José Gaal

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Parasympathetic paragangliomas are part of the Von Hippel-Lindau syndrome
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:4367-71. 2009
  2. doi request reprint Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Room Ae304, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 95:1274-8. 2010
  3. pmc SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mod Pathol 24:147-51. 2011
  4. doi request reprint SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors
    Lindsey Oudijk
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Mod Pathol 26:456-63. 2013
  5. doi request reprint An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, Netherlands
    Lancet Oncol 10:764-71. 2009
  6. doi request reprint High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome
    Floor A M Duijkers
    Department of Pediatric Oncology Hematology, Sophia Children s Hospital, Erasmus MC, Rotterdam, The Netherlands
    Am J Pathol 180:1223-31. 2012
  7. doi request reprint SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas
    Esther Korpershoek
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 96:E1472-6. 2011
  8. doi request reprint Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis
    Thomas G Papathomas
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 170:1-12. 2014
  9. doi request reprint Neuroendocrine tumors and tumor syndromes in childhood
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Pediatr Dev Pathol 13:427-41. 2010
  10. pmc Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels
    Floor A M Duijkers
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
    Cell Oncol (Dordr) 34:409-17. 2011

Collaborators

Detail Information

Publications10

  1. doi request reprint Parasympathetic paragangliomas are part of the Von Hippel-Lindau syndrome
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:4367-71. 2009
    ..However, in parasympathetic paragangliomas occurring in VHL disease, biallelic inactivation of the VHL gene has not been demonstrated to date...
  2. doi request reprint Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Room Ae304, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 95:1274-8. 2010
    ..Conclusion: IDH mutations are very rare in paragangliomas and pheochromocytomas and do not appear to play an important role in oncogenic HIF activation known to be present in these tumors...
  3. pmc SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mod Pathol 24:147-51. 2011
    ..In case of negative SDHB staining in GISTs, Carney-Stratakis syndrome or Carney triad should be considered and appropriate clinical surveillance should be instituted...
  4. doi request reprint SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors
    Lindsey Oudijk
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Mod Pathol 26:456-63. 2013
    ..Identifying GISTs with deficient SDH activity warrants additional genetic testing, evaluation and follow-up for inherited disorders and paragangliomas...
  5. doi request reprint An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, Netherlands
    Lancet Oncol 10:764-71. 2009
    ..We investigated whether SDHB immunohistochemistry could effectively discriminate between SDH-related and non-SDH-related phaeochromocytomas and paragangliomas in large retrospective and prospective tumour series...
  6. doi request reprint High anaplastic lymphoma kinase immunohistochemical staining in neuroblastoma and ganglioneuroblastoma is an independent predictor of poor outcome
    Floor A M Duijkers
    Department of Pediatric Oncology Hematology, Sophia Children s Hospital, Erasmus MC, Rotterdam, The Netherlands
    Am J Pathol 180:1223-31. 2012
    ..In conclusion, ALK positivity by IHC is an independent, poor prognostic factor in patients with GNBL and NBL. ALK IHC is an easy test suitable for future risk stratification in patients with NBL and GNBL...
  7. doi request reprint SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas
    Esther Korpershoek
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 96:E1472-6. 2011
    ..A recent report described a patient with an abdominal paraganglioma, immunohistochemically negative for SDHA, and identified a causal germline mutation in SDHA...
  8. doi request reprint Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis
    Thomas G Papathomas
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 170:1-12. 2014
    ..Absence of SDHB expression in tumors derived from tissues susceptible to SDH deficiency is not fully elucidated...
  9. doi request reprint Neuroendocrine tumors and tumor syndromes in childhood
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Pediatr Dev Pathol 13:427-41. 2010
    ..In addition, several individual neuroendocrine tumors are described, such as medullary thyroid carcinoma, gastroenteropancreatic tumors, pheochromocytoma, and paraganglioma, emphasizing specific histopathologic characteristics...
  10. pmc Anaplastic lymphoma kinase (ALK) inhibitor response in neuroblastoma is highly correlated with ALK mutation status, ALK mRNA and protein levels
    Floor A M Duijkers
    Department of Pediatric Oncology Hematology, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands
    Cell Oncol (Dordr) 34:409-17. 2011
    ..We examined the correlation between levels of ALK, phosphorylated ALK (pALK) and downstream signaling proteins and response to ALK inhibition in a large panel of both ALK mutated and wild type (WT) NBL cell lines...