P L A Fraaij

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Viral shedding and susceptibility to oseltamivir in hospitalized immunocompromised patients with influenza in the Influenza Resistance Information Study (IRIS)
    Pieter L Fraaij
    Viroscience, Erasmus MC, Rotterdam, The Netherlands
    Antivir Ther 20:633-42. 2015
  2. pmc Plasma concentrations of oseltamivir and oseltamivir carboxylate in critically ill children on extracorporeal membrane oxygenation support
    Enno D Wildschut
    Intensive Care and Department of Paediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    PLoS ONE 5:e10938. 2010
  3. pmc Evaluation of the antiviral response to zanamivir administered intravenously for treatment of critically ill patients with pandemic influenza A (H1N1) infection
    P L A Fraaij
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 204:777-82. 2011
  4. ncbi request reprint ['Acute respiratory distress syndrome' (ARDS) as a serious complication of influenza]
    Pieter L A Fraaij
    Erasmus MC Sophia, Afd Kinder intensive Care, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1640. 2010
  5. pmc Indinavir/low-dose ritonavir containing HAART in HIV-1 infected children has potent antiretroviral activity, but is associated with side effects and frequent discontinuation of treatment
    P L A Fraaij
    Dept of Pediatrics, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Infection 35:186-9. 2007
  6. ncbi request reprint ['Acute respiratory distress syndrome' (ARDS) as a serious complication of influenza]
    Pieter L A Fraaij
    Erasmus MC Sophia, Afd Kinder intensive Care, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 153:A1640. 2009
  7. doi request reprint Seasonal influenza: the burden of disease in children
    Pieter L A Fraaij
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    Vaccine 29:7524-8. 2011
  8. ncbi request reprint Changes in indinavir exposure over time: a case study in six HIV-1-infected children
    P L A Fraaij
    Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Antimicrob Chemother 52:727-30. 2003
  9. doi request reprint Human bocavirus infection as a cause of severe acute respiratory tract infection in children
    F M Moesker
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    Clin Microbiol Infect 21:964.e1-8. 2015
  10. pmc Pharmacokinetics of indinavir combined with low-dose ritonavir in human immunodeficiency virus type 1-infected children
    A S Bergshoeff
    University Medical Center, Department of Clinical Pharmacy, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:1904-7. 2004

Collaborators

  • D M Burger
  • M Schutten
  • Terho Heikkinen
  • F M Moesker
  • Enno D Wildschut
  • A M C van Rossum
  • A S Bergshoeff
  • J J A van Kampen
  • S L Smits
  • A D M E Osterhaus
  • M de Hoog
  • A A van der Eijk
  • R Bodewes
  • Maurice J Ahsman
  • Matthijs de Hoog
  • Albert D M E Osterhaus
  • Dick Tibboel
  • B Y T Nguyen
  • G A Winchell
  • L H Wynne
  • R de Groot
  • G Verweel
  • R Y Leavitt

Detail Information

Publications10

  1. doi request reprint Viral shedding and susceptibility to oseltamivir in hospitalized immunocompromised patients with influenza in the Influenza Resistance Information Study (IRIS)
    Pieter L Fraaij
    Viroscience, Erasmus MC, Rotterdam, The Netherlands
    Antivir Ther 20:633-42. 2015
    ..This observational substudy of the Influenza Resistance Information Study (NCT00884117) aimed to study antiviral resistance in immunocompromised patients with influenza and characterize its effect on clinical and virological outcomes...
  2. pmc Plasma concentrations of oseltamivir and oseltamivir carboxylate in critically ill children on extracorporeal membrane oxygenation support
    Enno D Wildschut
    Intensive Care and Department of Paediatric Surgery, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    PLoS ONE 5:e10938. 2010
    ..To evaluate the effect of extracorporeal membrane oxygenation (ECMO) support on pharmacokinetics of oseltamivir and oseltamivir carboxylate (OC) in children...
  3. pmc Evaluation of the antiviral response to zanamivir administered intravenously for treatment of critically ill patients with pandemic influenza A (H1N1) infection
    P L A Fraaij
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Infect Dis 204:777-82. 2011
    ..We conclude that IV zanamivir as late add-on therapy has limited effectiveness. The effect of an immediate start with IV zanamivir monotherapy or in combination with other drugs need to be evaluated...
  4. ncbi request reprint ['Acute respiratory distress syndrome' (ARDS) as a serious complication of influenza]
    Pieter L A Fraaij
    Erasmus MC Sophia, Afd Kinder intensive Care, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1640. 2010
    ..The first two patients eventually recovered following treatment with extracorporeal membrane oxygenation (ECMO), but the third patient's condition was too unstable for transfer to an ECMO centre. This patient died...
  5. pmc Indinavir/low-dose ritonavir containing HAART in HIV-1 infected children has potent antiretroviral activity, but is associated with side effects and frequent discontinuation of treatment
    P L A Fraaij
    Dept of Pediatrics, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Infection 35:186-9. 2007
    ..Although this q12h HAART regimen had potent antiretroviral activity, it was frequently associated with side effects and discontinuation of therapy...
  6. ncbi request reprint ['Acute respiratory distress syndrome' (ARDS) as a serious complication of influenza]
    Pieter L A Fraaij
    Erasmus MC Sophia, Afd Kinder intensive Care, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 153:A1640. 2009
    ..The first two patients eventually recovered following treatment with extracorporeal membrane oxygenation (ECMO), but the third patient's condition was too unstable for transfer to an ECMO centre. This patient died...
  7. doi request reprint Seasonal influenza: the burden of disease in children
    Pieter L A Fraaij
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    Vaccine 29:7524-8. 2011
    ..The bulk of the influenza-related disease burden is experienced in the outpatient setting. This results in sometimes very high consultation rates, frequent complications, and substantial parental work absenteeism...
  8. ncbi request reprint Changes in indinavir exposure over time: a case study in six HIV-1-infected children
    P L A Fraaij
    Department of Pediatrics, Erasmus MC Sophia Children s Hospital, Rotterdam, The Netherlands
    J Antimicrob Chemother 52:727-30. 2003
    ..To study changes in indinavir exposure over time in HIV-1-infected children...
  9. doi request reprint Human bocavirus infection as a cause of severe acute respiratory tract infection in children
    F M Moesker
    Department of Viroscience, Erasmus MC, Rotterdam, The Netherlands
    Clin Microbiol Infect 21:964.e1-8. 2015
    ..We identified 14 RSV-infected SARI patients with a single RSV infection (14/72, 19%). We conclude that our study provides strong support that HBoV can cause SARI in children in the absence of viral and bacterial co-infections...
  10. pmc Pharmacokinetics of indinavir combined with low-dose ritonavir in human immunodeficiency virus type 1-infected children
    A S Bergshoeff
    University Medical Center, Department of Clinical Pharmacy, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:1904-7. 2004
    ..1 (0.87 to 1.3), 0.96 (0.60 to 1.5), and 0.80 (0.68 to 0.94), respectively...