Research Topics
Genomes and Genes | John P HaysSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
| Collaborators
|
Detail Information
Publications
High-throughput amplification fragment length polymorphism (htAFLP) analysis identifies genetic lineage markers but not complement phenotype-specific markers in Moraxella catarrhalisJ P Hays
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
Clin Microbiol Infect 13:55-62. 2007..catarrhalis is probably defined by multiple genes, although not all of these genes may be present within all M. catarrhalis isolates...
Comparative analysis and supragenome modeling of twelve Moraxella catarrhalis clinical isolatesJeremiah J Davie
Department of Microbiology and Immunology, University at Buffalo, Buffalo, New York, USA
BMC Genomics 12:70. 2011..catarrhalis clinical isolates, a greater understanding of this pathogen's genome and its variability among isolates is needed...
The evaluation of putative endogenous control housekeeping genes for real-time polymerase chain reaction expression studies in Moraxella catarrhalisJohn P Hays
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
Diagn Microbiol Infect Dis 65:323-6. 2009..This study shows that a combination of the iron sequestering gene copB and 16S rRNA genes would be useful for lineage 1 (16S rRNA type 1) isolates, but not lineage 2 (16S rRNA types 2 and 3) isolates...- Identification and characterization of a novel outer membrane protein (OMP J) of Moraxella catarrhalis that exists in two major formsJohn P Hays
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
J Bacteriol 187:7977-84. 2005.... - Moraxella catarrhalis is only a weak activator of the mannose-binding lectin (MBL) pathway of complement activationJohn P Hays
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
FEMS Microbiol Lett 249:207-9. 2005..Results showed that this organism is only a poor activator of the lectin pathway of complement activation, with subsequent consequences for the etiology of otitis media by this organism... - A novel plasmid (pEMCJH03) isolated from moraxella catarrhalis possibly useful as a cloning and expression vector within this speciesJohn P Hays
Department of Medical Microbiology and Infectious Diseases, Erasmus MC Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Plasmid 53:263-8. 2005..catarrhalis using pEMCJH04 could help in the development of a vaccine expression vector, as well as providing a useful tool for studying promoter activity and in complementation studies of gene knockout mutants... - Pneumococcal vaccination does not affect the genetic diversity of Moraxella catarrhalis isolates in childrenJ P Hays
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam (EMCR, Dr Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands
Eur J Clin Microbiol Infect Dis 23:801-3. 2004 - Comparative analysis of the humoral immune response to Moraxella catarrhalis and Streptococcus pneumoniae surface antigens in children suffering from recurrent acute otitis media and chronic otitis media with effusionSuzanne J C Verhaegh
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
Clin Vaccine Immunol 19:914-8. 2012..Other factors, such as Eustachian tube dysfunction, viral load, and genetic and environmental factors, may play a more important role in the pathogenesis of OM and in particular in the development of rAOM or COME... - bro {beta}-lactamase and antibiotic resistances in a global cross-sectional study of Moraxella catarrhalis from children and adultsMushtaq A Khan
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
J Antimicrob Chemother 65:91-7. 2010..To compare and contrast the geographic and demographic distribution of bro beta-lactamase and antibiotic MIC(50/90) for 1440 global Moraxella catarrhalis isolates obtained from children and adults between 2001 and 2002... - Analysis of VanA vancomycin-resistant Enterococcus faecium isolates from Saudi Arabian hospitals reveals the presence of clonal cluster 17 and two new Tn1546 lineage typesMushtaq A Khan
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, s Gravendijkwal 230, 3015CE Rotterdam, The Netherlands
J Antimicrob Chemother 62:279-83. 2008..The aim of this study was to characterize 34 vancomycin-resistant VanA Enterococcus faecium isolates obtained from two hospitals in Saudi Arabia and to assess Tn1546 variation within these isolates... - Total genome polymorphism and low frequency of intra-genomic variation in the uspA1 and uspA2 genes of Moraxella catarrhalis in otitis prone and non-prone children up to 2 years of age. Consequences for vaccine design?John P Hays
Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Center Rotterdam, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Vaccine 21:1118-24. 2003..Variation in the uspA2 5' non-coding "AGAT" repeat region was also observed. These results may have implications for future M. catarrhalis vaccines comprising UspA1 or UspA2 components... - Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infantsSuzanne J C Verhaegh
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
Vaccine 29:5603-10. 2011..catarrhalis has not matured at 2 years of age. We provide evidence that a humoral antibody response to OMPs UspA1, UspA2 and Hag/MID may play a role in the immune response to community acquired M. catarrhalis colonization events... - Age-related genotypic and phenotypic differences in Moraxella catarrhalis isolates from children and adults presenting with respiratory disease in 2001-2002Suzanne J C Verhaegh
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
Microbiology 154:1178-84. 2008..Our results should also be useful in the choice of effective vaccine candidates against M. catarrhalis... - Colonization of healthy children by Moraxella catarrhalis is characterized by genotype heterogeneity, virulence gene diversity and co-colonization with Haemophilus influenzaeSuzanne J C Verhaegh
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
Microbiology 157:169-78. 2011..catarrhalis isolates, may be a result of immune evasion by this pathogen. Finally, the factors facilitating M. catarrhalis and H. influenzae co-colonization need to be further investigated... - Determinants of Moraxella catarrhalis colonization in healthy Dutch children during the first 14 months of lifeS J C Verhaegh
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
Clin Microbiol Infect 16:992-7. 2010..Apparently, crowding is an important risk factor for early and frequent colonization with M. catarrhalis in the first year of life... - Differential Virulence Gene Expression of Group A Streptococcus Serotype M3 in Response to Co-Culture with Moraxella catarrhalisSuzanne J C Verhaegh
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
PLoS ONE 8:e62549. 2013..This study provides the first evidence that M. catarrhalis increases GAS virulence gene expression during co-culture, and again shows the importance of polymicrobial infections in directing bacterial virulence... - Inflammation in the middle ear of children with recurrent or chronic otitis media is associated with bacterial loadKim Stol
Department of Pediatrics, Radboud University, Nijmegen Medical Centre, The Netherlands
Pediatr Infect Dis J 31:1128-34. 2012..To clarify the role of viral infections in OM, we compared the relative contribution of viruses and bacteria with the induction of inflammatory cytokine responses in the middle ear of children suffering from OM... - Highly specific protease-based approach for detection of porphyromonas gingivalis in diagnosis of periodontitisWendy E Kaman
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, Rotterdam, The Netherlands
J Clin Microbiol 50:104-12. 2012..We envisage that these substrates may improve the specificity of the current enzyme-based diagnosis of periodontitis associated with P. gingivalis... - Unveiling electrotransformation of Moraxella catarrhalis as a process of natural transformationPatricia Stutzmann Meier
Institute for Infectious Diseases, University of Bern, Bern, Switzerland
FEMS Microbiol Lett 262:72-6. 2006..Nontransformability of M. catarrhalis by electrotransformation was observed using double- as well as single-stranded DNA. In addition, the study showed that natural competence is a very constant feature of M. catarrhalis...