Wytske J Fokkens

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi request reprint Thoughts on the pathophysiology of nonallergic rhinitis
    Wytske J Fokkens
    Department of Otorhinolaryngology, Erasmus Medical Centre Rotterdam, Dr Molewaterplein 40, 3015 GD, The Netherlands
    Curr Allergy Asthma Rep 2:203-9. 2002
  2. ncbi request reprint Budesonide aqueous nasal spray is an effective treatment in children with perennial allergic rhinitis, with an onset of action within 12 hours
    Wytske J Fokkens
    Department of Otorhinolaryngology, Erasmus University Hospital Rotterdam, The Netherlands
    Ann Allergy Asthma Immunol 89:279-84. 2002
  3. ncbi request reprint The mold conundrum in chronic hyperplastic sinusitis
    Fenna A Ebbens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 9:114-20. 2009
  4. doi request reprint Fungus: a role in pathophysiology of chronic rhinosinusitis, disease modifier, a treatment target, or no role at all?
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center AMC, Meibergdreef 9, 1100 AZ Amsterdam, The Netherlands
    Immunol Allergy Clin North Am 29:677-88. 2009
  5. doi request reprint Fungus as the cause of chronic rhinosinusitis: the case remains unproven
    Fenna A Ebbens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Otolaryngol Head Neck Surg 17:43-9. 2009
  6. doi request reprint Disease-specific quality-of-life questionnaires in rhinitis and rhinosinusitis: review and evaluation
    Dirk A E Dietz de Loos
    Department of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 13:162-70. 2013
  7. doi request reprint Role of fungi in pathogenesis of chronic rhinosinusitis: the hypothesis rejected
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
    Curr Opin Otolaryngol Head Neck Surg 20:19-23. 2012
  8. pmc Role of innate immunity in the pathogenesis of chronic rhinosinusitis: progress and new avenues
    Cornelis M van Drunen
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 12:120-6. 2012
  9. doi request reprint No mucosal atrophy and reduced inflammatory cells: active-controlled trial with yearlong fluticasone furoate nasal spray
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Rhinol Allergy 26:36-44. 2012
  10. doi request reprint EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012

Detail Information

Publications26

  1. ncbi request reprint Thoughts on the pathophysiology of nonallergic rhinitis
    Wytske J Fokkens
    Department of Otorhinolaryngology, Erasmus Medical Centre Rotterdam, Dr Molewaterplein 40, 3015 GD, The Netherlands
    Curr Allergy Asthma Rep 2:203-9. 2002
    ..This review discusses the possible pathophysicologic mechanisms of nonallergic noninfectious rhinitis, with emphasis on idiopathic rhinitis...
  2. ncbi request reprint Budesonide aqueous nasal spray is an effective treatment in children with perennial allergic rhinitis, with an onset of action within 12 hours
    Wytske J Fokkens
    Department of Otorhinolaryngology, Erasmus University Hospital Rotterdam, The Netherlands
    Ann Allergy Asthma Immunol 89:279-84. 2002
    ..Budesonide aqueous nasal spray is a topical corticosteroid which at doses of 64 to 256 microg once daily has been found to be effective in the treatment of seasonal allergic rhinitis in adults and children...
  3. ncbi request reprint The mold conundrum in chronic hyperplastic sinusitis
    Fenna A Ebbens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 9:114-20. 2009
    ..However, in the absence of convincing immunologic data and evidence of clinical improvement of CRS after antifungal therapy, the case against the fungus remains unproven...
  4. doi request reprint Fungus: a role in pathophysiology of chronic rhinosinusitis, disease modifier, a treatment target, or no role at all?
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center AMC, Meibergdreef 9, 1100 AZ Amsterdam, The Netherlands
    Immunol Allergy Clin North Am 29:677-88. 2009
    ..There are not many arguments to suggest a causative role for fungi in CRS with or without nasal polyps. However, due to the intrinsic or induced change in immunity of CRS patients, fungi might have a disease-modifying role...
  5. doi request reprint Fungus as the cause of chronic rhinosinusitis: the case remains unproven
    Fenna A Ebbens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Opin Otolaryngol Head Neck Surg 17:43-9. 2009
    ..To review the literature on the role of fungi in chronic rhinosinusitis (CRS) pathogenesis and the effect of antifungal drug therapy and antifungal immunotherapy...
  6. doi request reprint Disease-specific quality-of-life questionnaires in rhinitis and rhinosinusitis: review and evaluation
    Dirk A E Dietz de Loos
    Department of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 13:162-70. 2013
    ..It is important, especially in research, to realize that disease-specific questionnaires are only validated for specific diseases and are not automatically valid for other diseases...
  7. doi request reprint Role of fungi in pathogenesis of chronic rhinosinusitis: the hypothesis rejected
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Centre, Amsterdam, The Netherlands
    Curr Opin Otolaryngol Head Neck Surg 20:19-23. 2012
    ..This review describes the recent knowledge concerning the role of fungi in the pathogenesis of CRS and allergic fungal rhinosinusitis (AFRS) and the clinical implications for treatment...
  8. pmc Role of innate immunity in the pathogenesis of chronic rhinosinusitis: progress and new avenues
    Cornelis M van Drunen
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 12:120-6. 2012
    ..New players that could play a role in the pathophysiology seem to surface at regular intervals, adding to our understanding (and the complexity) of the disease and opening new avenues that may help fight this incapacitating disease...
  9. doi request reprint No mucosal atrophy and reduced inflammatory cells: active-controlled trial with yearlong fluticasone furoate nasal spray
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Rhinol Allergy 26:36-44. 2012
    ..Effects of FFNS on the nasal histology have not been previously reported. This study examines the effects of FFNS and MFNS, administered daily for 1 year, on the nasal mucosa in subjects with perennial allergic rhinitis...
  10. doi request reprint EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists
    Wytske J Fokkens
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Rhinology 50:1-12. 2012
    ..This executive summary for otorhinolaryngologists focuses on the most important changes and issues for otorhinolaryngologists. The full document can be downloaded for free on the website of this journal: http://www.rhinologyjournal.com...
  11. doi request reprint Symptoms in chronic rhinosinusitis with and without nasal polyps
    Dirk A E Dietz de Loos
    Department of Otorhinolaryngology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Laryngoscope 123:57-63. 2013
    ..We wanted to know if it is possible to make an accurate distinction between patients with and without nasal polyps based on clinical impression...
  12. doi request reprint Inflammation in chronic rhinosinusitis and nasal polyposis
    Cornelis M van Drunen
    Department of Otorhinolaryngology, Academic Medical Center, Room L3 104 2, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Immunol Allergy Clin North Am 29:621-9. 2009
    ..This article summarizes current understanding, and discusses opportunities and potential pitfalls of inflammation-related research...
  13. ncbi request reprint Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis
    Fenna A Ebbens
    Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
    J Allergy Clin Immunol 118:1149-56. 2006
    ..On the basis of this hypothesis, intranasal treatment with amphotericin B should benefit patients with CRS. Data from 2 uncontrolled and 2 controlled trials are conflicting, however...
  14. ncbi request reprint The mold conundrum in chronic rhinosinusitis: where do we stand today?
    Fenna A Ebbens
    Department of Otorhinolaryngology, Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Curr Allergy Asthma Rep 8:93-101. 2008
    ..In the absence of convincing immunologic data and evidence of clinical improvement upon therapy with antifungal agents, the case against fungi remains unproven...
  15. doi request reprint Olfactory function in healthy children: normative data for odor identification
    Erik van Spronsen
    Department of Otorhinolaryngology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Rhinol Allergy 27:197-201. 2013
    ..Therefore, this study aimed to provide normative data in children and to determine possible parameters that influence odor identification test outcome...
  16. ncbi request reprint Treatment of nasal polyposis and chronic rhinosinusitis with fluticasone propionate nasal drops reduces need for sinus surgery
    Albertien A C Aukema
    Department of Otorhinolaryngology, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Allergy Clin Immunol 115:1017-23. 2005
    ..Oral steroids have considerable systemic side effects, and nasal sprays do not sufficiently reach the middle meatus, where polyps originate. Nasal drops might be a more useful formula to deliver steroids into the middle meatus...
  17. ncbi request reprint Influence of anatomy and head position on intranasal drug deposition
    Paul Merkus
    Department of Otorhinolaryngology and Head and Neck Surgery, VU University Medical Center, KNO 1D 116, P O Box 7057, 1007 MB, Amsterdam, The Netherlands
    Eur Arch Otorhinolaryngol 263:827-32. 2006
    ..Although results are preliminary, we conclude that anatomy and head position are important factors in the deposition of topical nasal drugs and may be the key to improving individual local nasal (steroid) treatment...
  18. ncbi request reprint Chronic rhinosinusitis: management for optimal outcomes
    Albertien A C Aukema
    Ear, Nose and Throat Department, Erasmus MC, Rotterdam, The Netherlands
    Treat Respir Med 3:97-105. 2004
    ..In the case of nasal polyposis surgery is more aggressive involving removal of the diseased polypous mucosa. It is recommended that medical treatment should be continued post sinus surgery...
  19. ncbi request reprint Objective computerized determination of the minimum cross-sectional area of the nasal passage on computed tomography
    Niels H Bakker
    Department of Man Machine Systems, Delft University of Technology, The Netherlands
    Laryngoscope 115:1809-12. 2005
    ..Objective measurement of the dimensions of the nasal passage may help in the diagnosis, as well as the choice and evaluation of surgical treatment for upper airway insufficiencies...
  20. ncbi request reprint Nasal airflow measurements: present and future
    Wytske J Fokkens
    Rhinology 44:1. 2006
  21. ncbi request reprint Repetitive endoscopic sinus surgery failure: a role for radical surgery?
    Ward J M Videler
    Department of Otorhinolaryngology Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Otolaryngol Head Neck Surg 134:586-91. 2006
    ..Radical surgery aimed at reduction of the inflammatory burden and optimization of drainage of the sinuses has been suggested as a last resort for these patients...
  22. ncbi request reprint Rhinosinusitis: Developing guidance for clinical trials
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center Department of Pediatrics, University of California, San Diego, San Diego, California
    Otolaryngol Head Neck Surg 135:S31-80. 2006
    ....
  23. ncbi request reprint Rhinosinusitis: developing guidance for clinical trials
    Eli O Meltzer
    Allergy and Asthma Medical Group and Research Center and Department of Pediatrics, University of California, San Diego, USA
    J Allergy Clin Immunol 118:S17-61. 2006
    ....
  24. ncbi request reprint Reconstructive surgery of the leprosy nose: a new approach
    Dirk Jan Menger
    Department of Otorhinolaryngology Head and Neck Surgery, Center for Facial Plastic and Reconstructive Surgery, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
    J Plast Reconstr Aesthet Surg 60:152-62. 2007
    ..The preoperative grade of severity was used as a basis for the development of guidelines for optimal long-term functional and aesthetic outcome...
  25. ncbi request reprint Radical surgery: effect on quality of life and pain in chronic rhinosinusitis
    Ward J M Videler
    Department of Otorhinolaryngology Head and Neck Surgery, Academic Medical Center, Amsterdam, The Netherlands
    Otolaryngol Head Neck Surg 136:261-7. 2007
    ..This study evaluates the effect of radical surgery on quality of life and pain in these patients with recalcitrant disease...
  26. ncbi request reprint Immuno-histological analysis of dendritic cells in nasal biopsies of IgA nephropathy patients
    Jan Willem Eijgenraam
    Department of Nephrology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA Leiden, The Netherlands
    Nephrol Dial Transplant 23:612-20. 2008
    ..Here, we investigated whether this IgA hyporesponse in IgAN patients can be explained by reduced numbers or altered subset distribution of dendritic cells (DCs) in nasal mucosa...