Lambert C J Dorssers

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint The prognostic value of BCAR1 in patients with primary breast cancer
    Lambert C J Dorssers
    Department of Pathology, Division of Molecular Biology, Erasmus MC Rotterdam, Rotterdam
    Clin Cancer Res 10:6194-202. 2004
  2. pmc Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway
    Lambert C J Dorssers
    Department of Pathology, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Breast Cancer Res 7:R82-92. 2005
  3. doi request reprint TSC22D1 and PSAP predict clinical outcome of tamoxifen treatment in patients with recurrent breast cancer
    Danielle Meijer
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Room Be 432, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Breast Cancer Res Treat 113:253-60. 2009
  4. doi request reprint Selective recruitment of breast cancer anti-estrogen resistance genes and relevance for breast cancer progression and tamoxifen therapy response
    Ton van Agthoven
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Be432, Erasmus MC PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Endocr Relat Cancer 17:215-30. 2010
  5. doi request reprint Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance
    Ton van Agthoven
    Department of Pathology, Cancer Genomics Center, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Oncol 27:542-9. 2009
  6. doi request reprint Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer
    Maurice P H M Jansen
    Department of Medical Oncology, Erasmus MC, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Breast Cancer Res Treat 116:263-71. 2009
  7. doi request reprint The substrate domain of BCAR1 is essential for anti-estrogen-resistant proliferation of human breast cancer cells
    Arend Brinkman
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Centter Rotterdam, Be432, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Breast Cancer Res Treat 120:401-8. 2010
  8. doi request reprint Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer
    Danielle Meijer
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Endocr Relat Cancer 15:101-11. 2008
  9. doi request reprint Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells
    Marcia Godinho
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Cell Physiol 226:1741-9. 2011
  10. ncbi request reprint Application of a newly developed ELISA for BCAR1 protein for prediction of clinical benefit of tamoxifen therapy in patients with advanced breast cancer
    Lambert C J Dorssers
    Department of Pathology, Division of Molecular Biology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Clin Chem 50:1445-7. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint The prognostic value of BCAR1 in patients with primary breast cancer
    Lambert C J Dorssers
    Department of Pathology, Division of Molecular Biology, Erasmus MC Rotterdam, Rotterdam
    Clin Cancer Res 10:6194-202. 2004
    ..Here, we study the prognostic value of quantitative BCAR1 levels in a large series of breast cancer specimens...
  2. pmc Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway
    Lambert C J Dorssers
    Department of Pathology, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Breast Cancer Res 7:R82-92. 2005
    ..The aim of this study was to investigate the growth control mediated by these BCAR genes by gene expression profiling...
  3. doi request reprint TSC22D1 and PSAP predict clinical outcome of tamoxifen treatment in patients with recurrent breast cancer
    Danielle Meijer
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Room Be 432, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Breast Cancer Res Treat 113:253-60. 2009
    ..Both TSC22D1 and PSAP are associated with clinical outcome and may have a functional role in therapy resistance...
  4. doi request reprint Selective recruitment of breast cancer anti-estrogen resistance genes and relevance for breast cancer progression and tamoxifen therapy response
    Ton van Agthoven
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Be432, Erasmus MC PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Endocr Relat Cancer 17:215-30. 2010
    ....
  5. doi request reprint Relevance of breast cancer antiestrogen resistance genes in human breast cancer progression and tamoxifen resistance
    Ton van Agthoven
    Department of Pathology, Cancer Genomics Center, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Clin Oncol 27:542-9. 2009
    ..Here, we explored whether these BCAR genes provide predictive value for tamoxifen resistance and prognostic information for tumor aggressiveness in breast cancer patients...
  6. doi request reprint Downregulation of SIAH2, an ubiquitin E3 ligase, is associated with resistance to endocrine therapy in breast cancer
    Maurice P H M Jansen
    Department of Medical Oncology, Erasmus MC, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Breast Cancer Res Treat 116:263-71. 2009
    ..The aim of this study was to evaluate SIAH2 for its (a) predictive/prognostic value, and (b) functional role in endocrine therapy resistance...
  7. doi request reprint The substrate domain of BCAR1 is essential for anti-estrogen-resistant proliferation of human breast cancer cells
    Arend Brinkman
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Centter Rotterdam, Be432, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Breast Cancer Res Treat 120:401-8. 2010
    ..This information may also help to devise alternative personalized treatment strategies with improved outcome for breast cancer patients...
  8. doi request reprint Fibroblast growth factor receptor 4 predicts failure on tamoxifen therapy in patients with recurrent breast cancer
    Danielle Meijer
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Endocr Relat Cancer 15:101-11. 2008
    ..In addition, as altered expression of FGF17 causes tamoxifen resistance in vitro, the FGF signaling pathway could be a valuable target in the treatment of breast cancer patients resistant to endocrine treatment...
  9. doi request reprint Characterization of BCAR4, a novel oncogene causing endocrine resistance in human breast cancer cells
    Marcia Godinho
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Cell Physiol 226:1741-9. 2011
    ..Due to its restricted expression, BCAR4 may be a good target for treating antiestrogen-resistant breast cancer...
  10. ncbi request reprint Application of a newly developed ELISA for BCAR1 protein for prediction of clinical benefit of tamoxifen therapy in patients with advanced breast cancer
    Lambert C J Dorssers
    Department of Pathology, Division of Molecular Biology, Erasmus MC Rotterdam, Rotterdam, The Netherlands
    Clin Chem 50:1445-7. 2004
  11. ncbi request reprint Molecular classification of tamoxifen-resistant breast carcinomas by gene expression profiling
    Maurice P H M Jansen
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    J Clin Oncol 23:732-40. 2005
    ..To discover a set of markers predictive for the type of response to endocrine therapy with the antiestrogen tamoxifen using gene expression profiling...
  12. pmc Text-derived concept profiles support assessment of DNA microarray data for acute myeloid leukemia and for androgen receptor stimulation
    Rob Jelier
    Department of Medical Informatics, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    BMC Bioinformatics 8:14. 2007
    ..We assign a weight to each concept in the profile based on a likelihood ratio measure. Gene concept profiles can then be clustered to find related genes and other concepts...
  13. doi request reprint Functional identification of genes causing estrogen independence of human breast cancer cells
    Ton van Agthoven
    Department of Pathology, Josephine Nefkens Institute, Be 432, Erasmus MC University Medical Center Rotterdam, P O Box 2040, Rotterdam, CA, 3000, The Netherlands
    Breast Cancer Res Treat 114:23-30. 2009
    ....
  14. doi request reprint Protein pathway activation mapping reveals molecular networks associated with antiestrogen resistance in breast cancer cell lines
    Ton van Agthoven
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Int J Cancer 131:1998-2007. 2012
    ..Our results show that this model provides insights into the molecular and cellular mechanisms of breast cancer progression and antiestrogen resistance. This knowledge may help the development of novel targeted treatments...
  15. ncbi request reprint Functional screen for genes responsible for tamoxifen resistance in human breast cancer cells
    Danielle Meijer
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Mol Cancer Res 4:379-86. 2006
    ..We conclude that retroviral transfer of cDNA libraries into human breast cancer cells is an efficient method for identifying genes involved in tamoxifen resistance...
  16. ncbi request reprint GO-Mapper: functional analysis of gene expression data using the expression level as a score to evaluate Gene Ontology terms
    Marcel Smid
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, P O Box 1738, 3000DR Rotterdam, The Netherlands
    Bioinformatics 20:2618-25. 2004
    ..An automated analysis utilizing all expression information would greatly increase our understanding of the samples under study...
  17. pmc Anni 2.0: a multipurpose text-mining tool for the life sciences
    Rob Jelier
    Department of Medical Informatics, Erasmus MC University Medical Center, Dr, Molewaterplein, Rotterdam, 3015 GE, The Netherlands
    Genome Biol 9:R96. 2008
    ..In this article we illustrate Anni's usability by applying the tool to two use cases: interpretation of a set of differentially expressed genes, and literature-based knowledge discovery...
  18. pmc Role of SOX2 in the Etiology of Embryonal Carcinoma, Based on Analysis of the NCCIT and NT2 Cell Lines
    Ronak Eini
    Erasmus MC, University Medical Center Rotterdam, Department of Pathology, Rotterdam, The Netherlands
    PLoS ONE 9:e83585. 2014
    ..This finding is likely related to the presence of wild type p53 in GCC, resulting in expression of downstream target genes, amongst others miR-34a, miR-145 and SOX2, associated to the unique sensitivity of GCC to DNA damaging agents. ..
  19. doi request reprint Targeted serum miRNA (TSmiR) test for diagnosis and follow-up of (testicular) germ cell cancer patients: a proof of principle
    Ad J M Gillis
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Building Be, Room 432, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Mol Oncol 7:1083-92. 2013
    ..In conclusion, TSmiR constitutes a highly sensitive and reproducible serum test for GCC patients, suitable to be prospectively tested for diagnostic and follow-up purposes...
  20. doi request reprint Deletion of exons 1a-2 of BRCA1: a rather frequent pathogenic abnormality
    Ans M W van den Ouweland
    Department of Clinical Genetics, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Genet Test Mol Biomarkers 13:399-406. 2009
    ..This observation, together with the previously described families with exon 1a-2 deletions of BRCA1, demonstrates that this type of deletions is relatively frequent in breast/ovarian cancer families...
  21. doi request reprint miMsg: a target enrichment algorithm for predicted miR-mRNA interactions based on relative ranking of matched expression data
    Martin A Rijlaarsdam
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Bioinformatics 29:1638-46. 2013
    ..It is desirable to develop a transparent, user-friendly, unbiased tool to enrich miR-mRNA predictions...
  22. ncbi request reprint Venn Mapping: clustering of heterologous microarray data based on the number of co-occurring differentially expressed genes
    Marcel Smid
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Bioinformatics 19:2065-71. 2003
    ..As the clustering algorithm searches for similarities between experiments, it will most likely first separate the data sets, masking relationships that exist between samples from different databases...
  23. doi request reprint Role of stem cell proteins and microRNAs in embryogenesis and germ cell cancer
    Ronak Eini
    Erasmus MC, University Medical Center Rotterdam, Department of Pathology, The Netherlands
    Int J Dev Biol 57:319-32. 2013
    ..In this review we discuss the current view of the biology of embryonic stem cell proteins and miRs in GCC, and their potential clinical impact...
  24. pmc Prevalence of the variant allele rs61764370 T>G in the 3'UTR of KRAS among Dutch BRCA1, BRCA2 and non-BRCA1/BRCA2 breast cancer families
    Antoinette Hollestelle
    Department of Medical Oncology, Josephine Nefkens Institute and Daniel den Hoed Cancer Center, Erasmus University Medical Center, Rotterdam, The Netherlands
    Breast Cancer Res Treat 128:79-84. 2011
    ..Importantly, results from the current study suggest that KRAS-variant frequencies might be increased among BRCA1 carriers, but solid proof requires confirmation in a larger cohort of BRCA1 carriers...
  25. ncbi request reprint Development of an ELISA for measurement of BCAR1 protein in human breast cancer tissue
    Nicolai Grebenchtchikov
    Department of Chemical Endocrinology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Chem 50:1356-63. 2004
    ..The aim of the present study was to develop an ELISA to measure BCAR1 quantitatively in extracts of human breast cancer tissue...
  26. ncbi request reprint Differential effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems by human breast fibroblasts
    Anieta M Sieuwerts
    Department of Medical Oncology, Rotterdam Cancer Institute Daniel den Hoed Kliniek and University Hospital Rotterdam, The Netherlands
    Thromb Haemost 87:674-83. 2002
    ....