Christian Hansel

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc When the B-team runs plasticity: GluR2 receptor trafficking in cerebellar long-term potentiation
    Christian Hansel
    Department of Neuroscience, Erasmus University Medical Center, 3000DR Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:18245-6. 2005
  2. doi request reprint betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses
    Geeske M van Woerden
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    Nat Neurosci 12:823-5. 2009
  3. pmc Alcohol impairs long-term depression at the cerebellar parallel fiber-Purkinje cell synapse
    Amor Belmeguenai
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurophysiol 100:3167-74. 2008
  4. pmc Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells
    Amor Belmeguenai
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurosci 30:13630-43. 2010
  5. ncbi request reprint alphaCaMKII Is essential for cerebellar LTD and motor learning
    Christian Hansel
    Department of Neuroscience, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neuron 51:835-43. 2006
  6. ncbi request reprint Voltage-gated sodium channels in cerebellar Purkinje cells of mormyrid fish
    Martijn M de Ruiter
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurophysiol 96:378-90. 2006
  7. ncbi request reprint Climbing fiber-evoked endocannabinoid signaling heterosynaptically suppresses presynaptic cerebellar long-term potentiation
    Boeke J van Beugen
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    J Neurosci 26:8289-94. 2006
  8. ncbi request reprint Climbing fiber synaptic plasticity and modifications in Purkinje cell excitability
    Matthew T Schmolesky
    Department of Neuroscience, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Prog Brain Res 148:81-94. 2005
  9. ncbi request reprint A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation
    Amor Belmeguenai
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    J Neurosci 25:10768-72. 2005
  10. ncbi request reprint Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control
    Michiel Coesmans
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Neuron 44:691-700. 2004

Collaborators

Detail Information

Publications14

  1. pmc When the B-team runs plasticity: GluR2 receptor trafficking in cerebellar long-term potentiation
    Christian Hansel
    Department of Neuroscience, Erasmus University Medical Center, 3000DR Rotterdam, The Netherlands
    Proc Natl Acad Sci U S A 102:18245-6. 2005
  2. doi request reprint betaCaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses
    Geeske M van Woerden
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    Nat Neurosci 12:823-5. 2009
    ..These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation...
  3. pmc Alcohol impairs long-term depression at the cerebellar parallel fiber-Purkinje cell synapse
    Amor Belmeguenai
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurophysiol 100:3167-74. 2008
    ....
  4. pmc Intrinsic plasticity complements long-term potentiation in parallel fiber input gain control in cerebellar Purkinje cells
    Amor Belmeguenai
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurosci 30:13630-43. 2010
    ....
  5. ncbi request reprint alphaCaMKII Is essential for cerebellar LTD and motor learning
    Christian Hansel
    Department of Neuroscience, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Neuron 51:835-43. 2006
    ..Since Purkinje cells are the only cells in the cerebellum that express alphaCaMKII, our data suggest that an impairment of parallel fiber LTD, while leaving LTP intact, is sufficient to disrupt this form of cerebellar learning...
  6. ncbi request reprint Voltage-gated sodium channels in cerebellar Purkinje cells of mormyrid fish
    Martijn M de Ruiter
    Department of Neuroscience, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Neurophysiol 96:378-90. 2006
    ..These data show that, despite prominent differences in electrophysiological response characteristics, Purkinje cells of rats and mormyrids share the same voltage-gated Na+ conductances...
  7. ncbi request reprint Climbing fiber-evoked endocannabinoid signaling heterosynaptically suppresses presynaptic cerebellar long-term potentiation
    Boeke J van Beugen
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    J Neurosci 26:8289-94. 2006
    ....
  8. ncbi request reprint Climbing fiber synaptic plasticity and modifications in Purkinje cell excitability
    Matthew T Schmolesky
    Department of Neuroscience, Erasmus Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Prog Brain Res 148:81-94. 2005
  9. ncbi request reprint A role for protein phosphatases 1, 2A, and 2B in cerebellar long-term potentiation
    Amor Belmeguenai
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    J Neurosci 25:10768-72. 2005
    ..Therefore, cerebellar LTP constitutes the only form of LTP described so far that depends on phosphatase rather than kinase activity...
  10. ncbi request reprint Bidirectional parallel fiber plasticity in the cerebellum under climbing fiber control
    Michiel Coesmans
    Department of Neuroscience, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Neuron 44:691-700. 2004
    ....
  11. ncbi request reprint Synaptic memories upside down: bidirectional plasticity at cerebellar parallel fiber-Purkinje cell synapses
    Henrik Jörntell
    Department of Experimental Medical Science, Section for Neuroscience, Lund University, BMC F10 Tornavägen 10, SE 221 84 Lund, Sweden
    Neuron 52:227-38. 2006
    ..We will also discuss how PF-LTP helps to explain reversibility observed in cerebellar motor learning...
  12. ncbi request reprint Climbing fiber-triggered metabotropic slow potentials enhance dendritic calcium transients and simple spike firing in cerebellar Purkinje cells
    Qi Yuan
    Laboratory for Neuronal Circuit Dynamics, Brain Science Institute, RIKEN, 2 1 Hirosawa, Wako Shi, Saitama 351 0198, Japan
    Mol Cell Neurosci 35:596-603. 2007
    ..In turn, these CF-triggered slow mGluR potentials enhance the complex spike-associated calcium signals throughout the dendrite. Moreover, they provide a mechanism by which CFs can modulate the simple spike frequency of PCs...
  13. ncbi request reprint Synaptic plasticity and calcium signaling in Purkinje cells of the central cerebellar lobes of mormyrid fish
    Victor Z Han
    Neurological Sciences Institute, Oregon Health and Science University, Beaverton, Oregon 97006, USA
    J Neurosci 27:13499-512. 2007
    ..A major source for dendritic calcium signaling is provided by P/Q-type calcium channels. Our data show that despite the spatial separation between the two inputs CF activity facilitates LTD induction at PF synapses...
  14. ncbi request reprint Glutamate release during LTD at cerebellar climbing fiber-Purkinje cell synapses
    Ying Shen
    Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe Street, Baltimore, Maryland 21205, USA
    Nat Neurosci 5:725-6. 2002
    ..Here we report that LTD at the climbing fiber-Purkinje cell synapse in rat cerebellum was not associated with changes in a synaptic cleft glutamate transient, indicating that this type of LTD is most likely expressed postsynaptically...