Johannes Hofland


Affiliation: Erasmus MC
Country: The Netherlands


  1. Hofland J, Zandee W, de Herder W. Role of biomarker tests for diagnosis of neuroendocrine tumours. Nat Rev Endocrinol. 2018;: pubmed publisher
    ..Here, we review the latest research on biomarkers in the NET field to provide clinicians with a comprehensive overview of relevant diagnostic biomarkers that can be implemented in dedicated situations. ..
  2. Hofland J, Van Weerden W, Steenbergen J, Dits N, Jenster G, de Jong F. Activin A stimulates AKR1C3 expression and growth in human prostate cancer. Endocrinology. 2012;153:5726-34 pubmed publisher
    ..In conclusion, activin A is controlled by androgens in PC models and regulates local androgen production. Activin A thus seems to mediate (residual) intratumoral androgen levels and could form a novel therapeutic target in CRPC. ..
  3. Hofland J, de Jong F. Inhibins and activins: their roles in the adrenal gland and the development of adrenocortical tumors. Mol Cell Endocrinol. 2012;359:92-100 pubmed publisher
    ..It is now clear that both peptides control adrenocortical physiology and are involved in adrenocortical tumorigenesis at multiple levels, both in murine models as well as in human patients. ..
  4. Hofland J, Van Weerden W, Dits N, Steenbergen J, van Leenders G, Jenster G, et al. Evidence of limited contributions for intratumoral steroidogenesis in prostate cancer. Cancer Res. 2010;70:1256-64 pubmed publisher
  5. Hofland J, Feelders R, van der Wal R, Kerstens M, Haak H, de Herder W, et al. Serum inhibin pro-?C is a tumor marker for adrenocortical carcinomas. Eur J Endocrinol. 2012;166:281-9 pubmed publisher
    ..0065). Inhibin pro-?C is produced by the adrenal gland. Differentiation between ADA and ACC by serum inhibin pro-?C is limited, but its levels may constitute a novel tumor marker for ACC. ..
  6. Hofland J, Delhanty P, Steenbergen J, Hofland L, van Koetsveld P, van Nederveen F, et al. Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness. J Clin Endocrinol Metab. 2012;97:E747-54 pubmed publisher
    ..MRAP and MC2R expression is induced by ACTH and AngII, which would facilitate cell surface receptor availability. Physiological expression levels of MRAP, MRAP2, and MC2R were not limiting for ACTH sensitivity. ..
  7. Snaterse G, Visser J, Arlt W, Hofland J. Circulating steroid hormone variations throughout different stages of prostate cancer. Endocr Relat Cancer. 2017;24:R403-R420 pubmed publisher
    ..Additionally, this review addresses the implications of these findings, highlights important studies in this field and identifies current gaps in literature. ..