Dick Jaarsma

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Distribution of RET immunoreactivity in the rodent spinal cord and changes after nerve injury
    Joost L M Jongen
    Department of Neuroscience, Erasmus MC University Medical Center Rotterdam, 3015 GE Rotterdam, The Netherlands
    J Comp Neurol 500:1136-53. 2007
  2. pmc Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology
    Dick Jaarsma
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 7:e1002405. 2011
  3. pmc Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons
    Vera van Dis
    Department of Neuroscience, Erasmus Medical Center, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    Acta Neuropathol Commun 2:38. 2014
  4. doi Cockayne syndrome pathogenesis: lessons from mouse models
    Dick Jaarsma
    Department of Neuroscience, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Mech Ageing Dev 134:180-95. 2013
  5. doi Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
    Dick Jaarsma
    Department of Neuroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Neurosci 28:2075-88. 2008
  6. doi Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice
    Mehdi Hossaini
    Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 70:662-77. 2011
  7. doi Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair
    Nils Z Borgesius
    Department of Neuroscience, Erasmus MC, 3015 GE, Rotterdam, The Netherlands, Cancer Genomics Center, Department of Genetics, Center for Biomedical Genetics, Erasmus MC, 3015 GE, Rotterdam, The Netherlands
    J Neurosci 31:12543-53. 2011
  8. pmc Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice
    Monique C de Waard
    Department of Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Acta Neuropathol 120:461-75. 2010
  9. ncbi Decrease of Hsp25 protein expression precedes degeneration of motoneurons in ALS-SOD1 mice
    Arjen Maatkamp
    Department of Neuroscience, EE12 10, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Neurosci 20:14-28. 2004
  10. ncbi A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice
    Eva Teuling
    Department of Neuroscience, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Hum Mol Genet 17:2849-62. 2008

Collaborators

Detail Information

Publications28

  1. ncbi Distribution of RET immunoreactivity in the rodent spinal cord and changes after nerve injury
    Joost L M Jongen
    Department of Neuroscience, Erasmus MC University Medical Center Rotterdam, 3015 GE Rotterdam, The Netherlands
    J Comp Neurol 500:1136-53. 2007
    ..This role may include mediating the effects of GDNF released from nociceptive afferent fibers...
  2. pmc Age-related neuronal degeneration: complementary roles of nucleotide excision repair and transcription-coupled repair in preventing neuropathology
    Dick Jaarsma
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 7:e1002405. 2011
    ....
  3. pmc Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons
    Vera van Dis
    Department of Neuroscience, Erasmus Medical Center, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    Acta Neuropathol Commun 2:38. 2014
    ..However, the role of Golgi fragmentation in motor neuron degeneration is not well understood...
  4. doi Cockayne syndrome pathogenesis: lessons from mouse models
    Dick Jaarsma
    Department of Neuroscience, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Mech Ageing Dev 134:180-95. 2013
    ..In conclusion, CS mouse models mice develop a range of CS phenotypes and open promising perspectives for testing interventional approaches...
  5. doi Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
    Dick Jaarsma
    Department of Neuroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Neurosci 28:2075-88. 2008
    ..Together, our findings support a pathogenic scenario in which mutant SOD1 in neurons triggers neuronal degeneration, which in turn may facilitate aggregate formation in surrounding glial cells...
  6. doi Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice
    Mehdi Hossaini
    Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 70:662-77. 2011
    ..The degeneration of spinal inhibitory interneurons may in turn facilitate degeneration of motor neurons and contribute to disease progression...
  7. doi Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair
    Nils Z Borgesius
    Department of Neuroscience, Erasmus MC, 3015 GE, Rotterdam, The Netherlands, Cancer Genomics Center, Department of Genetics, Center for Biomedical Genetics, Erasmus MC, 3015 GE, Rotterdam, The Netherlands
    J Neurosci 31:12543-53. 2011
    ..Hence, accumulated DNA damage could therefore be an important factor in the onset and progression of age-related cognitive decline and neurodegenerative diseases...
  8. pmc Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice
    Monique C de Waard
    Department of Genetics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Acta Neuropathol 120:461-75. 2010
    ..Our findings support the notion that accumulation of DNA damage and genotoxic stress may contribute to neuronal aging and motor neuron vulnerability in human neuromuscular disorders...
  9. ncbi Decrease of Hsp25 protein expression precedes degeneration of motoneurons in ALS-SOD1 mice
    Arjen Maatkamp
    Department of Neuroscience, EE12 10, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Neurosci 20:14-28. 2004
    ..These data are consistent with the idea that mutant SOD1 may reduce the availability of the protein quality control machinery in motoneurons...
  10. ncbi A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice
    Eva Teuling
    Department of Neuroscience, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Hum Mol Genet 17:2849-62. 2008
    ..Our findings indicate that impaired dynein/dynactin function can explain several pathological features observed in ALS patients, but may be beneficial in some forms of ALS...
  11. ncbi Differential expression of liprin-α family proteins in the brain suggests functional diversification
    Samantha A Spangler
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    J Comp Neurol 519:3040-60. 2011
    ..We conclude that liprin-α family proteins might perform independent and specialized synaptic and nonsynaptic functions in different regions of the brain...
  12. ncbi Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates
    Eva Teuling
    Department of Neuroscience, Erasmus Medical Center, 3000CA Rotterdam, The Netherlands
    J Neurosci 27:9801-15. 2007
    ..Our data support a model in which reduced levels of VAP family proteins result in decreased ER anchoring of lipid-binding proteins and cause motor neuron degeneration...
  13. ncbi Increased apolipoprotein E expression correlates with the onset of neuronal degeneration in the spinal cord of G93A-SOD1 mice
    Elize D Haasdijk
    Department of Neuroscience, Erasmus University, Rotterdam, The Netherlands
    Neurosci Lett 335:29-33. 2002
    ..The increase in apoE expression closely correlated in time and spatial distribution with axonal and neuronal degeneration as determined with a silver staining procedure, consistent with a role as an 'injury-response' protein...
  14. ncbi Long term proteasome inhibition does not preferentially afflict motor neurons in organotypical spinal cord cultures
    Angela S Vlug
    Department of Neuroscience, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Amyotroph Lateral Scler Other Motor Neuron Disord 5:16-21. 2004
    ..There was no difference between the viability of motor neurons from transgenic and non-transgenic mice...
  15. pmc Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Biol 8:e1000283. 2010
    ..The data uncover a new mechanism to achieve specificity and directionality in neuronal membrane receptor trafficking...
  16. pmc Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment
    Marijn Kuijpers
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Acta Neuropathol Commun 1:24. 2013
    ..Here we have characterized inclusions formed in transgenic mice carrying the P56S mutant form of VAPB that causes various motor neuron syndromes including ALS8...
  17. pmc The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites
    Marijn Kuijpers
    Division of Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    EMBO J 32:2056-72. 2013
    ..These data suggest that both VAPB and YIF1A are important for ER-to-Golgi transport and that missorting of YIF1A may contribute to VAPB-associated motor neuron disease...
  18. pmc Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry
    Daniël Splinter
    Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Biol 8:e1000350. 2010
    ....
  19. pmc Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice
    Jan C Holstege
    Department of Neuroscience, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 105:6338-43. 2008
    ..The data therefore suggest that a lower number of neurons in the upper spinal laminae and neuronal disorganization in the dorsal horn underlie the sensory defects including the excessive grooming of the Hoxb8 mutant...
  20. doi βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses
    Nils Z Borgesius
    Department of Neuroscience, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
    J Neurosci 31:10141-8. 2011
    ..Together, our data provide compelling support for a model of CaMKII function in which αCaMKII and βCaMKII act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning...
  21. ncbi Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level
    Chris I De Zeeuw
    Department of Neuroscience, Medical Faculty, Erasmus MC, 3000DR Rotterdam, The Netherlands
    J Neurosci 23:4700-11. 2003
    ....
  22. ncbi Priming of microglia in a DNA-repair deficient model of accelerated aging
    Divya D A Raj
    Department of Neuroscience, Section Medical Physiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Neurobiol Aging 35:2147-60. 2014
    ..Summarizing, these data show that neuronal genotoxic stress is sufficient to switch microglia from a resting to a primed state. ..
  23. doi A new paraneoplastic encephalomyelitis autoantibody reactive with the axon initial segment
    Setareh Shams'ili
    Department of Neurology, Erasmus University Medical Center, The Netherlands
    Neurosci Lett 467:169-72. 2009
    ..Screening a rat hippocampal cDNA library resulted in the isolation of ubiquitin-conjugating enzyme E2E1 (UBE2E1). However, blocking and elution experiments excluded UBE2E1 as the AIS autoantigen...
  24. pmc Characterization of the mouse neuroinvasiveness of selected European strains of West Nile virus
    Stephanie M Lim
    Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e74575. 2013
    ..Overall, the results indicate that strains circulating in Europe belonging to both lineage 1 and 2 are highly virulent and that Ita09 and 578/10 are more neurovirulent compared to the FIN strain. ..
  25. ncbi ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation
    Angela S Vlug
    Department of Neuroscience, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, Netherlands
    Eur J Neurosci 22:1881-94. 2005
    ....
  26. ncbi Swelling and vacuolisation of mitochondria in transgenic SOD1-ALS mice: a consequence of supranormal SOD1 expression?
    Dick Jaarsma
    Mitochondrion 6:48-9; author reply 50-1. 2006
  27. ncbi Attenuated mild colonic inflammation and improved survival from severe DSS-colitis of transgenic Cu/Zn-SOD mice
    Laurens Kruidenier
    Department of Gastroenterology Hepatology, Leiden University Medical Center, Leiden, The Netherlands
    Free Radic Biol Med 34:753-65. 2003
    ..As such, they support the concept of SOD-based (adjunct) antioxidant treatment strategies for inflammatory bowel disease...
  28. pmc Modulation of presynaptic plasticity and learning by the H-ras/extracellular signal-regulated kinase/synapsin I signaling pathway
    Steven A Kushner
    Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095 1761, USA
    J Neurosci 25:9721-34. 2005
    ..Together with previous invertebrate studies, these results demonstrate that presynaptic plasticity represents an important evolutionarily conserved mechanism for modulating learning and memory...