Hamida Hammad

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Allergy Clin Immunol 118:331-6. 2006
  2. pmc Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Pathol 164:263-71. 2004
  3. ncbi Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 171:3936-40. 2003
  4. pmc Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Invest 117:464-72. 2007
  5. pmc Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    J Exp Med 204:357-67. 2007
  6. pmc Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Invest 116:2935-44. 2006
  7. pmc Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen
    Hendrik Jan de Heer
    Department of Pulmonary Medicine, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, Netherlands
    J Exp Med 200:89-98. 2004
  8. ncbi Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus University MC, Rotterdam, The Netherlands
    J Immunol 171:3645-54. 2003
  9. ncbi Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, P O Box 1738, 3000 DR Rotterdan, The Netherlands
    Nat Med 13:913-9. 2007
  10. doi Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs
    Mirjam Kool
    Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
    J Leukoc Biol 90:1177-90. 2011

Collaborators

Detail Information

Publications34

  1. ncbi Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammation
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Allergy Clin Immunol 118:331-6. 2006
    ....
  2. pmc Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthma
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Pathol 164:263-71. 2004
    ..Our data suggest that PPAR-gamma activation prevents induction of Th2-dependent eosinophilic airway inflammation and might contribute to immune homeostasis in the lung...
  3. ncbi Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Immunol 171:3936-40. 2003
    ....
  4. pmc Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Invest 117:464-72. 2007
    ..These data should pave the way for a clinical effectiveness study using inhaled iloprost for the treatment of asthma...
  5. pmc Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cells
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
    J Exp Med 204:357-67. 2007
    ..Triggering DP1 on DCs is an important mechanism to induce regulatory T cells and to control the extent of airway inflammation. This pathway could be exploited to design novel treatments for asthma...
  6. pmc Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell function
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Invest 116:2935-44. 2006
    ..These data support the concept that targeting the function of airway DCs with locally acting drugs is a powerful new strategy in the treatment of asthma...
  7. pmc Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigen
    Hendrik Jan de Heer
    Department of Pulmonary Medicine, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, Netherlands
    J Exp Med 200:89-98. 2004
    ..These studies show that pDCs provide intrinsic protection against inflammatory responses to harmless antigen. Therapies exploiting pDC function might be clinically effective in preventing the development of asthma...
  8. ncbi Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cells
    Harmjan Kuipers
    Department of Pulmonary Medicine, Erasmus University MC, Rotterdam, The Netherlands
    J Immunol 171:3645-54. 2003
    ..These results suggest that LPS reduces sensitization to inhaled Ag by reducing DC-driven Th2 development, but that IL-12 is not necessary for this effect...
  9. ncbi Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cells
    Marco Idzko
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, P O Box 1738, 3000 DR Rotterdan, The Netherlands
    Nat Med 13:913-9. 2007
    ..Together these data show that purinergic signaling has a key role in allergen-driven lung inflammation that is likely to be amenable to therapeutic intervention...
  10. doi Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCs
    Mirjam Kool
    Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
    J Leukoc Biol 90:1177-90. 2011
    ..Thus, timing of TLR ligation and facilitated antigen uptake dictate the potential of pDCs to present endogenous or exogenous antigen by influencing endosomal traffic and antigen-processing machinery...
  11. doi An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammation
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Immunol 183:1074-82. 2009
    ..These findings suggest a specialized immunoregulatory role for pDCs in airway inflammation. Enhancing the antiinflammatory properties of pDCs could be employed as a novel strategy in asthma treatment...
  12. doi Asthma: the importance of dysregulated barrier immunity
    Bart N Lambrecht
    VIB Inflammation Research Center, Gent, Belgium Department of Respiratory Medicine, University of Gent, Gent, Belgium Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
    Eur J Immunol 43:3125-37. 2013
    ..Understanding this cytokine crosstalk between barrier epithelial cells, DCs, and immune cells provides important insights into the mechanisms of allergic sensitization and asthma progression as discussed in this review. ..
  13. pmc Evidence for local dendritic cell activation in pulmonary sarcoidosis
    Bregje Ten Berge
    Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Respir Res 13:33. 2012
    ..However, functional data on lung DCs in sarcoidosis are lacking. We hypothesized that at the site of disease DCs are mature, immunocompetent and involved in granuloma formation...
  14. ncbi Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasome
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Immunol 181:3755-9. 2008
    ..We propose that, in addition to TLR stimulators, agonists of the NALP3 inflammasome should also be considered as vaccine adjuvants...
  15. ncbi Lung dendritic cell migration
    Hamida Hammad
    Department of Pulmonary Medicine, Erasmus Medical Center, Dr Molewaterplein, 50, 3015 GE Rotterdam, The Netherlands
    Adv Immunol 93:265-78. 2007
    ..Since DCs play a central role in immune responses, both under steady-state and inflammatory conditions, detailed characterization of their migratory behavior may be essential for the development of future therapeutic strategies...
  16. pmc Gata1 regulates dendritic-cell development and survival
    Laura Gutierrez
    Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
    Blood 110:1933-41. 2007
    ..Our findings show that Gata1 is a transcriptional regulator of dendritic cell differentiation and suggest that Gata1 is involved in the dendritic cell and macrophage lineage separation...
  17. ncbi Dendritic cell subsets and immune regulation in the lung
    Hendrik Jan de Heer
    Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, Room Ee2251b, 3015 GE Rotterdam, The Netherlands
    Semin Immunol 17:295-303. 2005
    ..These novel concepts are of particular interest in understanding the pathogenesis of asthma, a disorder of aberrant immune reactivity to inhaled harmless allergens...
  18. ncbi Taking our breath away: dendritic cells in the pathogenesis of asthma
    Bart N Lambrecht
    Department of Pulmonary Medicine, Erasmus MC Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Nat Rev Immunol 3:994-1003. 2003
  19. pmc The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β
    Anouk K Gloudemans
    Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e59822. 2013
    ..This study highlights that synergism between CTB and MyD88-dependent TLR signals selectively imprints a TI IgA-inducing capacity in non-mucosal DCs, explaining how CTB acts as an IgA promoting adjuvant...
  20. doi Anti-inflammatory actions of phosphatidylinositol
    Jolanda M van Dieren
    Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Eur J Immunol 41:1047-57. 2011
    ..These data validate PI as a pluripotent inhibitor that can be applied mucosally as well as systemically. Its compelling functions render PI a promising novel physiological immune suppressant...
  21. ncbi The other cells in asthma: dendritic cell and epithelial cell crosstalk
    Bart N Lambrecht
    Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Opin Pulm Med 9:34-41. 2003
    ..The implications of the DC-epithelial interaction for the pathogenesis of asthma is becoming increasingly clear by the use of mouse models and culture systems of human cells...
  22. pmc Death at the airway epithelium in asthma
    Bart N Lambrecht
    Department for Molecular Biomedical Research, VIB, Gent, Belgium
    Cell Res 23:588-9. 2013
    ..Recent findings suggest that apoptotic cells are phagocytosed by airway epithelial cells in a Rac1-dependent manner and this leads to dampening of innate and adaptive immunity to allergens...
  23. doi The airway epithelium in asthma
    Bart N Lambrecht
    Laboratory of Immunoregulation and Mucosal Immunology, Department of Molecular Biomedical Research, VIB, Ghent, Belgium
    Nat Med 18:684-92. 2012
    ....
  24. ncbi Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7
    Hamida Hammad
    Institut National de la Sante et de la Recherche Medicale, Unité 416, Institut Pasteur de Lille, Lille, France
    J Immunol 169:1524-34. 2002
    ..These data in human PBMC-reconstituted SCID mice show that monocyte-derived DCs might play a key role in the pathogenesis of the pulmonary allergic response by inducing Th2 effector function following migration to the MLN...
  25. ncbi Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses
    Veronique Angeli
    Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
    J Immunol 172:3822-9. 2004
    ..We propose that DP1 activation by specific agonists may represent a strategy to control cutaneous inflammatory Th2-associated diseases...
  26. pmc Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells
    Mirjam Kool
    Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
    J Exp Med 205:869-82. 2008
    ..These findings suggest that alum adjuvant is immunogenic by exploiting "nature's adjuvant," the inflammatory DC through induction of the endogenous danger signal uric acid...
  27. ncbi Myeloid dendritic cells make it to the top
    Bart N Lambrecht
    Clin Exp Allergy 32:805-10. 2002
  28. ncbi Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infection
    Hermelijn H Smits
    Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
    J Allergy Clin Immunol 120:932-40. 2007
    ..Population studies have suggested that chronic and intense helminth infections, in contrast to acute and mild helminth infections, might suppress allergic airway inflammation...
  29. ncbi Der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell response
    Anne Sophie Charbonnier
    Unité INSERM U416, IFR 17, Institut Pasteur de Lille, 1 rue du Professeur Calmette, B P 245, 59019 Lille Cedex, France
    J Leukoc Biol 73:91-9. 2003
    ..In addition, P-DC could contribute to the steady state in healthy donors or to the development of a Th2 response in allergic donors...
  30. ncbi Peroxisome proliferator-activated receptor gamma inhibits the migration of dendritic cells: consequences for the immune response
    Veronique Angeli
    Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Pasteur de Lille, Lille, France
    J Immunol 170:5295-301. 2003
    ..Our results suggest a novel regulatory pathway via PPAR gamma for DC migration from epithelia that could contribute to the initiation of immune responses...
  31. ncbi Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22
    Hamida Hammad
    INSERM U416, IFR 17, Institut Pasteur de Lille, France
    Eur Cytokine Netw 14:219-28. 2003
    ..These results suggest that in allergic patients exposed to house dust mites, DC may favour the exacerbation of the Th2 response via the increase in type 2 chemokine production...
  32. ncbi Direct regulatory immune activity of lactic acid bacteria on Der p 1-pulsed dendritic cells from allergic patients
    Pierre Pochard
    Unité INSERM U 416, Institut Pasteur de Lille, France
    J Allergy Clin Immunol 116:198-204. 2005
    ..Lactic acid bacteria (LAB) are suggested to play a regulatory role in the development of allergic reactions. However, their potential effects on dendritic cells (DCs) directing the immune polarization remain unclear...
  33. ncbi Involvement of the mannose receptor in the uptake of Der p 1, a major mite allergen, by human dendritic cells
    Gaetan Deslee
    Unité INSERM U 416, Institut Pasteur de Lille, France
    J Allergy Clin Immunol 110:763-70. 2002
    ..In allergic airway diseases DCs have been shown to be involved in the induction and maintenance of a T(H)2-type profile...
  34. doi Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthma
    Hamida Hammad
    Department of Respiratory Diseases, Laboratory of Immunoregulation and Mucosal Immunology, University Hospital Ghent, Belgium
    Nat Rev Immunol 8:193-204. 2008
    ..A better understanding of these interactions, ascertained from human and animal studies, might lead to better prevention and treatment of asthma...