H A Drexhage

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Are there more than antibodies to the thyroid-stimulating hormone receptor that meet the eye in Graves' disease?
    H A Drexhage
    Department of Immunology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Endocrinology 147:9-12. 2006
  2. pmc Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness
    Michael Berk
    School of Medicine, Deakin University, 75 Pigdon s Road, Waurn Ponds, Geelong, Victoria 3216, Australia
    BMC Med 11:74. 2013
  3. doi request reprint Changes in serum adhesion molecules, chemokines, cytokines, and tissue remodeling factors in euthyroid women without thyroid antibodies who are at risk for autoimmune thyroid disease: a hypothesis on the early phases of the endocrine autoimmune reaction
    Wouter Beumer
    Department of Immunology, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:2460-8. 2013
  4. pmc Altered fractalkine cleavage potentially promotes local inflammation in NOD salivary gland
    Manon E Wildenberg
    Department of Immunology, Erasmus MC, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    Arthritis Res Ther 10:R69. 2008
  5. ncbi request reprint 1-alpha,25-Dihydroxyvitamin D3 (1,25(OH)(2)D(3)) hampers the maturation of fully active immature dendritic cells from monocytes
    M O Canning
    Department of Immunology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Eur J Endocrinol 145:351-7. 2001
  6. pmc Glucocorticoids hamper the ex vivo maturation of lung dendritic cells from their low autofluorescent precursors in the human bronchoalveolar lavage: decreases in allostimulatory capacity and expression of CD80 and CD86
    G T Verhoeven
    Department of Immunology, University Hospital Dijkzigt, EMCR, Rotterdam, The Netherlands
    Clin Exp Immunol 122:232-40. 2000
  7. doi request reprint Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndrome
    M E Wildenberg
    Department of Immunology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Ann Rheum Dis 68:420-6. 2009
  8. ncbi request reprint Splenic dendritic cells from the non-obese diabetic mouse induce a prolonged proliferation of syngeneic T cells. A role for an impaired apoptosis of NOD T cells?
    K Radosevic
    Department of Immunology, Erasmus University Rotterdam, The Netherlands
    J Autoimmun 13:373-82. 1999
  9. ncbi request reprint Human hepatic lymph nodes contain normal numbers of mature myeloid dendritic cells but few plasmacytoid dendritic cells
    W Tanis
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Immunol 110:81-8. 2004
  10. ncbi request reprint Homotypic cluster formation of dendritic cells, a close correlate of their state of maturation. Defects in the biobreeding diabetes-prone rat
    F G Delemarre
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    J Leukoc Biol 69:373-80. 2001

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Are there more than antibodies to the thyroid-stimulating hormone receptor that meet the eye in Graves' disease?
    H A Drexhage
    Department of Immunology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Endocrinology 147:9-12. 2006
  2. pmc Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness
    Michael Berk
    School of Medicine, Deakin University, 75 Pigdon s Road, Waurn Ponds, Geelong, Victoria 3216, Australia
    BMC Med 11:74. 2013
    ....
  3. doi request reprint Changes in serum adhesion molecules, chemokines, cytokines, and tissue remodeling factors in euthyroid women without thyroid antibodies who are at risk for autoimmune thyroid disease: a hypothesis on the early phases of the endocrine autoimmune reaction
    Wouter Beumer
    Department of Immunology, Erasmus Medical Center, Erasmus University, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 98:2460-8. 2013
    ....
  4. pmc Altered fractalkine cleavage potentially promotes local inflammation in NOD salivary gland
    Manon E Wildenberg
    Department of Immunology, Erasmus MC, P, O, Box 2040, 3000 CA Rotterdam, The Netherlands
    Arthritis Res Ther 10:R69. 2008
    ..To unravel further the role played by fractalkine-CX3CR1 interactions in the salivary gland inflammation, we studied the expression of fractalkine in NOD SMGs...
  5. ncbi request reprint 1-alpha,25-Dihydroxyvitamin D3 (1,25(OH)(2)D(3)) hampers the maturation of fully active immature dendritic cells from monocytes
    M O Canning
    Department of Immunology, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Eur J Endocrinol 145:351-7. 2001
    ..Collectively, these data are in line with earlier descriptions of suppressive activities of this steroid-like hormone with respect to the stimulation of cell-mediated immunity...
  6. pmc Glucocorticoids hamper the ex vivo maturation of lung dendritic cells from their low autofluorescent precursors in the human bronchoalveolar lavage: decreases in allostimulatory capacity and expression of CD80 and CD86
    G T Verhoeven
    Department of Immunology, University Hospital Dijkzigt, EMCR, Rotterdam, The Netherlands
    Clin Exp Immunol 122:232-40. 2000
    ..The veiled/dendritic morphology and the expression of other relevant cell surface markers and adhesion molecules was not affected by DEX exposure. It is concluded that DEX hampers the maturation of CD1a+ LAF cells into active lung DCs...
  7. doi request reprint Increased frequency of CD16+ monocytes and the presence of activated dendritic cells in salivary glands in primary Sjögren syndrome
    M E Wildenberg
    Department of Immunology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Ann Rheum Dis 68:420-6. 2009
    ..This study is aimed at determining the level of mature CD14lowCD16+ monocytes in pSjS and their contribution to the accumulation of DCs in pSjS...
  8. ncbi request reprint Splenic dendritic cells from the non-obese diabetic mouse induce a prolonged proliferation of syngeneic T cells. A role for an impaired apoptosis of NOD T cells?
    K Radosevic
    Department of Immunology, Erasmus University Rotterdam, The Netherlands
    J Autoimmun 13:373-82. 1999
    ..The impaired apoptosis might be of critical importance in the development of islet autoimmunity in the NOD mouse...
  9. ncbi request reprint Human hepatic lymph nodes contain normal numbers of mature myeloid dendritic cells but few plasmacytoid dendritic cells
    W Tanis
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Immunol 110:81-8. 2004
    ..In conclusion, hepatic LN contain similar numbers of myeloid DC as muscle/skin lymph-draining LN, with no signs of immaturity, but relatively few plasmacytoid DC...
  10. ncbi request reprint Homotypic cluster formation of dendritic cells, a close correlate of their state of maturation. Defects in the biobreeding diabetes-prone rat
    F G Delemarre
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    J Leukoc Biol 69:373-80. 2001
    ..Anti-CD43 completely restored the clustering defect BB-DP DCs in vitro, yet T cell-stimulating capability was only restored to a limited extent. Ag transfer in BB-DP DC clusters was similar...
  11. ncbi request reprint Human liver myeloid dendritic cells maturate in vivo into effector DC with a poor allogeneic T-cell stimulatory capacity
    J Kwekkeboom
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Transplant Proc 37:15-6. 2005
    ..Hepatic MDC maturate in vivo to a mature type of effector MDC with relatively poor allogeneic T-cell stimulatory capacity...
  12. ncbi request reprint Cellular composition of pancreas-associated lymphoid tissue during human fetal pancreatic development
    E Korpershoek
    Department of Pathology, Josephine Nefkens Institute and Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Histopathology 45:291-7. 2004
    ..DCs are antigen-presenting cells which are capable of initiating immunity, but are also essential in inducing and maintaining T-cell tolerance...
  13. ncbi request reprint Effect of thyroid hormones and other iodinated compounds on the transition of monocytes into veiled/dendritic cells: role of granulocyte-macrophage colony-stimulating factor, tumour-necrosis factor-alpha and interleukin-6
    P Mooij
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    J Endocrinol 140:503-12. 1994
    ..The mechanisms by which such iodinated compounds act on the monocyte to veiled/dendritic cell transition can only be speculated on (interference H2O2-generating system?)...
  14. ncbi request reprint Professional antigen presenting cells in minor salivary glands in Sjögren's syndrome: potential contribution to the histopathological diagnosis?
    S C van Blokland
    Department of Immunology, Erasmus University Rotterdam and University Hospital Rotterdam Dijkzigt, The Netherlands
    Lab Invest 80:1935-41. 2000
    ..This study therefore prompts further investigation focusing on the presence of CD1a+ and RFD9+ cells in the MSG of a large cohort of patients...
  15. ncbi request reprint Signs of immaturity of splenic dendritic cells from the autoimmune prone biobreeding rat: consequences for the in vitro expansion of regulator and effector T cells
    F G Delemarre
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    J Immunol 162:1795-801. 1999
    ..The dysfunction of DC from BB-DP rats is likely to be caused by their relative immaturity as indicated by their low class II and costimulatory molecule expression and relatively high phagocytic activity...
  16. pmc An increased MRP8/14 expression and adhesion, but a decreased migration towards proinflammatory chemokines of type 1 diabetes monocytes
    G Bouma
    Department of Immunology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Clin Exp Immunol 141:509-17. 2005
    ....
  17. doi request reprint PDGF enhances orbital fibroblast responses to TSHR stimulating autoantibodies in Graves' ophthalmopathy patients
    L van Steensel
    Department of Immunology, Erasmus Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Clin Endocrinol Metab 97:E944-53. 2012
    ..We investigated the possible relationship between PDGF and TSHR expression on orbital fibroblasts and how that influences the immunopathological effects of TSHR autoantibodies on orbital fibroblast activity...
  18. ncbi request reprint Islet abnormalities associated with an early influx of dendritic cells and macrophages in NOD and NODscid mice
    J G Rosmalen
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    Lab Invest 80:769-77. 2000
    ..In conclusion, mega-islet formation in mice with the NOD genetic background takes place under the influence of both beta-cell hyperactivity and leukocytes...
  19. ncbi request reprint Two different types of sialoadenitis in the NOD- and MRL/lpr mouse models for Sjögren's syndrome: a differential role for dendritic cells in the initiation of sialoadenitis?
    S C van Blokland
    Department of Immunology, Erasmus University Rotterdam and University Hospital Rotterdam Dijzigt, The Netherlands
    Lab Invest 80:575-85. 2000
    ..It is possible that different types of sialoadenitis also exist in humans and that the pathogenetic process in both the early and late phases of the autoimmune reaction differs among patients...
  20. ncbi request reprint Aberrancies in antigen-presenting cells and T cells in autoimmune thyroid disease. A role in faulty tolerance induction
    M O Canning
    Department of Immunology, Erasmus MC, Rotterdam, The Netherlands
    Autoimmunity 36:429-42. 2003
    ....
  21. pmc An abnormal adherence of monocytes to fibronectin in thyroid autoimmunity has consequences for cell polarization and the development of veiled cells
    M O Canning
    Department of Immunology, Erasmus University Rotterdam, The Netherlands
    Clin Exp Immunol 125:10-8. 2001
    ....
  22. ncbi request reprint Subsets of macrophages and dendritic cells in nonobese diabetic mouse pancreatic inflammatory infiltrates: correlation with the development of diabetes
    J G Rosmalen
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    Lab Invest 80:23-30. 2000
    ..It is, therefore, important to recognize this heterogeneity when interpreting both in vivo and in vitro studies concerning non-lymphoid cells in diabetes...
  23. ncbi request reprint Sex steroids influence pancreatic islet hypertrophy and subsequent autoimmune infiltration in nonobese diabetic (NOD) and NODscid mice
    J G Rosmalen
    Department of Immunology, Erasmus University, Rotterdam, The Netherlands
    Lab Invest 81:231-9. 2001
    ..This suggests that the gender difference in diabetes incidence in NOD mice is related to target organ-specific androgen effects...
  24. ncbi request reprint Antigen-presenting dendritic cells as regulators of the growth of thyrocytes: a role of interleukin-1beta and interleukin-6
    P J Simons
    Department of Immunology, Erasmus University Rotterdam, The Netherlands
    Endocrinology 139:3148-56. 1998
    ....
  25. ncbi request reprint Angiogenic murine endothelial progenitor cells are derived from a myeloid bone marrow fraction and can be identified by endothelial NO synthase expression
    C J M Loomans
    Department of Immunology, Erasmus Medical Center, Dr Molewaterplein 50, 3015GE Rotterdam, Netherlands
    Arterioscler Thromb Vasc Biol 26:1760-7. 2006
    ..However, the origin and functional properties of these EPCs are still in debate...
  26. ncbi request reprint A reduced IL2R (CD25) expression level in first and second degree female relatives of autoimmune thyroid disease patients. A sign of a poor capability to preserve tolerance?
    Thea G A Strieder
    Academic Medical Center, University of Amsterdam, Department of Endocrinology, 1105 AZ, Amsterdam Zuidoost, The Netherlands
    Autoimmunity 39:93-8. 2006
    ..It is hypothesized that this reduced expansion capability may affect T cell tolerance mechanisms more than T effector mechanisms...
  27. ncbi request reprint Thyroid peroxidase antibodies during gestation are a marker for subsequent depression postpartum
    J L Kuijpens
    Faculty of Social and Behavioural Sciences, University of Tilburg, 5000 LE Tilburg, The Netherlands
    Eur J Endocrinol 145:579-84. 2001
    ..9 (1.8-4.3). CONCLUSIONS: The presence of TPOAbs during gestation is associated with the occurrence of subsequent depression during the postpartum period and as such can be regarded as a marker for depression...
  28. ncbi request reprint Immune activation, steroid resistancy and bipolar disorder
    R W Kupka
    Altrecht Institute for Mental Health Care, and University Medical Center Utrecht, Utrecht, The Netherlands
    Bipolar Disord 4:73-4. 2002
  29. ncbi request reprint Abnormalities in dendritic cell and macrophage accumulation in the pancreas of nonobese diabetic (NOD) mice during the early neonatal period
    S Charre
    CNRS UMR 8603, University Paris V, Necker Hospital, Paris, France
    Histol Histopathol 17:393-401. 2002
    ..Our data showed that different types of APC were present in the pancreas during postnatal development in various control mouse strains and some differences were observed in NOD and NODscid mice from birth onwards...