurology and Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Ann Neurol 53:570-9. 2003
    ..These data document the capacity of anti-GM1 IgG antibodies to activate leukocyte inflammatory functions, and suggest an important role for anti-ganglioside IgG antibodies in the pathogenesis of GBS...
  57. ncbi request reprint Presence or absence of cytomegalovirus in cerebrospinal fluid from patients with Guillain-Barré syndrome?
    Mark L Kuijf
    J Infect Dis 193:1471-2; author reply 1472-3. 2006
  58. ncbi request reprint Predicting the course of Guillain-Barré syndrome
    Pieter A van Doorn
    Lancet Neurol 5:991-3. 2006