Albert Hofman

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint The Rotterdam Study: 2014 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:889-926. 2013
  2. pmc Children's eating behavior, feeding practices of parents and weight problems in early childhood: results from the population-based Generation R Study
    Pauline W Jansen
    The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Behav Nutr Phys Act 9:130. 2012
  3. pmc Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort
    Agnes M M Sonnenschein-van der Voort
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:91. 2012
  4. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
  5. pmc Differences in problem behaviour among ethnic minority and majority preschoolers in the Netherlands and the role of family functioning and parenting factors as mediators: the Generation R Study
    Ilse J E Flink
    The Generation R Study Group, Erasmus University Medical Centre, Rotterdam, The Netherlands
    BMC Public Health 12:1092. 2012
  6. pmc Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    BMC Med 10:158. 2012
  7. pmc Air pollution exposure estimation using dispersion modelling and continuous monitoring data in a prospective birth cohort study in The Netherlands
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:9. 2012
  8. pmc Residential traffic exposure and pregnancy-related outcomes: a prospective birth cohort study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 8:59. 2009
  9. pmc Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial
    Esther Hafkamp-de Groen
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    BMC Public Health 10:555. 2010
  10. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010

Detail Information

Publications135 found, 100 shown here

  1. doi request reprint The Rotterdam Study: 2014 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:889-926. 2013
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  2. pmc Children's eating behavior, feeding practices of parents and weight problems in early childhood: results from the population-based Generation R Study
    Pauline W Jansen
    The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Int J Behav Nutr Phys Act 9:130. 2012
    ....
  3. pmc Air pollution, fetal and infant tobacco smoke exposure, and wheezing in preschool children: a population-based prospective birth cohort
    Agnes M M Sonnenschein-van der Voort
    Department of Pediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:91. 2012
    ..We examined the associations of exposure to ambient particulate matter (PM10) and nitrogen dioxide (NO2) with the risk of wheezing in preschool children, and assessed whether these associations were modified by tobacco smoke exposure...
  4. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
    ..Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown...
  5. pmc Differences in problem behaviour among ethnic minority and majority preschoolers in the Netherlands and the role of family functioning and parenting factors as mediators: the Generation R Study
    Ilse J E Flink
    The Generation R Study Group, Erasmus University Medical Centre, Rotterdam, The Netherlands
    BMC Public Health 12:1092. 2012
    ..This study aimed to further unravel the differences in problem behaviour among ethnic minority and native preschoolers by examining the mediating role of family functioning and parenting factors...
  6. pmc Validation of a model to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD: the rotterdam ischemic heart disease and stroke computer simulation (RISC) model
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC Rotterdam, Dr Molewaterplein 50, Rotterdam, 3015 GE, The Netherlands
    BMC Med 10:158. 2012
    ..We developed a Monte Carlo Markov model designed to investigate the effects of modifying cardiovascular disease (CVD) risk factors on the burden of CVD. Internal, predictive, and external validity of the model have not yet been established...
  7. pmc Air pollution exposure estimation using dispersion modelling and continuous monitoring data in a prospective birth cohort study in The Netherlands
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 11:9. 2012
    ..The Generation R Study provides unique possibilities to examine effects of short- and long-term air pollution exposure on various maternal and childhood outcomes and to identify potential critical windows of exposure...
  8. pmc Residential traffic exposure and pregnancy-related outcomes: a prospective birth cohort study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health 8:59. 2009
    ..The considerable traffic-related intra-urban spatial variation needs to be considered in exposure assessment. Residential proximity to traffic is a proxy for traffic-related exposures that takes into account within-city contrasts...
  9. pmc Early detection and counselling intervention of asthma symptoms in preschool children: study design of a cluster randomised controlled trial
    Esther Hafkamp-de Groen
    The Generation R Study Group, Erasmus MC, Rotterdam, The Netherlands
    BMC Public Health 10:555. 2010
    ..Early detection and counselling is expected to reduce the prevalence of asthma symptoms and improve health-related quality of life at age 6 years...
  10. pmc Common genetic variation in the Estrogen Receptor Beta (ESR2) gene and osteoarthritis: results of a meta-analysis
    Hanneke J M Kerkhof
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:164. 2010
    ..The objective of this study was to examine the relationship between common genetic variation of the ESR2 gene and osteoarthritis...
  11. pmc Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 10:67. 2009
    ..The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy...
  12. pmc Age, gender and disability predict future disability in older people: the Rotterdam Study
    Umit Tas
    Department of General Practice, Erasmus MC University Medical Centre Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    BMC Geriatr 11:22. 2011
    ..To develop a prediction model that predicts disability in community-dwelling older people. Insight in the predictors of disability is needed to target preventive strategies for people at increased risk...
  13. pmc The Rotterdam Study: 2010 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam The Netherlands
    Eur J Epidemiol 24:553-72. 2009
    ..epib.nl/rotterdamstudy). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  14. pmc The Rotterdam Study: objectives and design update
    Albert Hofman
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 22:819-29. 2007
    ..epib.nl/rotterdamstudy). This article gives the reasons for the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  15. pmc The Rotterdam Study: 2012 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 26:657-86. 2011
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  16. ncbi request reprint Growth, development and health from early fetal life until young adulthood: the Generation R Study
    Albert Hofman
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Sophia Children s Hospital, Rotterdam, The Netherlands
    Paediatr Perinat Epidemiol 18:61-72. 2004
    ..The study entered its pilot phase to test the logistics in December 2001. Full participant recruitment and complete data collection started in 2002...
  17. ncbi request reprint Epidemiology of neurological diseases in elderly people: what did we learn from the Rotterdam Study?
    Albert Hofman
    Department of Epidemiology Biostatistics, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet Neurol 5:545-50. 2006
    ..Perhaps the most important message from the Rotterdam Study is the great potential for prevention or postponement of neurological diseases in elderly people. The time for preventive nihilism is over...
  18. pmc Personalized prediction of lifetime benefits with statin therapy for asymptomatic individuals: a modeling study
    Bart S Ferket
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    PLoS Med 9:e1001361. 2012
    ..However, current prediction models focus on short-term outcomes and ignore the competing risk of death due to other causes. We aimed to predict the potential lifetime benefits with statin therapy, taking into account competing risks...
  19. ncbi request reprint ACE gene is associated with Alzheimer's disease and atrophy of hippocampus and amygdala
    Kristel Sleegers
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Neurobiol Aging 26:1153-9. 2005
    ..Vascular pathology was not significantly associated with ACE. This suggests a modest but significant increase in risk of AD and early AD pathology in women homozygous for the ACE I-allele independent of vascular factors...
  20. doi request reprint Unrecognized myocardial infarction in relation to risk of dementia and cerebral small vessel disease
    M Arfan Ikram
    Department of Epidemiology and Biostatistics, Erasmus MC University Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Stroke 39:1421-6. 2008
    ..We investigated whether unrecognized MI is also a risk factor for dementia and cerebral small vessel disease (white matter lesions and brain infarction) in 2 population-based cohort studies...
  21. doi request reprint Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
    ..We tested the hypothesis that the cumulative effects of common genetic variants for lipids are collectively associated with subclinical atherosclerosis and incident coronary heart disease...
  22. doi request reprint Renin-angiotensin system inhibitors, angiotensin I-converting enzyme gene insertion/deletion polymorphism, and cancer: the Rotterdam Study
    Ronald van der Knaap
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, Netherlands
    Cancer 112:748-57. 2008
    ....
  23. ncbi request reprint Genetic variation in the renin-angiotensin system and arterial stiffness. The Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Clin Exp Hypertens 31:389-99. 2009
    ..Our findings suggest that genetic variation in the renin-angiotensin system may play a role in determining carotid distensibility and pulse pressure...
  24. doi request reprint Levels of antibodies against tissue transglutaminase during pregnancy are associated with reduced fetal weight and birth weight
    Jessica C Kiefte-de Jong
    Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands
    Gastroenterology 144:726-735.e2. 2013
    ..We assessed the associations between levels of antibodies against tissue transglutaminase (anti-tTG, a marker of celiac disease) and fetal growth and birth outcomes for pregnant women...
  25. doi request reprint The Generation R Study: design and cohort update 2012
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 27:739-56. 2012
    ..Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  26. ncbi request reprint Complement factor h polymorphism, inflammatory mediators, and retinal vessel diameters: the rotterdam study
    Frank Jan de Jong
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:3014-8. 2007
    ..Possible effect modification by smoking and inflammatory markers was examined...
  27. ncbi request reprint Height in pre- and postmenopausal women is influenced by estrogen receptor alpha gene polymorphisms
    Stephanie C E Schuit
    Department of Internal Medicine, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:303-9. 2004
    ..5 cm shorter per allele copy of the ESR1 haplotype 1 (P for trend = 0.03). In conclusion, we demonstrate a role for genetic variations in the estrogen receptor alpha gene in determining adult stature in women...
  28. pmc The interleukin-6-174 G/C promoter polymorphism and arterial stiffness; the Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Vasc Health Risk Manag 4:863-9. 2008
    ..CRP levels were associated with pulse wave velocity (p = 0.007). In conclusion, the interleukin-6-174 G/C polymorphism is associated with increased arterial stiffness and pulse pressure...
  29. ncbi request reprint The influence of an insulin-like growth factor I gene promoter polymorphism on hip bone geometry and the risk of nonvertebral fracture in the elderly: the Rotterdam Study
    Fernando Rivadeneira
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 19:1280-90. 2004
    ..5; 95% CI, 1.1-2.0) of fragility fracture in women (n = 4212) but not in men (n = 2799). An approximation of hip bone geometry (from DXA) suggested the polymorphism is associated with bone strength and stability in gender-specific ways...
  30. ncbi request reprint Blood pressure components and cardiovascular events in older adults: the Rotterdam study
    Francesco U S Mattace-Raso
    Section of Geriatric Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Geriatr Soc 52:1538-42. 2004
    ..To compare the strength of the relative risks of systolic (SBP) diastolic blood pressure (DBP) and pulse pressure (PP) as predictors of myocardial infarction and stroke in older adults...
  31. ncbi request reprint An igf-I gene polymorphism modifies the risk of diabetic retinopathy
    Ingrid Rietveld
    Department of Internal Medicine, Erasmus Medical Center, Room D 436, Dr Molewaterplein 40, 3015 GD, Rotterdam, Netherlands
    Diabetes 55:2387-91. 2006
    ..04) in the risk of retinopathy was observed compared with participants with the wild-type genotype. In conclusion, our findings suggest that this IGF-I gene polymorphism is associated with an increased risk of diabetic retinopathy...
  32. ncbi request reprint Usefulness of combining complement factor H and C-reactive protein genetic profiles for predicting myocardial infarction (from the Rotterdam Study)
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 100:646-8. 2007
    ..1 to 16.5) to develop MI compared with the reference group. In conclusion, this population-based study suggests that the combined presence of unfavorable CFH and CRP genetic profiles is associated with risk of MI...
  33. doi request reprint C-reactive protein levels in early pregnancy, fetal growth patterns, and the risk for neonatal complications: the Generation R Study
    Gesina D S Ernst
    Generation R Study Group, Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Obstet Gynecol 205:132.e1-12. 2011
    ..We sought to examine the associations of maternal C-reactive protein (CRP) levels with fetal growth and the risks of neonatal complications...
  34. ncbi request reprint Insulin-like growth factor-I gene polymorphism and risk of heart failure (the Rotterdam Study)
    Gysèle S Bleumink
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Cardiol 94:384-6. 2004
    ....
  35. doi request reprint Haplotypes of the NR4A2/NURR1 gene and cardiovascular disease: the Rotterdam Study
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Hum Mutat 30:417-23. 2009
    ..Associations for NR4A2 were found with both HDL levels and blood pressure. It remains to be investigated which pathophysiological mechanisms pertain to NR4A2 function in cardiovascular disease...
  36. ncbi request reprint Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers
    Hedi Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 15:478-84. 2007
    ..ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke...
  37. ncbi request reprint Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women
    Fernando Rivadeneira
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 21:1443-56. 2006
    ..Interaction of ESR2 with ESR1 and IGF1 was determined and revealed a deleterious genetic combination that enhances the risk of osteoporotic fracture...
  38. doi request reprint Fetal programming of infant neuromotor development: the generation R study
    Tamara van Batenburg-Eddes
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, 3000 CA, The Netherlands
    Pediatr Res 67:132-7. 2010
    ..These results suggest that differences in infant neuromotor development, a marker of behavioral and cognitive problems, are at least partly caused by processes occurring early in fetal life...
  39. ncbi request reprint The cholesteryl ester transfer protein I405V polymorphism is associated with increased high-density lipoprotein levels and decreased risk of myocardial infarction: the Rotterdam Study
    Aaron Isaacs
    Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Cardiovasc Prev Rehabil 14:419-21. 2007
    ..The effect of the cholesteryl ester transfer protein (CETP) I405V polymorphism on lipid levels, atherosclerosis and myocardial infarction (MI) was examined in 6421 participants from the Rotterdam Study...
  40. doi request reprint Association between the CYP2D6*4 polymorphism and depression or anxiety in the elderly
    Monique J Bijl
    Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Pharmacogenomics 10:541-7. 2009
    ..Relative to extensive metabolizers, these poor metabolizers may have lower baseline serotonin concentrations in various brain regions, and may be more prone to depression or anxiety...
  41. ncbi request reprint Low dietary riboflavin but not folate predicts increased fracture risk in postmenopausal women homozygous for the MTHFR 677 T allele
    Nahid Yazdanpanah
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Bone Miner Res 23:86-94. 2008
    ..We found that the MTHFR C677T variant interacts with dietary riboflavin intake to influence fracture risk in women...
  42. ncbi request reprint Plasma levels of antioxidants are not associated with Alzheimer's disease or cognitive decline
    Marianne J Engelhart
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Dement Geriatr Cogn Disord 19:134-9. 2005
    ..87 (95% CI 0.64-1.19) for vitamin A and 0.94 (95% CI 0.60-1.48) for vitamin E. Antioxidants were not related to CD in non-demented subjects. Our findings suggest no association between plasma levels of vitamin A and E and AD or CD...
  43. pmc Air pollution exposure and markers of placental growth and function: the generation R study
    Edith H van den Hooven
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Environ Health Perspect 120:1753-9. 2012
    ..Air pollution exposure during pregnancy might affect placental growth and function, perhaps leading to pregnancy complications...
  44. pmc Variation in the glucocorticoid receptor gene at rs41423247 moderates the effect of prenatal maternal psychological symptoms on child cortisol reactivity and behavior
    Fleur P Velders
    Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    Neuropsychopharmacology 37:2541-9. 2012
    ..05). These findings emphasize the potential effect of prenatal gene-environment interaction, and give insight in possible mechanisms accounting for children's individual vulnerability to develop emotional and behavioral problems...
  45. doi request reprint Clinical implications of old and new genes for open-angle glaucoma
    Wishal D Ramdas
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Ophthalmology 118:2389-97. 2011
    ..This study was performed to determine to what extent variants within established genes (MYOC, OPTN, and WDR36) and newly identified common genetic variants (ATOH7, CDKN2B, and SIX1) contribute to the risk of OAG...
  46. pmc HFE gene mutations increase the risk of coronary heart disease in women
    M Carolina Pardo Silva
    Department of Epidemiology, Erasmus University Medical Center Rotterdam, The Netherlands
    Eur J Epidemiol 25:643-9. 2010
    ..8, 95% CI 1.1-2.8) and current smokers (HR = 3.1, 95% CI 1.4-7.1), but not in former smokers (HR = 1.3, 95% CI 0.7-2.4). HFE mutations are associated with increased risk of incident CHD in women...
  47. ncbi request reprint A common polymorphism in the complement factor H gene is associated with increased risk of myocardial infarction: the Rotterdam Study
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Am Coll Cardiol 47:1568-75. 2006
    ..This study was designed to investigate the association between a common polymorphism (Tyr402His, rs1061170) in the complement factor H (CFH) gene and risk of coronary heart disease...
  48. ncbi request reprint C-reactive protein predicts progression of atherosclerosis measured at various sites in the arterial tree: the Rotterdam Study
    Irene M van der Meer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 33:2750-5. 2002
    ..Its role as a predictor of the progression of subclinical atherosclerosis is not yet known. We investigated whether CRP predicts progression of atherosclerosis measured at various sites in the arterial tree...
  49. doi request reprint White matter microstructural integrity and cognitive function in a general elderly population
    Meike W Vernooij
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 66:545-53. 2009
    ..Measures reflecting white matter microstructural integrity may provide additional information to investigate the relation between white matter changes and cognition...
  50. ncbi request reprint Polymorphisms and haplotypes in the C-reactive protein gene and risk of dementia
    Marieke van Oijen
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Neurobiol Aging 28:1361-6. 2007
    ..Since serum levels of C-reactive protein are partly determined by genetic factors, we examined the association between genetic variation in the C-reactive protein gene with dementia and AD...
  51. ncbi request reprint Fibrinogen gene haplotypes in relation to risk of coronary events and coronary and extracoronary atherosclerosis: the Rotterdam Study
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Thromb Haemost 97:288-95. 2007
    ..In conclusion, fibrinogen FGG and FGA gene haplotypes are not associated with coronary events, coronary atherosclerosis or extracoronary atherosclerosis. Confirmation of these findings by future population-based studies is warranted...
  52. doi request reprint SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
    ..Correction of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes...
  53. pmc Genetic variation in NOS1AP is associated with sudden cardiac death: evidence from the Rotterdam Study
    Mark Eijgelsheim
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Hum Mol Genet 18:4213-8. 2009
    ..69, P = 0.23; joint HR = 0.60, P = 0.0018). In conclusion, this study provided additional evidence for association between genetic variation within NOS1AP and SCD. The mechanism by which this effect is exerted remains to be elucidated...
  54. ncbi request reprint ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the Rotterdam study
    Mariette W C J Schoofs
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam 300 DR, The Netherlands
    J Bone Miner Res 19:1490-6. 2004
    ..We did not observe an association between the ApoE polymorphism and osteoporosis in this study, which is thus far the largest study on ApoE and osteoporosis...
  55. doi request reprint Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study)
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Am J Cardiol 113:1-6. 2014
    ..In men, the prognosis is as unfavorable as that of patients with recognized MIs. ..
  56. pmc FTO at rs9939609, food responsiveness, emotional control and symptoms of ADHD in preschool children
    Fleur P Velders
    Department of Child and Adolescent Psychiatry, Erasmus Medical Center Sophia Children s Hospital, Rotterdam, The Netherlands
    PLoS ONE 7:e49131. 2012
    ..Future studies are needed to investigate whether these findings represent one single mechanism or reflect pleiotropic effects of FTO...
  57. doi request reprint Parental, fetal, and infant risk factors for preschool overweight: the Generation R Study
    Denise H M Heppe
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Pediatr Res 73:120-7. 2013
    ..Overweight has its origins largely in early life. We aimed to identify the most important parental, fetal, and infant risk factors of preschool overweight...
  58. doi request reprint The Mediterranean diet and fetal size parameters: the Generation R Study
    Sarah Timmermans
    Generation R Study Group, Erasmus Medical Center, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Br J Nutr 108:1399-409. 2012
    ..To conclude, low adherence to a Mediterranean diet in early pregnancy seems associated with decreased intra-uterine size with a lower placental and a lower birth weight...
  59. doi request reprint Common carotid intima-media thickness in cardiovascular risk stratification of older people: the Rotterdam Study
    Suzette E Elias-Smale
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Prev Cardiol 19:698-705. 2012
    ..The aim of this study was to determine whether common carotid IMT in addition to traditional risk factors improves risk classification in a general population of older people...
  60. doi request reprint Estrogen receptors alpha and beta and the risk of open-angle glaucoma: the Rotterdam Study
    Simone de Voogd
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Ophthalmol 126:110-4. 2008
    ..To investigate whether polymorphisms in the estrogen receptor alpha (ESR1) and beta (ESR2) genes were a risk factor for open-angle glaucoma (OAG)...
  61. doi request reprint Cyclin-dependent kinase 5 is associated with risk for Alzheimer's disease in a Dutch population-based study
    Alejandro Arias-Vasquez
    Genetic Epidemiology Unit, Dept of Epidemiology and Biostatistics, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol 255:655-62. 2008
    ..In our analysis, the haplotype tagged by the G allele of SNP rs2069442 was significantly associated with AD (p = 0.05). In conclusion, our study suggests that CDK5 may be associated with AD...
  62. doi request reprint Angiotensinogen M235T polymorphism and symptoms of depression in a population-based study and a family-based study
    Sandra Lopez-Leon
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Psychiatr Genet 18:162-6. 2008
    ..The aim of this paper is to examine the association between the AGT M235T polymorphism and symptoms of depression in two independent populations; a population-based study, and a family-based study...
  63. doi request reprint Arterial stiffness as determinant of increased amino terminal pro-B-type natriuretic peptide levels in individuals with and without cardiovascular disease--the Rotterdam Study
    Joost H W Rutten
    Department of Internal Medicine, Section of Pharmacology, Vascular and Metabolic Diseases, Rotterdam, The Netherlands
    J Hypertens 28:2061-7. 2010
    ..Large artery stiffening has adverse effects on cardiac structure and function and, therefore, may be associated with elevated circulating levels of amino-terminal pro-B-type natriuretic peptide (NT-proBNP)...
  64. doi request reprint Calcium channel blockers, NOS1AP, and heart-rate-corrected QT prolongation
    Charlotte van Noord
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Pharmacogenet Genomics 19:260-6. 2009
    ..To study whether NOS1AP single nucleotide polymorphisms (SNPs), rs10494366 T>G and rs10918594 C>G, modify the heart-rate-corrected QT (QTc) prolonging effect of calcium channel blockers...
  65. pmc Predicting survival and morbidity-free survival to very old age
    Rachel S Newson
    Department of Epidemiology, Erasmus University Medical Centre, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Age (Dordr) 32:521-34. 2010
    ....
  66. ncbi request reprint Patients with an ApoE epsilon4 allele require lower doses of coumarin anticoagulants
    Loes E Visser
    Pharmacoepidemiology Unit, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Pharmacogenet Genomics 15:69-74. 2005
    ..Therefore, we investigated whether this common genetic polymorphism influenced dose requirements and effects of coumarin anticoagulants...
  67. ncbi request reprint C-reactive protein levels, variation in the C-reactive protein gene, and cancer risk: the Rotterdam Study
    Claire Siemes
    Department of Epidemiology and Biostatistics, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 24:5216-22. 2006
    ..The aim of this study was to examine whether C-reactive protein (CRP) levels and CRP gene variations were associated with an altered risk of colorectal, lung, breast, or prostate cancer...
  68. ncbi request reprint TGF-beta 1 polymorphisms and risk of myocardial infarction and stroke: the Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Stroke 37:2667-71. 2006
    ..We therefore investigated 5 polymorphisms in the TGF-beta1 gene (-800 G/A, -509 C/T, codon 10 Leu/Pro, codon 25 Arg/Pro, and codon 263 Thr/Ile) in relation to the risk of myocardial infarction and stroke in a population-based study...
  69. pmc Vitamin D binding protein genotype and osteoporosis
    Yue Fang
    Department of Internal Medicine, Erasmus Medical Center, Genetic Laboratory, Rotterdam, The Netherlands
    Calcif Tissue Int 85:85-93. 2009
    ..05). All associations were independent of age and gender. Our study demonstrated that the genetic effect of the DBP gene on fracture risk appears only in combination with other genetic and environmental risk factors for bone metabolism...
  70. ncbi request reprint The female advantage in cardiovascular disease: do vascular beds contribute equally?
    Isabella Kardys
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Epidemiol 166:403-12. 2007
    ..Remarkably, it is absent in the aorta and the lower-extremity vessels. Factors causing this site-specific gender difference require further investigation...
  71. ncbi request reprint Arterial stiffness and risk of coronary heart disease and stroke: the Rotterdam Study
    Francesco U S Mattace-Raso
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Circulation 113:657-63. 2006
    ..We evaluated whether arterial stiffness is a predictor of coronary heart disease and stroke in a population-based study among apparently healthy subjects...
  72. ncbi request reprint Retinal vessel diameters and cerebral small vessel disease: the Rotterdam Scan Study
    M Kamran Ikram
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Brain 129:182-8. 2006
    ..The mechanisms underlying venular dilatation deserve more attention, as they may provide new clues into the pathophysiology of cerebral small vessel disease...
  73. doi request reprint Associations of serum cortisol with cognitive function and dementia: the Rotterdam Study
    Elisabeth M C Schrijvers
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    J Alzheimers Dis 25:671-7. 2011
    ..There was no relation between serum levels of cortisol and the risk of developing dementia or Alzheimer's disease. These results suggest that that morning serum cortisol is not a causal factor in the development of dementia...
  74. ncbi request reprint Allelic variants of cytochrome P450 2C9 modify the interaction between nonsteroidal anti-inflammatory drugs and coumarin anticoagulants
    Loes E Visser
    Pharmacoepidemiology Unit, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Clin Pharmacol Ther 77:479-85. 2005
    ..We investigated whether NSAIDs were associated with overanticoagulation during therapy with coumarins and evaluated the effect of the CYP2C9 polymorphisms on this potential interaction...
  75. ncbi request reprint Complement factor H polymorphism, complement activators, and risk of age-related macular degeneration
    Dominiek D G Despriet
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 296:301-9. 2006
    ..Recent case-control studies demonstrated an association between the complement factor H (CFH) gene, a regulator of complement, and AMD...
  76. pmc Glucocorticoid receptor gene polymorphisms do not affect growth in fetal and early postnatal life. The Generation R Study
    Miranda J J Geelhoed
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med Genet 11:39. 2010
    ..We examined whether these glucocorticoid receptor gene polymorphisms are associated with growth in fetal and early postnatal life...
  77. pmc Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med 6:30. 2008
    ..We examined the SNPs in relation to the risk of CHD and MI in a large population based study of elderly population...
  78. doi request reprint Fetal and infant growth and the risk of obesity during early childhood: the Generation R Study
    Dennis O Mook-Kanamori
    The Generation R Study Group AE 006, Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 165:623-30. 2011
    ..To examine whether infant growth rates are influenced by fetal growth characteristics and are associated with the risks of overweight and obesity in early childhood...
  79. pmc Breast-feeding modifies the association of PPARgamma2 polymorphism Pro12Ala with growth in early life: the Generation R Study
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 58:992-8. 2009
    ..We examined whether the PPARgamma2 Ala12 allele influences growth in early life and whether this association is modified by breast-feeding...
  80. doi request reprint Cardiac structures track during the first 2 years of life and are associated with fetal growth and hemodynamics: the Generation R Study
    J J Miranda Geelhoed
    Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Am Heart J 158:71-7. 2009
    ..The aim of this study is to examine whether cardiac size and function track in early childhood and are associated with fetal and early postnatal growth and blood flow characteristics...
  81. ncbi request reprint Glucocorticoid receptor variant and risk of dementia and white matter lesions
    Elisabeth F C van Rossum
    Department of Internal Medicine, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neurobiol Aging 29:716-23. 2008
    ..A glucocorticoid receptor gene variant (ER22/23EK) is related to relative glucocorticoid resistance. We investigated whether the ER22/23EK allele is associated with dementia and structural brain abnormalities...
  82. pmc The Generation R Study: design and cohort update 2010
    Vincent W V Jaddoe
    The Generation R Study Group AE006, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 25:823-41. 2010
    ..Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  83. ncbi request reprint Use of hippocampal and amygdalar volumes on magnetic resonance imaging to predict dementia in cognitively intact elderly people
    Tom den Heijer
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Arch Gen Psychiatry 63:57-62. 2006
    ..Whether atrophy of these structures is also present in persons without cognitive impairment who later develop dementia is unknown...
  84. ncbi request reprint Angiotensin converting enzyme insertion/deletion polymorphism and the risk of heart failure in hypertensive subjects
    Anna F C Schut
    Genetic Epidemiology Unit, Department of Epidemiology, Eramus Medical Centre Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Heart J 25:2143-8. 2004
    ..We assessed the relation between the ACE I/D polymorphism and the risk of incident heart failure in normotensive and hypertensive subjects...
  85. doi request reprint Dependency of phenprocoumon dosage on polymorphisms in the VKORC1, CYP2C9, and CYP4F2 genes
    Martina Teichert
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Pharmacogenet Genomics 21:26-34. 2011
    ..For phenprocoumon dosage, the genes encoding CYP3A4 and ApoE might play a role...
  86. ncbi request reprint The catechol-O-methyltransferase Met158 low-activity allele and association with nonvertebral fracture risk in elderly men
    Lisette Stolk
    Department of Internal Medicine, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:3206-12. 2007
    ..An example is catechol-O-methyltransferase (COMT), an estrogen-degrading enzyme involved in inactivation of catechol-estrogens. Its gene contains a functional valine to methionine substitution at codon 158...
  87. ncbi request reprint Estrogen receptor alpha gene polymorphisms associated with incident aging macula disorder
    Sharmila S Boekhoorn
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Invest Ophthalmol Vis Sci 48:1012-7. 2007
    ..This study was undertaken to investigate whether genetic variations in the estrogen receptor alpha (ESR1) gene are associated with incident AMD...
  88. ncbi request reprint The risk of myocardial infarction in patients with reduced activity of cytochrome P450 2C9
    Loes E Visser
    Department of Epidemiology, Erasmus MC, Rotterdam, Inspectorate for Health Care, The Hague, The Netherlands
    Pharmacogenet Genomics 17:473-9. 2007
    ..The aim of the present follow-up study was to investigate whether the enzyme activity of the human cytochrome P450 (CYP) 2C9 isoenzyme is associated with myocardial infarction...
  89. ncbi request reprint IGF-I gene promoter polymorphism is a predictor of survival after myocardial infarction in patients with type 2 diabetes
    Mojgan Yazdanpanah
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 155:751-6. 2006
    ....
  90. doi request reprint Socioeconomic inequalities in infant temperament: the generation R study
    Pauline W Jansen
    The Generation R Study Group, Erasmus MC University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Soc Psychiatry Psychiatr Epidemiol 44:87-95. 2009
    ..Furthermore, they generally did not examine explanatory mechanisms underlying the association between SES and temperament. We investigated the association between SES and temperament in infancy...
  91. doi request reprint Genetic variation in the fibrinogen-alpha and fibrinogen-gamma genes in relation to arterial stiffness: the Rotterdam Study
    Mark P S Sie
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 27:1392-8. 2009
    ....
  92. doi request reprint A variant of the IGF-I gene is associated with blood pressure but not with left heart dimensions at the age of 2 years: the Generation R Study
    Vera A A van Houten
    The Generation R Study Group AE 006, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 159:209-16. 2008
    ..The objective of this study was to examine whether this variant of the IGF-I gene is associated with blood pressure and left heart dimensions in early childhood...
  93. doi request reprint Host polymorphisms in interleukin 4, complement factor H, and C-reactive protein associated with nasal carriage of Staphylococcus aureus and occurrence of boils
    Marieke Emonts
    Department of Pediatrics, Sophia Children s Hospital, University Medical Center, Rotterdam, The Netherlands
    J Infect Dis 197:1244-53. 2008
    ..We hypothesized that polymorphisms in host inflammatory response genes and genetic variation in S. aureus contribute to susceptibility to S. aureus carriage and infection...
  94. ncbi request reprint The association of polymorphisms in the type 1 and 2 deiodinase genes with circulating thyroid hormone parameters and atrophy of the medial temporal lobe
    Frank Jan de Jong
    Department of Epidemiology, Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:636-40. 2007
    ..Variations in the deiodinase type 1 (DIO1) and type 2 (DIO2) genes that potentially alter thyroid hormone bioactivity may help in elucidating the role of thyroid function in AD...
  95. ncbi request reprint Mutations in the hemochromatosis gene (HFE) and stroke
    Omer T Njajou
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Stroke 33:2363-6. 2002
    ..Carriers of HFE C282Y and H63D mutations have elevated serum iron levels and may have an increased risk for stroke. We studied the association between HFE gene mutations, carotid atherosclerosis, and stroke...
  96. ncbi request reprint Silent brain infarcts and white matter lesions increase stroke risk in the general population: the Rotterdam Scan Study
    Sarah E Vermeer
    Dept of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 34:1126-9. 2003
    ..In healthy elderly people, silent brain infarcts and white matter lesions are common, but little is known about their relevance. We examined the risk of stroke associated with these lesions in the general population...
  97. doi request reprint Risk factors and outcomes associated with first-trimester fetal growth restriction
    Dennis O Mook-Kanamori
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA 303:527-34. 2010
    ..Adverse environmental exposures lead to developmental adaptations in fetal life. The influences of maternal physical characteristics and lifestyle habits on first-trimester fetal adaptations and the postnatal consequences are not known...
  98. doi request reprint Evaluation of risk prediction updates from commercial genome-wide scans
    Raluca Mihaescu
    Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Genet Med 11:588-94. 2009
    ..Commercial internet-based companies offer genome-wide scans to predict the risk of common diseases and personalize nutrition and lifestyle recommendations. These risk estimates are updated with every new gene discovery...
  99. ncbi request reprint Apolipoprotein E epsilon4 allele is associated with left ventricular systolic dysfunction
    Gysèle S Bleumink
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Am Heart J 147:685-9. 2004
    ..We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects...
  100. ncbi request reprint Association between an insulin-like growth factor I gene promoter polymorphism and bone mineral density in the elderly: the Rotterdam Study
    Fernando Rivadeneira
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:3878-84. 2003
    ..Our findings suggest that this promoter polymorphism or another functional polymorphism in linkage disequilibrium may be a genetic determinant of BMD levels and rate of bone loss in postmenopausal women...
  101. ncbi request reprint Genetic variation in Fcgamma receptor IIa protects against advanced peripheral atherosclerosis. The Rotterdam Study
    Irene M van der Meer
    Erasmus Medical Center, Department of Epidemiology and Biostatistics, 3000 DR Rotterdam, The Netherlands
    Thromb Haemost 92:1273-6. 2004
    ..52 (0.29-0.93) and 0.45 (0.23-0.86), for heterozygotes and H131 homozygotes, respectively; P trend=0.02). This is the first study showing that the H131 allele of FcgammaRIIa protects against advanced peripheral atherosclerosis...