Hendrikus J Dubbink

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor
    Hendrikus J Dubbink
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Endocrinol 18:2132-50. 2004
  2. ncbi request reprint Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping
    Hendrikus J Dubbink
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Mol Endocrinol 20:1742-55. 2006
  3. doi request reprint Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression
    Dennis J van de Wijngaart
    Department of Urology, Josephine Nefkens Institute, Erasmus Medical College, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Endocrinol 23:1776-86. 2009
  4. ncbi request reprint Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain
    Dennis J van de Wijngaart
    Department of Urology, Josephine Nefkens Institute, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Biol Chem 281:19407-16. 2006
  5. pmc Compartmentalization of androgen receptor protein-protein interactions in living cells
    Martin E van Royen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, 3000 CA Rotterdam, Netherlands
    J Cell Biol 177:63-72. 2007
  6. doi request reprint Inhibition of androgen receptor functions by gelsolin FxxFF peptide delivered by transfection, cell-penetrating peptides, and lentiviral infection
    Dennis J van de Wijngaart
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Prostate 71:241-53. 2011
  7. ncbi request reprint Amino acids 3-13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor
    Karine Steketee
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Biochem 269:5780-91. 2002
  8. doi request reprint Interlaboratory comparison of IDH mutation detection
    Martin J van den Bent
    Department of Neurology Neuro Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075EA, Rotterdam, The Netherlands
    J Neurooncol 112:173-8. 2013
  9. ncbi request reprint The androgen receptor ligand-binding domain stabilizes DNA binding in living cells
    Pascal Farla
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Struct Biol 147:50-61. 2004
  10. pmc Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H
    Dennis J van de Wijngaart
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Biol Chem 285:5097-105. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor
    Hendrikus J Dubbink
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    Mol Endocrinol 18:2132-50. 2004
    ..In conclusion, our data demonstrate the importance of a deep hydrophobic groove and alternative usage of charged amino acids in specifying peptide binding to the AR LBD...
  2. ncbi request reprint Androgen receptor ligand-binding domain interaction and nuclear receptor specificity of FXXLF and LXXLL motifs as determined by L/F swapping
    Hendrikus J Dubbink
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Mol Endocrinol 20:1742-55. 2006
    ..In conclusion, F residues determine strong and selective peptide interactions with AR. Sequences flanking the core motif determine the specific mode of FXXLF and LXXLL interactions...
  3. doi request reprint Functional screening of FxxLF-like peptide motifs identifies SMARCD1/BAF60a as an androgen receptor cofactor that modulates TMPRSS2 expression
    Dennis J van de Wijngaart
    Department of Urology, Josephine Nefkens Institute, Erasmus Medical College, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Endocrinol 23:1776-86. 2009
    ..In summary, our data demonstrate that BAF60a directly interacts with the coactivator groove in the AR ligand-binding domain via its FxxFF motif, thereby selectively activating specific AR-driven promoters...
  4. ncbi request reprint Novel FXXFF and FXXMF motifs in androgen receptor cofactors mediate high affinity and specific interactions with the ligand-binding domain
    Dennis J van de Wijngaart
    Department of Urology, Josephine Nefkens Institute, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Biol Chem 281:19407-16. 2006
    ..In conclusion, we have demonstrated strong interaction of FXXFF and FXXMF motifs to the AR coactivator binding groove, thereby mediating specific binding of a subgroup of cofactors to the AR LBD...
  5. pmc Compartmentalization of androgen receptor protein-protein interactions in living cells
    Martin E van Royen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, 3000 CA Rotterdam, Netherlands
    J Cell Biol 177:63-72. 2007
    ..N/C interactions are largely lost when AR transiently binds to DNA, predominantly in foci partly overlapping transcription sites. AR coregulator interactions occur preferentially when ARs are bound to DNA...
  6. doi request reprint Inhibition of androgen receptor functions by gelsolin FxxFF peptide delivered by transfection, cell-penetrating peptides, and lentiviral infection
    Dennis J van de Wijngaart
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands
    Prostate 71:241-53. 2011
    ..Prostate cancer (PC) growth is dependent on the androgen-androgen receptor (AR) axis. Because current androgen ablation therapies of PC lead to resistance, novel approaches to block AR activity are urgently needed...
  7. ncbi request reprint Amino acids 3-13 and amino acids in and flanking the 23FxxLF27 motif modulate the interaction between the N-terminal and ligand-binding domain of the androgen receptor
    Karine Steketee
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Biochem 269:5780-91. 2002
    ..Substitution of Q24 and N25 by alanine residues enhances N/C interaction. Substitution of amino acids flanking the 23FxxLF27 motif by alanines are inhibitory to LBD interaction...
  8. doi request reprint Interlaboratory comparison of IDH mutation detection
    Martin J van den Bent
    Department of Neurology Neuro Oncology, Erasmus MC Cancer Institute, Groene Hilledijk 301, 3075EA, Rotterdam, The Netherlands
    J Neurooncol 112:173-8. 2013
    ..IDH sequencing procedures yielded inconsistent results in 2 out of 6 laboratories. Quality assurance is pivotal before IDH testing is made part of clinical management of patients...
  9. ncbi request reprint The androgen receptor ligand-binding domain stabilizes DNA binding in living cells
    Pascal Farla
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Struct Biol 147:50-61. 2004
    ..Our data suggest the LBD has a role in maintaining the stability of AR-DNA complexes...
  10. pmc Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H
    Dennis J van de Wijngaart
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    J Biol Chem 285:5097-105. 2010
    ....
  11. doi request reprint Yield of routine molecular analyses in colorectal cancer patients ≤70 years to detect underlying Lynch syndrome
    Margot G F Van Lier
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    J Pathol 226:764-74. 2012
    ..Routine use of MSI testing may be considered in CRC patients up to the age of 70 years, with a central role for the pathologist in the selection of patients...
  12. pmc First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response
    Walter Taal
    Department of Neuro Oncology Neurology, Erasmus MC, Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands
    Neuro Oncol 13:235-41. 2011
    ..01) and a methylated MGMT promoter (P = .02). We conclude that MGMT promoter methylation and IDH1 mutations seem to predict survival from the time of diagnosis, but not PFS to TMZ...
  13. doi request reprint Somatic aberrations of mismatch repair genes as a cause of microsatellite-unstable cancers
    Willemina R R Geurts-Giele
    Department of Pathology, Erasmus MC Cancer Institute, University Medical Centre, Rotterdam, The Netherlands
    J Pathol 234:548-59. 2014
    ..Therefore, we advocate adding somatic mutation and LOH analysis of the MMR genes to the molecular diagnostic workflow of LS...
  14. pmc MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951
    Martin J van den Bent
    Department of Neuro Oncology and Pathology, Daniel den Hoed Cancer Center and Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 27:5881-6. 2009
    ..It is unknown if MGMT promoter methylation is also predictive to outcome to RT followed by adjuvant procarbazine, lomustine, and vincristine (PCV) chemotherapy in patients with anaplastic oligodendroglial tumors (AOT)...
  15. doi request reprint IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
    Martin J van den Bent
    Dept Neuro Oncology and Pathology, Daniel den Hoed Cancer Center and Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Cancer Res 16:1597-604. 2010
    ....
  16. doi request reprint Identification of Familial Adenomatous Polyposis carriers among children with desmoid tumours
    Anna A Kattentidt Mouravieva
    Department of Clinical Genetics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Eur J Cancer 48:1867-74. 2012
    ..The aim of this study is to form guidelines for the identification of possible APC germline mutation carriers among children with desmoid tumours, based on CTNNB1 mutation analysis and immunohistochemical analysis (IHC) for β-catenin...
  17. pmc MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation
    Floris H Groenendijk
    Department of Pathology, Josephine Nefkens Institute, Be320a, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurooncol 101:405-17. 2011
    ..These results argue against the putative TP53 G:C>A:T transition mutations suggested to occur preferentially in MGMT hypermethylated tumors...
  18. doi request reprint Aberrant SOX2 expression in colorectal cancers does not correlate with mucinous differentiation and gastric mucin MUC5AC expression
    Lalini Raghoebir
    Department of Pediatric Surgery, Erasmus Medical Centre, Rotterdam, The Netherlands
    Virchows Arch 465:395-400. 2014
    ..In conclusion, we show that aberrant SOX2 expression is specifically linked neither to mucinous CRCs nor to the induction of MUC5AC, in contrast to previous suggestions...
  19. doi request reprint TERT promoter mutations and BRAF mutations are rare in sporadic, and TERT promoter mutations are absent in NF1-related malignant peripheral nerve sheath tumors
    Hendrikus J Dubbink
    Department of Pathology, Erasmus MC Cancer Institute, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurooncol 120:267-72. 2014
    ....
  20. doi request reprint Next generation diagnostic molecular pathology: critical appraisal of quality assurance in Europe
    Hendrikus J Dubbink
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Oncol 8:830-9. 2014
    ....
  21. doi request reprint Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer ≤ 70 years
    Celine H M Leenen
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Gynecol Oncol 125:414-20. 2012
    ....
  22. doi request reprint TP53 mutation analysis of malignant peripheral nerve sheath tumors
    Robert M Verdijk
    Department of Pathology, Erasmus MC, University, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 69:16-26. 2010
    ..These results indicate that TP53 mutations are relatively rare in human MPNST and that they are not positively correlated with the presence of NF1...