D Fekkes

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi Sequential serotonin and noradrenalin associated processes involved in postpartum blues
    Bennard Doornbos
    Graduate School of Behavioural and Cognitive Neuroscience, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 32:1320-5. 2008
  2. ncbi The relation between plasma tyrosine concentration and fatigue in primary biliary cirrhosis and primary sclerosing cholangitis
    Pieter C J ter Borg
    Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
    BMC Gastroenterol 5:11. 2005
  3. ncbi Norharman and alcohol-dependency in male Wistar rats
    Durk Fekkes
    Department of Psychiatry, Laboratory of Psychiatry, Room Ee 1438, Erasmus University Medical Centre, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Neuropsychopharmacol 14:361-6. 2004
  4. ncbi Influence of pegylated interferon-alpha therapy on plasma levels of citrulline and arginine in melanoma patients
    D Fekkes
    Department of Neuroscience, Erasmus MC, The Netherlands
    Amino Acids 32:121-6. 2007
  5. ncbi Quantitation of total biopterin and tetrahydrobiopterin in plasma
    Durk Fekkes
    Department of Neuroscience, Laboratory of Neurobiology, Room Ee 1438, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Clin Biochem 40:411-3. 2007
  6. ncbi Automated analysis of primary amino acids in plasma by high-performance liquid chromatography
    Durk Fekkes
    Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
    Methods Mol Biol 828:183-200. 2012
  7. ncbi Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-alpha therapy
    Durk Fekkes
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    Amino Acids 37:703-8. 2009
  8. ncbi Plasma activity of prolyl endopeptidase in relation to psychopathology during immunotherapy with IFN-alpha in patients with renal cell carcinoma
    A R Van Gool
    Department of Psychiatry, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Interferon Cytokine Res 28:283-6. 2008
  9. ncbi Psychiatric side effects and fluctuations in serotonergic parameters in the treatment of chronic hepatitis C infection
    G Bezemer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neuropsychobiology 65:126-32. 2012
  10. ncbi Serum activity of prolyl endopeptidase, but not of dipeptidyl peptidase IV, is decreased by immunotherapy with IFN-alpha in high-risk melanoma patients
    A R Van Gool
    Department of Psychiatry, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Interferon Cytokine Res 24:411-5. 2004

Collaborators

Detail Information

Publications34

  1. ncbi Sequential serotonin and noradrenalin associated processes involved in postpartum blues
    Bennard Doornbos
    Graduate School of Behavioural and Cognitive Neuroscience, Department of Psychiatry, University Medical Center Groningen, Groningen, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 32:1320-5. 2008
    ..We investigated whether postpartum blues was related to changes in parameters of noradrenergic and serotonergic functioning...
  2. ncbi The relation between plasma tyrosine concentration and fatigue in primary biliary cirrhosis and primary sclerosing cholangitis
    Pieter C J ter Borg
    Department of Gastroenterology and Hepatology, Erasmus MC, Rotterdam, The Netherlands
    BMC Gastroenterol 5:11. 2005
    ..This study aimed to identify abnormalities in AA patterns and to define their relation with fatigue...
  3. ncbi Norharman and alcohol-dependency in male Wistar rats
    Durk Fekkes
    Department of Psychiatry, Laboratory of Psychiatry, Room Ee 1438, Erasmus University Medical Centre, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur Neuropsychopharmacol 14:361-6. 2004
    ..The mechanism behind the increased norharman levels in alcohol-dependent rats may be inhibition of the synthesis and/or activity of liver enzyme(s) responsible for the breakdown of norharman...
  4. ncbi Influence of pegylated interferon-alpha therapy on plasma levels of citrulline and arginine in melanoma patients
    D Fekkes
    Department of Neuroscience, Erasmus MC, The Netherlands
    Amino Acids 32:121-6. 2007
    ..The data suggest that therapy with PEG-IFN-alpha results in a marked decrease in the synthesis of NO in melanoma patients...
  5. ncbi Quantitation of total biopterin and tetrahydrobiopterin in plasma
    Durk Fekkes
    Department of Neuroscience, Laboratory of Neurobiology, Room Ee 1438, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Clin Biochem 40:411-3. 2007
    ..To develop a reliable method for the determination of tetrahydrobiopterin and total biopterin in plasma...
  6. ncbi Automated analysis of primary amino acids in plasma by high-performance liquid chromatography
    Durk Fekkes
    Department of Psychiatry, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands
    Methods Mol Biol 828:183-200. 2012
    ..In addition, interassay resolution times have very low variation and the use of two internal standards guarantees reliable quantification...
  7. ncbi Nitric oxide production and monoamine oxidase activity in cancer patients during interferon-alpha therapy
    Durk Fekkes
    Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands
    Amino Acids 37:703-8. 2009
    ....
  8. ncbi Plasma activity of prolyl endopeptidase in relation to psychopathology during immunotherapy with IFN-alpha in patients with renal cell carcinoma
    A R Van Gool
    Department of Psychiatry, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Interferon Cytokine Res 28:283-6. 2008
    ..As more subtle relationships between PEP activity and psychiatric status could have easily been obscured, a role for PEP in the pathophysiology of IFN-alpha-induced mood disturbance can neither be confirmed nor excluded...
  9. ncbi Psychiatric side effects and fluctuations in serotonergic parameters in the treatment of chronic hepatitis C infection
    G Bezemer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Neuropsychobiology 65:126-32. 2012
    ..Treatment of hepatitis C with peginterferon induces psychiatric side effects. These might include changes in serotonergic function...
  10. ncbi Serum activity of prolyl endopeptidase, but not of dipeptidyl peptidase IV, is decreased by immunotherapy with IFN-alpha in high-risk melanoma patients
    A R Van Gool
    Department of Psychiatry, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Interferon Cytokine Res 24:411-5. 2004
    ..In contrast, serum activity of DPP-IV did not change. Further studies focusing on a possible role of PEP in the pathophysiology of IFN-alpha-induced depression are warranted...
  11. ncbi Tryptophan: a precursor for the endogenous synthesis of norharman in man
    D Fekkes
    Department of Psychiatry, Section Pathophysiology of Behaviour, Erasmus University, The, Rotterdam, Netherlands
    Neurosci Lett 303:145-8. 2001
    ..These results add some proof to the hypothesis that in humans tryptophan may serve as a precursor for the synthesis of norharman...
  12. ncbi Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations
    A M W Coppus
    Centre for the Intellectually Disabled, Dichterbij, Gennep, The Netherlands
    Amino Acids 38:923-8. 2010
    ..Neopterin concentrations correlated to the Cit/Arg ratio only in the group of prevalent demented subjects (rho = 0.48, P = 0.006). The results of this study are suggestive for an increase in oxidative processes in DS subjects with AD...
  13. ncbi Effect of electroconvulsive therapy on biopterin and large neutral amino acids in severe, medication-resistant depression
    R Hoekstra
    Department of Psychiatry, University Hospital Rotterdam Dijkzigt, Rotterdam, The Netherlands
    Psychiatry Res 103:115-23. 2001
    ....
  14. ncbi The acute effects of norharman on cocaine self-administration and sensorimotor function in male Wistar rats
    S L Cappendijk
    Department of Psychiatry, Faculty of Medicine and Health Science, Section of Pathophysiology of Behavior, Erasmus University Rotterdam, P O Box 1700, 3000 DR, Rotterdam, The Netherlands
    Eur Neuropsychopharmacol 11:233-9. 2001
    ..However, only in the naïve animals a significant effect of norharman on the grasp reflex was observed...
  15. ncbi Increased plasma glutamate, glycine, and arginine levels in complex regional pain syndrome type 1
    F Wesseldijk
    Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands
    Acta Anaesthesiol Scand 52:688-94. 2008
    ..The objective of this study was to investigate the role of amino acids in the pathogenesis of CRPS1...
  16. ncbi Mood correlates with blood serotonin, but not with glucose measures in patients with recurrent suicidal behavior
    R J Verkes
    Department of Psychiatry, University Hospital of Nijmegen, The Netherlands
    Psychiatry Res 80:239-48. 1998
    ..long-term effects. The results do support an association between serotonergic function and mood, but not between glucose metabolism and mood, in recurrent suicide attempters...
  17. ncbi Pharmacokinetics of the beta-carboline norharman in man
    D Fekkes
    Department of Psychiatry, Erasmus University, Rotterdam, The Netherlands
    Life Sci 69:2113-21. 2001
    ..In addition, the subjects did neither report any effects nor any side-effects during the experiment. This is the first study in which the kinetics of ingested norharman have been measured in humans...
  18. ncbi Plasma amino acids and sports injuries
    M T M van den Baar
    Department of Psychiatry, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands
    Amino Acids 26:71-6. 2004
    ..Whether a role for glycine substitution will be indicative to reduce the occurrence of sports injuries will need to be investigated in future studies...
  19. ncbi Platelet MAO activity during treatment with pegylated interferon-alfa in melanoma patients
    Marjolein Bannink
    Department of Psychiatry, Erasmus MC Daniel den Hoed Cancer Center, P O Box 5201, 3008 AE Rotterdam, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 29:109-14. 2005
    ..In that case, increased platelet MAO activity reflects an increased number of mitochondria per platelet...
  20. ncbi Hypotension caused by extracorporeal circulation: serotonin from pump-activated platelets triggers nitric oxide release
    Piet Borgdorff
    Laboratory for Physiology, Institute for Cardiovascular Research, Vrije Universiteit Medical Center, Amsterdam, The Netherlands
    Circulation 106:2588-93. 2002
    ..Cardiopulmonary bypass and hemodialysis often cause hypotension. We investigated a possible role of pump-induced platelet activation with consequent serotonin release...
  21. ncbi Serum amino acids, biopterin and neopterin during long-term immunotherapy with interferon-alpha in high-risk melanoma patients
    Arthur R Van Gool
    Department of Psychosocial Oncology, Erasmus Medical Center Daniel den Hoed Cancer Center, P O Box 5201, 3008 AE, Rotterdam, The Netherlands
    Psychiatry Res 119:125-32. 2003
    ..Changes in tryptophan metabolism may play a role in the pathophysiology of the neuropsychiatric side effects of IFN-alpha, and further research into the predictive potential of NEOP is warranted...
  22. ncbi Increased plasma serotonin in complex regional pain syndrome type 1
    Feikje Wesseldijk
    Department of Anesthesiology, Erasmus MC, Rotterdam, The Netherlands
    Anesth Analg 106:1862-7. 2008
    ..We measured plasma levels of serotonin (5-HT) during CRPS1 and correlated these levels with disease characteristics...
  23. ncbi Effect of light therapy on biopterin, neopterin and tryptophan in patients with seasonal affective disorder
    Rocco Hoekstra
    DeltaBouman Psychiatric Teaching Hospital, Postbus 800, Poortugaal 3170 DZ, The Netherlands
    Psychiatry Res 120:37-42. 2003
    ..It is concluded that the vulnerability for a depressive episode is enhanced by lowered levels of biopterin that, however, in SAD becomes symptomatically manifest in the presence of increased immune activity at the same time...
  24. ncbi Chorionic gonadotropin induces dendritic cells to express a tolerogenic phenotype
    Hui Wan
    Department of Immunology, Erasmus MC, Dr Molewaterplein 50, NL 3015 GE Rotterdam, The Netherlands
    J Leukoc Biol 83:894-901. 2008
    ..These data are suggestive for a contribution of hCG to the maternal-fetal tolerance during pregnancy by modifying DC toward a tolerogenic phenotype...
  25. ncbi Interferon-alpha influences tryptophan metabolism without inducing psychiatric side effects
    Marjolein Bannink
    Department of Psychiatry, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuropsychobiology 55:225-31. 2007
    ..The alterations in tryptophan metabolism might underlie the psychiatric side effects during treatment with IFN-alpha...
  26. ncbi Lithium addition in antidepressant-resistant depression: effects on platelet 5-HT, plasma 5-HT and plasma 5-HIAA concentration
    Tom K Birkenhager
    Department of Psychiatry, Erasmus Medical Centre, Rotterdam, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 31:1084-8. 2007
    ..The increments in 5-HIAA concentration during lithium addition are indicative of an increased 5-HT turnover...
  27. ncbi Plasma pterins and folate in late life depression: the Rotterdam Study
    Henning Tiemeier
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Psychiatry Res 145:199-206. 2006
    ..17, 0.03, P=0.18). The interaction between depressive symptoms, folate and neopterin was significant (P=0.03). The study suggests that the relation between folate and pterins is altered in the depressed elderly...
  28. ncbi Abnormal neurotransmitter metabolite levels in Alzheimer patients with a delirium
    Tischa J M van der Cammen
    Section of Geriatric Medicine, Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Geriatr Psychiatry 21:838-43. 2006
    ..The aim of this study was to investigate amino acid and neurotransmitter metabolite levels in plasma of AD patients with a concurrent delirium...
  29. ncbi Schizophrenia-associated neural growth factors in peripheral blood. A review
    Nico J M van Beveren
    Erasmus University Medical Center, Department of Psychiatry, Post Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur Neuropsychopharmacol 16:469-80. 2006
    ....
  30. ncbi Pegylated interferon-alpha2b treatment in melanoma patients: influence on amino acids, 5-hydroxyindolacetic acid and pteridine plasma concentrations
    Arthur R Van Gool
    Department of Psychiatry, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Anticancer Drugs 15:587-91. 2004
    ....
  31. ncbi The effects of high-dose and low-dose tryptophan depletion on mood and cognitive functions of remitted depressed patients
    Linda Booij
    Department of Psychology, Leiden University, Leiden, The Netherlands and Psychomedical Center Parnassia, The Hague, The Netherlands
    J Psychopharmacol 19:267-75. 2005
    ..The comparison of the effects of high-dose and low-dose ATD is useful for those studies aiming to investigate the relationships among 5-HT, mood and cognition...
  32. ncbi Craving for cigarettes among low and high dependent smokers: impact of norharman
    Regina Van Den Eijnden
    Addiction Research Institute, Heemraadssingel 194, 3021 DM Rotterdam, The Netherlands
    Addict Biol 8:463-72. 2003
    ..Measurements during periods of ad libitum smoking indicate that plasma levels of norharman are related negatively to craving among low nicotine-dependent smokers, but not among high dependent smokers...
  33. ncbi Responsivity to stress in chronic posttraumatic stress disorder due to childhood sexual abuse
    Ursula M Klumpers
    Delta Psychiatric Hospital, Poortugaal, The Netherlands
    Psychol Rep 94:408-10. 2004
    ....
  34. ncbi The impact of smoking and drinking on plasma levels of norharman
    Renske Spijkerman
    Addiction Research Institute, Rotterdam, The Netherlands
    Eur Neuropsychopharmacol 12:61-71. 2002
    ..The norharman plasma levels of nonsmoking excessive drinkers showed a similar pattern to that of the control group. The findings indicate that elevated plasma levels of norharman are due to heavy smoking and not to excessive drinking...