M Arfan Ikram

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc International epidemiology of intracerebral hemorrhage
    M Arfan Ikram
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Curr Atheroscler Rep 14:300-6. 2012
  2. pmc Common variants at 6q22 and 17q21 are associated with intracranial volume
    M Arfan Ikram
    Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:539-44. 2012
  3. pmc The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    BMC Med Genet 11:162. 2010
  4. pmc The Rotterdam Scan Study: design and update up to 2012
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Epidemiol 26:811-24. 2011
  5. doi request reprint Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
  6. doi request reprint Determinants of cerebellar and cerebral volume in the general elderly population
    Yoo Young Hoogendam
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 33:2774-81. 2012
  7. doi request reprint Cerebral vasomotor reactivity and risk of mortality: the Rotterdam Study
    Marileen L P Portegies
    From the Departments of Epidemiology M L P P, R F A G d B, A H, M A I, Radiology M A I, and Neurology M L P P, R F A G d B, P J K, M A I, Erasmus MC University Medical Center, Rotterdam, The Netherlands and Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands R F A G d B, M A I
    Stroke 45:42-7. 2014
  8. doi request reprint Alzheimer's disease genes and cognition in the nondemented general population
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Biol Psychiatry 73:429-34. 2013
  9. doi request reprint White matter microstructural integrity and cognitive function in a general elderly population
    Meike W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 66:545-53. 2009
  10. ncbi request reprint Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification
    Daniel Bos
    Departments of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Circ Cardiovasc Genet 6:47-53. 2013

Detail Information

Publications70

  1. pmc International epidemiology of intracerebral hemorrhage
    M Arfan Ikram
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Curr Atheroscler Rep 14:300-6. 2012
    ..In this review the latest developments in research on intracerebral hemorrhage are highlighted from an epidemiologic point of view. Special focus is on frequency, etiologic factors and pre-clinical markers of intracerebral hemorrhage...
  2. pmc Common variants at 6q22 and 17q21 are associated with intracranial volume
    M Arfan Ikram
    Department of Epidemiology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:539-44. 2012
    ..5 months). Our data identify two loci associated with head size, with the inversion at 17q21 also likely to be involved in attaining maximal brain size...
  3. pmc The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project
    Onofre Combarros
    Neurology Service and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, Marqués de Valdecilla University Hospital University of Cantabria, 39008 Santander, Spain
    BMC Med Genet 11:162. 2010
    ..We therefore examined the associations with AD of the DBH -1021T allele and of the above interactions in the Epistasis Project, with 1757 cases of AD and 6294 elderly controls...
  4. pmc The Rotterdam Scan Study: design and update up to 2012
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Epidemiol 26:811-24. 2011
    ..Finally, we make recommendations for future research, which will also be the main focus of investigation in the Rotterdam Scan Study...
  5. doi request reprint Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
    ..We tested the hypothesis that the cumulative effects of common genetic variants for lipids are collectively associated with subclinical atherosclerosis and incident coronary heart disease...
  6. doi request reprint Determinants of cerebellar and cerebral volume in the general elderly population
    Yoo Young Hoogendam
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 33:2774-81. 2012
    ..This study suggests that determinants of cerebellar volume do not entirely overlap with those established for cerebral volume. Furthermore, presence of infarcts or WMLs in the cerebrum can affect cerebellar volume...
  7. doi request reprint Cerebral vasomotor reactivity and risk of mortality: the Rotterdam Study
    Marileen L P Portegies
    From the Departments of Epidemiology M L P P, R F A G d B, A H, M A I, Radiology M A I, and Neurology M L P P, R F A G d B, P J K, M A I, Erasmus MC University Medical Center, Rotterdam, The Netherlands and Netherlands Consortium for Healthy Ageing, Leiden, the Netherlands R F A G d B, M A I
    Stroke 45:42-7. 2014
    ..We investigated whether cerebral vasomotor reactivity is associated with the risk of mortality, focusing particularly on cardiovascular mortality independent from stroke...
  8. doi request reprint Alzheimer's disease genes and cognition in the nondemented general population
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Biol Psychiatry 73:429-34. 2013
    ..Genome-wide association studies have established 11 genes for late-onset Alzheimer's disease (AD). We investigated whether these genes jointly affect cognition in a nondemented population and improve prediction of AD...
  9. doi request reprint White matter microstructural integrity and cognitive function in a general elderly population
    Meike W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 66:545-53. 2009
    ..Measures reflecting white matter microstructural integrity may provide additional information to investigate the relation between white matter changes and cognition...
  10. ncbi request reprint Genetic loci for coronary calcification and serum lipids relate to aortic and carotid calcification
    Daniel Bos
    Departments of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Circ Cardiovasc Genet 6:47-53. 2013
    ..Hence, for the current study genetic loci for coronary artery calcification and serum lipid levels, one of the strongest risk factors for atherosclerosis, were used to assess their relation with atherosclerosis in different vessel beds...
  11. doi request reprint Atherosclerotic calcification relates to cognitive function and to brain changes on magnetic resonance imaging
    Daniel Bos
    Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Alzheimers Dement 8:S104-11. 2012
    ..This study investigates associations of atherosclerosis (measured using CT) at four locations with cognition and brain changes on magnetic resonance imaging (MRI)...
  12. pmc Trends in stroke incidence rates and stroke risk factors in Rotterdam, the Netherlands from 1990 to 2008
    Renske G Wieberdink
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 27:287-95. 2012
    ..Our findings suggest that in Rotterdam between 1990 and 2008 stroke incidence rates have decreased in men but not in women...
  13. ncbi request reprint Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the rotterdam study
    Daniel Bos
    Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands2Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA Neurol 71:405-11. 2014
    ....
  14. doi request reprint The Rotterdam Study: 2014 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:889-926. 2013
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  15. doi request reprint The relation of uric acid to brain atrophy and cognition: the Rotterdam Scan Study
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, NL 3000 CA Rotterdam, The Netherlands
    Neuroepidemiology 41:29-34. 2013
    ..However, it is unknown whether uric acid also relates to global brain changes such as brain atrophy. We therefore studied the relation of uric acid to brain atrophy and whether this is accompanied by worse cognitive function...
  16. ncbi request reprint Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study
    Mariëlle M F Poels
    Department of Epidemiology, Erasmus Medical Center, University Medical Center, Rotterdam, The Netherlands
    Stroke 43:2637-42. 2012
    ..In a population-based study, we investigated the association between arterial stiffness, as measured by aortic pulse wave velocity (aPWV), and small vessel disease...
  17. doi request reprint Brain tissue volumes in relation to cognitive function and risk of dementia
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neurobiol Aging 31:378-86. 2010
    ....
  18. doi request reprint Brain cortical thickness in the general elderly population: the Rotterdam Scan Study
    Evert F S van Velsen
    Department of Epidemiology, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Neurosci Lett 550:189-94. 2013
    ..Additionally, higher education, higher diastolic blood pressure and larger intra-cranial volume were related to a larger cortical thickness, whilst diabetes mellitus and higher HDL cholesterol levels were related to a thinner cortex. ..
  19. doi request reprint Insulin resistance and the risk of stroke and stroke subtypes in the nondiabetic elderly
    Renske G Wieberdink
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am J Epidemiol 176:699-707. 2012
    ..In conclusion, in this population-based cohort study among nondiabetic elderly, insulin resistance markers were not associated with risk of stroke or any of its subtypes...
  20. doi request reprint Rating method for dilated Virchow-Robin spaces on magnetic resonance imaging
    Hieab H H Adams
    Department of Epidemiology, Erasmus MC, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Stroke 44:1732-5. 2013
    ..Dilated Virchow-Robin spaces are an emerging neuroimaging biomarker, but their assessment on MRI needs standardization...
  21. ncbi request reprint Plasma amyloid β, depression, and dementia in community-dwelling elderly
    Nese Direk
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Psychiatr Res 47:479-85. 2013
    ..In contrast, the longitudinal association between low plasma Aβ levels and depressive symptoms could not be explained by dementia during follow-up suggesting that Aβ peptides may play a distinct role on depression etiology...
  22. doi request reprint Lobar distribution of cerebral microbleeds: the Rotterdam Scan Study
    Dymph J Mesker
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Neurol 68:656-9. 2011
    ..To investigate the distribution of lobar microbleeds over the different lobes, taking into account lobar volume and clustering effects of multiple microbleeds...
  23. doi request reprint Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study
    Mariëlle M F Poels
    Department of Radiology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 42:656-61. 2011
    ..Cerebral microbleeds are frequently seen in the general elderly population, but it is unknown at what rate they occur with aging and whether once present can disappear over time...
  24. doi request reprint Statistical analysis of minimum cost path based structural brain connectivity
    Renske de Boer
    Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 55:557-65. 2011
    ....
  25. doi request reprint Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study)
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Am J Cardiol 113:1-6. 2014
    ..In men, the prognosis is as unfavorable as that of patients with recognized MIs. ..
  26. doi request reprint High blood pressure and cerebral white matter lesion progression in the general population
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Hypertension 61:1354-9. 2013
    ..12 [0.00; 0.23] mL/y). The present study further establishes high blood pressure to precede WMLs and implies that hypertension treatment could reduce WML progression in the general population...
  27. doi request reprint White matter lesion extension to automatic brain tissue segmentation on MRI
    Renske de Boer
    Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 45:1151-61. 2009
    ..The results indicated that the automatic segmentation accuracy is close to the interobserver variability of manual segmentations...
  28. doi request reprint Changes in normal-appearing white matter precede development of white matter lesions
    Marius de Groot
    Department of Radiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 44:1037-42. 2013
    ..We therefore investigated whether development of WML is preceded by quantifiable changes in normal-appearing white matter (NAWM)...
  29. doi request reprint Intracranial carotid artery atherosclerosis: prevalence and risk factors in the general population
    Daniel Bos
    Department of Radiology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Stroke 43:1878-84. 2012
    ..In this study, we determined the prevalence and investigated risk factors of intracranial internal carotid artery calcification (ICAC) as a marker of intracranial atherosclerosis...
  30. ncbi request reprint Statistical analysis of structural brain connectivity
    Renske de Boer
    Biomedical Imaging Group Rotterdam, Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Med Image Comput Comput Assist Interv 13:101-8. 2010
    ..Principal component regression outperformed all other prediction models, demonstrating the age and gender information encoded in the connectivity network...
  31. doi request reprint Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods
    Renske de Boer
    Department of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 51:1047-56. 2010
    ..Example sample size calculations demonstrate a rather large effect of the choice of segmentation method on the required number of subjects...
  32. ncbi request reprint Comparison of application of the ACC/AHA guidelines, Adult Treatment Panel III guidelines, and European Society of Cardiology guidelines for cardiovascular disease prevention in a European cohort
    Maryam Kavousi
    Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    JAMA 311:1416-23. 2014
    ..5% 10-year hard atherosclerotic cardiovascular disease (ASCVD) risk. Implications of the new guideline's threshold and model have not been addressed in non-US populations or compared with previous guidelines...
  33. doi request reprint Replication study of chr17q25 with cerebral white matter lesion volume
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Stroke 42:3297-9. 2011
    ..We report on the first independent replication study of this genetic association...
  34. doi request reprint Vascular brain disease and depression in the elderly
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Epidemiology 21:78-81. 2010
    ..Cross-sectional studies have shown an association between vascular brain disease and depression. Longitudinal data are scarce. In a population-based study we investigated this relationship both cross-sectionally and longitudinally...
  35. doi request reprint Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study
    Mariëlle M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 41:S103-6. 2010
    ..We examined the prevalence and determinants of microbleeds in this larger and younger cohort from the general population...
  36. doi request reprint Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2
    Carla A Ibrahim-Verbaas
    Department of Neurology, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1869-76. 2012
    ..1 × 10(-3) for rs2514299). This linkage study of plasma concentrations of Aβ40 and Aβ42 yielded two suggestive regions, of which one points toward a known locus for familial AD...
  37. doi request reprint Serum lipid levels and the risk of intracerebral hemorrhage: the Rotterdam Study
    Renske G Wieberdink
    Department of Epidemiology, Erasmus University Medical Center, 3000 CA Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 31:2982-9. 2011
    ..We determined whether serum HDL-cholesterol, LDL-cholesterol, and triglycerides are associated with risk of intracerebral hemorrhage and presence of cerebral microbleeds...
  38. ncbi request reprint Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Stroke 39:1421-6. 2008
    ..We investigated whether unrecognized MI is also a risk factor for dementia and cerebral small vessel disease (white matter lesions and brain infarction) in 2 population-based cohort studies...
  39. doi request reprint Performance of Framingham cardiovascular disease (CVD) predictions in the Rotterdam Study taking into account competing risks and disentangling CVD into coronary heart disease (CHD) and stroke
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Int J Cardiol 171:413-8. 2014
    ....
  40. doi request reprint Assessment of cerebral small vessel disease predicts individual stroke risk
    Mariëlle M F Poels
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 83:1174-9. 2012
    ..Vascular brain damage, visualised with MRI, reflects how the brain tolerates the effects of vascular risk factors and may therefore be relevant in predicting individual stroke risk...
  41. ncbi request reprint Brain tissue volumes and small vessel disease in relation to the risk of mortality
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 30:450-6. 2009
    ..Censoring at either incident dementia or stroke did not change the risk associated with brain atrophy and WML. Moreover, WML were particularly associated with cardiovascular mortality...
  42. ncbi request reprint Incidental findings on brain MRI in the general population
    Meike W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 357:1821-8. 2007
    ..We conducted a study to determine the prevalence of such incidental brain findings in the general population...
  43. doi request reprint Psoriasis is not associated with atherosclerosis and incident cardiovascular events: the Rotterdam Study
    Emmilia A Dowlatshahi
    Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Invest Dermatol 133:2347-54. 2013
    ..Psoriasis patients with predominantly mild disease from the general population are as likely to develop atherosclerosis and cardiovascular events as subjects without psoriasis. ..
  44. doi request reprint Calcification in major vessel beds relates to vascular brain disease
    Daniel Bos
    Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 31:2331-7. 2011
    ..However, its relationship with cerebrovascular disease has not been investigated extensively. We investigated the relationship between calcification in various vessel beds outside the brain and imaging markers of vascular brain disease...
  45. pmc Total antioxidant capacity of the diet and major neurologic outcomes in older adults
    ELIZABETH E DEVORE
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurology 80:904-10. 2013
    ..To evaluate total antioxidant capacity of the diet, measured by the ferric-reducing antioxidant power (FRAP) assay, in relation to risks of dementia and stroke, as well as key structural brain volumes, in the elderly...
  46. pmc The Rotterdam Study: 2012 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 26:657-86. 2011
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  47. ncbi request reprint Kidney function is related to cerebral small vessel disease
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Stroke 39:55-61. 2008
    ..We investigated this association in a population-based study of elderly persons...
  48. pmc Clopidogrel use is associated with an increased prevalence of cerebral microbleeds in a stroke-free population: the Rotterdam study
    Sirwan K L Darweesh
    Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Am Heart Assoc 2:e000359. 2013
    ..We examined the association between use of clopidogrel and CMBs in persons without a history of stroke...
  49. doi request reprint Improving alignment in Tract-based spatial statistics: evaluation and optimization of image registration
    Marius de Groot
    Department of Radiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Neuroimage 76:400-11. 2013
    ..At optimal parameters, both algorithms outperformed the registration of TBSS, showing feasibility of adopting such approaches in TBSS. This was further confirmed in the example experiment...
  50. doi request reprint Comparative effectiveness and cost-effectiveness of computed tomography screening for coronary artery calcium in asymptomatic individuals
    Bob J H van Kempen
    Department of Epidemiology, Erasmus Medical Center, Dr Molewaterplein 40, Rotterdam, The Netherlands
    J Am Coll Cardiol 58:1690-701. 2011
    ..The aim of this study was to assess the (cost-) effectiveness of screening asymptomatic individuals at intermediate risk of coronary heart disease (CHD) for coronary artery calcium with computed tomography (CT)...
  51. ncbi request reprint Brain tissue volumes in the general elderly population. The Rotterdam Scan Study
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Neurobiol Aging 29:882-90. 2008
    ..In the elderly, higher age, small vessel disease and cardiovascular risk factors are associated with smaller brain volume, especially WM volume...
  52. pmc The thyroid hormone receptor alpha locus and white matter lesions: a role for the clock gene REV-ERBα
    Marco Medici
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Thyroid 22:1181-6. 2012
    ..We therefore studied genetic variation in the TRα/REV-ERBα locus in relation to brain imaging data, as early markers for small vessel disease and neurodegeneration...
  53. ncbi request reprint Arteriolar oxygen saturation, cerebral blood flow, and retinal vessel diameters. The Rotterdam Study
    Frank Jan de Jong
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands Department of Neurology, Erasmus Medical Center, Rotterdam, Netherlands
    Ophthalmology 115:887-92. 2008
    ..The authors investigated whether arteriolar oxygen saturation (SaO2) and total cerebral blood flow (CBF), indicators of cerebral oxygen supply, are associated with retinal arteriolar or venular diameters...
  54. pmc Genomewide association studies of stroke
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    N Engl J Med 360:1718-28. 2009
    ..The genes underlying the risk of stroke in the general population remain undetermined...
  55. pmc Genome-wide profiling of blood pressure in adults and children
    Hendrik R Taal
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Hypertension 59:241-7. 2012
    ....
  56. ncbi request reprint Cerebral microbleeds: accelerated 3D T2*-weighted GRE MR imaging versus conventional 2D T2*-weighted GRE MR imaging for detection
    Meike W Vernooij
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Radiology 248:272-7. 2008
    ..In conclusion, accelerated 3D T2*-weighted GRE images depict more microbleeds than do conventional 2D T2*-weighted GRE images...
  57. ncbi request reprint Hippocampal shape is predictive for the development of dementia in a normal, elderly population
    Hakim C Achterberg
    Biomedical Imaging Group Rotterdam, Departments of Radiology and Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Hum Brain Mapp 35:2359-71. 2014
    ..Furthermore, the results suggest that hippocampal shape provides additional predictive value over hippocampal volume and that combining shape and volume leads to better prediction...
  58. doi request reprint Apolipoprotein E genotype influences spatial distribution of cerebral microbleeds
    Elizabeth Loehrer
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands Netherlands Institute for Health Sciences, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 35:899-905. 2014
    ..Similar to cerebral amyloid angiopathy patients, microbleeds in the general population cluster and the distribution is affected by APOE genotype...
  59. ncbi request reprint Multi-spectral brain tissue segmentation using automatically trained k-Nearest-Neighbor classification
    Henri A Vrooman
    Department of Radiology, Erasmus MC, P O Box 1738, Rotterdam, The Netherlands
    Neuroimage 37:71-81. 2007
    ..It can be concluded that our fully automated method using non-rigid registration may replace manual segmentation, and thus that automated brain tissue segmentation without laborious manual training is feasible...
  60. pmc Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo
    M Kamran Ikram
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Genet 6:e1001184. 2010
    ..These data provide further insights into the contribution and biological mechanisms of microcirculatory changes that underlie cardiovascular disease...
  61. doi request reprint Cerebral hemodynamics and incident depression: the Rotterdam Study
    Nese Direk
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Biol Psychiatry 72:318-23. 2012
    ..To test this hypothesis, several cross-sectional studies have assessed structural brain parameters, but few have examined hemodynamic alterations in the brain...
  62. pmc A genome-wide association study identifies five loci influencing facial morphology in Europeans
    Fan Liu
    Department of Forensic Molecular Biology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS Genet 8:e1002932. 2012
    ....
  63. ncbi request reprint Genome-wide association study of vascular dementia
    Elisabeth M C Schrijvers
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 43:315-9. 2012
    ..Most studies investigating the genetics of dementia have focused on Alzheimer disease, but little is known about the genetics of vascular dementia. The aim of our study was to identify new loci associated with vascular dementia...
  64. pmc Common variants at 12q15 and 12q24 are associated with infant head circumference
    H Rob Taal
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Nat Genet 44:532-8. 2012
    ....
  65. doi request reprint Serum levels of pregnancy zone protein are elevated in presymptomatic Alzheimer's disease
    Linda Ijsselstijn
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Proteome Res 10:4902-10. 2011
    ..Immunohistochemical validation of the findings on brain tissue sections showed strong PZP expression in senile plaques and in microglial and glial cells in AD with only low expression in some scattered glial cells in controls...
  66. doi request reprint Automated measurement of local white matter lesion volume
    Fedde van der Lijn
    Department of Medical Informatics, Erasmus MC, Rotterdam, The Netherlands
    Neuroimage 59:3901-8. 2012
    ..But the proposed method can localize the region of association with greater precision than techniques that distinguish between periventricular and subcortical lesions only...
  67. doi request reprint Association of two single nucleotide polymorphisms from genomewide association studies with clinical phenotypes of cerebral ischemia
    Evita G van den Herik
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Int J Stroke 7:219-23. 2012
    ..Recent genomewide association studies have revealed an association between two single nucleotide polymorphisms, rs11833579 and rs12425791, and ischemic stroke...
  68. pmc Genetic, physiological, and lifestyle predictors of mortality in the general population
    Stefan Walter
    Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Public Health 102:e3-10. 2012
    ..We investigated the quality of 162 variables, focusing on the contribution of genetic markers, used solely or in combination with other characteristics, when predicting mortality...
  69. doi request reprint The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis
    M Arfan Ikram
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam 3000 CA, The Netherlands
    Biol Psychiatry 65:995-9. 2009
    ..Recently, GAB2 has been suggested to modify the risk of late-onset Alzheimer's disease (AD) among APOEepsilon4 carriers. However, replication data are inconsistent...
  70. doi request reprint A study of the SORL1 gene in Alzheimer's disease and cognitive function
    Fan Liu
    Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    J Alzheimers Dis 18:51-64. 2009
    ..In conclusion, our data do not support the hypothesis that genetic variants in SORL1 are related to the risk of AD...