F Grosveld

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. pmc The role of the -50 region of the human gamma-globin gene in switching
    M S Ristaldi
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    EMBO J 20:5242-9. 2001
  2. ncbi Gp96/GRP94 is a putative high density lipoprotein-binding protein in liver
    R de Crom
    The Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University Rotterdam, Dr Molenwaterplein 50, P O Box 1738, 3000 DR, Rotterdam, The
    Biochim Biophys Acta 1437:378-92. 1999
  3. ncbi Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expression
    M Koutsourakis
    Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, P O Box 1738, 3000 DR, The, Rotterdam, Netherlands
    Mech Dev 105:105-14. 2001
  4. ncbi The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region
    C C Hoogenraad
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, 3000 DR, The Netherlands
    Genomics 53:348-58. 1998
  5. ncbi The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development
    R Keijzer
    Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Development 128:503-11. 2001
  6. ncbi Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
    R W Hendriks
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    Eur J Immunol 29:1912-8. 1999
  7. ncbi Activation by locus control regions?
    F Grosveld
    Department of Cell Biology and Genetics, Medical Genetics Centre, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Curr Opin Genet Dev 9:152-7. 1999
  8. pmc Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci
    T Trimborn
    MGC Department of Cell Biology and Genetics, Erasmus University, 3000 DR, Rotterdam, The Netherlands
    Genes Dev 13:112-24. 1999
  9. ncbi Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse
    F Levavasseur
    MGC, Dept of Cell Biology and Genetics, Erasmus University Rotterdam, P O Box 1738, The Netherlands
    Mech Dev 74:89-98. 1998
  10. ncbi Locus control regions, chromatin activation and transcription
    P Fraser
    Erasmus University, Faculty of Medicine, Department of Cell Biology and Genetics, Rotterdam, The Netherlands
    Curr Opin Cell Biol 10:361-5. 1998

Collaborators

  • P Fraser
  • C H Wouters
  • A Winterpacht
  • R Janssens
  • M Vidal
  • Q Liu
  • James Briscoe
  • Michele Studer
  • Yi Gu
  • Bernd Fritzsch
  • I Pata
  • Antonio Cao
  • F W Van Leeuwen
  • C Cordon-Cardo
  • A Karis
  • R W Hendriks
  • C I De Zeeuw
  • J D Engel
  • P Visser
  • G M Dingjan
  • C C Hoogenraad
  • M C Nawijn
  • M Koutsourakis
  • N Galjart
  • G Lakshmanan
  • S Philipsen
  • A Maas
  • W Mandemakers
  • D Drabek
  • A Akhmanova
  • R Keijzer
  • J Gribnau
  • J H van Doorninck
  • K C Lim
  • A Langeveld
  • C M Chow
  • D Meijer
  • R Ferreira
  • M Post
  • I Simon
  • M S Ristaldi
  • L Zagoraiou
  • D Tibboel
  • M Jaegle
  • K H Lieuw
  • K Tanimoto
  • R Willemsen
  • G Zafarana
  • P Bouwman
  • D Michalovich
  • T Verkerk
  • T Trimborn
  • M Wijgerde
  • B Nuez
  • N Dillon
  • C Meijers
  • S Raguz
  • R de Crom
  • R van Haperen
  • E Goedknegt
  • E Payen
  • F Levavasseur
  • R Zwart
  • Z G Wang
  • R Tewari
  • M Marin
  • D A Kleinjan
  • L Broos
  • G T Ma
  • L G Wilming
  • N Mazarakis
  • L Psiouri
  • M A Aitken
  • A Athanassiadou
  • M Malik
  • L Harland
  • M Antoniou
  • A Ronchi
  • N Yannoutsous
  • G Skavdis
  • M van Tuyl
  • B N Lambrecht
  • O Kahre
  • H Savelkoul
  • A G Klinakis
  • E Milot
  • B R Dortland
  • L Lande
  • C Savakis
  • T Stepanova

Detail Information

Publications51

  1. pmc The role of the -50 region of the human gamma-globin gene in switching
    M S Ristaldi
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    EMBO J 20:5242-9. 2001
    ....
  2. ncbi Gp96/GRP94 is a putative high density lipoprotein-binding protein in liver
    R de Crom
    The Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University Rotterdam, Dr Molenwaterplein 50, P O Box 1738, 3000 DR, Rotterdam, The
    Biochim Biophys Acta 1437:378-92. 1999
    ..It appeared to be difficult to obtain a prolonged high level expression of gp96. In these cases, however, a marked increase of HDL-binding activity compared with the control cells could be observed...
  3. ncbi Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expression
    M Koutsourakis
    Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, P O Box 1738, 3000 DR, The, Rotterdam, Netherlands
    Mech Dev 105:105-14. 2001
    ..Thus, elevated levels of GATA6 protein affect early lung development and in analogy to other GATA factors in other tissues, GATA6 also plays a crucial role in the terminal differentiation in this case of the distal pulmonary epithelium...
  4. ncbi The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical region
    C C Hoogenraad
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, 3000 DR, The Netherlands
    Genomics 53:348-58. 1998
    ..23, which is commonly deleted in Williams syndrome. It spans at least 140 kb at the 3' end of the deletion. Human CYLN2 is very likely identical to the previously characterized, incomplete WSCR4 and WSCR3 transcription units...
  5. ncbi The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary development
    R Keijzer
    Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Development 128:503-11. 2001
    ..Taken together, these data demonstrate that GATA6 is not essential for endoderm specification, but is required for normal branching morphogenesis and late epithelial cell differentiation...
  6. ncbi Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus
    R W Hendriks
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    Eur J Immunol 29:1912-8. 1999
    ..We therefore propose that GATA-3 is required for the expansion of T cell progenitors, and for the control of subsequent proliferation steps, which alternate periods of TCR recombination in the thymus...
  7. ncbi Activation by locus control regions?
    F Grosveld
    Department of Cell Biology and Genetics, Medical Genetics Centre, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
    Curr Opin Genet Dev 9:152-7. 1999
    ....
  8. pmc Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci
    T Trimborn
    MGC Department of Cell Biology and Genetics, Erasmus University, 3000 DR, Rotterdam, The Netherlands
    Genes Dev 13:112-24. 1999
    ....
  9. ncbi Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouse
    F Levavasseur
    MGC, Dept of Cell Biology and Genetics, Erasmus University Rotterdam, P O Box 1738, The Netherlands
    Mech Dev 74:89-98. 1998
    ....
  10. ncbi Locus control regions, chromatin activation and transcription
    P Fraser
    Erasmus University, Faculty of Medicine, Department of Cell Biology and Genetics, Rotterdam, The Netherlands
    Curr Opin Cell Biol 10:361-5. 1998
    ..The emerging picture indicates that several very different types of negative regulation ensure that transcriptional activation occurs only in the appropriate cells...
  11. ncbi The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domains
    E Payen
    Department of Cell Biology and Genetics, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Biol Chem 273:9099-109. 1998
    ..Thus we suggest that ZFP-37 is a structural protein of the neuronal nucleus which plays a role in the maintenance of specialized chromatin domains...
  12. ncbi Early arrest in B cell development in transgenic mice that express the E41K Bruton's tyrosine kinase mutant under the control of the CD19 promoter region
    A Maas
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
    J Immunol 162:6526-33. 1999
    ..We conclude that the residual peripheral B cells were efficiently driven into IgM+ plasma cell differentiation, apparently without functional selection...
  13. ncbi Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic mice
    M C Nawijn
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Dr Molewaterplein 50, 3000 DR Rotterdam, The Netherlands
    J Immunol 167:715-23. 2001
    ..In the spleen and lymph nodes, the numbers of CD8(+) T cells were significantly reduced. These findings indicate that GATA-3 supports development of the CD4 lineage and inhibits maturation of CD8 SP cells in the thymus...
  14. pmc Erythroid overexpression of C/EBPgamma in transgenic mice affects gamma-globin expression and fetal liver erythropoiesis
    G Zafarana
    Erasmus University Rotterdam, MGC Department of Cell Biology, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 19:5856-63. 2000
    ..We suggest that targeted expression of dominant-negative leucine zipper proteins is a generally applicable approach to ablate specific tissues in mice...
  15. ncbi Embryonic expression and cloning of the murine GATA-3 gene
    K M George
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500
    Development 120:2673-86. 1994
    ..Furthermore, this same region of the locus confers developmentally appropriate expression in transgenic mice, but only in a subset of the tissues that naturally express the gene...
  16. ncbi Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous system
    K C Lim
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA
    Nat Genet 25:209-12. 2000
    ..Thus we have shown that Gata3 has a role in the differentiation of multiple cell lineages during embryogenesis...
  17. pmc Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locus
    G Lakshmanan
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
    Mol Cell Biol 19:1558-68. 1999
    ....
  18. ncbi The transcription factor GATA6 is essential for early extraembryonic development
    M Koutsourakis
    Erasmus University, Medical Genetics Centre, Department of Cell Biology and Genetics, The Netherlands
    Development 126:723-32. 1999
    ..Inactivation leads to a lethality shortly after implantation (5.5 days postcoitum). Chimeric experiments show this to be caused by an indirect effect on the epiblast due to a defect in an extraembryonic tissue...
  19. pmc In vivo transposition of Minos, a Drosophila mobile element, in mammalian tissues
    L Zagoraiou
    Institute for Molecular Biology and Biotechnology-Foundation for Research and Technology, Hellas, P.O. Box 1527, Heraklion 71110, Greece
    Proc Natl Acad Sci U S A 98:11474-8. 2001
    ..These results are a first step toward a reversible insertional mutagenesis system in the mouse, opening the way to develop powerful technologies for functional genomic analysis in mammals...
  20. pmc Transcription factor Sp3 is essential for post-natal survival and late tooth development
    P Bouwman
    Institut fur Molekularbiologie und Tumorforschung, Emil Mannkopff Strasse 2
    EMBO J 19:655-61. 2000
    ..Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy...
  21. ncbi Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear
    A Karis
    Department of Animal Development and Systematics, University of Tartu, 51014 Tartu, Estonia
    J Comp Neurol 429:615-30. 2001
    ..This study shows for the first time that a zinc finger factor is involved in axonal navigation of the inner ear efferent neurons and, simultaneously, in the morphogenesis of the inner ear...
  22. ncbi GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nuclei
    J H van Doorninck
    Departments of Cell Biology and Genetics and Anatomy, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Neurosci 19:RC12. 1999
    ..In sum, we conclude that GATA-3 plays a major role in the development of the serotonergic neurons of the caudal raphe nuclei, and that it is crucial for their role in locomotion...
  23. ncbi Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivo
    M C Nawijn
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Dr Molewaterplein 50, 3000 DR Rotterdam, The Netherlands
    J Immunol 167:724-32. 2001
    ..The increased functional capacity to secrete Th2 cytokines, along with the increased expression of surface markers for Ag-experienced Th2-committed cells, would argue for a role of GATA-3 in Th2 memory formation...
  24. ncbi The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4
    I Pata
    Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
    Development 126:5523-31. 1999
    ..These findings demonstrate that GATA2 and GATA3 lie downstream of Hoxb1 and provide the first example of Hox pathway transcription factors within a defined population of vertebrate motor neurons...
  25. ncbi Partial rescue of GATA-3 by yeast artificial chromosome transgenes
    G Lakshmanan
    Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, 60208, USA
    Dev Biol 204:451-63. 1998
    ..While not complete in its regulatory capacity, the YAC transgene is nonetheless able to complement several homozygous GATA-3 mutant phenotypes and thereby prolong embryonic life...
  26. ncbi The POU factor Oct-6 and Schwann cell differentiation
    M Jaegle
    Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
    Science 273:507-10. 1996
    ..Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally...
  27. pmc Role of the duplicated CCAAT box region in gamma-globin gene regulation and hereditary persistence of fetal haemoglobin
    A Ronchi
    Universita degli Studi di Milano, Dipartimento di Genetica e di Biologia di Microrganisimi, 20133 Milano, Italy
    EMBO J 15:143-9. 1996
    ..We present a model for gamma-globin gene silencing that has significant implications for attempts to reactivate the gamma promoters in human adults by pharmacological means...
  28. ncbi Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in neurons of the developing and adult CNS
    N Mazarakis
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Genomics 33:247-57. 1996
    ..Together, these results suggest that ZFP-37 is a transcriptional regulator predominantly present in postmitotic cells from two different lineages...
  29. ncbi Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene
    B Nuez
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 375:316-8. 1995
    ..Enucleated erythrocytes are formed but these do not contain the proper amount of haemoglobin. We conclude that the transcription factor EKLF is essential for the final steps of definitive erythropoiesis in fetal liver...
  30. ncbi GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo
    G T Ma
    Department of Biochemistry, Northwestern University, Evanston, Illinois 60208, USA
    Development 124:907-14. 1997
    ....
  31. ncbi The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patients
    L G Wilming
    Institute of Pediatric Surgery, Erasmus University, Rotterdam, The Netherlands
    Hum Mol Genet 6:247-58. 1997
    ..Since many of the structures affected in DiGeorge syndrome derive from these Hira expressing cell populations we propose that haploinsufficiency of HIRA contributes to at least some of the features of the DiGeorge phenotype...
  32. ncbi Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiation
    M Marin
    Erasmus University Rotterdam, Department of Cell Biology, The Netherlands
    Cell 89:619-28. 1997
    ..MeCP2 is thought to be required for the maintenance of differentiated cells. We suggest that Sp1 is an important regulator of this process...
  33. pmc Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage
    R W Hendriks
    Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
    EMBO J 15:4862-72. 1996
    ..Our results show that Btk expression is essential at two distinct differentiation steps, both past the pre-B cell stage...
  34. ncbi Role of PML in cell growth and the retinoic acid pathway
    Z G Wang
    Department of Human Genetics and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
    Science 279:1547-51. 1998
    ..These results indicate that PML is a critical component of the RA pathway and that disruption of its activity by the PML-RARalpha fusion protein may be important in APL pathogenesis...
  35. pmc Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic mice
    K Tanimoto
    Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
    Genes Dev 14:2778-94. 2000
    ..We conclude that the suppression of epsilon-globin transcription during definitive erythropoiesis is mediated by the binding of a repressor that prevents EKLF from activating the epsilon-globin gene...
  36. pmc Structure of the murine Thy-1 gene
    V Giguere
    EMBO J 4:2017-24. 1985
    ..The 5' end of the gene has multiple initiation sites and a non-TATA box promoter. The 3' end shows a single polyadenylation site after a very long untranslated region...
  37. ncbi Enhancer sequences located 3' of the mouse immunoglobulin lambda locus specify high-level expression of an immunoglobulin lambda gene in B cells of transgenic mice
    S Eccles
    MRC Collaborative Centre, London, UK
    New Biol 2:801-11. 1990
    ....
  38. pmc Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexes
    C C Hoogenraad
    MGC Department of Cell Biology, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 20:4041-54. 2001
    ..Taken together, these data suggest that mammalian BICD2 plays a role in the dynein- dynactin interaction on the surface of membranous organelles, by associating with these complexes...
  39. pmc Erythroid Kr├╝ppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region
    R Tewari
    Sars International Centre for Molecular Marine Biology, Bergen High Technology Centre, Thormohlensgt 55, N 5020 Bergen, Norway
    EMBO J 17:2334-41. 1998
    ..Interestingly, the EKLF transgene rescues the lethal phenotype of EKLF null mice, setting the stage for future studies aimed at the analysis of the EKLF protein and its role in beta-globin gene activation...
  40. ncbi Developmental regulation of a complete 70-kb human beta-globin locus in transgenic mice
    J Strouboulis
    Laboratory of Gene Structure and Expression, National Institute for Medical Research, London, UK
    Genes Dev 6:1857-64. 1992
    ..These results suggest that multiple changes in DNA sequences and transcription factor balance must have occurred for the human gamma-globin gene to have evolved into a fetal gene...
  41. pmc Developmental regulation of DNA replication timing at the human beta globin locus
    I Simon
    Department of Cellular Biochemistry, Hebrew University Medical School, Jerusalem, Israel
    EMBO J 20:6150-7. 2001
    ..These results also show that the pattern of replication timing is set up by mechanisms that work independently of gene transcription...
  42. pmc Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse
    G M Dingjan
    Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    J Exp Med 193:1169-78. 2001
    ..These results implicate Btk in the regulation of the activation of the lambda locus for V(D)J recombination in pre-B cells...
  43. ncbi Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts
    A Akhmanova
    MGC Department of Cell Biology and Genetics, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Cell 104:923-35. 2001
    ..We propose that CLASPs are involved in the local regulation of microtubule dynamics in response to positional cues...
  44. ncbi Transcription complex stability and chromatin dynamics in vivo
    M Wijgerde
    MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
    Nature 377:209-13. 1995
    ..The regulator may stably complex with one gene at a time and switch back and forth between genes in a flip-flop mechanism...
  45. ncbi The mode of anchorage to the cell surface determines both the function and the membrane location of Thy-1 glycoprotein
    M C Tiveron
    Laboratory of Neurobiology Norman and Sadie Lee Centre, National Institute for Medical Research, Mill Hill, London, UK
    J Cell Sci 107:1783-96. 1994
    ..Thus the membrane anchor, in targetting Thy-1 to different microdomains on the cell surface, determines its ability to inhibit neurite outgrowth on astrocytes...
  46. ncbi Chromatin domains as potential units of eukaryotic gene function
    N Dillon
    National Institute for Medical Research, London, UK
    Curr Opin Genet Dev 4:260-4. 1994
    ....
  47. pmc A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration
    W Mandemakers
    Department of Cell Biology and Genetics and Department of Plastic Surgery, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    EMBO J 19:2992-3003. 2000
    ..Thus, our isolation and characterization of the Oct-6 SCE provides the first description of a cis-acting genetic element that responds to converging signalling pathways to drive myelination in the peripheral nervous system...
  48. ncbi A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobin
    M Berry
    Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK
    Nature 358:499-502. 1992
    ..We show that these changes correlate with the loss of binding of the transcription factor GATA1 to the gamma-globin promoter, suggesting that it may act as a negative regulator of the gamma-globin gene in adults...
  49. ncbi Regulation of the CRABP-I gene during mouse embryogenesis
    D A Kleinjan
    Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands
    Mech Dev 67:157-69. 1997
    ..One of these regulatory elements has the hallmarks of an RA response element, suggesting that CRABP-I expression in neural tissue can be directly modulated by RA via the RARs/RXRs...
  50. ncbi CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies
    C I De Zeeuw
    Department of Anatomy, Erasmus University Rotterdam, The Netherlands
    Neuron 19:1187-99. 1997
    ..Local microtubule depolymerization leads to a temporary reduction of DLBs. These results suggest that CLIP-115 operates in the control of brain-specific organelle translocations...
  51. ncbi LCR-mediated, long-term tissue-specific gene expression within replicating episomal plasmid and cosmid vectors
    C M Chow
    Nuclear Biology Group, Division of Medical and Molecular Genetics, GKT School of Medicine, Guy s Hospital, London, UK
    Gene Ther 9:327-36. 2002
    ..Our data suggest that LCRs can contribute to this vital function...