C Gauna

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 293:E697-704. 2007
  2. ncbi Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes
    Carlotta Gauna
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:1055-60. 2005
  3. ncbi Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Room Ee542, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Endocrinology 148:5278-87. 2007
  4. ncbi Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Mol Cell Endocrinol 251:103-11. 2006
  5. ncbi Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity
    C Gauna
    Department of Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:5035-42. 2004
  6. ncbi Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans
    F Broglio
    Division of Endocrinology, Department of Internal Medicine, Erasmus University of Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:3062-5. 2004
  7. ncbi The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state
    F Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Erasmus University, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 60:592-9. 2004
  8. ncbi Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH
    M Maccario
    Division of Endocrinology, Department of Internal Medicine, University of Turin, Italy
    Eur J Endocrinol 144:251-6. 2001
  9. ncbi Standard light breakfast inhibits circulating ghrelin level to the same extent of oral glucose load in humans, despite different impact on glucose and insulin levels
    C Gottero
    Division of Endocrinology, Department of Internal Medicine, University of Turin, Turin, Italy
    J Endocrinol Invest 26:1203-7. 2003
  10. ncbi Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway
    P J D Delhanty
    Department of Internal Medicine, Rm Ee542, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 293:E302-9. 2007

Detail Information

Publications23

  1. ncbi Unacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 293:E697-704. 2007
    ..Our data demonstrate that, in glucose-stimulated conditions, exogenous UAG acts as a potent insulin secretagogue, whereas endogenous AG exerts a maximal tonic inhibition on glucose-induced insulin release...
  2. ncbi Ghrelin stimulates, whereas des-octanoyl ghrelin inhibits, glucose output by primary hepatocytes
    Carlotta Gauna
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:1055-60. 2005
    ..These actions might be mediated by a different receptor than GHS-R1a, and apparently, we must consider AG and UAG as separate hormones that can modify each other's actions on glucose handling, at least in the liver...
  3. ncbi Intravenous glucose administration in fasting rats has differential effects on acylated and unacylated ghrelin in the portal and systemic circulation: a comparison between portal and peripheral concentrations in anesthetized rats
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Room Ee542, Erasmus Medical Center, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Endocrinology 148:5278-87. 2007
    ..Thus, our results suggest that peripheral AG metabolic regulation and action are mainly confined within the gastrointestinal tract...
  4. ncbi Unacylated ghrelin is active on the INS-1E rat insulinoma cell line independently of the growth hormone secretagogue receptor type 1a and the corticotropin releasing factor 2 receptor
    Carlotta Gauna
    Division of Endocrinology, Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Mol Cell Endocrinol 251:103-11. 2006
    ..Our data support the existence of a specific receptor for UAG, other than the CRF2R and GHS-R1a. The stimulatory effect on insulin secretion by AG in this cell line is mediated by the GHS-R1a...
  5. ncbi Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity
    C Gauna
    Department of Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:5035-42. 2004
    ....
  6. ncbi Non-acylated ghrelin counteracts the metabolic but not the neuroendocrine response to acylated ghrelin in humans
    F Broglio
    Division of Endocrinology, Department of Internal Medicine, Erasmus University of Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:3062-5. 2004
    ..As GHS-R1a is not bound by unacylated ghrelin, these findings suggest that GHS receptor subtypes mediate the metabolic actions of both acylated and unacylated ghrelin...
  7. ncbi The endocrine response to acute ghrelin administration is blunted in patients with anorexia nervosa, a ghrelin hypersecretory state
    F Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Erasmus University, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 60:592-9. 2004
    ..The aim of this study was to define the endocrine actions of ghrelin in patients with anorexia nervosa...
  8. ncbi Effects of short-term administration of low-dose rhGH on IGF-I levels in obesity and Cushing's syndrome: indirect evaluation of sensitivity to GH
    M Maccario
    Division of Endocrinology, Department of Internal Medicine, University of Turin, Italy
    Eur J Endocrinol 144:251-6. 2001
    ..These findings support the hypothesis that hyperinsulinism and hypercortisolism enhance the sensitivity to GH in humans...
  9. ncbi Standard light breakfast inhibits circulating ghrelin level to the same extent of oral glucose load in humans, despite different impact on glucose and insulin levels
    C Gottero
    Division of Endocrinology, Department of Internal Medicine, University of Turin, Turin, Italy
    J Endocrinol Invest 26:1203-7. 2003
    ..In conclusion, these findings show that light breakfast inhibits ghrelin secretion to the same extent of OGTT in adults despite lower variations in glucose and insulin levels...
  10. ncbi Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway
    P J D Delhanty
    Department of Internal Medicine, Rm Ee542, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 293:E302-9. 2007
    ....
  11. ncbi Somatostatin, cortistatin, ghrelin and glucose metabolism
    C Gauna
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    J Endocrinol Invest 28:127-31. 2005
    ....
  12. ncbi Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a
    P J D Delhanty
    Department of Internal Medicine, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GD Rotterdam, The Netherlands
    J Endocrinol 188:37-47. 2006
    ..Overall, our data suggest new roles for ghrelin and UAG in modulating human osteoblast proliferation via a novel signal transduction pathway...
  13. ncbi Concomitant impairment of growth hormone secretion and peripheral sensitivity in obese patients with obstructive sleep apnea syndrome
    L Gianotti
    Division of Endocrinology, Department of Internal Medicine, University of Turin, C so Dogliotti 14, 10126 Turin, Italy
    J Clin Endocrinol Metab 87:5052-7. 2002
    ..These findings suggest that OSAS is connoted by a concomitant impairment of GH secretion and sensitivity...
  14. doi Bolus administration of obestatin does not change glucose and insulin levels neither in the systemic nor in the portal circulation of the rat
    Rosalie M Kiewiet
    Department of Internal Medicine, Section of Endocrinology, Erasmus University Medical Centre, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Peptides 29:2144-9. 2008
    ..In the present study, we demonstrated that intravenously administered obestatin does not influence glucose and insulin concentrations, neither in the portal nor in the systemic circulation...
  15. doi Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization
    Patric J D Delhanty
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 299:E497-505. 2010
    ....
  16. ncbi Ghrelin secretion is inhibited by glucose load and insulin-induced hypoglycaemia but unaffected by glucagon and arginine in humans
    Fabio Broglio
    Division of Endocrinology, Department of Internal Medicine, Erasmus University of Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 61:503-9. 2004
    ..Whether hyperglycaemia and insulin directly inhibit ghrelin secretion still remains matter of debate. The aim of the present study was therefore to investigate further the regulatory effects of glucose and insulin on ghrelin secretion...
  17. ncbi Unacylated ghrelin is not a functional antagonist but a full agonist of the type 1a growth hormone secretagogue receptor (GHS-R)
    Carlotta Gauna
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Mol Cell Endocrinol 274:30-4. 2007
    ..Where local concentrations of UAG may reach the high nanomolar to micromolar range, assignment of GHS-R independent effects should be made with caution...
  18. ncbi Acetylcholine regulates ghrelin secretion in humans
    Fabio Broglio
    Department of Internal Medicine, Erasmus University of Rotterdam, Rotterdam 3015, The Netherlands
    J Clin Endocrinol Metab 89:2429-33. 2004
    ..Thus, ghrelin secretion is under cholinergic, namely muscarinic, control in humans. The variations in circulating ghrelin levels induced by PD and PZ are unlikely to mediate the cholinergic influence on GH secretion...
  19. ncbi Pituitary function during severe and life-threatening illnesses
    C Gauna
    Department of Internal Medicine, Head of Endocrinology, Erasmus MC, CA Rotterdam, The Netherlands
    Pituitary 8:213-7. 2005
    ....
  20. doi Unacylated ghrelin and obestatin increase islet cell mass and prevent diabetes in streptozotocin-treated newborn rats
    Riccarda Granata
    Division of Endocrinology, Diabetology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    J Mol Endocrinol 45:9-17. 2010
    ..Taken together, our results suggest that in STZ-treated newborn rats, UAG and Ob improve glucose metabolism and preserve islet cell mass, granting a therapeutic potential in medical conditions associated with impaired beta-cell function...
  21. ncbi The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects
    Fabio Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, 10126 Turin, Italy
    J Clin Endocrinol Metab 88:1537-42. 2003
    ..The effect of ghrelin on lactotroph and corticotroph secretion is age and gender independent. In both ES and YS, ghrelin influences insulin secretion and glucose metabolism...
  22. ncbi Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans
    Fabio Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Turin, Italy
    J Clin Endocrinol Metab 87:4829-32. 2002
    ..05) than those at baseline. In conclusion, this study first shows that SRIF and CST strongly inhibits ghrelin secretion that, differently from GH and insulin secretion, persists inhibited even after stopping the infusion of SRIF or CST...
  23. ncbi Ghrelin and the endocrine pancreas
    Fabio Broglio
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Turin, Ospedale Molinette, Corso Dogliotti 14, 10126 Turin, Italy
    Endocrine 22:19-24. 2003
    ..This evidence indicates that the endocrine pancreas plays a role in directly or indirectly modulating ghrelin secretion...