Riccardo Fodde

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation
    Yaser Atlasi
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS Genet 9:e1003424. 2013
  2. pmc Identification of quiescent, stem-like cells in the distal female reproductive tract
    Yongyi Wang
    Department of Obstetrics and Gynecology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 7:e40691. 2012
  3. pmc Paneth cells in intestinal homeostasis and tissue injury
    Sabrina Roth
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 7:e38965. 2012
  4. pmc Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness
    N H Le
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Erasmus MC, Rotterdam, The Netherlands
    Br J Cancer 98:1886-93. 2008
  5. pmc Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors
    Razvan L Miclea
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    BMC Dev Biol 9:26. 2009
  6. ncbi request reprint Wnt/beta-catenin signaling in cancer stemness and malignant behavior
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Opin Cell Biol 19:150-8. 2007
  7. pmc Smad4 haploinsufficiency: a matter of dosage
    Paola Alberici
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Pathogenetics 1:2. 2008
  8. ncbi request reprint Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    J Pathol 221:239-41. 2010
  9. pmc Stem cells and metastatic cancer: fatal attraction?
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Med 3:e482. 2006
  10. doi request reprint The stem of cancer
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer Cell 15:87-9. 2009

Collaborators

Detail Information

Publications42

  1. pmc Wnt signaling regulates the lineage differentiation potential of mouse embryonic stem cells through Tcf3 down-regulation
    Yaser Atlasi
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS Genet 9:e1003424. 2013
    ....
  2. pmc Identification of quiescent, stem-like cells in the distal female reproductive tract
    Yongyi Wang
    Department of Obstetrics and Gynecology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 7:e40691. 2012
    ..Future lineage-tracing studies will elucidate the role played by these cells in homeostasis, tissue injury and cancer of the female reproductive tract in the mouse and eventually in man...
  3. pmc Paneth cells in intestinal homeostasis and tissue injury
    Sabrina Roth
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 7:e38965. 2012
    ..Hence, they are likely to contribute to the regenerative process following tissue insults such as chronic inflammation...
  4. pmc Tumour-stroma interactions in colorectal cancer: converging on beta-catenin activation and cancer stemness
    N H Le
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, Erasmus MC, Rotterdam, The Netherlands
    Br J Cancer 98:1886-93. 2008
    ..As such, the tumour microenvironment is likely to maintain the cancer stem cell phenotype in a subset of cells, thus mediating invasion and metastasis...
  5. pmc Adenomatous polyposis coli-mediated control of beta-catenin is essential for both chondrogenic and osteogenic differentiation of skeletal precursors
    Razvan L Miclea
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, Enschede, The Netherlands
    BMC Dev Biol 9:26. 2009
    ..Adenomatous polyposis coli (Apc) is a key controller of beta-catenin turnover by down-regulating intracellular levels of beta-catenin...
  6. ncbi request reprint Wnt/beta-catenin signaling in cancer stemness and malignant behavior
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Opin Cell Biol 19:150-8. 2007
    ..Several intrinsic (cell-autonomous and/or autocrine) and extrinsic (paracrine, derived from the tumor microenvironment) factors may explain this heterogeneity of Wnt/beta-catenin signaling activity within the tumor mass...
  7. pmc Smad4 haploinsufficiency: a matter of dosage
    Paola Alberici
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Pathogenetics 1:2. 2008
    ..To date, the molecular and cellular consequences of SMAD4 haploinsufficiency on TGF-beta and BMP signaling and on genome-wide gene expression have not been investigated...
  8. ncbi request reprint Nuclear beta-catenin expression and Wnt signalling: in defence of the dogma
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    J Pathol 221:239-41. 2010
    ....
  9. pmc Stem cells and metastatic cancer: fatal attraction?
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS Med 3:e482. 2006
  10. doi request reprint The stem of cancer
    Riccardo Fodde
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer Cell 15:87-9. 2009
    ..Two recent publications provide experimental evidence that normal intestinal stem cells are the cells of origin of intestinal cancer in the mouse...
  11. pmc Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis
    Claudia Gaspar
    Dept of Pathology, Erasmus MC, PO Box 2040, 3000CA Rotterdam, The Netherlands
    Am J Pathol 172:1363-80. 2008
    ....
  12. doi request reprint Alterations in Wnt-β-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression
    Marten van der Zee
    Department of Obstetrics and Gynaecology, Erasmus MC University Medical Centre, Rotterdam, The Netherlands
    J Pathol 230:48-58. 2013
    ..These observations are indicative of the synergistic action between the Wnt-β-catenin and Pten signalling pathways in endometrial cancer onset and progression...
  13. ncbi request reprint Chromosomal instability in MYH- and APC-mutant adenomatous polyps
    Joana Cardoso
    Department of Pathology, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Cancer Res 66:2514-9. 2006
    ..The aneuploid changes detected at early stages of MYH-driven tumorigenesis may underlie accelerated tumor progression, increased cancer risk, and poor prognosis in MAP...
  14. pmc Cancer stemness in Apc- vs. Apc/KRAS-driven intestinal tumorigenesis
    Mehrnaz Ghazvini
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 8:e73872. 2013
    ..Overall, our results indicate that oncogenic KRAS activation in Apc-driven tumours results in the expansion of the CSCs compartment by increasing ®-catenin intracellular stabilization. ..
  15. pmc A targeted constitutive mutation in the APC tumor suppressor gene underlies mammary but not intestinal tumorigenesis
    Claudia Gaspar
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    PLoS Genet 5:e1000547. 2009
    ..The striking phenotype of Apc(+/1572T) mice suggests that specific dosages of Wnt/beta-catenin signaling activity differentially affect tissue homeostasis and initiate tumorigenesis in an organ-specific fashion...
  16. doi request reprint Loss of APC function in mesenchymal cells surrounding the Müllerian duct leads to myometrial defects in adult mice
    Yongyi Wang
    Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Mol Cell Endocrinol 341:48-54. 2011
    ....
  17. doi request reprint Quiescent stem cells in intestinal homeostasis and cancer
    Sabrina Roth
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Cell Commun Adhes 18:33-44. 2011
    ..Because of their infrequent cycling, quiescent CSCs are refractory to chemo- and radiotherapy and are likely to play a role in tumour dissemination, dormancy and recurrence...
  18. doi request reprint Cancer stemness in Wnt-driven mammary tumorigenesis
    Joana Monteiro
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC 3000 CA Rotterdam, The Netherlands and
    Carcinogenesis 35:2-13. 2014
    ..Overall, our data indicate that constitutive Wnt signaling activation affects self-renewal and differentiation of MaSCs leading to metaplasia and basal-like adenocarcinomas. ..
  19. pmc Aneuploidy arises at early stages of Apc-driven intestinal tumorigenesis and pinpoints conserved chromosomal loci of allelic imbalance between mouse and human
    Paola Alberici
    Department of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Am J Pathol 170:377-87. 2007
    ....
  20. doi request reprint Generation of a tightly regulated doxycycline-inducible model for studying mouse intestinal biology
    Sabrina Roth
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Genesis 47:7-13. 2009
    ..Thus, we have generated a novel doxycycline-inducible mouse model, providing a valuable tool to study the effect of different gene dosages on intestinal physiology and pathology...
  21. pmc Wnt/Β-catenin and sex hormone signaling in endometrial homeostasis and cancer
    Yongyi Wang
    Department of Obstetrics and Gynaecology, Josephine Nefkens Institute, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Oncotarget 1:674-84. 2010
    ..In case of enhanced or unopposed estrogen signaling, constitutive activation of Wnt/β-catenin signaling will trigger endometrial hyperplasia, which may develop further into endometrial cancer...
  22. ncbi request reprint APC dosage effects in tumorigenesis and stem cell differentiation
    Claudia Gaspar
    Dept of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, 3000 DR Rotterdam, The Netherlands
    Int J Dev Biol 48:377-86. 2004
    ..Hence, beta-catenin dosage-dependent effects may not only explain how a single pathway is involved in the development and homeostasis of different tissues, but also its pleiotrophic role in tumorigenesis...
  23. doi request reprint Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers
    Brechtje A Grotenhuis
    Department of Surgery, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Pathol 221:379-89. 2010
    ..However, antibodies directed against novel surface antigens are needed to detect subpopulations enriched for CSCs in EA by transplantation assays...
  24. ncbi request reprint Cancer stem cells and metastasis
    Katia Sampieri
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Semin Cancer Biol 22:187-93. 2012
    ..Nevertheless, several studies have already provided pre-clinical evidence of the efficacy of novel therapies directed against disseminated CSCs...
  25. pmc Genomic profiling by DNA amplification of laser capture microdissected tissues and array CGH
    Joana Cardoso
    Department of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Nucleic Acids Res 32:e146. 2004
    ....
  26. pmc Generation and characterization of an inducible transgenic model for studying mouse esophageal biology
    Sabrina Roth
    Department of Pathology, Josephine Nefkens Institute, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    BMC Dev Biol 12:18. 2012
    ..To this aim, we developed and studied a mouse model to allow labeling of esophageal cells with the histone 2B-GFP (H2B-GFP) fusion protein...
  27. pmc β-catenin tyrosine 654 phosphorylation increases Wnt signalling and intestinal tumorigenesis
    Wendy Van Veelen
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Centre, room L 63, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Gut 60:1204-12. 2011
    ..In addition, in contrast to the current belief that β-catenin Y654 phosphorylation increases tumour progression to a more invasive phenotype, these results show that it rather increases tumour initiation by enhancing Wnt signalling...
  28. doi request reprint Progesterone inhibition of Wnt/beta-catenin signaling in normal endometrium and endometrial cancer
    Yongyi Wang
    Department of Obstetrics and Gynecology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Clin Cancer Res 15:5784-93. 2009
    ....
  29. doi request reprint Proximal fluid proteome profiling of mouse colon tumors reveals biomarkers for early diagnosis of human colorectal cancer
    Remond J A Fijneman
    Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands
    Clin Cancer Res 18:2613-24. 2012
    ..Early detection of colorectal cancer (CRC) and its precursor lesions is an effective approach to reduce CRC mortality rates. This study aimed to identify novel protein biomarkers for the early diagnosis of CRC...
  30. doi request reprint Cancer stemness and metastasis: therapeutic consequences and perspectives
    Joana Monteiro
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Eur J Cancer 46:1198-203. 2010
    ....
  31. ncbi request reprint Role of CLASP2 in microtubule stabilization and the regulation of persistent motility
    Ksenija Drabek
    Department of Cell Biology and Genetics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Curr Biol 16:2259-64. 2006
    ..Our results suggest that the regional immobilization of CLASP2 allows MT stabilization and promotes directionally persistent motility in fibroblasts...
  32. doi request reprint Cancer stem cells, pluripotency, and cellular heterogeneity: a WNTer perspective
    Yaser Atlasi
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Curr Top Dev Biol 107:373-404. 2014
    ....
  33. ncbi request reprint Morphological changes in tumour type after radiotherapy are accompanied by changes in gene expression profile but not in clinical behaviour
    Iris Nagtegaal
    Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    J Pathol 204:183-92. 2004
    ..It is concluded that tumour morphology equates to expression profile, but that external factors might influence both, leading to sub-optimal prognostication...
  34. ncbi request reprint Cancer biology. A matter of dosage
    Riccardo Fodde
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, Netherlands
    Science 298:761-3. 2002
  35. ncbi request reprint Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling
    Menno F Kielman
    Center for Human and Clinical Genetics, Leiden University Medical Center, Sylvius Laboratory, Wassenaarseweg 72, 2333 RA Leiden, The Netherlands
    Nat Genet 32:594-605. 2002
    ..Our results imply that constitutive activation of the Apc/beta-catenin signaling pathway results in differentiation defects in tissue homeostasis, and possibly underlies tumorigenesis in the colon and other self-renewing tissues...
  36. ncbi request reprint Serrated adenomas and mixed polyposis caused by a splice acceptor deletion in the mouse Smad4 gene
    Peter Hohenstein
    Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 36:273-82. 2003
    ..Identification of a Smad4 mutation in the Sad mouse model provides further support for the involvement of the Smad genes, and thus the TGFB pathway, in the serrated/hyperplastic route to colorectal cancer...
  37. ncbi request reprint Premature chromosome condensation revisited: a novel chemical approach permits efficient cytogenetic analysis of cancers
    Vladimir Bezrookove
    Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands
    Genes Chromosomes Cancer 38:177-86. 2003
    ....
  38. ncbi request reprint Cancer risk in hereditary nonpolyposis colorectal cancer due to MSH6 mutations: impact on counseling and surveillance
    Yvonne M C Hendriks
    Center of Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Gastroenterology 127:17-25. 2004
    ..Hereditary nonpolyposis colorectal carcinoma (HNPCC) is caused by a mutated mismatch repair (MMR) gene. The aim of our study was to determine the cumulative risk of developing cancer in a large series of MSH6 mutation carriers...
  39. pmc SET-CAN, the product of the t(9;9) in acute undifferentiated leukemia, causes expansion of early hematopoietic progenitors and hyperproliferation of stomach mucosa in transgenic mice
    Ugur Ozbek
    Department of Genetics and Tumor Cell Biology, St Jude Children s Research Hospital, Memphis, Tennessee 38105, USA
    Am J Pathol 171:654-66. 2007
    ....
  40. ncbi request reprint The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade
    Cristina Albuquerque
    Centro de Investigacao de Patobiologia Molecular CIPM, Instituto Portugues de Oncologia Francisco Gentil, 1093 Lisbon, Portugal
    Hum Mol Genet 11:1549-60. 2002
    ..We propose that this selection process is aimed at a specific degree of beta-catenin signaling optimal for tumor formation, rather than at its constitutive activation by deletion of all of the beta-catenin downregulating motifs in APC...
  41. ncbi request reprint Somatic acquisition and signaling of TGFBR1*6A in cancer
    Boris Pasche
    Cancer Genetics Program, Division of Hematology Oncology, Department of Medicine, The Feinberg School of Medicine, Northwestern, University, Chicago, Ill 60611, USA
    JAMA 294:1634-46. 2005
    ..Epidemiological studies suggest that TGFBR1*6A may act as a tumor susceptibility allele. How TGFBR1*6A contributes to cancer development is largely unknown...
  42. pmc cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo
    Ramakrishnaiah Siddappa
    Department of Tissue Regeneration, Institute for Biomedical Technology, University of Twente, 7500 AE, Enschede, The Netherlands
    Proc Natl Acad Sci U S A 105:7281-6. 2008
    ..As a consequence, PKA activation results in robust in vivo bone formation by hMSCs derived from orthopedic patients...