Rudolf W Hendriks

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
    R W Hendriks
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    Eur J Immunol 29:1912-8. 1999
  2. pmc Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse
    G M Dingjan
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Exp Med 193:1169-78. 2001
  3. ncbi Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement
    Rogier Kersseboom
    Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 176:4543-52. 2006
  4. ncbi Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice
    Sabine Middendorp
    Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 168:2695-703. 2002
  5. ncbi Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing
    Sabine Middendorp
    Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    J Immunol 172:1371-9. 2004
  6. ncbi Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity
    Sabine Middendorp
    Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    J Immunol 171:5988-96. 2003
  7. ncbi GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development
    Kam Wing Ling
    Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Eur J Immunol 37:1043-52. 2007
  8. ncbi Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity
    Sabine Middendorp
    Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Blood 105:259-65. 2005
  9. ncbi Impaired hematopoiesis in mice lacking the transcription factor Sp3
    Pieter Fokko Van Loo
    Department of Cell Biology, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Blood 102:858-66. 2003
  10. ncbi A subfraction of B220(+) cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics
    Tatjana Nikolic
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Eur J Immunol 32:686-92. 2002

Collaborators

  • Elaine Dzierzak
  • Frank Grosveld
  • S Middendorp
  • Sjaak Philipsen
  • Tatjana Nikolic
  • Kam Wing Ling
  • Pieter Fokko Van Loo
  • Rogier Kersseboom
  • Jeroen G Noordzij
  • G M Dingjan
  • Dorota Kurek
  • Gemma M Dingjan
  • Marjolein J W de Bruijn
  • Jan Piet van Hamburg
  • A J Esther Zijlstra
  • Hassan Jumaa
  • Van B T Ta
  • Peter Bouwman
  • Guntram Suske
  • Ronald De Groot
  • Nico G Hartwig
  • W Marieke Comans-Bitter
  • Sandra de Bruin-Versteeg
  • Jacques J M van Dongen
  • K Dahlenborg
  • A Maas

Detail Information

Publications11

  1. ncbi Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
    R W Hendriks
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    Eur J Immunol 29:1912-8. 1999
    ..We therefore propose that GATA-3 is required for the expansion of T cell progenitors, and for the control of subsequent proliferation steps, which alternate periods of TCR recombination in the thymus...
  2. pmc Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse
    G M Dingjan
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Exp Med 193:1169-78. 2001
    ..These results implicate Btk in the regulation of the activation of the lambda locus for V(D)J recombination in pre-B cells...
  3. ncbi Bruton's tyrosine kinase and SLP-65 regulate pre-B cell differentiation and the induction of Ig light chain gene rearrangement
    Rogier Kersseboom
    Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 176:4543-52. 2006
    ..These findings demonstrate that Btk and SLP-65 transmit signals that induce cellular maturation and Ig L chain rearrangement independently of their role in termination of pre-B cell expansion...
  4. ncbi Impaired precursor B cell differentiation in Bruton's tyrosine kinase-deficient mice
    Sabine Middendorp
    Department of Immunology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 168:2695-703. 2002
    ....
  5. ncbi Cellular maturation defects in Bruton's tyrosine kinase-deficient immature B cells are amplified by premature B cell receptor expression and reduced by receptor editing
    Sabine Middendorp
    Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    J Immunol 172:1371-9. 2004
    ..We conclude that premature B cell receptor expression amplifies the cellular maturation defects in Btk-deficient B cells, while extensive receptor editing reduces these defects...
  6. ncbi Function of Bruton's tyrosine kinase during B cell development is partially independent of its catalytic activity
    Sabine Middendorp
    Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    J Immunol 171:5988-96. 2003
    ....
  7. ncbi GATA3 controls the expression of CD5 and the T cell receptor during CD4 T cell lineage development
    Kam Wing Ling
    Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Eur J Immunol 37:1043-52. 2007
    ..Because GATA3 is induced by TCR signaling in DP thymocytes, our findings indicate that GATA3 establishes a positive feedback loop that increases TCR surface expression in developing CD4 lineage cells...
  8. ncbi Tumor suppressor function of Bruton tyrosine kinase is independent of its catalytic activity
    Sabine Middendorp
    Department of Immunology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Blood 105:259-65. 2005
    ..Therefore, we conclude that Btk exerts its tumor suppressor function in pre-B cells as an adaptor protein, independent of its catalytic activity...
  9. ncbi Impaired hematopoiesis in mice lacking the transcription factor Sp3
    Pieter Fokko Van Loo
    Department of Cell Biology, Erasmus MC, 3000 DR Rotterdam, The Netherlands
    Blood 102:858-66. 2003
    ..Thus, the absence of Sp3 results in cell-autonomous hematopoietic defects, affecting in particular the erythroid and myeloid cell lineages...
  10. ncbi A subfraction of B220(+) cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics
    Tatjana Nikolic
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Eur J Immunol 32:686-92. 2002
    ..Taken together, our findings indicate that the mouse bone marrow contains a recirculating population of B220(+)CD19(-) CD11c(+) plasmacytoid DC, the development of which is largely independent of the presence of mature T and B cells...
  11. ncbi Composition of precursor B-cell compartment in bone marrow from patients with X-linked agammaglobulinemia compared with healthy children
    Jeroen G Noordzij
    Department of Immunology, Erasmus University Rotterdam University Hospital Rotterdam Dijkzigt, 3000 DR, Rotterdam, The Netherlands
    Pediatr Res 51:159-68. 2002
    ....