Casper C Hoogenraad

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Synapse pathology in psychiatric and neurologic disease
    Myrrhe van Spronsen
    Department of Neuroscience, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Curr Neurol Neurosci Rep 10:207-14. 2010
  2. pmc Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity
    Stephane Martin
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, United Kingdom
    PLoS ONE 4:e4714. 2009
  3. pmc Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Biol 8:e1000283. 2010
  4. doi Dendritic spine plasticity: new regulatory roles of dynamic microtubules
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuroscientist 16:650-61. 2010
  5. ncbi LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Bioessays 26:141-50. 2004
  6. ncbi Control of neuronal polarity and plasticity--a renaissance for microtubules?
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus Medical Center, 3015GE, Rotterdam, The Netherlands
    Trends Cell Biol 19:669-76. 2009
  7. pmc Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis
    Max A Schlager
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    EMBO J 29:1637-51. 2010
  8. ncbi A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice
    Eva Teuling
    Department of Neuroscience, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Hum Mol Genet 17:2849-62. 2008
  9. doi Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity
    Jacek Jaworski
    Department of Neuroscience, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands
    Neuron 61:85-100. 2009
  10. doi CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor
    Babet van der Vaart
    Department of Cell Biology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Dev Cell 27:145-60. 2013

Detail Information

Publications43

  1. pmc Synapse pathology in psychiatric and neurologic disease
    Myrrhe van Spronsen
    Department of Neuroscience, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Curr Neurol Neurosci Rep 10:207-14. 2010
    ..In this review, we highlight the structure and molecular organization of synapses and discuss functional effects of synapse pathology in brain disease...
  2. pmc Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity
    Stephane Martin
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, Bristol, United Kingdom
    PLoS ONE 4:e4714. 2009
    ..In this study we investigate the relationship between corticosterone and AMPA receptors which play a critical role in activity-dependent plasticity and hippocampal-dependent learning...
  3. pmc Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Biol 8:e1000283. 2010
    ..The data uncover a new mechanism to achieve specificity and directionality in neuronal membrane receptor trafficking...
  4. doi Dendritic spine plasticity: new regulatory roles of dynamic microtubules
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuroscientist 16:650-61. 2010
    ....
  5. ncbi LIMK1 and CLIP-115: linking cytoskeletal defects to Williams syndrome
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Bioessays 26:141-50. 2004
    ....
  6. ncbi Control of neuronal polarity and plasticity--a renaissance for microtubules?
    Casper C Hoogenraad
    Department of Neuroscience, Erasmus Medical Center, 3015GE, Rotterdam, The Netherlands
    Trends Cell Biol 19:669-76. 2009
    ..We review the novel role of microtubules during neuronal development and discuss models for microtubule-dependent signaling in neuronal plasticity...
  7. pmc Pericentrosomal targeting of Rab6 secretory vesicles by Bicaudal-D-related protein 1 (BICDR-1) regulates neuritogenesis
    Max A Schlager
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    EMBO J 29:1637-51. 2010
    ..These results indicate an important role for BICDR-1 as temporal regulator of secretory trafficking during the early phase of neuronal differentiation...
  8. ncbi A novel mouse model with impaired dynein/dynactin function develops amyotrophic lateral sclerosis (ALS)-like features in motor neurons and improves lifespan in SOD1-ALS mice
    Eva Teuling
    Department of Neuroscience, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Hum Mol Genet 17:2849-62. 2008
    ..Our findings indicate that impaired dynein/dynactin function can explain several pathological features observed in ALS patients, but may be beneficial in some forms of ALS...
  9. doi Dynamic microtubules regulate dendritic spine morphology and synaptic plasticity
    Jacek Jaworski
    Department of Neuroscience, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands
    Neuron 61:85-100. 2009
    ....
  10. doi CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor
    Babet van der Vaart
    Department of Cell Biology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Dev Cell 27:145-60. 2013
    ..Our study provides mechanistic insight into cortical microtubule regulation and suggests that altered microtubule dynamics contribute to CFEOM1 pathogenesis...
  11. ncbi Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice
    Dick Jaarsma
    Department of Neuroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Neurosci 28:2075-88. 2008
    ..Together, our findings support a pathogenic scenario in which mutant SOD1 in neurons triggers neuronal degeneration, which in turn may facilitate aggregate formation in surrounding glial cells...
  12. doi Mixed microtubules steer dynein-driven cargo transport into dendrites
    Lukas C Kapitein
    Department of Neuroscience, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Curr Biol 20:290-9. 2010
    ..However, the basic traffic rules governing polarized transport on neuronal microtubule arrays are unclear...
  13. pmc STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER
    Ilya Grigoriev
    Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Curr Biol 18:177-82. 2008
    ..Depletion of STIM1 and EB1 decreases TAC-dependent ER protrusion, indicating that microtubule growth-dependent concentration of STIM1 in the ER membrane plays a role in ER remodeling...
  14. pmc Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission
    Samantha A Spangler
    Department of Neuroscience, Erasmus Medical Center, 3015GE Rotterdam, Netherlands
    J Cell Biol 201:915-28. 2013
    ..Therefore, liprin-α2 plays an important role in maintaining active zone dynamics to modulate synaptic efficacy in response to changes in network activity...
  15. doi Rab6, Rab8, and MICAL3 cooperate in controlling docking and fusion of exocytotic carriers
    Ilya Grigoriev
    Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Curr Biol 21:967-74. 2011
    ..Taken together, the results of our study illustrate cooperation of two Rab proteins in constitutive exocytosis and implicates a redox enzyme in this process...
  16. ncbi Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates
    Eva Teuling
    Department of Neuroscience, Erasmus Medical Center, 3000CA Rotterdam, The Netherlands
    J Neurosci 27:9801-15. 2007
    ..Our data support a model in which reduced levels of VAP family proteins result in decreased ER anchoring of lipid-binding proteins and cause motor neuron degeneration...
  17. doi Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice
    Mehdi Hossaini
    Department of Neuroscience, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 70:662-77. 2011
    ..The degeneration of spinal inhibitory interneurons may in turn facilitate degeneration of motor neurons and contribute to disease progression...
  18. ncbi Rab6 regulates transport and targeting of exocytotic carriers
    Ilya Grigoriev
    Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Dev Cell 13:305-14. 2007
    ..Our data demonstrate that although Rab6 is not essential for secretion, it controls the organization of exocytosis within the cellular space...
  19. ncbi Visualization of microtubule growth in cultured neurons via the use of EB3-GFP (end-binding protein 3-green fluorescent protein)
    Tatiana Stepanova
    Medical Genetics Center Department of Cell Biology and Genetics, Erasmus University, 3000 DR Rotterdam, The Netherlands
    J Neurosci 23:2655-64. 2003
    ..We propose that similar mechanisms underlie the specific association of CLIPs and EB1-related proteins with the ends of growing microtubules in non-neuronal and neuronal cells...
  20. doi βCaMKII plays a nonenzymatic role in hippocampal synaptic plasticity and learning by targeting αCaMKII to synapses
    Nils Z Borgesius
    Department of Neuroscience, Erasmus University Medical Centre, 3015 GE, Rotterdam, The Netherlands
    J Neurosci 31:10141-8. 2011
    ..Together, our data provide compelling support for a model of CaMKII function in which αCaMKII and βCaMKII act in concert, but with distinct functions, to regulate hippocampal synaptic plasticity and learning...
  21. ncbi Differential expression of liprin-α family proteins in the brain suggests functional diversification
    Samantha A Spangler
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    J Comp Neurol 519:3040-60. 2011
    ..We conclude that liprin-α family proteins might perform independent and specialized synaptic and nonsynaptic functions in different regions of the brain...
  22. pmc Bicaudal D2, dynein, and kinesin-1 associate with nuclear pore complexes and regulate centrosome and nuclear positioning during mitotic entry
    Daniël Splinter
    Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Biol 8:e1000350. 2010
    ....
  23. pmc Developmental and activity-dependent miRNA expression profiling in primary hippocampal neuron cultures
    Myrrhe van Spronsen
    Cell Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e74907. 2013
    ..Identification and characterization of miRNA targets may further elucidate translational control mechanisms involved in hippocampal development, differentiation and activity-depended processes. ..
  24. pmc Bicaudal D induces selective dynein-mediated microtubule minus end-directed transport
    Casper C Hoogenraad
    MGC Department of Neuroscience, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 22:6004-15. 2003
    ..Our findings provide a novel model system for dissection of the molecular mechanism of dynein motility...
  25. pmc The microtubule plus-end-tracking protein CLIP-170 associates with the spermatid manchette and is essential for spermatogenesis
    Anna Akhmanova
    Department of Cell Biology and Genetics, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Genes Dev 19:2501-15. 2005
    ..We propose that CLIP-170 has a structural function in the male germline, in particular in spermatid differentiation and sperm head shaping...
  26. ncbi Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development
    Kah Wai Yau
    Cell Biology, Faculty of Science, Utrecht University, 3584 CH, Utrecht, The Netherlands Department of Neuroscience, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Neuron 82:1058-73. 2014
    ..We propose a two-step model in which γ-Tubulin initiates the formation of non-centrosomal microtubules and CAMSAP2 stabilizes the free microtubule minus-ends in order to control neuronal polarity and development...
  27. pmc Probing intracellular motor protein activity using an inducible cargo trafficking assay
    Lukas C Kapitein
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Biophys J 99:2143-52. 2010
    ..Our assay directly demonstrates that robust cargo motility does not require the presence of opposite-polarity motors, and can therefore be used to characterize the motile properties of specific types of motor proteins...
  28. doi In vitro reconstitution of the functional interplay between MCAK and EB3 at microtubule plus ends
    Susana Montenegro Gouveia
    Department of Cell Biology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Biol 20:1717-22. 2010
    ..The combination of MCAK and EB3 thus promotes rapid switching between microtubule growth and shortening, which can be important for remodeling of the microtubule cytoskeleton...
  29. ncbi betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses
    Geeske M van Woerden
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    Nat Neurosci 12:823-5. 2009
    ..These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation...
  30. ncbi Deformation of network connectivity in the inferior olive of connexin 36-deficient mice is compensated by morphological and electrophysiological changes at the single neuron level
    Chris I De Zeeuw
    Department of Neuroscience, Medical Faculty, Erasmus MC, 3000DR Rotterdam, The Netherlands
    J Neurosci 23:4700-11. 2003
    ....
  31. doi TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and dendrites
    Myrrhe van Spronsen
    Cell Biology, Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands
    Neuron 77:485-502. 2013
    ..Our study demonstrates how the molecular interplay between bidirectional adaptor proteins and distinct microtubule-based motors drives polarized mitochondrial transport...
  32. ncbi Microtubule plus-end-tracking proteins: mechanisms and functions
    Anna Akhmanova
    Department of Cell Biology and Genetics, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Curr Opin Cell Biol 17:47-54. 2005
    ..Regulation of the activity of +TIPs has profound effects on the shape of the microtubule network and plays an essential role in cell division, motility and morphogenesis...
  33. doi Which way to go? Cytoskeletal organization and polarized transport in neurons
    Lukas C Kapitein
    Department of Neuroscience, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Mol Cell Neurosci 46:9-20. 2011
    ....
  34. pmc Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons
    Vera van Dis
    Department of Neuroscience, Erasmus Medical Center, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    Acta Neuropathol Commun 2:38. 2014
    ..However, the role of Golgi fragmentation in motor neuron degeneration is not well understood...
  35. pmc The ALS8 protein VAPB interacts with the ER-Golgi recycling protein YIF1A and regulates membrane delivery into dendrites
    Marijn Kuijpers
    Division of Cell Biology, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands
    EMBO J 32:2056-72. 2013
    ..These data suggest that both VAPB and YIF1A are important for ER-to-Golgi transport and that missorting of YIF1A may contribute to VAPB-associated motor neuron disease...
  36. doi Microtubule plus-end tracking proteins SLAIN1/2 and ch-TOG promote axonal development
    Babet van der Vaart
    Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Neurosci 32:14722-8. 2012
    ..Our study shows that proper control of microtubule dynamics is important for axon elongation in developing neurons...
  37. doi Isolation of novel +TIPs and their binding partners using affinity purification techniques
    Ka Lou Yu
    Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    Methods Mol Biol 777:293-316. 2011
    ..We also discuss cytological techniques that can be applied to confirm plus-end localization of newly identified proteins...
  38. pmc Conformational changes in CLIP-170 regulate its binding to microtubules and dynactin localization
    Gideon Lansbergen
    MGC Dept of Cell Biology and of Genetics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, Netherlands
    J Cell Biol 166:1003-14. 2004
    ..This interaction interferes with the binding of the CLIP-170 to MTs. We propose that conformational changes in CLIP-170 are important for binding to dynactin, LIS1, and the MT tips...
  39. pmc Basic mechanisms for recognition and transport of synaptic cargos
    Max A Schlager
    Department of Neuroscience, Erasmus Medical Center, 3015GE, Rotterdam, The Netherlands
    Mol Brain 2:25. 2009
    ..We discuss here how different motors recognize their synaptic cargo and how motor-cargo interactions are regulated by neuronal activity...
  40. pmc Amyotrophic lateral sclerosis (ALS)-associated VAPB-P56S inclusions represent an ER quality control compartment
    Marijn Kuijpers
    Department of Neuroscience, Erasmus Medical Center, Rotterdam, The Netherlands
    Acta Neuropathol Commun 1:24. 2013
    ..Here we have characterized inclusions formed in transgenic mice carrying the P56S mutant form of VAPB that causes various motor neuron syndromes including ALS8...
  41. ncbi Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice
    Casper C Hoogenraad
    MGC Department of Cell Biology and Genetics, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Nat Genet 32:116-27. 2002
    ..This protein redistribution may affect dynein motor regulation and, together with the loss of CLIP-115-specific functions, underlie neurological alterations in Williams syndrome...
  42. doi Microtubule dynamics in dendritic spines
    Lukas C Kapitein
    Department of Neuroscience, Erasmus Medical Center, 3015 GE, Rotterdam, The Netherlands
    Methods Cell Biol 97:111-32. 2010
    ..We describe protocols for culturing and transfecting mature hippocampal neurons and visualizing microtubules and microtubule plus-EB proteins by total internal reflection fluorescence microscopy and spinning disk confocal microscopy...
  43. ncbi ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation
    Angela S Vlug
    Department of Neuroscience, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, Netherlands
    Eur J Neurosci 22:1881-94. 2005
    ....