Adrian V Hernandez

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Covariate adjustment in randomized controlled trials with dichotomous outcomes increases statistical power and reduces sample size requirements
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus Medical Center, P O Box 1738, Rotterdam 3000 DR, The Netherlands
    J Clin Epidemiol 57:454-60. 2004
  2. ncbi Randomized controlled trials with time-to-event outcomes: how much does prespecified covariate adjustment increase power?
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Epidemiol 16:41-8. 2006
  3. ncbi Subgroup analysis and covariate adjustment in randomized clinical trials of traumatic brain injury: a systematic review
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurosurgery 57:1244-53; discussion 1244-53. 2005
  4. ncbi Subgroup analyses in therapeutic cardiovascular clinical trials: are most of them misleading?
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am Heart J 151:257-64. 2006
  5. ncbi Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study
    Adrian V Hernandez
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Neurotrauma 23:1295-303. 2006
  6. ncbi A systematic review finds methodological improvements necessary for prognostic models in determining traumatic brain injury outcomes
    Nino A Mushkudiani
    Center for Medical Decision Making, Department of Public Health, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Epidemiol 61:331-43. 2008

Collaborators

Detail Information

Publications6

  1. ncbi Covariate adjustment in randomized controlled trials with dichotomous outcomes increases statistical power and reduces sample size requirements
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus Medical Center, P O Box 1738, Rotterdam 3000 DR, The Netherlands
    J Clin Epidemiol 57:454-60. 2004
    ..We studied type I error, power, and potential reduction in sample size with several covariate adjustment strategies...
  2. ncbi Randomized controlled trials with time-to-event outcomes: how much does prespecified covariate adjustment increase power?
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ann Epidemiol 16:41-8. 2006
    ..We evaluated the effects of various strategies of covariate adjustment on type I error, power, and potential reduction in sample size in randomized controlled trials (RCTs) with time-to-event outcomes...
  3. ncbi Subgroup analysis and covariate adjustment in randomized clinical trials of traumatic brain injury: a systematic review
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Neurosurgery 57:1244-53; discussion 1244-53. 2005
    ..We critically reviewed the use of two types of secondary analyses, covariate adjustment and subgroup analysis, which are common in TBI trials...
  4. ncbi Subgroup analyses in therapeutic cardiovascular clinical trials: are most of them misleading?
    Adrian V Hernandez
    Center for Clinical Decision Sciences, Department of Public Health, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands
    Am Heart J 151:257-64. 2006
    ..Treatment decisions in clinical cardiology are directed by results from randomized clinical trials (RCTs). We studied the appropriateness of the use and interpretation of subgroup analysis in current therapeutic cardiovascular RCTs...
  5. ncbi Adjustment for strong predictors of outcome in traumatic brain injury trials: 25% reduction in sample size requirements in the IMPACT study
    Adrian V Hernandez
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Neurotrauma 23:1295-303. 2006
    ..A major reduction in sample size can be obtained with covariate adjustment in TBI trials. Covariate adjustment for strong predictors should be incorporated in the analysis of future TBI trials...
  6. ncbi A systematic review finds methodological improvements necessary for prognostic models in determining traumatic brain injury outcomes
    Nino A Mushkudiani
    Center for Medical Decision Making, Department of Public Health, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Epidemiol 61:331-43. 2008
    ..To describe the modeling techniques used for early prediction of outcome in traumatic brain injury (TBI) and to identify aspects for potential improvements...