P L A Fraaij

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Indinavir/low-dose ritonavir containing HAART in HIV-1 infected children has potent antiretroviral activity, but is associated with side effects and frequent discontinuation of treatment
    P L A Fraaij
    Dept of Pediatrics, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Infection 35:186-9. 2007
  2. ncbi ['Acute respiratory distress syndrome' (ARDS) as a serious complication of influenza]
    Pieter L A Fraaij
    Erasmus MC Sophia, Afd Kinder intensive Care, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 153:A1640. 2009
  3. ncbi ['Acute respiratory distress syndrome' (ARDS) as a serious complication of influenza]
    Pieter L A Fraaij
    Erasmus MC Sophia, Afd Kinder intensive Care, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1640. 2010
  4. ncbi Seasonal influenza: the burden of disease in children
    Pieter L A Fraaij
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    Vaccine 29:7524-8. 2011
  5. ncbi Changes in indinavir exposure over time: a case study in six HIV-1-infected children
    P L A Fraaij
    Department of Pediatrics, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands
    J Antimicrob Chemother 52:727-30. 2003
  6. ncbi Pharmacokinetics of indinavir combined with low-dose ritonavir in human immunodeficiency virus type 1-infected children
    A S Bergshoeff
    University Medical Center, Department of Clinical Pharmacy, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:1904-7. 2004

Collaborators

Detail Information

Publications6

  1. ncbi Indinavir/low-dose ritonavir containing HAART in HIV-1 infected children has potent antiretroviral activity, but is associated with side effects and frequent discontinuation of treatment
    P L A Fraaij
    Dept of Pediatrics, Erasmus MC Sophia Children s Hospital, Dr Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands
    Infection 35:186-9. 2007
    ..Although this q12h HAART regimen had potent antiretroviral activity, it was frequently associated with side effects and discontinuation of therapy...
  2. ncbi ['Acute respiratory distress syndrome' (ARDS) as a serious complication of influenza]
    Pieter L A Fraaij
    Erasmus MC Sophia, Afd Kinder intensive Care, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 153:A1640. 2009
    ..The first two patients eventually recovered following treatment with extracorporeal membrane oxygenation (ECMO), but the third patient's condition was too unstable for transfer to an ECMO centre. This patient died...
  3. ncbi ['Acute respiratory distress syndrome' (ARDS) as a serious complication of influenza]
    Pieter L A Fraaij
    Erasmus MC Sophia, Afd Kinder intensive Care, Rotterdam, The Netherlands
    Ned Tijdschr Geneeskd 154:A1640. 2010
    ..The first two patients eventually recovered following treatment with extracorporeal membrane oxygenation (ECMO), but the third patient's condition was too unstable for transfer to an ECMO centre. This patient died...
  4. ncbi Seasonal influenza: the burden of disease in children
    Pieter L A Fraaij
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    Vaccine 29:7524-8. 2011
    ..The bulk of the influenza-related disease burden is experienced in the outpatient setting. This results in sometimes very high consultation rates, frequent complications, and substantial parental work absenteeism...
  5. ncbi Changes in indinavir exposure over time: a case study in six HIV-1-infected children
    P L A Fraaij
    Department of Pediatrics, Erasmus MC/Sophia Children's Hospital, Rotterdam, The Netherlands
    J Antimicrob Chemother 52:727-30. 2003
    ..In two patients, decreased indinavir exposure was associated with virological failure. Therapeutic drug monitoring should be carried out over time since this may prevent subtherapeutic dosing in children...
  6. ncbi Pharmacokinetics of indinavir combined with low-dose ritonavir in human immunodeficiency virus type 1-infected children
    A S Bergshoeff
    University Medical Center, Department of Clinical Pharmacy, Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands
    Antimicrob Agents Chemother 48:1904-7. 2004
    ..1 (0.87 to 1.3), 0.96 (0.60 to 1.5), and 0.80 (0.68 to 0.94), respectively...