Richard A Feelders

Summary

Affiliation: Erasmus Medisch Centrum
Country: The Netherlands

Publications

  1. ncbi Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro
    Richard A Feelders
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:230-7. 2003
  2. doi Interferon-β is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane
    Peter M van Koetsveld
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 20:443-54. 2013
  3. ncbi Somatostatin receptor imaging for neuroendocrine tumors
    Wouter W de Herder
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Pituitary 9:243-8. 2006
  4. doi The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells
    Maria Cristina De Martino
    Division of Endocrinology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 19:351-64. 2012
  5. doi Medical therapy of acromegaly: efficacy and safety of somatostatin analogues
    Richard A Feelders
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    Drugs 69:2207-26. 2009
  6. doi Immunoreactivity score using an anti-sst2A receptor monoclonal antibody strongly predicts the biochemical response to adjuvant treatment with somatostatin analogs in acromegaly
    Federico Gatto
    Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:E66-71. 2013
  7. doi Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 168:67-74. 2013
  8. pmc ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitro responses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase
    Johannes Hofland
    Department of Internal Medicine, Section of Endocrinology, P, O, Box 2040, Rotterdam, CA, 3000, The Netherlands
    Orphanet J Rare Dis 8:142. 2013
  9. doi Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Room Ee 532, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:E747-54. 2012
  10. doi Mutational analyses of epidermal growth factor receptor and downstream pathways in adrenocortical carcinoma
    Ilse G C Hermsen
    Department of Internal Medicine, Maxima Medical Centre, PO Box 90052, 5600 PD Eindhoven, The Netherlands
    Eur J Endocrinol 169:51-8. 2013

Collaborators

Detail Information

Publications29

  1. ncbi Luteinizing hormone (LH)-responsive Cushing's syndrome: the demonstration of LH receptor messenger ribonucleic acid in hyperplastic adrenal cells, which respond to chorionic gonadotropin and serotonin agonists in vitro
    Richard A Feelders
    Department of Internal Medicine, Erasmus University Medical Center Rotterdam, 3015 GD Rotterdam, The Netherlands
    J Clin Endocrinol Metab 88:230-7. 2003
    ..Despite the regulatory potential of LH and 5-HT4 receptor agonists on cortisol production in our patients, their adrenals seemed to be still sensitive to ACTH, both in vivo and in vitro...
  2. doi Interferon-β is a potent inhibitor of cell growth and cortisol production in vitro and sensitizes human adrenocortical carcinoma cells to mitotane
    Peter M van Koetsveld
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 20:443-54. 2013
    ..The inhibition of the expression of steroidogenic enzymes by IFN-β is a novel mechanism that may explain its inhibitory effect on cortisol production...
  3. ncbi Somatostatin receptor imaging for neuroendocrine tumors
    Wouter W de Herder
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Pituitary 9:243-8. 2006
    ..However, a large variety of lesions in and around the pituitary region also express somatostatin receptors and, therefore, can be visualized by (111)In-pentetreotide scintigraphy...
  4. doi The role of mTOR inhibitors in the inhibition of growth and cortisol secretion in human adrenocortical carcinoma cells
    Maria Cristina De Martino
    Division of Endocrinology, Department of Internal Medicine, Room Ee530b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Endocr Relat Cancer 19:351-64. 2012
    ..mTOR could be a target for the treatment of human ACCs, but variable responses might be expected. In selected cases of ACC, the combined targeting of mTOR and IGF2 could have greater effects than mTOR inhibitors alone...
  5. doi Medical therapy of acromegaly: efficacy and safety of somatostatin analogues
    Richard A Feelders
    Department of Internal Medicine, Section of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    Drugs 69:2207-26. 2009
    ....
  6. doi Immunoreactivity score using an anti-sst2A receptor monoclonal antibody strongly predicts the biochemical response to adjuvant treatment with somatostatin analogs in acromegaly
    Federico Gatto
    Department of Internal Medicine, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:E66-71. 2013
    ..Recently, a new rabbit monoclonal anti-sst2A antibody (clone UMB-1) has been validated as a reliable method to selectively detect sst2A protein levels in formalin-fixed tissues...
  7. doi Regulation of steroidogenesis in a primary pigmented nodular adrenocortical disease-associated adenoma leading to virilization and subclinical Cushing's syndrome
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Endocrinol 168:67-74. 2013
    ..Mutations in the cAMP protein kinase A regulatory subunit type 1A (PRKAR1A) are causative of PPNAD. Steroidogenesis in PPNAD can be modified through a local glucocorticoid feed-forward loop...
  8. pmc ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitro responses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase
    Johannes Hofland
    Department of Internal Medicine, Section of Endocrinology, P, O, Box 2040, Rotterdam, CA, 3000, The Netherlands
    Orphanet J Rare Dis 8:142. 2013
    ..We investigated the prevalence of adrenocortical reactions to these stimuli in a large cohort of AIMAH patients, both in vivo and in vitro...
  9. doi Melanocortin 2 receptor-associated protein (MRAP) and MRAP2 in human adrenocortical tissues: regulation of expression and association with ACTH responsiveness
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Room Ee 532, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:E747-54. 2012
    ..MC2R trafficking and signaling are dependent on the MC2R accessory protein (MRAP). The MRAP homolog MRAP2 also transports the MC2R to the cell surface but might prevent activation...
  10. doi Mutational analyses of epidermal growth factor receptor and downstream pathways in adrenocortical carcinoma
    Ilse G C Hermsen
    Department of Internal Medicine, Maxima Medical Centre, PO Box 90052, 5600 PD Eindhoven, The Netherlands
    Eur J Endocrinol 169:51-8. 2013
    ..The epidermal growth factor receptor (EGFR) has been implicated in the development of one-third of all malignancies. EGFR pathway members in ACC have been investigated, however, without available clinical data and relation to survival...
  11. doi Treatment with the radiolabeled somatostatin analog [177 Lu-DOTA 0,Tyr3]octreotate: toxicity, efficacy, and survival
    Dik J Kwekkeboom
    Department of Nuclear Medicine, Erasmus Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    J Clin Oncol 26:2124-30. 2008
    ..Here we report on the toxicity and efficacy of this treatment, performed in over 500 patients...
  12. doi Pituitary tumours: the sst/D2 receptors as molecular targets
    Leo J Hofland
    Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    Mol Cell Endocrinol 326:89-98. 2010
    ..In this review the current knowledge on the expression and functional roles of sst and D2 in pituitary tumours is discussed...
  13. doi Recent developments in drug therapy for Cushing's disease
    Rob van der Pas
    Division of Endocrinology, Department of Internal Medicine, Erasmus Medical Center, sGravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Drugs 73:907-18. 2013
    ..In this review, the efficacy and limitations of drugs that have been used in the treatment of CD will be discussed as well as recent developments with respect to new pituitary- and adrenal-targeting compounds...
  14. ncbi New therapeutic options for metastatic malignant insulinomas
    Wouter W de Herder
    Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Clin Endocrinol (Oxf) 75:277-84. 2011
    ..With the introduction of these new therapeutic modalities, the therapeutic arsenal for the 'tailor-made' approach of patients with metastatic insulinomas is further expanded...
  15. pmc Conversion of daily pegvisomant to weekly pegvisomant combined with long-acting somatostatin analogs, in controlled acromegaly patients
    Sebastian J C M M Neggers
    Department of Medicine, Erasmus University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Pituitary 14:253-8. 2011
    ..However, there seems to be a wide variation in the reduction of PEG-V dose, which can be obtained after conversion to combined treatment...
  16. doi Coexpression of dopamine and somatostatin receptor subtypes in corticotroph adenomas
    Christiaan de Bruin
    Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:1118-24. 2009
    ..To what extent these receptor subtypes are coexpressed within individual adenomas, is not known however...
  17. doi Medical treatment of Cushing's disease
    Richard A Feelders
    Department of Internal Medicine, Division of Endocrinology, Erasmus Medical Center, 3015 CE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:425-38. 2013
    ..Considering the deleterious effects of uncontrolled CD, there is a clear need for effective medical therapy...
  18. doi Serum inhibin pro-αC is a tumor marker for adrenocortical carcinomas
    Johannes Hofland
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, Room Ee 532, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Eur J Endocrinol 166:281-9. 2012
    ....
  19. ncbi Potent inhibitory effects of type I interferons on human adrenocortical carcinoma cell growth
    Peter M van Koetsveld
    Department of Internal Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 91:4537-43. 2006
    ..Despite efforts to develop new therapeutic regimens for metastatic ACC, surgery remains the mainstay of treatment. Interferons are known to exert tumor-suppressive effects in several types of human cancer...
  20. doi Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole
    Richard A Feelders
    Department of Internal Medicine, Endocrine Section, Erasmus Medical Center, Rotterdam, The Netherlands
    Neuroendocrinology 92:111-5. 2010
    ..e. the universal somatostatin analogue pasireotide and/or the dopamine agonist cabergoline, and low-dose ketoconazole seems a rational approach to achieve biochemical control...
  21. doi Role of somatostatin receptors in normal and tumoral pituitary corticotropic cells
    Leo J Hofland
    Department of Internal Medicine, Division of Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Neuroendocrinology 92:11-6. 2010
    ....
  22. ncbi Long-term efficacy and safety of combined treatment of somatostatin analogs and pegvisomant in acromegaly
    Sebastian J C M M Neggers
    Department of Internal Medicine, Erasmus University MC Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 92:4598-601. 2007
    ..We previously reported the efficacy of a combined treatment of active acromegaly with both long-acting somatostatin analogs (SSA) and pegvisomant (PEG-V)...
  23. doi Occurrence of second primary malignancies in patients with neuroendocrine tumors of the digestive tract and pancreas
    Kimberly Kamp
    Department of Internal Medicine, Sector of Endocrinology, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Endocr Relat Cancer 19:95-9. 2012
    ....
  24. pmc Polymorphisms in the glucocorticoid receptor gene that modulate glucocorticoid sensitivity are associated with rheumatoid arthritis
    Manon J M van Oosten
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, s Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands
    Arthritis Res Ther 12:R159. 2010
    ..Because differences in GC sensitivity may influence immune effector functions, we examined whether these polymorphisms are associated with the susceptibility to develop Rheumatoid Arthritis (RA) and RA disease severity...
  25. ncbi Dopamine agonist therapy of clinically non-functioning pituitary macroadenomas. Is there a role for 123I-epidepride dopamine D2 receptor imaging?
    Wouter W de Herder
    Department of Internal Medicine, Section of Endocrinology, Erasmus MC, s Gravendijkwal 230, 3015 CE Rotterdam, The Netherlands
    Eur J Endocrinol 155:717-23. 2006
    ..We have studied the correlation between in vivo imaging of D2 receptors using (123)I-epidepride and the radiological response of NFPA to DA in 18 patients...
  26. doi Urinary renin, but not angiotensinogen or aldosterone, reflects the renal renin-angiotensin-aldosterone system activity and the efficacy of renin-angiotensin-aldosterone system blockade in the kidney
    Mieke van den Heuvel
    Division of Pharmacology and Vascular Medicine, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 29:2147-55. 2011
    ..To study which renin-angiotensin-aldosterone system (RAAS) component best reflects renal RAAS activity...
  27. ncbi Expression of the human glucocorticoid receptor splice variants alpha, beta, and P in peripheral blood mononuclear leukocytes in healthy controls and in patients with hyper- and hypocortisolism
    Antje Hagendorf
    Department of Internal Medicine, Section of Endocrinology, Room Ee 585, Erasmus Medical Center, P O B 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:6237-43. 2005
    ..The effects of cortisol are mediated by the alpha-isoform of the glucocorticoid receptor (GR). GR-alpha levels and activity are modulated by alternative splicing of the common pre-mRNA into mRNAs for the GR-beta and GR-P isoforms...
  28. ncbi Octreotide exerts only acute, but no sustained, effects on MRI enhancement of liver metastases in carcinoid syndrome
    Menno T Zomerhuis
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Neuroendocrinology 82:41-8. 2005
    ..This study further shows that contrast-enhanced dynamic MRI can be a very useful tool for studying hemodynamic effects of medical therapies on liver metastases in patients with metastatic midgut carcinoids...
  29. ncbi Thyroid hormone concentrations, disease, physical function, and mortality in elderly men
    Annewieke W van den Beld
    Department of Internal Medicine, Room Bd230, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 90:6403-9. 2005
    ..Physiological changes in thyroid hormone concentrations might be related to changes in the overall physical function in the elderly...