Aaron Isaacs

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
  2. pmc A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    BMC Med Genet 11:41. 2010
  3. ncbi request reprint The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study
    Aaron Isaacs
    Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 14:419-21. 2007
  4. doi request reprint Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study
    Alejandro Arias-Vasquez
    Genetic Epidemiology Unit, Dept of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol 255:655-62. 2008
  5. doi request reprint Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2
    Carla A Ibrahim-Verbaas
    Department of Neurology, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1869-76. 2012
  6. ncbi request reprint Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels
    Aaron Isaacs
    Genetic Epidemiology Unit, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:2680-7. 2007
  7. ncbi request reprint The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease
    Alejandro Arias-Vasquez
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurogenetics 8:189-93. 2007
  8. doi request reprint The apolipoprotein E gene and its age-specific effects on cognitive function
    Fan Liu
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands
    Neurobiol Aging 31:1831-3. 2010
  9. ncbi request reprint Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study
    Sharmila S Boekhoorn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 115:1899-903. 2008
  10. doi request reprint A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals
    Jasper J Brugts
    Department of Cardiology, Erasmus MC Thoraxcenter, Rotterdam, The Netherlands
    J Hypertens 29:509-19. 2011

Detail Information

Publications31

  1. doi request reprint Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
    ..We tested the hypothesis that the cumulative effects of common genetic variants for lipids are collectively associated with subclinical atherosclerosis and incident coronary heart disease...
  2. pmc A meta-analysis of genome-wide data from five European isolates reveals an association of COL22A1, SYT1, and GABRR2 with serum creatinine level
    Cristian Pattaro
    Institute of Genetic Medicine, European Academy Bozen Bolzano EURAC, Bolzano, Italy
    BMC Med Genet 11:41. 2010
    ..A substantial proportion of the inter-individual variability in S CR level is explicable by genetic factors...
  3. ncbi request reprint The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study
    Aaron Isaacs
    Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 14:419-21. 2007
    ..The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study...
  4. doi request reprint Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study
    Alejandro Arias-Vasquez
    Genetic Epidemiology Unit, Dept of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol 255:655-62. 2008
    ..In our analysis, the haplotype tagged by the G allele of SNP rs2069442 was significantly associated with AD (p = 0.05). In conclusion, our study suggests that CDK5 may be associated with AD...
  5. doi request reprint Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2
    Carla A Ibrahim-Verbaas
    Department of Neurology, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1869-76. 2012
    ..1 × 10(-3) for rs2514299). This linkage study of plasma concentrations of Aβ40 and Aβ42 yielded two suggestive regions, of which one points toward a known locus for familial AD...
  6. ncbi request reprint Epistatic effect of cholesteryl ester transfer protein and hepatic lipase on serum high-density lipoprotein cholesterol levels
    Aaron Isaacs
    Genetic Epidemiology Unit, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:2680-7. 2007
    ..The objectives of the current study were to characterize the effect of the hepatic lipase variant, and its interaction with the CETP variant, in terms of cholesterol levels, atherosclerosis, and risk of myocardial infarction (MI)...
  7. ncbi request reprint The cholesteryl ester transfer protein (CETP) gene and the risk of Alzheimer's disease
    Alejandro Arias-Vasquez
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurogenetics 8:189-93. 2007
    ..04). Our results suggest that the VV genotype of the I405V polymorphism of the CETP gene increases the risk of AD in the absence of the APOE*4 allele, probably through a cholesterol metabolism pathway in the brain...
  8. doi request reprint The apolipoprotein E gene and its age-specific effects on cognitive function
    Fan Liu
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands
    Neurobiol Aging 31:1831-3. 2010
    ..Our findings suggest that APOE*E4 has an effect on cognitive function predominantly in the elderly, independent of vascular risk factors...
  9. ncbi request reprint Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study
    Sharmila S Boekhoorn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 115:1899-903. 2008
    ..The purpose of this study was to examine whether genetic variation in the VEGF gene is associated with AMD and, especially, with its wet end stage...
  10. doi request reprint A pharmacogenetic analysis of determinants of hypertension and blood pressure response to angiotensin-converting enzyme inhibitor therapy in patients with vascular disease and healthy individuals
    Jasper J Brugts
    Department of Cardiology, Erasmus MC Thoraxcenter, Rotterdam, The Netherlands
    J Hypertens 29:509-19. 2011
    ....
  11. ncbi request reprint Relationship of the Ubiquilin 1 gene with Alzheimer's and Parkinson's disease and cognitive function
    Alejandro Arias-Vasquez
    Epidemiology and Biostatistics Department, Erasmus MC, Rotterdam, The Netherlands
    Neurosci Lett 424:1-5. 2007
    ..Our results suggest that it is unlikely that the SNP rs12344615 of the UBQLN1 gene is related to the onset of AD, PD or cognitive function...
  12. ncbi request reprint Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification
    Daniel Bos
    Departments of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Circ Cardiovasc Genet 6:47-53. 2013
    ..Hence, for the current study genetic loci for coronary artery calcification and serum lipid levels, one of the strongest risk factors for atherosclerosis, were used to assess their relation with atherosclerosis in different vessel beds...
  13. doi request reprint A study of the SORL1 gene in Alzheimer's disease and cognitive function
    Fan Liu
    Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    J Alzheimers Dis 18:51-64. 2009
    ..In conclusion, our data do not support the hypothesis that genetic variants in SORL1 are related to the risk of AD...
  14. ncbi request reprint Plasma phosphatidylcholine and sphingomyelin concentrations are associated with depression and anxiety symptoms in a Dutch family-based lipidomics study
    Ayse Demirkan
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Psychiatr Res 47:357-62. 2013
    ....
  15. pmc Heritabilities, apolipoprotein E, and effects of inbreeding on plasma lipids in a genetically isolated population: the Erasmus Rucphen Family Study
    Aaron Isaacs
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Postbus 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Epidemiol 22:99-105. 2007
    ..02 and p (trend) = 0.05, respectively). These data provide estimates of lipid heritability unbiased due to selection and suggest that this population represents a good opportunity to localize novel genes influencing plasma lipid levels...
  16. doi request reprint Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 27:1392-8. 2009
    ....
  17. doi request reprint Variation in the von Willebrand factor gene is associated with von Willebrand factor levels and with the risk for cardiovascular disease
    Marianne C van Schie
    Department of Hematology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    Blood 117:1393-9. 2011
    ..44; 95% confidence interval [CI], 1.12-1.86 per minor allele). We confirmed the association between rs1063857 and CVD risk. Our data show that common variants in the VWF gene are associated with VWF levels and with the risk for CVD...
  18. ncbi request reprint Heritability of blood pressure traits and the genetic contribution to blood pressure variance explained by four blood-pressure-related genes
    Marie Josee E van Rijn
    Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 25:565-70. 2007
    ..To study the heritability of four blood pressure traits and the proportion of variance explained by four blood-pressure-related genes...
  19. pmc Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations
    Ayse Demirkan
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS Genet 8:e1002490. 2012
    ..In conclusion, our study identified nine novel phospho- and sphingolipid loci, substantially increasing our knowledge of the genetic basis for these traits...
  20. pmc Refining genome-wide linkage intervals using a meta-analysis of genome-wide association studies identifies loci influencing personality dimensions
    Najaf Amin
    Unit of Genetic Epidemiology, Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Hum Genet 21:876-82. 2013
    ..6 × 10(-06), KCNJ1). The findings of our linkage meta-analysis and those of the GWAS suggest that 11q24 is a susceptible locus for openness, with KCNJ1 as the possible candidate gene. ..
  21. pmc A genome-wide association study of optic disc parameters
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1000978. 2010
    ..Three of the loci were marginally associated with open-angle glaucoma. The protein pathways in which the loci of optic disc area are involved overlap with those identified for VCDR, suggesting a common genetic origin...
  22. doi request reprint Genetic determinants of treatment benefit of the angiotensin-converting enzyme-inhibitor perindopril in patients with stable coronary artery disease
    Jasper Jan Brugts
    Department of Cardiology, Erasmus MC, Thoraxcenter, s Gravendijkwal 230, Rotterdam, The Netherlands
    Eur Heart J 31:1854-64. 2010
    ..However, these patients cannot be identified by clinical characteristics. We developed a genetic profile to predict the treatment benefit of ACE-inhibitors exist and to optimize therapy with ACE-inhibitors...
  23. ncbi request reprint Alpha-adducin polymorphism, atherosclerosis, and cardiovascular and cerebrovascular risk
    Marie Josee E van Rijn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Stroke 37:2930-4. 2006
    ..We studied the association between the Gly460Trp polymorphism and atherosclerosis, cardiovascular disease, and cerebrovascular disease...
  24. pmc Genetic architecture of circulating lipid levels
    Ayse Demirkan
    Genetic Epidemiology Unit, Department of Epidemiology and Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Hum Genet 19:813-9. 2011
    ....
  25. pmc Meta-analysis of telomere length in 19,713 subjects reveals high heritability, stronger maternal inheritance and a paternal age effect
    Linda Broer
    1 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands 2 Netherlands Consortium for Healthy Aging, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 21:1163-8. 2013
    ..20; P-value=3.24 × 10(-10)). In summary, we find a high and very consistent heritability estimate for TL, evidence for a maternal inheritance component and a positive association with paternal age...
  26. doi request reprint A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14
    Abbas M Solouki
    Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 42:897-901. 2010
    ..Our data suggest that common variants at 15q14 influence susceptibility for refractive errors in the general population...
  27. doi request reprint Haplotype of the angiotensinogen gene is associated with coronary heart disease in familial hypercholesterolemia
    Jeroen B van der Net
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Hypertens 26:462-7. 2008
    ..Therefore, we analyzed the angiotensinogen gene as a modifier gene for coronary heart disease risk in patients with familial hypercholesterolemia...
  28. doi request reprint Rescue of dendritic spine phenotype in Fmr1 KO mice with the mGluR5 antagonist AFQ056/Mavoglurant
    Andreea S Pop
    CBG Department of Clinical Genetics, Erasmus Medical Centre, Dr Molewaterplein 55, 3015GE, Rotterdam, The Netherlands
    Psychopharmacology (Berl) 231:1227-35. 2014
    ..This finding suggests that long-term treatment at later stage is sufficient to reverse the structural spine abnormalities and represents a starting point for future studies aimed at improving treatments for FXS...
  29. doi request reprint General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect
    Sylvia A Obermann-Borst
    Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynecology, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    Am J Obstet Gynecol 204:236.e1-8. 2011
    ..We sought to investigate maternal and child functional MDR1 C3435T polymorphism, periconception medication, folic acid use, and the risk of a congenital heart defect (CHD) in the offspring...
  30. pmc The molecular genetic architecture of self-employment
    Matthijs J H M van der Loos
    Department of Applied Economics, Erasmus School of Economics, Erasmus University Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 8:e60542. 2013
    ....
  31. pmc Genome-wide association analysis identifies multiple loci related to resting heart rate
    Mark Eijgelsheim
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Mol Genet 19:3885-94. 2010
    ..6%, suggesting that some loci falling short of genome-wide significance are likely truly associated. Future research is warranted to elucidate underlying mechanisms that may impact clinical care...