Johannes Hofland

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitro responses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase
    Johannes Hofland
    Department of Internal Medicine, Section of Endocrinology, P, O, Box 2040, Rotterdam, CA, 3000, The Netherlands
    Orphanet J Rare Dis 8:142. 2013
  2. doi request reprint Inhibins and activins: their roles in the adrenal gland and the development of adrenocortical tumors
    Johannes Hofland
    Department of Internal Medicine, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Cell Endocrinol 359:92-100. 2012
  3. doi request reprint Serum inhibin pro-αC is a tumor marker for adrenocortical carcinomas
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Room Ee 532, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Endocrinol 166:281-9. 2012
  4. doi request reprint Activin A stimulates AKR1C3 expression and growth in human prostate cancer
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Endocrinology 153:5726-34. 2012
  5. doi request reprint Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Room Ee 532, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:E747-54. 2012
  6. doi request reprint Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer
    Johannes Hofland
    Departments of Internal Medicine, Urology, and Pathology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Cancer Res 70:1256-64. 2010
  7. pmc Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 168:67-74. 2013
  8. doi request reprint Interferon-β is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane
    Peter M van Koetsveld
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 20:443-54. 2013
  9. doi request reprint Intratumoral conversion of adrenal androgen precursors drives androgen receptor-activated cell growth in prostate cancer more potently than de novo steroidogenesis
    Jinpei Kumagai
    Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Prostate 73:1636-50. 2013
  10. pmc Inhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation
    Johannes Hofland
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 9:e104944. 2014

Collaborators

Detail Information

Publications13

  1. pmc ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitro responses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase
    Johannes Hofland
    Department of Internal Medicine, Section of Endocrinology, P, O, Box 2040, Rotterdam, CA, 3000, The Netherlands
    Orphanet J Rare Dis 8:142. 2013
    ..We investigated the prevalence of adrenocortical reactions to these stimuli in a large cohort of AIMAH patients, both in vivo and in vitro...
  2. doi request reprint Inhibins and activins: their roles in the adrenal gland and the development of adrenocortical tumors
    Johannes Hofland
    Department of Internal Medicine, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Cell Endocrinol 359:92-100. 2012
    ..It is now clear that both peptides control adrenocortical physiology and are involved in adrenocortical tumorigenesis at multiple levels, both in murine models as well as in human patients...
  3. doi request reprint Serum inhibin pro-αC is a tumor marker for adrenocortical carcinomas
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Room Ee 532, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Endocrinol 166:281-9. 2012
    ....
  4. doi request reprint Activin A stimulates AKR1C3 expression and growth in human prostate cancer
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Endocrinology 153:5726-34. 2012
    ..In conclusion, activin A is controlled by androgens in PC models and regulates local androgen production. Activin A thus seems to mediate (residual) intratumoral androgen levels and could form a novel therapeutic target in CRPC...
  5. doi request reprint Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Room Ee 532, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:E747-54. 2012
    ..MC2R trafficking and signaling are dependent on the MC2R accessory protein (MRAP). The MRAP homolog MRAP2 also transports the MC2R to the cell surface but might prevent activation...
  6. doi request reprint Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer
    Johannes Hofland
    Departments of Internal Medicine, Urology, and Pathology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Cancer Res 70:1256-64. 2010
    ....
  7. pmc Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 168:67-74. 2013
    ..Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD. Steroidogenesis in PPNAD can be modified through a local glucocorticoid feed-forward loop...
  8. doi request reprint Interferon-β is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane
    Peter M van Koetsveld
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 20:443-54. 2013
    ..The inhibition of the expression of steroidogenic enzymes by IFN-β is a novel mechanism that may explain its inhibitory effect on cortisol production...
  9. doi request reprint Intratumoral conversion of adrenal androgen precursors drives androgen receptor-activated cell growth in prostate cancer more potently than de novo steroidogenesis
    Jinpei Kumagai
    Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Prostate 73:1636-50. 2013
    ..These levels could originate from intratumoral conversion of adrenal androgens and/or from de novo steroid synthesis. However, the relative contribution of de novo steroidogenesis to AR-driven cell growth is unknown...
  10. pmc Inhibin alpha-subunit (INHA) expression in adrenocortical cancer is linked to genetic and epigenetic INHA promoter variation
    Johannes Hofland
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 9:e104944. 2014
    ..701, p = 0.0036), but not associated with serum inhibin pro-αC levels. In conclusion, aberrant methylation and common genetic variation in the INHA promoter occur in human ACCs and are associated with decreased INHA expression. ..
  11. doi request reprint Renin and prorenin have no direct effect on aldosterone synthesis in the human adrenocortical cell lines H295R and HAC15
    Pieter M Jansen
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus Medical Centre Rotterdam, The Netherlands
    J Renin Angiotensin Aldosterone Syst 13:360-6. 2012
    ..Transgenic rats expressing the human (pro)renin receptor (h(P)RR) have elevated plasma aldosterone levels despite unaltered levels, in plasma and adrenal, of renin and angiotensin II...
  12. doi request reprint Expression and gene variation studies deny association of human HSD3B1 gene with aldosterone production or blood pressure
    Germaine C Verwoert
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Am J Hypertens 28:113-20. 2015
    ..These findings challenge the long-standing hypothesis that all adrenocortical steroidogenesis is executed by the type II iso-enzyme, encoded by HSD3B2...
  13. doi request reprint Steroidogenesis vs. steroid uptake in the heart: do corticosteroids mediate effects via cardiac mineralocorticoid receptors?
    Wenxia Chai
    Division of Pharmacology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 28:1044-53. 2010
    ..To test whether glucocorticoids act as the endogenous agonist of cardiac mineralocorticoid receptors, we evaluated the cardiac effects of aldosterone and corticosterone and cardiac steroidogenesis vs. steroid uptake from plasma...