Elaine A Dzierzak

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi The emergence of definitive hematopoietic stem cells in the mammal
    Elaine Dzierzak
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Opin Hematol 12:197-202. 2005
  2. ncbi Expression analysis of the TAB2 protein in adult mouse tissues
    C Orelio
    Erasmus University Medical Centre, Dept of Cell Biology and Genetics, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Inflamm Res 56:98-104. 2007
  3. ncbi Of lineage and legacy: the development of mammalian hematopoietic stem cells
    Elaine Dzierzak
    Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Nat Immunol 9:129-36. 2008
  4. ncbi Stem cell researchers find their niche
    Elaine Dzierzak
    Erasmus Medical Center, Department of Cell Biology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Development 135:1569-73. 2008
  5. ncbi The discovery of a source of adult hematopoietic cells in the embryo
    Elaine Dzierzak
    Erasmus MC, Erasmus Stem Cell Institute, Department of Cell Biology, Rotterdam, The Netherlands
    Development 135:2343-6. 2008
  6. ncbi Placenta as a source of hematopoietic stem cells
    Elaine Dzierzak
    Erasmus MC Stem Cell Institute, Dept of Cell Biology, Erasmus University Medical Center Rotterdam, The Netherlands
    Trends Mol Med 16:361-7. 2010
  7. ncbi Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures
    Robert A J Oostendorp
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands
    Stem Cells 23:842-51. 2005
  8. ncbi Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity
    Robert A J Oostendorp
    Department of Cell Biology, Erasmus University, Rotterdam, The Netherlands
    Blood 99:1183-9. 2002
  9. ncbi Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells
    Bartosz Grzywacz
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 425 E. River Rd, Suite 660, Minneapolis, MN 55455, USA
    Blood 108:3824-33. 2006

Research Grants

  1. Characterization of the First HSCs During Mouse Ontogeny
    Elaine Dzierzak; Fiscal Year: 2007
  2. Characterization of the First HSCs During Mouse Ontogeny
    Elaine Dzierzak; Fiscal Year: 2005
  3. FIRST HSCS DURING MOUSE ONTOGENY
    Elaine Dzierzak; Fiscal Year: 2000

Collaborators

Detail Information

Publications9

  1. ncbi The emergence of definitive hematopoietic stem cells in the mammal
    Elaine Dzierzak
    Department of Cell Biology and Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands
    Curr Opin Hematol 12:197-202. 2005
    ....
  2. ncbi Expression analysis of the TAB2 protein in adult mouse tissues
    C Orelio
    Erasmus University Medical Centre, Dept of Cell Biology and Genetics, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Inflamm Res 56:98-104. 2007
    ..The Interleukin-1 (IL-1) signaling component TAK1 binding protein 2 (TAB2) plays a role in activating the NFkappaB and JNK signaling pathways. Additionally, TAB2 functions in the nucleus as a repressor of NFkappaB-mediated gene regulation...
  3. ncbi Of lineage and legacy: the development of mammalian hematopoietic stem cells
    Elaine Dzierzak
    Department of Cell Biology, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Nat Immunol 9:129-36. 2008
    ..This review presents a historical overview of and the most recent data on the developmental origins of hematopoiesis...
  4. ncbi Stem cell researchers find their niche
    Elaine Dzierzak
    Erasmus Medical Center, Department of Cell Biology, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Development 135:1569-73. 2008
    ....
  5. ncbi The discovery of a source of adult hematopoietic cells in the embryo
    Elaine Dzierzak
    Erasmus MC, Erasmus Stem Cell Institute, Department of Cell Biology, Rotterdam, The Netherlands
    Development 135:2343-6. 2008
    ..Dieterlen-Lièvre's 1975 paper created a paradigm shift in hematopoietic research, and provided a new and lasting focus on hematopoietic activity within the embryo body...
  6. ncbi Placenta as a source of hematopoietic stem cells
    Elaine Dzierzak
    Erasmus MC Stem Cell Institute, Dept of Cell Biology, Erasmus University Medical Center Rotterdam, The Netherlands
    Trends Mol Med 16:361-7. 2010
    ..As a rest tissue that contains potent hematopoietic stem cells (HSCs), the human placenta could represent (in addition to umbilical cord blood cells) an accessible supplemental source of cells for therapeutic strategies...
  7. ncbi Long-term maintenance of hematopoietic stem cells does not require contact with embryo-derived stromal cells in cocultures
    Robert A J Oostendorp
    Department of Cell Biology and Genetics, Erasmus University, Rotterdam, Netherlands
    Stem Cells 23:842-51. 2005
    ..In summary, we show for the first time long-term maintenance of adult bone marrow HSCs in stroma noncontact cultures and identify some secreted molecules that may be involved in this support...
  8. ncbi Stromal cell lines from mouse aorta-gonads-mesonephros subregions are potent supporters of hematopoietic stem cell activity
    Robert A J Oostendorp
    Department of Cell Biology, Erasmus University, Rotterdam, The Netherlands
    Blood 99:1183-9. 2002
    ..These results strongly suggest that during midgestation, not only the AM but also the UG subregion provides a potent microenvironment for growth and maintenance of the first HSCs...
  9. ncbi Coordinated acquisition of inhibitory and activating receptors and functional properties by developing human natural killer cells
    Bartosz Grzywacz
    Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, 425 E. River Rd, Suite 660, Minneapolis, MN 55455, USA
    Blood 108:3824-33. 2006
    ..The identified stages of NK-cell differentiation provide evidence for coordinated acquisition of HLA-specific inhibitory receptors (ie, CD94/NKG2A) and function in developing human NK cells...

Research Grants10

  1. Characterization of the First HSCs During Mouse Ontogeny
    Elaine Dzierzak; Fiscal Year: 2007
    ..If indeed embryonic aorta-derived HSCs migrate and colonize the adult bone marrow, our insights into their generation and expansion should lead to novel methods for clinical HSC expansion and thus, improve transplantation therapies. ..
  2. Characterization of the First HSCs During Mouse Ontogeny
    Elaine Dzierzak; Fiscal Year: 2005
    ..These results should give insight into the source and complexity of adult HSC production. ..
  3. FIRST HSCS DURING MOUSE ONTOGENY
    Elaine Dzierzak; Fiscal Year: 2000
    ..This information will be compared to immunohistochemistry of embryo tissues which has been done previously or will be done in parallel with the RT-PCR analysis. ..