Ron A M Fouchier

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. Linster M, Schrauwen E, van der Vliet S, Burke D, Lexmond P, Bestebroer T, et al. The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses. J Virol. 2019;93: pubmed publisher
    ..This study adds to our understanding of virus evolution with respect to antigenic variability, rates of virus evolution, and potential escape mutants of A/H2N2. ..
  2. Fouchier R, Schneeberger P, Rozendaal F, Broekman J, Kemink S, Munster V, et al. Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. Proc Natl Acad Sci U S A. 2004;101:1356-61 pubmed
    ..Because H7N7 viruses have caused disease in mammals, including horses, seals, and humans, on several occasions in the past, they may be unusual in their zoonotic potential and, thus, form a pandemic threat to humans. ..
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    Fouchier R, Rimmelzwaan G, Kuiken T, Osterhaus A. Newer respiratory virus infections: human metapneumovirus, avian influenza virus, and human coronaviruses. Curr Opin Infect Dis. 2005;18:141-6 pubmed
    ..Previously unknown and emerging respiratory viruses are an important threat to human health. Development of virus diagnostic tests, antiviral strategies, and vaccines for each of these pathogens is crucial to limit their impact. ..
  4. Richard M, Fouchier R. H10N8 and H6N1 maintain avian receptor binding. Cell Host Microbe. 2015;17:292-294 pubmed publisher
    ..2015) describe crystal structures and receptor-binding properties of hemagglutinins of avian-origin H10N8 and H6N1 influenza viruses. Human infections with these viruses are not associated with a switch favoring human receptor binding. ..
  5. Buijs P, van Nieuwkoop S, Vaes V, Fouchier R, van Eijck C, van den Hoogen B. Recombinant Immunomodulating Lentogenic or Mesogenic Oncolytic Newcastle Disease Virus for Treatment of Pancreatic Adenocarcinoma. Viruses. 2015;7:2980-98 pubmed publisher
    ..We conclude that although lentogenic rNDVs harboring proteins that modulate the type I interferon pathway proteins do have an oncolytic effect, a more virulent mesogenic rNDV might be needed to improve oncolytic efficacy. ..
  6. Richard M, Fouchier R. Influenza A virus transmission via respiratory aerosols or droplets as it relates to pandemic potential. FEMS Microbiol Rev. 2016;40:68-85 pubmed publisher
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    Fouchier R, Smith D. Use of antigenic cartography in vaccine seed strain selection. Avian Dis. 2010;54:220-3 pubmed
    ..Considerable antigenic variation was also observed within and between H5N1 clades. These observations have important implications for the efficacy and long-term use of poultry vaccines. ..
  8. Couzens L, Gao J, Westgeest K, Sandbulte M, Lugovtsev V, Fouchier R, et al. An optimized enzyme-linked lectin assay to measure influenza A virus neuraminidase inhibition antibody titers in human sera. J Virol Methods. 2014;210:7-14 pubmed publisher
    ..The ELLA described in this report provides a practical format for routine evaluation of human antibody responses to NA. ..
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    Fouchier R, Munster V. Epidemiology of low pathogenic avian influenza viruses in wild birds. Rev Sci Tech. 2009;28:49-58 pubmed
    ..Here, the authors review the current knowledge of the (molecular) epidemiology, genetics and evolution of LPAI viruses in wild birds, and identify some important gaps in current knowledge. ..

More Information

Publications11

  1. Linster M, van Boheemen S, de Graaf M, Schrauwen E, Lexmond P, Mänz B, et al. Identification, characterization, and natural selection of mutations driving airborne transmission of A/H5N1 virus. Cell. 2014;157:329-339 pubmed publisher
  2. Mänz B, de Graaf M, Mögling R, Richard M, Bestebroer T, Rimmelzwaan G, et al. Multiple Natural Substitutions in Avian Influenza A Virus PB2 Facilitate Efficient Replication in Human Cells. J Virol. 2016;90:5928-5938 pubmed publisher
    ..Here, we show that substantial numbers of amino acid substitutions are functionally compensating for the lack of the above-mentioned mutations in PB2 and could facilitate influenza virus emergence in humans. ..