Research Topics
Genomes and Genes | F GrosveldSummaryAffiliation: Erasmus University Country: The Netherlands Publications
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Detail Information
Publications
The role of the -50 region of the human gamma-globin gene in switchingM S Ristaldi
Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
EMBO J 20:5242-9. 2001....
Gp96/GRP94 is a putative high density lipoprotein-binding protein in liverR de Crom
The Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University Rotterdam, Dr Molenwaterplein 50, P O Box 1738, 3000 DR, Rotterdam, The
Biochim Biophys Acta 1437:378-92. 1999..It appeared to be difficult to obtain a prolonged high level expression of gp96. In these cases, however, a marked increase of HDL-binding activity compared with the control cells could be observed...- Branching and differentiation defects in pulmonary epithelium with elevated Gata6 expressionM Koutsourakis
Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, P O Box 1738, 3000 DR, The, Rotterdam, Netherlands
Mech Dev 105:105-14. 2001..Thus, elevated levels of GATA6 protein affect early lung development and in analogy to other GATA factors in other tissues, GATA6 also plays a crucial role in the terminal differentiation in this case of the distal pulmonary epithelium... - The murine CYLN2 gene: genomic organization, chromosome localization, and comparison to the human gene that is located within the 7q11.23 Williams syndrome critical regionC C Hoogenraad
MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, 3000 DR, The Netherlands
Genomics 53:348-58. 1998..23, which is commonly deleted in Williams syndrome. It spans at least 140 kb at the 3' end of the deletion. Human CYLN2 is very likely identical to the previously characterized, incomplete WSCR4 and WSCR3 transcription units... - The transcription factor GATA6 is essential for branching morphogenesis and epithelial cell differentiation during fetal pulmonary developmentR Keijzer
Department of Cell Biology and Genetics, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
Development 128:503-11. 2001..Taken together, these data demonstrate that GATA6 is not essential for endoderm specification, but is required for normal branching morphogenesis and late epithelial cell differentiation... - Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymusR W Hendriks
Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
Eur J Immunol 29:1912-8. 1999..We therefore propose that GATA-3 is required for the expansion of T cell progenitors, and for the control of subsequent proliferation steps, which alternate periods of TCR recombination in the thymus... - Activation by locus control regions?F Grosveld
Department of Cell Biology and Genetics, Medical Genetics Centre, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
Curr Opin Genet Dev 9:152-7. 1999.... - Mechanisms of developmental control of transcription in the murine alpha- and beta-globin lociT Trimborn
MGC Department of Cell Biology and Genetics, Erasmus University, 3000 DR, Rotterdam, The Netherlands
Genes Dev 13:112-24. 1999.... - Comparison of sequence and function of the Oct-6 genes in zebrafish, chicken and mouseF Levavasseur
MGC, Dept of Cell Biology and Genetics, Erasmus University Rotterdam, P O Box 1738, The Netherlands
Mech Dev 74:89-98. 1998.... - Locus control regions, chromatin activation and transcriptionP Fraser
Erasmus University, Faculty of Medicine, Department of Cell Biology and Genetics, Rotterdam, The Netherlands
Curr Opin Cell Biol 10:361-5. 1998..The emerging picture indicates that several very different types of negative regulation ensure that transcriptional activation occurs only in the appropriate cells... - The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domainsE Payen
Department of Cell Biology and Genetics, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
J Biol Chem 273:9099-109. 1998..Thus we suggest that ZFP-37 is a structural protein of the neuronal nucleus which plays a role in the maintenance of specialized chromatin domains... - Early arrest in B cell development in transgenic mice that express the E41K Bruton's tyrosine kinase mutant under the control of the CD19 promoter regionA Maas
Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University, Rotterdam, The Netherlands
J Immunol 162:6526-33. 1999..We conclude that the residual peripheral B cells were efficiently driven into IgM+ plasma cell differentiation, apparently without functional selection... - Enforced expression of GATA-3 during T cell development inhibits maturation of CD8 single-positive cells and induces thymic lymphoma in transgenic miceM C Nawijn
Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Dr Molewaterplein 50, 3000 DR Rotterdam, The Netherlands
J Immunol 167:715-23. 2001..In the spleen and lymph nodes, the numbers of CD8(+) T cells were significantly reduced. These findings indicate that GATA-3 supports development of the CD4 lineage and inhibits maturation of CD8 SP cells in the thymus... - Erythroid overexpression of C/EBPgamma in transgenic mice affects gamma-globin expression and fetal liver erythropoiesisG Zafarana
Erasmus University Rotterdam, MGC Department of Cell Biology, PO Box 1738, 3000 DR Rotterdam, The Netherlands
EMBO J 19:5856-63. 2000..We suggest that targeted expression of dominant-negative leucine zipper proteins is a generally applicable approach to ablate specific tissues in mice... - Embryonic expression and cloning of the murine GATA-3 geneK M George
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL 60208 3500
Development 120:2673-86. 1994..Furthermore, this same region of the locus confers developmentally appropriate expression in transgenic mice, but only in a subset of the tissues that naturally express the gene... - Gata3 loss leads to embryonic lethality due to noradrenaline deficiency of the sympathetic nervous systemK C Lim
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, USA
Nat Genet 25:209-12. 2000..Thus we have shown that Gata3 has a role in the differentiation of multiple cell lineages during embryogenesis... - Localization of distant urogenital system-, central nervous system-, and endocardium-specific transcriptional regulatory elements in the GATA-3 locusG Lakshmanan
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA
Mol Cell Biol 19:1558-68. 1999.... - The transcription factor GATA6 is essential for early extraembryonic developmentM Koutsourakis
Erasmus University, Medical Genetics Centre, Department of Cell Biology and Genetics, The Netherlands
Development 126:723-32. 1999..Inactivation leads to a lethality shortly after implantation (5.5 days postcoitum). Chimeric experiments show this to be caused by an indirect effect on the epiblast due to a defect in an extraembryonic tissue... - In vivo transposition of Minos, a Drosophila mobile element, in mammalian tissuesL Zagoraiou
Institute for Molecular Biology and Biotechnology-Foundation for Research and Technology, Hellas, P.O. Box 1527, Heraklion 71110, Greece
Proc Natl Acad Sci U S A 98:11474-8. 2001..These results are a first step toward a reversible insertional mutagenesis system in the mouse, opening the way to develop powerful technologies for functional genomic analysis in mammals... - Transcription factor Sp3 is essential for post-natal survival and late tooth developmentP Bouwman
Institut fur Molekularbiologie und Tumorforschung, Emil Mannkopff Strasse 2
EMBO J 19:655-61. 2000..Comparison of the Sp1 and Sp3 knockout phenotype shows that Sp1 and Sp3 have distinct functions in vivo, but also suggests a degree of functional redundancy... - Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the earA Karis
Department of Animal Development and Systematics, University of Tartu, 51014 Tartu, Estonia
J Comp Neurol 429:615-30. 2001..This study shows for the first time that a zinc finger factor is involved in axonal navigation of the inner ear efferent neurons and, simultaneously, in the morphogenesis of the inner ear... - GATA-3 is involved in the development of serotonergic neurons in the caudal raphe nucleiJ H van Doorninck
Departments of Cell Biology and Genetics and Anatomy, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
J Neurosci 19:RC12. 1999..In sum, we conclude that GATA-3 plays a major role in the development of the serotonergic neurons of the caudal raphe nuclei, and that it is crucial for their role in locomotion... - Enforced expression of GATA-3 in transgenic mice inhibits Th1 differentiation and induces the formation of a T1/ST2-expressing Th2-committed T cell compartment in vivoM C Nawijn
Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, Dr Molewaterplein 50, 3000 DR Rotterdam, The Netherlands
J Immunol 167:724-32. 2001..The increased functional capacity to secrete Th2 cytokines, along with the increased expression of surface markers for Ag-experienced Th2-committed cells, would argue for a role of GATA-3 in Th2 memory formation... - The transcription factor GATA3 is a downstream effector of Hoxb1 specification in rhombomere 4I Pata
Institute of Molecular and Cell Biology, University of Tartu, 51010 Tartu, Estonia
Development 126:5523-31. 1999..These findings demonstrate that GATA2 and GATA3 lie downstream of Hoxb1 and provide the first example of Hox pathway transcription factors within a defined population of vertebrate motor neurons... - Partial rescue of GATA-3 by yeast artificial chromosome transgenesG Lakshmanan
Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois, 60208, USA
Dev Biol 204:451-63. 1998..While not complete in its regulatory capacity, the YAC transgene is nonetheless able to complement several homozygous GATA-3 mutant phenotypes and thereby prolong embryonic life... - The POU factor Oct-6 and Schwann cell differentiationM Jaegle
Medical Genetics Center, Department of Cell Biology and Genetics, Erasmus University, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
Science 273:507-10. 1996..Thus, Oct-6 appears to be required for the transition of promyelin cells to myelinating cells. Once these cells progress past this point, Oct-6 is no longer required, and myelination occurs normally... - Role of the duplicated CCAAT box region in gamma-globin gene regulation and hereditary persistence of fetal haemoglobinA Ronchi
Universita degli Studi di Milano, Dipartimento di Genetica e di Biologia di Microrganisimi, 20133 Milano, Italy
EMBO J 15:143-9. 1996..We present a model for gamma-globin gene silencing that has significant implications for attempts to reactivate the gamma promoters in human adults by pharmacological means... - Zfp-37 is a member of the KRAB zinc finger gene family and is expressed in neurons of the developing and adult CNSN Mazarakis
MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
Genomics 33:247-57. 1996..Together, these results suggest that ZFP-37 is a transcriptional regulator predominantly present in postmitotic cells from two different lineages... - Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF geneB Nuez
MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
Nature 375:316-8. 1995..Enucleated erythrocytes are formed but these do not contain the proper amount of haemoglobin. We conclude that the transcription factor EKLF is essential for the final steps of definitive erythropoiesis in fetal liver... - GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivoG T Ma
Department of Biochemistry, Northwestern University, Evanston, Illinois 60208, USA
Development 124:907-14. 1997.... - The murine homologue of HIRA, a DiGeorge syndrome candidate gene, is expressed in embryonic structures affected in human CATCH22 patientsL G Wilming
Institute of Pediatric Surgery, Erasmus University, Rotterdam, The Netherlands
Hum Mol Genet 6:247-58. 1997..Since many of the structures affected in DiGeorge syndrome derive from these Hira expressing cell populations we propose that haploinsufficiency of HIRA contributes to at least some of the features of the DiGeorge phenotype... - Transcription factor Sp1 is essential for early embryonic development but dispensable for cell growth and differentiationM Marin
Erasmus University Rotterdam, Department of Cell Biology, The Netherlands
Cell 89:619-28. 1997..MeCP2 is thought to be required for the maintenance of differentiated cells. We suggest that Sp1 is an important regulator of this process... - Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stageR W Hendriks
Department of Cell Biology and Genetics, Faculty of Medicine, Erasmus University Rotterdam, The Netherlands
EMBO J 15:4862-72. 1996..Our results show that Btk expression is essential at two distinct differentiation steps, both past the pre-B cell stage... - Role of PML in cell growth and the retinoic acid pathwayZ G Wang
Department of Human Genetics and Molecular Biology Program, Memorial Sloan Kettering Cancer Center, Sloan Kettering Division, Graduate School of Medical Sciences, Cornell University, New York, NY 10021, USA
Science 279:1547-51. 1998..These results indicate that PML is a critical component of the RA pathway and that disruption of its activity by the PML-RARalpha fusion protein may be important in APL pathogenesis... - Context-dependent EKLF responsiveness defines the developmental specificity of the human epsilon-globin gene in erythroid cells of YAC transgenic miceK Tanimoto
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208 3500, USA
Genes Dev 14:2778-94. 2000..We conclude that the suppression of epsilon-globin transcription during definitive erythropoiesis is mediated by the binding of a repressor that prevents EKLF from activating the epsilon-globin gene... - Structure of the murine Thy-1 geneV Giguere
EMBO J 4:2017-24. 1985..The 5' end of the gene has multiple initiation sites and a non-TATA box promoter. The 3' end shows a single polyadenylation site after a very long untranslated region... - Enhancer sequences located 3' of the mouse immunoglobulin lambda locus specify high-level expression of an immunoglobulin lambda gene in B cells of transgenic miceS Eccles
MRC Collaborative Centre, London, UK
New Biol 2:801-11. 1990.... - Mammalian Golgi-associated Bicaudal-D2 functions in the dynein-dynactin pathway by interacting with these complexesC C Hoogenraad
MGC Department of Cell Biology, Erasmus University, PO Box 1738, 3000 DR Rotterdam, The Netherlands
EMBO J 20:4041-54. 2001..Taken together, these data suggest that mammalian BICD2 plays a role in the dynein- dynactin interaction on the surface of membranous organelles, by associating with these complexes... - Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control regionR Tewari
Sars International Centre for Molecular Marine Biology, Bergen High Technology Centre, Thormohlensgt 55, N 5020 Bergen, Norway
EMBO J 17:2334-41. 1998..Interestingly, the EKLF transgene rescues the lethal phenotype of EKLF null mice, setting the stage for future studies aimed at the analysis of the EKLF protein and its role in beta-globin gene activation... - Developmental regulation of a complete 70-kb human beta-globin locus in transgenic miceJ Strouboulis
Laboratory of Gene Structure and Expression, National Institute for Medical Research, London, UK
Genes Dev 6:1857-64. 1992..These results suggest that multiple changes in DNA sequences and transcription factor balance must have occurred for the human gamma-globin gene to have evolved into a fetal gene... - Developmental regulation of DNA replication timing at the human beta globin locusI Simon
Department of Cellular Biochemistry, Hebrew University Medical School, Jerusalem, Israel
EMBO J 20:6150-7. 2001..These results also show that the pattern of replication timing is set up by mechanisms that work independently of gene transcription... - Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouseG M Dingjan
Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
J Exp Med 193:1169-78. 2001..These results implicate Btk in the regulation of the activation of the lambda locus for V(D)J recombination in pre-B cells... - Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblastsA Akhmanova
MGC Department of Cell Biology and Genetics, Erasmus University, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Cell 104:923-35. 2001..We propose that CLASPs are involved in the local regulation of microtubule dynamics in response to positional cues... - Transcription complex stability and chromatin dynamics in vivoM Wijgerde
MGC Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands
Nature 377:209-13. 1995..The regulator may stably complex with one gene at a time and switch back and forth between genes in a flip-flop mechanism... - The mode of anchorage to the cell surface determines both the function and the membrane location of Thy-1 glycoproteinM C Tiveron
Laboratory of Neurobiology Norman and Sadie Lee Centre, National Institute for Medical Research, Mill Hill, London, UK
J Cell Sci 107:1783-96. 1994..Thus the membrane anchor, in targetting Thy-1 to different microdomains on the cell surface, determines its ability to inhibit neurite outgrowth on astrocytes... - Chromatin domains as potential units of eukaryotic gene functionN Dillon
National Institute for Medical Research, London, UK
Curr Opin Genet Dev 4:260-4. 1994.... - A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regenerationW Mandemakers
Department of Cell Biology and Genetics and Department of Plastic Surgery, Erasmus University Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
EMBO J 19:2992-3003. 2000..Thus, our isolation and characterization of the Oct-6 SCE provides the first description of a cis-acting genetic element that responds to converging signalling pathways to drive myelination in the peripheral nervous system... - A single point mutation is the cause of the Greek form of hereditary persistence of fetal haemoglobinM Berry
Laboratory of Gene Structure and Expression, National Institute for Medical Research, Mill Hill, London, UK
Nature 358:499-502. 1992..We show that these changes correlate with the loss of binding of the transcription factor GATA1 to the gamma-globin promoter, suggesting that it may act as a negative regulator of the gamma-globin gene in adults... - Regulation of the CRABP-I gene during mouse embryogenesisD A Kleinjan
Department of Cell Biology and Genetics, Erasmus University Rotterdam, The Netherlands
Mech Dev 67:157-69. 1997..One of these regulatory elements has the hallmarks of an RA response element, suggesting that CRABP-I expression in neural tissue can be directly modulated by RA via the RARs/RXRs... - CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodiesC I De Zeeuw
Department of Anatomy, Erasmus University Rotterdam, The Netherlands
Neuron 19:1187-99. 1997..Local microtubule depolymerization leads to a temporary reduction of DLBs. These results suggest that CLIP-115 operates in the control of brain-specific organelle translocations... - LCR-mediated, long-term tissue-specific gene expression within replicating episomal plasmid and cosmid vectorsC-M Chow
Nuclear Biology Group, Division of Medical and Molecular Genetics, GKT School of Medicine, Guy's Hospital, London, UK
Gene Ther 9:327-36. 2002..Our data suggest that LCRs can contribute to this vital function...