Research Topics
Genomes and GenesSpecies | Hamida HammadSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Activation of peroxisome proliferator-activated receptor-gamma in dendritic cells inhibits the development of eosinophilic airway inflammation in a mouse model of asthmaHamida Hammad
Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Am J Pathol 164:263-71. 2004..Our data suggest that PPAR-gamma activation prevents induction of Th2-dependent eosinophilic airway inflammation and might contribute to immune homeostasis in the lung...
Recent progress in the biology of airway dendritic cells and implications for understanding the regulation of asthmatic inflammationHamida Hammad
Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
J Allergy Clin Immunol 118:331-6. 2006....- Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation of the D prostanoid receptor 1Hamida Hammad
Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
J Immunol 171:3936-40. 2003.... - Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell functionMarco Idzko
Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Clin Invest 117:464-72. 2007..These data should pave the way for a clinical effectiveness study using inhaled iloprost for the treatment of asthma... - Activation of the D prostanoid 1 receptor suppresses asthma by modulation of lung dendritic cell function and induction of regulatory T cellsHamida Hammad
Department of Pulmonary Medicine, Erasmus Medical Center, 3015 GE Rotterdam, Netherlands
J Exp Med 204:357-67. 2007..Triggering DP1 on DCs is an important mechanism to induce regulatory T cells and to control the extent of airway inflammation. This pathway could be exploited to design novel treatments for asthma... - Local application of FTY720 to the lung abrogates experimental asthma by altering dendritic cell functionMarco Idzko
Department of Pulmonary Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
J Clin Invest 116:2935-44. 2006..These data support the concept that targeting the function of airway DCs with locally acting drugs is a powerful new strategy in the treatment of asthma... - Lipopolysaccharide-induced suppression of airway Th2 responses does not require IL-12 production by dendritic cellsHarmjan Kuipers
Department of Pulmonary Medicine, Erasmus University MC, Rotterdam, The Netherlands
J Immunol 171:3645-54. 2003..These results suggest that LPS reduces sensitization to inhaled Ag by reducing DC-driven Th2 development, but that IL-12 is not necessary for this effect... - Essential role of lung plasmacytoid dendritic cells in preventing asthmatic reactions to harmless inhaled antigenHendrik Jan de Heer
Department of Pulmonary Medicine, Erasmus Medical Center, Dr. Molewaterplein 50, 3015 GE Rotterdam, Netherlands
J Exp Med 200:89-98. 2004..These studies show that pDCs provide intrinsic protection against inflammatory responses to harmless antigen. Therapies exploiting pDC function might be clinically effective in preventing the development of asthma... - Extracellular ATP triggers and maintains asthmatic airway inflammation by activating dendritic cellsMarco Idzko
Department of Pulmonary Medicine, Erasmus University Medical Center, Dr Molewaterplein 50, P O Box 1738, 3000 DR Rotterdan, The Netherlands
Nat Med 13:913-9. 2007..Together these data show that purinergic signaling has a key role in allergen-driven lung inflammation that is likely to be amenable to therapeutic intervention... 
Facilitated antigen uptake and timed exposure to TLR ligands dictate the antigen-presenting potential of plasmacytoid DCsMirjam Kool
Department of Pulmonary Medicine, ErasmusMC, Rotterdam, The Netherlands
J Leukoc Biol 90:1177-90. 2011..Thus, timing of TLR ligation and facilitated antigen uptake dictate the potential of pDCs to present endogenous or exogenous antigen by influencing endosomal traffic and antigen-processing machinery...- An anti-inflammatory role for plasmacytoid dendritic cells in allergic airway inflammationMirjam Kool
Department of Pulmonary Medicine, Erasmus MC, Rotterdam, The Netherlands
J Immunol 183:1074-82. 2009..These findings suggest a specialized immunoregulatory role for pDCs in airway inflammation. Enhancing the antiinflammatory properties of pDCs could be employed as a novel strategy in asthma treatment... - Evidence for local dendritic cell activation in pulmonary sarcoidosisBregje Ten Berge
Department of Pulmonary Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Respir Res 13:33. 2012..However, functional data on lung DCs in sarcoidosis are lacking. We hypothesized that at the site of disease DCs are mature, immunocompetent and involved in granuloma formation... - Cutting edge: alum adjuvant stimulates inflammatory dendritic cells through activation of the NALP3 inflammasomeMirjam Kool
Department of Pulmonary Medicine, Erasmus University Medical Centre, Rotterdam, The Netherlands
J Immunol 181:3755-9. 2008..We propose that, in addition to TLR stimulators, agonists of the NALP3 inflammasome should also be considered as vaccine adjuvants... - Lung dendritic cell migrationHamida Hammad
Department of Pulmonary Medicine, Erasmus Medical Center, Dr Molewaterplein, 50, 3015 GE Rotterdam, The Netherlands
Adv Immunol 93:265-78. 2007..Since DCs play a central role in immune responses, both under steady-state and inflammatory conditions, detailed characterization of their migratory behavior may be essential for the development of future therapeutic strategies... - Gata1 regulates dendritic-cell development and survivalLaura Gutierrez
Department of Cell Biology, Erasmus Medical Center, Rotterdam, The Netherlands
Blood 110:1933-41. 2007..Our findings show that Gata1 is a transcriptional regulator of dendritic cell differentiation and suggest that Gata1 is involved in the dendritic cell and macrophage lineage separation... - Dendritic cell subsets and immune regulation in the lungHendrik Jan de Heer
Department of Pulmonary Medicine, Erasmus University Medical Center, Dr. Molewaterplein 50, Room Ee2251b, 3015 GE Rotterdam, The Netherlands
Semin Immunol 17:295-303. 2005..These novel concepts are of particular interest in understanding the pathogenesis of asthma, a disorder of aberrant immune reactivity to inhaled harmless allergens... - Taking our breath away: dendritic cells in the pathogenesis of asthmaBart N Lambrecht
Department of Pulmonary Medicine, Erasmus MC Rotterdam, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
Nat Rev Immunol 3:994-1003. 2003 - Anti-inflammatory actions of phosphatidylinositolJolanda M van Dieren
Laboratory of Pediatrics, Division of Gastroenterology and Nutrition, Erasmus MC University Medical Center, Rotterdam, The Netherlands
Eur J Immunol 41:1047-57. 2011..These data validate PI as a pluripotent inhibitor that can be applied mucosally as well as systemically. Its compelling functions render PI a promising novel physiological immune suppressant... - The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-βAnouk K Gloudemans
Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
PLoS ONE 8:e59822. 2013..This study highlights that synergism between CTB and MyD88-dependent TLR signals selectively imprints a TI IgA-inducing capacity in non-mucosal DCs, explaining how CTB acts as an IgA promoting adjuvant... - The other cells in asthma: dendritic cell and epithelial cell crosstalkBart N Lambrecht
Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Curr Opin Pulm Med 9:34-41. 2003..The implications of the DC-epithelial interaction for the pathogenesis of asthma is becoming increasingly clear by the use of mouse models and culture systems of human cells... - The airway epithelium in asthmaBart N Lambrecht
Laboratory of Immunoregulation and Mucosal Immunology, Department of Molecular Biomedical Research, VIB, Ghent, Belgium
Nat Med 18:684-92. 2012.... - Monocyte-derived dendritic cells induce a house dust mite-specific Th2 allergic inflammation in the lung of humanized SCID mice: involvement of CCR7Hamida Hammad
, , Institut Pasteur de Lille, Lille, France
J Immunol 169:1524-34. 2002..These data in human PBMC-reconstituted SCID mice show that monocyte-derived DCs might play a key role in the pathogenesis of the pulmonary allergic response by inducing Th2 effector function following migration to the MLN... - Der p 1-pulsed myeloid and plasmacytoid dendritic cells from house dust mite-sensitized allergic patients dysregulate the T cell responseAnne Sophie Charbonnier
Unité INSERM U416, IFR 17, Institut Pasteur de Lille, 1 rue du Professeur Calmette, B P 245, 59019 Lille Cedex, France
J Leukoc Biol 73:91-9. 2003..In addition, P-DC could contribute to the steady state in healthy donors or to the development of a Th2 response in allergic donors... - Peroxisome proliferator-activated receptor gamma inhibits the migration of dendritic cells: consequences for the immune responseVeronique Angeli
Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Pasteur de Lille, Lille, France
J Immunol 170:5295-301. 2003..Our results suggest a novel regulatory pathway via PPAR gamma for DC migration from epithelia that could contribute to the initiation of immune responses... - Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cellsMirjam Kool
Department of Pulmonary Medicine, Erasmus University Medical Centre, 3015 GD Rotterdam, Netherlands
J Exp Med 205:869-82. 2008..These findings suggest that alum adjuvant is immunogenic by exploiting "nature's adjuvant," the inflammatory DC through induction of the endogenous danger signal uric acid... - Protective effect of Schistosoma mansoni infection on allergic airway inflammation depends on the intensity and chronicity of infectionHermelijn H Smits
Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands
J Allergy Clin Immunol 120:932-40. 2007..Population studies have suggested that chronic and intense helminth infections, in contrast to acute and mild helminth infections, might suppress allergic airway inflammation... - Monocyte-derived dendritic cells exposed to Der p 1 allergen enhance the recruitment of Th2 cells: major involvement of the chemokines TARC/CCL17 and MDC/CCL22Hamida Hammad
INSERM U416, IFR 17, Institut Pasteur de Lille, France
Eur Cytokine Netw 14:219-28. 2003..These results suggest that in allergic patients exposed to house dust mites, DC may favour the exacerbation of the Th2 response via the increase in type 2 chemokine production... - Activation of the D prostanoid receptor 1 regulates immune and skin allergic responsesVeronique Angeli
Unite 547, Institut National de la Sante et de la Recherche Medicale, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France
J Immunol 172:3822-9. 2004..We propose that DP1 activation by specific agonists may represent a strategy to control cutaneous inflammatory Th2-associated diseases... - Direct regulatory immune activity of lactic acid bacteria on Der p 1-pulsed dendritic cells from allergic patientsPierre Pochard
, Institut Pasteur de Lille, France
J Allergy Clin Immunol 116:198-204. 2005..CONCLUSION: Thus in the presence of LAB1, MD-DCs from allergic patients tend to reorientate the T-cell response toward a beneficial T H 1 profile... - Myeloid dendritic cells make it to the topBart N Lambrecht
Clin Exp Allergy 32:805-10. 2002 - Dendritic cells and epithelial cells: linking innate and adaptive immunity in asthmaHamida Hammad
Department of Respiratory Diseases, Laboratory of Immunoregulation and Mucosal Immunology, University Hospital Ghent, Belgium
Nat Rev Immunol 8:193-204. 2008..A better understanding of these interactions, ascertained from human and animal studies, might lead to better prevention and treatment of asthma... - Involvement of the mannose receptor in the uptake of Der p 1, a major mite allergen, by human dendritic cellsGaetan Deslee
Unité INSERM U 416, Institut Pasteur de Lille, France
J Allergy Clin Immunol 110:763-70. 2002..In allergic airway diseases DCs have been shown to be involved in the induction and maintenance of a T(H)2-type profile...