Leo J Hofland

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi request reprint The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5
    Leo J Hofland
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Centre, GD Rotterdam, The Netherlands
    Eur J Endocrinol 152:645-54. 2005
  2. ncbi request reprint The pathophysiological consequences of somatostatin receptor internalization and resistance
    Leo J Hofland
    Department of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    Endocr Rev 24:28-47. 2003
  3. ncbi request reprint Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells
    Virgil A S H Dalm
    Dept of Internal Medicine, Rm Bd 240, Erasmus MC, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 285:E344-53. 2003
  4. doi request reprint Effects of type I interferons on IGF-mediated autocrine/paracrine growth of human neuroendocrine tumor cells
    Giovanni Vitale
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 296:E559-66. 2009
  5. doi request reprint The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells
    Maria Cristina De Martino
    Division of Endocrinology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 19:351-64. 2012
  6. ncbi request reprint Pro-inflammatory cytokines affect pancreatic carcinoma cell. Endothelial cell interactions
    Miranda ten Kate
    Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    JOP 7:454-64. 2006
  7. doi request reprint Correlation of in vitro and in vivo somatotropic adenoma responsiveness to somatostatin analogs and dopamine agonists with immunohistochemical evaluation of somatostatin and dopamine receptors and electron microscopy
    Diego Ferone
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:1412-7. 2008
  8. ncbi request reprint Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Room Ee542, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Endocrinology 148:5278-87. 2007
  9. pmc Type I interferons in the treatment of pancreatic cancer: mechanisms of action and role of related receptors
    Giovanni Vitale
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Ann Surg 246:259-68. 2007
  10. ncbi request reprint Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth
    Peter M van Koetsveld
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:4537-43. 2006

Collaborators

Detail Information

Publications64

  1. ncbi request reprint The multi-ligand somatostatin analogue SOM230 inhibits ACTH secretion by cultured human corticotroph adenomas via somatostatin receptor type 5
    Leo J Hofland
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Centre, GD Rotterdam, The Netherlands
    Eur J Endocrinol 152:645-54. 2005
    ..We compared the in vitro effects of the sst(2)-preferring SS analogue octreotide (OCT) and the multi-ligand SOM230 on ACTH release by human and mouse corticotroph tumour cells...
  2. ncbi request reprint The pathophysiological consequences of somatostatin receptor internalization and resistance
    Leo J Hofland
    Department of Internal Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    Endocr Rev 24:28-47. 2003
    ..Herein, the development and potential role of novel somatostatin analogs is discussed...
  3. ncbi request reprint Expression of somatostatin, cortistatin, and somatostatin receptors in human monocytes, macrophages, and dendritic cells
    Virgil A S H Dalm
    Dept of Internal Medicine, Rm Bd 240, Erasmus MC, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 285:E344-53. 2003
    ....
  4. doi request reprint Effects of type I interferons on IGF-mediated autocrine/paracrine growth of human neuroendocrine tumor cells
    Giovanni Vitale
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 296:E559-66. 2009
    ....
  5. doi request reprint The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells
    Maria Cristina De Martino
    Division of Endocrinology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 19:351-64. 2012
    ..mTOR could be a target for the treatment of human ACCs, but variable responses might be expected. In selected cases of ACC, the combined targeting of mTOR and IGF2 could have greater effects than mTOR inhibitors alone...
  6. ncbi request reprint Pro-inflammatory cytokines affect pancreatic carcinoma cell. Endothelial cell interactions
    Miranda ten Kate
    Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    JOP 7:454-64. 2006
    ..The potential role of surgery-induced pro-inflammatory cytokines on the development of tumor recurrence in pancreatic cancer was investigated...
  7. doi request reprint Correlation of in vitro and in vivo somatotropic adenoma responsiveness to somatostatin analogs and dopamine agonists with immunohistochemical evaluation of somatostatin and dopamine receptors and electron microscopy
    Diego Ferone
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:1412-7. 2008
    ..In nine cases, GH and PRL content was further studied by immunoelectron microscopy...
  8. ncbi request reprint Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Room Ee542, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Endocrinology 148:5278-87. 2007
    ..Thus, our results suggest that peripheral AG metabolic regulation and action are mainly confined within the gastrointestinal tract...
  9. pmc Type I interferons in the treatment of pancreatic cancer: mechanisms of action and role of related receptors
    Giovanni Vitale
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Ann Surg 246:259-68. 2007
    ..We evaluated the role of type I interferons (IFNs) and IFN receptors in the regulation of cell growth in 3 human pancreatic adenocarcinoma cell lines (BxPC-3, MiaPaCa-2, and Panc-1)...
  10. ncbi request reprint Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth
    Peter M van Koetsveld
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:4537-43. 2006
    ..Despite efforts to develop new therapeutic regimens for metastatic ACC, surgery remains the mainstay of treatment. Interferons are known to exert tumor-suppressive effects in several types of human cancer...
  11. doi request reprint Medical therapy of acromegaly: efficacy and safety of somatostatin analogues
    Richard A Feelders
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    Drugs 69:2207-26. 2009
    ....
  12. ncbi request reprint Dopamine receptor expression and function in corticotroph ectopic tumors
    Rosario Pivonello
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:65-9. 2007
    ..Dopamine receptor (DR) expression and dopamine agonist (DA) effectiveness have never been demonstrated in neuroendocrine tumors associated with ectopic ACTH syndrome (EAS)...
  13. ncbi request reprint Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Mol Cell Endocrinol 251:103-11. 2006
    ..Our data support the existence of a specific receptor for UAG, other than the CRF2R and GHS-R1a. The stimulatory effect on insulin secretion by AG in this cell line is mediated by the GHS-R1a...
  14. doi request reprint Immunoreactivity score using an anti-sst2A receptor monoclonal antibody strongly predicts the biochemical response to adjuvant treatment with somatostatin analogs in acromegaly
    Federico Gatto
    Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:E66-71. 2013
    ..Recently, a new rabbit monoclonal anti-sst2A antibody (clone UMB-1) has been validated as a reliable method to selectively detect sst2A protein levels in formalin-fixed tissues...
  15. ncbi request reprint Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 293:E697-704. 2007
    ..Our data demonstrate that, in glucose-stimulated conditions, exogenous UAG acts as a potent insulin secretagogue, whereas endogenous AG exerts a maximal tonic inhibition on glucose-induced insulin release...
  16. ncbi request reprint The somatostatin analogue SOM230, compared with octreotide, induces differential effects in several metabolic pathways in acromegalic patients
    Joost van der Hoek
    Department of Internal Medicine, Section Endocrinology, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 63:176-84. 2005
    ..c. injection SOM230 100 and 250 microg, were compared to those following OCT 100 microg...
  17. ncbi request reprint The novel somatostatin analog SOM230 is a potent inhibitor of hormone release by growth hormone- and prolactin-secreting pituitary adenomas in vitro
    Leo J Hofland
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:1577-85. 2004
    ..Second, compared with OCT, SOM230 is more potent in inhibiting PRL release by mixed GH/PRL-secreting adenoma and prolactinoma cells...
  18. ncbi request reprint Somatostatin receptors in malignant lymphomas: targets for radiotherapy?
    Virgil A S H Dalm
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nucl Med 45:8-16. 2004
    ..Therefore, we investigated in vitro the characteristics of lymphoma tissues and lymphoid cell lines to evaluate whether lymphomas can be targets for radiotherapy...
  19. ncbi request reprint Cortistatin rather than somatostatin as a potential endogenous ligand for somatostatin receptors in the human immune system
    Virgil A Dalm
    Department of Internal Medicine, Erasmus Medical Center, 3015 GD, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:270-6. 2003
    ..On the basis of these observations, we hypothesize a role for CST as an endogenous ligand of at least the sst2 receptor in the human immune system, rather than SS itself...
  20. doi request reprint Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 168:67-74. 2013
    ..Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD. Steroidogenesis in PPNAD can be modified through a local glucocorticoid feed-forward loop...
  21. doi request reprint Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Room Ee 532, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:E747-54. 2012
    ..MC2R trafficking and signaling are dependent on the MC2R accessory protein (MRAP). The MRAP homolog MRAP2 also transports the MC2R to the cell surface but might prevent activation...
  22. ncbi request reprint Distribution pattern of somatostatin and cortistatin mRNA in human central and peripheral tissues
    Virgil A S H Dalm
    Department of Internal Medicine, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 60:625-9. 2004
    ..Further studies demonstrated a selective expression of CST in tissues and cells of the human immune system, while SS was not expressed...
  23. ncbi request reprint Differential expression of somatostatin receptor subtypes in human peripheral blood mononuclear cell subsets
    Elgin G R Lichtenauer-Kaligis
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Endocrinol 150:565-77. 2004
    ..However, not much is known with respect to the SS receptor subtype (sst) expression pattern and the expression of SS itself in the immune system...
  24. ncbi request reprint Dopamine receptor expression and function in corticotroph pituitary tumors
    Rosario Pivonello
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:2452-62. 2004
    ..The effectiveness of cabergoline in normalizing cortisol secretion in 40% of cases supports its therapeutic use in the management of Cushing's disease...
  25. doi request reprint Interferon-β is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane
    Peter M van Koetsveld
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 20:443-54. 2013
    ..The inhibition of the expression of steroidogenic enzymes by IFN-β is a novel mechanism that may explain its inhibitory effect on cortisol production...
  26. pmc Future treatment strategies of aggressive pituitary tumors
    Steven W J Lamberts
    Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands
    Pituitary 12:261-4. 2009
    ....
  27. doi request reprint Coexpression of dopamine and somatostatin receptor subtypes in corticotroph adenomas
    Christiaan de Bruin
    Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:1118-24. 2009
    ..To what extent these receptor subtypes are coexpressed within individual adenomas, is not known however...
  28. doi request reprint The somatostatin receptor subtype 5 in neuroendocrine tumours
    Joost van der Hoek
    Department of Internal Medicine, Division of Endocrinology, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Expert Opin Investig Drugs 19:385-99. 2010
    ....
  29. ncbi request reprint Novel subtype specific and universal somatostatin analogues: clinical potential and pitfalls
    Joost van der Hoek
    Department of Internal Medicine, Section Endocrinology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Curr Pharm Des 11:1573-92. 2005
    ..Finally, acknowledged side effects and possible pitfalls of the use of SS-analogues are discussed...
  30. doi request reprint Somatostatin and somatostatin receptors in Cushing's disease
    Leo J Hofland
    Department of Internal Medicine, Division Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Mol Cell Endocrinol 286:199-205. 2008
    ..In this review an overview of the current insights into the role of SS and sst in the regulation of normal and pathological ACTH secretion is provided...
  31. ncbi request reprint Crucial role for somatostatin receptor subtype 2 in determining the uptake of [111In-DTPA-D-Phe1]octreotide in somatostatin receptor-positive organs
    Leo J Hofland
    Department of Internal Medicine Room Bd240, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Nucl Med 44:1315-21. 2003
    ....
  32. doi request reprint Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling
    Aimee J Varewijck
    Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Mol Cell Endocrinol 365:17-24. 2013
    ..The aim of this study was to determine total serum insulin-like activity mediated via the insulin receptor isoform A (IR-A) and isoform B (IR-B) by using kinase receptor activation (KIRA) assays specific for the IR-A and IR-B...
  33. ncbi request reprint The role of somatostatin analogs in Cushing's disease
    Joost van der Hoek
    Department of Internal Medicine, Section Endocrinology, Erasmus MC, 3015 Rotterdam, The Netherlands
    Pituitary 7:257-64. 2004
    ....
  34. ncbi request reprint Preclinical and clinical experiences with the role of somatostatin receptors in the treatment of pituitary adenomas
    Joost van der Hoek
    Department of Internal Medicine, Section Endocrinology, Room Ee30b, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Eur J Endocrinol 156:S45-51. 2007
    ..In the present review, the functional role of sst in all types of pituitary adenomas, based on recent preclinical and clinical studies, is being discussed...
  35. ncbi request reprint Novel insights in dopamine receptor physiology
    Rosario Pivonello
    Departments of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands, Molecular and Clinical Endocrinology and Oncology, Federico II University, Via Sergio Pansini, 5, 80131 Naples, Italy
    Eur J Endocrinol 156:S13-21. 2007
    ..In addition, the recent findings on the relationship between dopamine receptors and neuroendocrine tumors are summarized...
  36. doi request reprint Pituitary tumours: the sst/D2 receptors as molecular targets
    Leo J Hofland
    Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    Mol Cell Endocrinol 326:89-98. 2010
    ..In this review the current knowledge on the expression and functional roles of sst and D2 in pituitary tumours is discussed...
  37. ncbi request reprint IFN-beta is a highly potent inhibitor of gastroenteropancreatic neuroendocrine tumor cell growth in vitro
    Giovanni Vitale
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer Res 66:554-62. 2006
    ..Further studies are required to establish whether IFN-beta has comparable potent tumor growth inhibitory effects in vivo...
  38. doi request reprint Medical Treatment of Cushing's Disease
    Richard A Feelders
    Erasmus Medical Center, Department of Internal Medicine, Section of Endocrinology, sGravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:425-38. 2013
    ..Conclusion: Medical therapy for CD can be targeted at different levels and should be tailored in each individual patient. Future studies should examine the optimal dose and combination of medical treatment modalities for CD...
  39. pmc Igf-I bioactivity in an elderly population: relation to insulin sensitivity, insulin levels, and the metabolic syndrome
    Michael P Brugts
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes 59:505-8. 2010
    ..The purpose of our study was to investigate whether IGF-I bioactivity was related to insulin sensitivity and the metabolic syndrome...
  40. ncbi request reprint Induction of apoptosis with hybrids of Arg-Gly-Asp molecules and peptides and antimitotic effects of hybrids of cytostatic drugs and peptides
    Leo J Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nucl Med 46:191S-8S. 2005
    ..Here we discuss the development of the different cytotoxic somatostatin analogs and their antitumor effects in vitro and in vivo in experimental models...
  41. doi request reprint IGF-I Bioactivity Might Reflect Different Aspects of Quality of Life Than Total IGF-I in GH-Deficient Patients During GH Treatment
    Aimee J Varewijck
    MD, PhD, Department of Internal Medicine, Erasmus Medical Center, Room D 443, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:761-8. 2013
    ..This suggests that IGF-I bioactivity reflects different aspects of QOL than total IGF-I in GHD patients during GH treatment...
  42. ncbi request reprint Associations between promoter usage and alternative splicing of the glucocorticoid receptor gene
    Henk Russcher
    Department of Internal Medicine, Erasmus MC, University Medical Center Dr Molewaterplein 40, Rotterdam, The Netherlands
    J Mol Endocrinol 38:91-8. 2007
    ..This indicates that regulation of GR splice variants could partly occur through selective use of the multiple promoters, and that this is another way to sensitize cells and tissues to the different activities of the GR isoforms...
  43. ncbi request reprint A single-dose comparison of the acute effects between the new somatostatin analog SOM230 and octreotide in acromegalic patients
    Joost van der Hoek
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:638-45. 2004
    ..We conclude that SOM230 is an effective GH-lowering drug in acromegalic patients with the potential to increase the number of patients controlled during long-term medical treatment...
  44. doi request reprint Role of somatostatin receptors in normal and tumoral pituitary corticotropic cells
    Leo J Hofland
    Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Neuroendocrinology 92:11-6. 2010
    ....
  45. ncbi request reprint Somatostatin receptors in pituitary function, diagnosis and therapy
    Leo J Hofland
    Section Endocrinology, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Front Horm Res 32:235-52. 2004
    ..This review discusses the expression and potential role of sst subtypes in the different types of human pituitary adenomas...
  46. doi request reprint Somatostatin and somatostatin receptors: from basic concepts to clinical applications
    Maria Cristina De Martino
    Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    Prog Brain Res 182:255-80. 2010
    ..The development of novel SS-analogues with new pharmacokinetic and pharmacodynamic characteristics may further improve the clinical applications of such compounds...
  47. doi request reprint Recent developments in drug therapy for Cushing's disease
    Rob van der Pas
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, sGravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Drugs 73:907-18. 2013
    ..In this review, the efficacy and limitations of drugs that have been used in the treatment of CD will be discussed as well as recent developments with respect to new pituitary- and adrenal-targeting compounds...
  48. doi request reprint Circulating IgGs May Modulate IGF-I Receptor Stimulating Activity in a Subset of Patients With Graves' Ophthalmopathy
    Aimee J Varewijck
    MD, PhD, Department of Internal Medicine, Erasmus MC, Room D 443, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:769-76. 2013
    ..In a subgroup of these patients, depletion of IgGs significantly decreased IGF-IR stimulating activity, suggesting that, in a subset of patients with GO, IgGs may have IGF-IR stimulating activities...
  49. ncbi request reprint Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro
    Richard A Feelders
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:230-7. 2003
    ..Despite the regulatory potential of LH and 5-HT4 receptor agonists on cortisol production in our patients, their adrenals seemed to be still sensitive to ACTH, both in vivo and in vitro...
  50. doi request reprint Temozolomide-induced shrinkage of a pituitary carcinoma causing Cushing's disease--report of a case and literature review
    Lorenzo Curto
    Department of Medicine and Pharmacology, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    ScientificWorldJournal 10:2132-8. 2010
    ..Clinical conditions improved progressively and, after 17 months from the beginning of TMZ administration, the patient is still alive. The treatment was well tolerated except for a transient thrombocytopenia (grade 4 WHO)...
  51. doi request reprint The role of somatostatin and dopamine D2 receptors in endocrine tumors
    Federico Gatto
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Room Ee530b, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 18:R233-51. 2011
    ..Moreover, the most recent insights in SSTR and D(2) pathophysiology and the future perspectives for treatment with SSA, DA agonists, and SS/DA chimeric compounds are discussed...
  52. doi request reprint Normal values of circulating insulin-like growth factor-I bioactivity in the healthy population: comparison with five widely used IGF-I immunoassays
    Michael P Brugts
    Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 93:2539-45. 2008
    ..Recently an IGF-I-specific kinase receptor activation assay (KIRA) has been developed as an alternative method. However, no normative values have been established for the IGF-I KIRA...
  53. ncbi request reprint Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes
    Diego Ferone
    Department of Internal Medicine, Erasmus Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 283:E1056-66. 2002
    ....
  54. ncbi request reprint Somatostatin analogs in the diagnosis and treatment of cancer
    Steven W J Lamberts
    Dept Medicine, Erasmus Medical Centre, 40 Dr Molewaterplein, 3015 GD Rotterdam, The Netherlands
    Trends Endocrinol Metab 13:451-7. 2002
    ..Knowledge about the differential anti-tumor effects of the sst subtypes on tumor cells might have clinical significance after the development of new subtype-specific somatostatin analogs...
  55. ncbi request reprint Somatostatin receptors in pheochromocytoma
    Wouter W de Herder
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Front Horm Res 31:145-54. 2004
  56. doi request reprint Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole
    Richard A Feelders
    Department of Internal Medicine, Endocrine Section, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuroendocrinology 92:111-5. 2010
    ..e. the universal somatostatin analogue pasireotide and/or the dopamine agonist cabergoline, and low-dose ketoconazole seems a rational approach to achieve biochemical control...
  57. ncbi request reprint Influence of proinflammatory cytokines on the adhesion of human colon carcinoma cells to lung microvascular endothelium
    Miranda ten Kate
    Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    Int J Cancer 112:943-50. 2004
    ..Probably not one but a complex of adhesion molecules is responsible for enhanced adhesion to HMVECs-L...
  58. ncbi request reprint Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes
    Carlotta Gauna
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:1055-60. 2005
    ..These actions might be mediated by a different receptor than GHS-R1a, and apparently, we must consider AG and UAG as separate hormones that can modify each other's actions on glucose handling, at least in the liver...
  59. ncbi request reprint Sequential ACTH and catecholamine secretion in a phaeochromocytoma
    P Sytze van Dam
    Department of Clinical Endocrinology, University Medical Center, Utrecht, The Netherlands
    Eur J Endocrinol 147:201-6. 2002
    ..In vitro studies were carried out on the tumour to evaluate the interaction between the tumour cells and normal adrenal cortex...
  60. doi request reprint Efficacy of a dopamine-somatostatin chimeric molecule, BIM-23A760, in the control of cell growth from primary cultures of human non-functioning pituitary adenomas: a multi-center study
    Tullio Florio
    Department of Oncology, Biology and Genetics, University of Genova, Viale Benedetto XV, 2, 16132 Genova, Italy
    Endocr Relat Cancer 15:583-96. 2008
    ....
  61. ncbi request reprint Distinct functional properties of native somatostatin receptor subtype 5 compared with subtype 2 in the regulation of ACTH release by corticotroph tumor cells
    Joost van der Hoek
    Dept of Internal Medicine, Section Endocrinology, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 289:E278-87. 2005
    ..In conclusion, our data support the concept that the sst5 receptor might be a target for new therapeutic agents to treat Cushing's disease...
  62. ncbi request reprint Selective alkylation and acylation of alpha and epsilon amino groups with PEG in a somatostatin analogue: tailored chemistry for optimized bioconjugates
    Margherita Morpurgo
    Universita degli Studi di Padova, Dipartimento Scienze Farmaceutiche, Via Marzolo, 5, 35131 Padova, Italy
    Bioconjug Chem 13:1238-43. 2002
    ..The results obtained suggest the importance of preliminary studies in the development of new polymer-peptide conjugates with improved pharmacological properties...
  63. ncbi request reprint Discovery of iodinated somatostatin analogues selective for hsst2 and hsst5 with excellent inhibition of growth hormone and prolactin release from rat pituitary cells
    Sandra Blaj Moore
    University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0343, and Erasmus MC, Rotterdam, The Netherlands
    J Med Chem 48:6643-52. 2005
    ....
  64. ncbi request reprint Somatostatin is a selective chemoattractant for primitive (CD34(+)) hematopoietic progenitor cells
    Sigrid P M A Oomen
    Institute of Hematology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Exp Hematol 30:116-25. 2002
    ..Despite the broad use of SST and its analogs in clinical practice, the spectrum of activities of SST is incompletely defined. Here, we examined the role of SST and its receptors in hematopoiesis...