Oscar H Franco

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%
    Oscar H Franco
    Department of Public Health, Erasmus MC University Medical Centre Rotterdam, PO Box 1738, 3000 DR Rotterdam, Netherlands
    BMJ 329:1447-50. 2004
  2. pmc The polypill: at what price would it become cost effective?
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, 3000 DR Rotterdam, Netherlands
    J Epidemiol Community Health 60:213-7. 2006
  3. ncbi Effects of physical activity on life expectancy with cardiovascular disease
    Oscar H Franco
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Arch Intern Med 165:2355-60. 2005
  4. pmc Cost effectiveness of statins in coronary heart disease
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, PO Box 1738, office Ee 2006, 3000 DR Rotterdam, Netherlands
    J Epidemiol Community Health 59:927-33. 2005
  5. ncbi Blood pressure in adulthood and life expectancy with cardiovascular disease in men and women: life course analysis
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Hypertension 46:280-6. 2005
  6. doi Arterial stiffness is associated with carotid intraplaque hemorrhage in the general population: the Rotterdam study
    Mariana Selwaness
    From the Departments of Epidemiology M S, G C V, A H, O H F, J C M W, M W V, Radiology Q v d B, A v d L, M W V, Internal Medicine F U S M R, and Cardiology, Biomedical Engineering J J W, Erasmus MC, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 34:927-32. 2014
  7. doi The Rotterdam Study: 2014 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:889-926. 2013
  8. doi Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study)
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Am J Cardiol 113:1-6. 2014
  9. doi The global impact of non-communicable diseases on healthcare spending and national income: a systematic review
    Taulant Muka
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Office NA29 16, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 30:251-77. 2015
  10. doi Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the Rotterdam Study
    Daniel Bos
    Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands2Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA Neurol 71:405-11. 2014

Detail Information

Publications74

  1. pmc The Polymeal: a more natural, safer, and probably tastier (than the Polypill) strategy to reduce cardiovascular disease by more than 75%
    Oscar H Franco
    Department of Public Health, Erasmus MC University Medical Centre Rotterdam, PO Box 1738, 3000 DR Rotterdam, Netherlands
    BMJ 329:1447-50. 2004
    ..The objective of this study was to identify a tastier and safer alternative to the Polypill: the Polymeal...
  2. pmc The polypill: at what price would it become cost effective?
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, 3000 DR Rotterdam, Netherlands
    J Epidemiol Community Health 60:213-7. 2006
    ..The aim of this study was to determine the maximum price of the polypill for it to be a cost effective alternative in the primary prevention of cardiovascular disease...
  3. ncbi Effects of physical activity on life expectancy with cardiovascular disease
    Oscar H Franco
    Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Arch Intern Med 165:2355-60. 2005
    ..Our objective was to calculate the consequences of different physical activity levels after age 50 years on total life expectancy and life expectancy with and without cardiovascular disease...
  4. pmc Cost effectiveness of statins in coronary heart disease
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, PO Box 1738, office Ee 2006, 3000 DR Rotterdam, Netherlands
    J Epidemiol Community Health 59:927-33. 2005
    ..This article reviewed cost effectiveness analyses of statins and sought to synthesise cost effectiveness ratios for categories of risk of coronary heart disease and age...
  5. ncbi Blood pressure in adulthood and life expectancy with cardiovascular disease in men and women: life course analysis
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Hypertension 46:280-6. 2005
    ..This effect is larger than estimated previously and affects both sexes similarly. Our findings underline the tremendous importance of preventing high blood pressure and its consequences in the population...
  6. doi Arterial stiffness is associated with carotid intraplaque hemorrhage in the general population: the Rotterdam study
    Mariana Selwaness
    From the Departments of Epidemiology M S, G C V, A H, O H F, J C M W, M W V, Radiology Q v d B, A v d L, M W V, Internal Medicine F U S M R, and Cardiology, Biomedical Engineering J J W, Erasmus MC, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 34:927-32. 2014
    ..In a population-based study, we investigated the association between arterial stiffness and the presence and composition of carotid atherosclerotic plaques...
  7. doi The Rotterdam Study: 2014 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:889-926. 2013
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  8. doi Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study)
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Am J Cardiol 113:1-6. 2014
    ..In men, the prognosis is as unfavorable as that of patients with recognized MIs. ..
  9. doi The global impact of non-communicable diseases on healthcare spending and national income: a systematic review
    Taulant Muka
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Office NA29 16, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 30:251-77. 2015
    ..However further work is required to standardize more consistently the methods available to assess the economic impact of NCDs and to involve (hitherto under-addressed) LMI populations across the globe...
  10. doi Intracranial carotid artery atherosclerosis and the risk of stroke in whites: the Rotterdam Study
    Daniel Bos
    Department of Radiology, Erasmus Medical Center, Rotterdam, the Netherlands2Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    JAMA Neurol 71:405-11. 2014
    ..Intracranial atherosclerosis represents a relatively unexplored, but potentially important, cause of stroke in a white population...
  11. doi Comparison of application of the ACC/AHA guidelines, Adult Treatment Panel III guidelines, and European Society of Cardiology guidelines for cardiovascular disease prevention in a European cohort
    Maryam Kavousi
    Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    JAMA 311:1416-23. 2014
    ..5% 10-year hard atherosclerotic cardiovascular disease (ASCVD) risk. Implications of the new guideline's threshold and model have not been addressed in non-US populations or compared with previous guidelines...
  12. pmc Effectiveness calculation in economic analysis: the case of statins for cardiovascular disease prevention
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Netherlands
    J Epidemiol Community Health 60:839-45. 2006
    ..This report aimed to evaluate the calculation of estimates of effectiveness in cost effectiveness analyses of statins for cardiovascular disease prevention...
  13. pmc Sex differences in lifetime risk and first manifestation of cardiovascular disease: prospective population based cohort study
    Maarten J G Leening
    Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands Department of Cardiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, Netherlands Department of Epidemiology, Harvard School of Public Health, Boston, MA, US
    BMJ 349:g5992. 2014
    ..To evaluate differences in first manifestations of cardiovascular disease between men and women in a competing risks framework...
  14. doi Serum potassium levels and the risk of atrial fibrillation: the Rotterdam Study
    Bouwe P Krijthe
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Consortium for Healthy Aging NCHA, The Netherlands
    Int J Cardiol 168:5411-5. 2013
    ..Little is known about the association of serum potassium with atrial fibrillation. The objective of this study was to investigate the association of serum potassium and the risk of atrial fibrillation in a population based setting...
  15. ncbi Physical activity and life expectancy with and without diabetes: life table analysis of the Framingham Heart Study
    Jacqueline T Jonker
    Department of Public Health, Erasmus Medical Center, P O Box 1738, 3000 DR, Rotterdam, Netherlands
    Diabetes Care 29:38-43. 2006
    ..Our aim is to calculate the differences in life expectancy with and without type 2 diabetes associated with different levels of physical activity...
  16. doi Kidney function and microstructural integrity of brain white matter
    Sanaz Sedaghat
    From the Departments of Epidemiology S S, L G M C, M D G, A H, O H F, M W V, A D, M A I, Radiology L G M C, M D G, A v d L, M W V, M A I, Medical informatics M d G, Internal Medicine E J H, and Neurology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Neurology 85:154-61. 2015
    ..To investigate the association of kidney function with white matter microstructural integrity...
  17. doi Bidirectional associations between fussy eating and functional constipation in preschool children
    Anne Tharner
    Department of Epidemiology, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, The Netherlands Department of Child and Adolescent Psychiatry Psychology, Erasmus Medical Center, Erasmus University Rotterdam, Rotterdam, The Netherlands Electronic address
    J Pediatr 166:91-6. 2015
    ..To examine bidirectional associations between a child's fussy eating behavior and functional constipation...
  18. doi The Generation R Study: Biobank update 2015
    Claudia J Kruithof
    The Generation R Study Group NA 2915, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 29:911-27. 2014
    ....
  19. pmc Serum uric acid and chronic kidney disease: the role of hypertension
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e76827. 2013
    ..In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension moderates this association...
  20. doi Bone mineral density and chronic lung disease mortality: the rotterdam study
    Natalia Campos-Obando
    Departments of Internal Medicine N C O, M C C B, L O, B H C S, H T, F R, A G U, M C Z and Epidemiology M C C B, O H F, B H C S, G G B, L L, A H, F R, A G U, M C Z, Erasmus MC, 3000 CA Rotterdam, The Netherlands Department of Respiratory Medicine G G B, L L, Ghent University Hospital, B 9000 Ghent, Belgium Departments of Respiratory Medicine G G B and Psychiatric Epidemiology H T, Erasmus MC, 3000 CA Rotterdam, The Netherlands and Netherlands Genomics Initiative Sponsored Netherlands Consortium for Healthy Ageing M C C B, L O, O H F, A H, F R, A G U, M C Z, 2300 RC Leiden, The Netherlands
    J Clin Endocrinol Metab 99:1834-42. 2014
    ..Low bone mineral density (BMD) has been associated with increased all-cause mortality. Cause-specific mortality studies have been controversial...
  21. doi Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
    ..We tested the hypothesis that the cumulative effects of common genetic variants for lipids are collectively associated with subclinical atherosclerosis and incident coronary heart disease...
  22. doi Psoriasis is not associated with atherosclerosis and incident cardiovascular events: the Rotterdam Study
    Emmilia A Dowlatshahi
    Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    J Invest Dermatol 133:2347-54. 2013
    ..Psoriasis patients with predominantly mild disease from the general population are as likely to develop atherosclerosis and cardiovascular events as subjects without psoriasis. ..
  23. pmc Living healthier for longer: comparative effects of three heart-healthy behaviors on life expectancy with and without cardiovascular disease
    Wilma J Nusselder
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, Rotterdam, The Netherlands
    BMC Public Health 9:487. 2009
    ..We aimed to calculate and compare the effects of non-smoking, normal weight and physical activity in middle-aged populations on life expectancy with and without cardiovascular disease...
  24. ncbi Associations of diabetes mellitus with total life expectancy and life expectancy with and without cardiovascular disease
    Oscar H Franco
    Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Arch Intern Med 167:1145-51. 2007
    ..We aimed to calculate the association of diabetes after age 50 years with life expectancy and the number of years lived with and without CVD...
  25. doi Association of uric acid genetic risk score with blood pressure: the Rotterdam study
    Sanaz Sedaghat
    Departments of Epidemiology S S, R P, A G U, A H, B H Ch S, O H F, A D, M A I, Internal Medicine A G U, Radiology M A I, and Neurology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Hypertension 64:1061-6. 2014
    ..Our study suggests that genome wide association study's findings can be associated with an intermediate factor or have a pleiotropic role and, therefore, should be applied for Mendelian Randomization with caution. ..
  26. doi Association of renal function with vascular stiffness in older adults: the Rotterdam study
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Age Ageing 43:827-33. 2014
    ..A potential mechanism linking cardiovascular disease to chronic kidney disease might be the change in arterial elasticity. We aim to determine the association between renal function and arterial stiffness in older subjects...
  27. doi Atherosclerotic plaque in the left carotid artery is more vulnerable than in the right
    Mariana Selwaness
    From the Departments of Epidemiology M S, Q v d B, R S v O, A H, O H F, M V, Radiology Q v d B, A v d L, M V, and Cardiology J J W, Erasmus MC, Rotterdam, The Netherlands
    Stroke 45:3226-30. 2014
    ..It is unknown whether this asymmetrical prevalence relates to differences in carotid atherosclerosis. We compared atherosclerotic plaque prevalence, severity, and composition between left and right carotid arteries...
  28. pmc Toward an operative diagnosis of fussy/picky eating: a latent profile approach in a population-based cohort
    Anne Tharner
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Behav Nutr Phys Act 11:14. 2014
    ..Definitions and assessment methods of fussy/picky eating are heterogeneous and remain unclear.We aimed to identify an eating behavior profile reflecting fussy/picky eating in children and to describe characteristics of fussy eaters...
  29. pmc Thyroid function and age-related macular degeneration: a prospective population-based cohort study--the Rotterdam Study
    Layal Chaker
    Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Med 13:94. 2015
    ..The association between thyroid function and age-related macular degeneration (AMD) has not been investigated in the general population...
  30. doi Sedentary behaviors, physical activity behaviors, and body fat in 6-year-old children: the Generation R Study
    Anne I Wijtzes
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Int J Behav Nutr Phys Act 11:96. 2014
    ..e., percent fat mass, body mass index (BMI) standard deviation scores, and weight status (normal weight, overweight)...
  31. pmc First trimester fetal growth restriction and cardiovascular risk factors in school age children: population based cohort study
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, Netherlands
    BMJ 348:g14. 2014
    ..To examine whether first trimester fetal growth restriction correlates with cardiovascular outcomes in childhood...
  32. doi Performance of Framingham cardiovascular disease (CVD) predictions in the Rotterdam Study taking into account competing risks and disentangling CVD into coronary heart disease (CHD) and stroke
    Bob J H van Kempen
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    Int J Cardiol 171:413-8. 2014
    ....
  33. doi Fish consumption in infancy and asthma-like symptoms at preschool age
    Jessica C Kiefte-de Jong
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Pediatrics 130:1060-8. 2012
    ..To assess whether timing of introduction of fish and the amount of fish consumption in infancy were associated with asthmalike symptoms at preschool age...
  34. ncbi Primary prevention of cardiovascular disease: cost-effectiveness comparison
    Oscar H Franco
    Department of Public Health, University Medical Center Rotterdam, 50 Dr Molewaterplein, 3000 CA Rotterdam, Zuid Holland
    Int J Technol Assess Health Care 23:71-9. 2007
    ..The aim of this study was to evaluate the cost-effectiveness of four risk-lowering interventions (smoking cessation, antihypertensives, aspirin, and statins) in primary prevention of cardiovascular disease...
  35. doi Coffee consumption and incident dementia
    Saira Saeed Mirza
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 29:735-41. 2014
    ..Our data suggest that coffee consumption is not associated with incident dementia during long-term. The protective association observed in the short-term might be driven by reverse causality. ..
  36. doi First-trimester maternal protein intake and childhood kidney outcomes: the Generation R Study
    Kozeta Miliku
    The Generation R Study Group and the Departments of Epidemiology and Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Am J Clin Nutr 102:123-9. 2015
    ..Nutritional exposures during in utero development may have long-lasting consequences for postnatal renal health. Animal studies suggest that specifically maternal dietary protein intake during pregnancy influences childhood kidney function...
  37. doi Declining incidence of sudden cardiac death from 1990-2010 in a general middle-aged and elderly population: The Rotterdam Study
    Maartje N Niemeijer
    Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Heart Rhythm 12:123-9. 2015
    ..Although sudden cardiac death (SCD) is relatively common, contemporary data on its incidence are lacking...
  38. pmc Associations of heart failure with sleep quality: the Rotterdam Study
    Lisette A Zuurbier
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Sleep Med 11:117-21. 2015
    ..The prevalence of sleep disturbances and heart failure increases with age. We aimed to evaluate the associations of incident heart failure and cardiac dysfunction with changes in sleep quality...
  39. doi Effects of protein intake on blood pressure, insulin sensitivity and blood lipids in children: a systematic review
    Trudy Voortman
    Department of Epidemiology, Erasmus MC, University Medical Center, PO Box 2040, 3000CA, Rotterdam, The Netherlands
    Br J Nutr 113:383-402. 2015
    ..Future studies could be improved by adequately adjusting for key confounders such as energy intake and obesity. ..
  40. doi Unrecognized myocardial infarction and risk of atrial fibrillation: the Rotterdam Study
    Bouwe P Krijthe
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands Netherlands Consortium for Healthy Aging NCHA, The Netherlands
    Int J Cardiol 168:1453-7. 2013
    ..The objective of this study was to investigate whether unrecognized myocardial infarction was associated with an increased risk of atrial fibrillation in a prospective population-based cohort study...
  41. pmc Predictive value of updating Framingham risk scores with novel risk markers in the U.S. general population
    Bart S Ferket
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands Department of Radiology, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 9:e88312. 2014
    ..Their impact in the U.S. general population is however uncertain. Our aim was to estimate the predictive value of four novel cardiovascular risk markers for the U.S. general population...
  42. doi The association between physical activity and dementia in an elderly population: the Rotterdam Study
    Renée F A G de Bruijn
    Department of Epidemiology, Erasmus MC University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 28:277-83. 2013
    ..This association was confined to follow-up for up to 4 years and not to longer follow-up, suggesting either a role for reverse causality or only a short term effect of late-life physical activity in an elderly population...
  43. doi Maternal first-trimester diet and childhood bone mass: the Generation R Study
    Denise H M Heppe
    Generation R Study Group and the Department of Paediatrics, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Clin Nutr 98:224-32. 2013
    ..Maternal diet during pregnancy has been suggested to influence bone health in later life...
  44. doi Comparing a marginal structural model with a Cox proportional hazard model to estimate the effect of time-dependent drug use in observational studies: statin use for primary prevention of cardiovascular disease as an example from the Rotterdam Study
    Catherine E de Keyser
    Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 29:841-50. 2014
    ..Confounding remains a hurdle in observational effectiveness research on preventive drugs with a multitude of prescription determinants...
  45. doi Infant Breastfeeding and Kidney Function in School-Aged Children
    Kozeta Miliku
    The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands Department of Pediatrics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Am J Kidney Dis 66:421-8. 2015
    ..Early life factors may influence kidney growth and function throughout the life course. We examined the associations of breastfeeding duration and exclusivity and age at introduction of solid foods with kidney outcomes at school age...
  46. doi Vitamin D deficiency in school-age children is associated with sociodemographic and lifestyle factors
    Trudy Voortman
    Departments of Epidemiology and The Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, The Netherlands and
    J Nutr 145:791-8. 2015
    ..There is concern about a reemergence of vitamin D deficiency in children in developed countries...
  47. doi The global impact of non-communicable diseases on households and impoverishment: a systematic review
    Loes Jaspers
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Office NA 29 16, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 30:163-88. 2015
    ..Given the scarcity of information on specific regions, further research to estimate impact of NCDs on households and impoverishment in LMIC, especially the Middle Eastern, African and Latin American regions is required...
  48. doi EN-RAGE: a novel inflammatory marker for incident coronary heart disease
    Symen Ligthart
    From the Department of Epidemiology S L, S S, M A I, A H, O H F, A D, Department of Neurology M A I, and Department of Radiology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 34:2695-9. 2014
    ..Inflammation plays a key role in atherosclerosis. We hypothesized that novel inflammatory markers may predict the risk of coronary heart disease (CHD)...
  49. doi BMI, total and abdominal fat distribution, and cardiovascular risk factors in school-age children
    Olta Gishti
    1 The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands 2 Department of Pediatrics, Erasmus Medical Center, Rotterdam, The Netherlands 3 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Pediatr Res 77:710-8. 2015
    ..We examined the independent associations of total and abdominal fat measures with cardiovascular risk factors in school age children...
  50. pmc Vitamin d and the risk of atrial fibrillation - the rotterdam study
    Anna Vitezova
    Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0125161. 2015
    ..91-1.02; HR for insufficiency: 0.82, 95%CI: 0.60-1.11,and HR for adequate status: 0.76, 95%CI: 0.52-1.12 compared to deficiency). This prospective cohort study does not support the hypothesis that vitamin D status is associated with AF. ..
  51. doi Subclinical thyroid dysfunction and the risk of stroke: a systematic review and meta-analysis
    Layal Chaker
    Department of Internal Medicine, Thyroid Center, Erasmus University Medical Center, Room Ee502, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 29:791-800. 2014
    ..Also, there were insufficient events to exclude clinically significant risk from subclinical hyperthyroidism, and more data are required for subgroup analyses...
  52. doi Total dietary antioxidant capacity, individual antioxidant intake and breast cancer risk: the Rotterdam Study
    Athanasios Pantavos
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Int J Cancer 136:2178-86. 2015
    ..Individual effects of dietary carotenoids and dietary flavonoids may be restricted to subgroups such as smokers and elderly. ..
  53. pmc Non-steroidal anti-inflammatory drugs and the risk of atrial fibrillation: a population-based follow-up study
    Bouwe P Krijthe
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMJ Open 4:e004059. 2014
    ....
  54. pmc Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein
    Symen Ligthart
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0118859. 2015
    ..In addition to reverse causation, our data suggests that pleiotropic genetic variants partially underlie the association between CRP and cardiometabolic phenotypes. ..
  55. doi Kidney size and function in a multi-ethnic population-based cohort of school-age children
    Hanneke Bakker
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Pediatr Nephrol 29:1589-98. 2014
    ..We assessed the cross-sectional associations of childhood characteristics with kidney size and function in a multi-ethnic cohort...
  56. doi Health in children: a conceptual framework for use in healthy ageing research
    Janine F Felix
    Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands Electronic address
    Maturitas 77:47-51. 2014
    ..The aim of this paper was to develop a conceptual framework for child health, which can be used as a starting point for healthy ageing research from a life course perspective...
  57. doi Blood pressure parameters and carotid intraplaque hemorrhage as measured by magnetic resonance imaging: The Rotterdam Study
    Mariana Selwaness
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 61:76-81. 2013
    ..The association between pulsatile flow and IPH may provide novel insights in the development of the vulnerable plaque...
  58. doi The Generation R Study: design and cohort update 2012
    Vincent W V Jaddoe
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 27:739-56. 2012
    ..Eventually, results forthcoming from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children...
  59. pmc Predicting survival and morbidity-free survival to very old age
    Rachel S Newson
    Department of Epidemiology, Erasmus University Medical Centre, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Age (Dordr) 32:521-34. 2010
    ....
  60. doi The association between vasomotor symptoms and metabolic health in peri- and postmenopausal women: a systematic review
    Gabriella M van Dijk
    Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands
    Maturitas 80:140-7. 2015
    ..These findings suggest that there is an association between vasomotor symptoms and metabolic health outcomes. To confirm this and to strengthen the evidence, more high quality longitudinal research on this topic is needed. ..
  61. doi Anthropometric measures in cardiovascular disease prediction: comparison of laboratory-based versus non-laboratory-based model
    Klodian Dhana
    Department of Epidemiology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Heart 101:377-83. 2015
    ..We aimed to find the most predictive anthropometric measure for CVD risk to construct a non-laboratory-based model and to compare it with the model including laboratory measurements...
  62. doi Infant feeding patterns are associated with cardiovascular structures and function in childhood
    Layla L de Jonge
    The Generation R Study Group, Erasmus Medical Center, Rotterdam, The Netherlands
    J Nutr 143:1959-65. 2013
    ..Further research is required to replicate these findings and to investigate whether these changes contribute to an increased risk of cardiovascular disease in later life. ..
  63. pmc The Rotterdam Study: 2012 objectives and design update
    Albert Hofman
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Epidemiol 26:657-86. 2011
    ..erasmus-epidemiology.nl/rotterdamstudy ). This article gives the rationale of the study and its design. It also presents a summary of the major findings and an update of the objectives and methods...
  64. doi Effects of lifestyle-related interventions on blood pressure in low and middle-income countries: systematic review and meta-analysis
    Cristina P Baena
    aDepartment of Epidemiology, Erasmus MC, University Medical Center Rotterdam, The Netherlands bPontifical University of ParanĂ¡, School of Medicine, Curitiba, Brazil cDepartment of Cardiology dDepartment of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, The Netherlands eDepartment of Epidemiology and Preventive Medicine, Faculty of Medicine, Nursing and Health Sciences, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia fDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK Both authors contributed equally to this manuscript
    J Hypertens 32:961-73. 2014
    ..Nevertheless, the overall quality and sample size of the studies included were low. Improvements in the size and quality of studies evaluating lifestyle interventions are required...
  65. doi Nutrition and healthy ageing: the key ingredients
    Jessica C Kiefte-de Jong
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Proc Nutr Soc 73:249-59. 2014
    ....
  66. pmc Combined impact of lifestyle factors on mortality: prospective cohort study in US women
    Rob M van Dam
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    BMJ 337:a1440. 2008
    ..To evaluate the impact of combinations of lifestyle factors on mortality in middle aged women...
  67. pmc Dietary patterns and risk of mortality from cardiovascular disease, cancer, and all causes in a prospective cohort of women
    Christin Heidemann
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02215, USA
    Circulation 118:230-7. 2008
    ..The impact of overall dietary patterns that reflect actual eating behaviors on mortality caused by cardiovascular or other chronic diseases is largely unknown...
  68. ncbi Dietary nutrient intakes and skin-aging appearance among middle-aged American women
    Maeve C Cosgrove
    Corporate Research, Unilever Colworth Park, Bedford, United Kingdom
    Am J Clin Nutr 86:1225-31. 2007
    ..Nutritional factors play a key role in normal dermatologic functioning. However, little is known about the effects of diet on skin-aging appearance...
  69. pmc Ten commandments for the future of ageing research in the UK: a vision for action
    Oscar H Franco
    BMC Geriatr 7:10. 2007
    ....
  70. ncbi Prevalence and geographic disparity of depressive symptoms among middle-aged and elderly in China
    An Pan
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Affect Disord 105:167-75. 2008
    ..To evaluate the prevalence of and risk factors for depressive symptoms among middle-aged and elderly Chinese in northern and southern China...
  71. ncbi Distributions of C-reactive protein and its association with metabolic syndrome in middle-aged and older Chinese people
    Xingwang Ye
    Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Am Coll Cardiol 49:1798-805. 2007
    ..We evaluated the distributions of C-reactive protein (CRP) and its association with metabolic syndrome (MetS) in middle-aged and older Chinese people...
  72. ncbi Higher dietary intake of lignans is associated with better cognitive performance in postmenopausal women
    Oscar H Franco
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    J Nutr 135:1190-5. 2005
    ..02 (1.11-3.71)]. Isoflavone intake was not related to cognitive function. From our results we conclude that higher dietary intake of lignans is associated with better cognitive function in postmenopausal women...
  73. ncbi Insulin resistance and depressive symptoms in middle-aged and elderly Chinese: findings from the Nutrition and Health of Aging Population in China Study
    An Pan
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai, China
    J Affect Disord 109:75-82. 2008
    ..Nevertheless, only a few studies have explored the association between insulin resistance and depression with contradictory results, and none have been conducted in Chinese populations...
  74. ncbi Elevated retinol-binding protein 4 levels are associated with metabolic syndrome in Chinese people
    Qibin Qi
    Key Laboratory of Systems Biology, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Graduate School of the Chinese Academy of Sciences, Shanghai 200031, China
    J Clin Endocrinol Metab 92:4827-34. 2007
    ..High retinol-binding protein 4 (RBP4) is thought to be associated with insulin resistance in humans. However, evidence from large-scale populations about the relationship between RBP4 and metabolic diseases is scarce...