Winand N M Dinjens

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. pmc MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation
    Floris H Groenendijk
    Department of Pathology, Josephine Nefkens Institute, Be320a, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurooncol 101:405-17. 2011
  2. pmc Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear beta-catenin expression
    L B Koppert
    Department of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Br J Cancer 90:892-9. 2004
  3. pmc The CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis
    L B Koppert
    Department of Pathology, Erasmus University Medical Center, Josephine Nefkens Institute, PO Box 1738, Rotterdam 3000 DR, The Netherlands
    Br J Cancer 90:888-91. 2004
  4. pmc Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro
    Andrea De Gottardi
    Division of Gastroenterology, University Hospital, Micheli du Crest 24, 1205 Geneva, Switzerland
    Mol Cancer 5:48. 2006
  5. pmc Chemotherapy followed by surgery versus surgery alone in patients with resectable oesophageal squamous cell carcinoma: long-term results of a randomized controlled trial
    Jurjen J Boonstra
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    BMC Cancer 11:181. 2011
  6. ncbi request reprint Clinical importance of molecular determinations in gynecologic patients with multiple tumors
    Winand N M Dinjens
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer 97:1766-74. 2003
  7. ncbi request reprint Identification of a 7.1-mega base pairs minimal deletion at 14q31.1-32.11 in adenocarcinomas of the gastroesophageal junction
    Winand N M Dinjens
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Hum Pathol 37:534-41. 2006
  8. pmc MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951
    Martin J van den Bent
    Department of Neuro Oncology and Pathology, Daniel den Hoed Cancer Center and Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 27:5881-6. 2009
  9. doi request reprint Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas
    Bart Jeroen Petri
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Mod Pathol 21:407-13. 2008
  10. ncbi request reprint Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, JNI room 222, PO Box 2040, 3000 CR Rotterdam, The Netherlands
    Endocr Relat Cancer 14:453-62. 2007

Collaborators

Detail Information

Publications70

  1. pmc MGMT promoter hypermethylation is a frequent, early, and consistent event in astrocytoma progression, and not correlated with TP53 mutation
    Floris H Groenendijk
    Department of Pathology, Josephine Nefkens Institute, Be320a, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurooncol 101:405-17. 2011
    ..These results argue against the putative TP53 G:C>A:T transition mutations suggested to occur preferentially in MGMT hypermethylated tumors...
  2. pmc Frequent loss of the AXIN1 locus but absence of AXIN1 gene mutations in adenocarcinomas of the gastro-oesophageal junction with nuclear beta-catenin expression
    L B Koppert
    Department of Pathology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    Br J Cancer 90:892-9. 2004
    ..These data indicate that nuclear beta-catenin expression is indicative for activated Wnt signalling and that neither AXIN1 gene mutations nor AXIN1 locus LOH are involved in Wnt pathway activation in GEJ adenocarcinomas...
  3. pmc The CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis
    L B Koppert
    Department of Pathology, Erasmus University Medical Center, Josephine Nefkens Institute, PO Box 1738, Rotterdam 3000 DR, The Netherlands
    Br J Cancer 90:888-91. 2004
    ....
  4. pmc Expression of the bile acid receptor FXR in Barrett's esophagus and enhancement of apoptosis by guggulsterone in vitro
    Andrea De Gottardi
    Division of Gastroenterology, University Hospital, Micheli du Crest 24, 1205 Geneva, Switzerland
    Mol Cancer 5:48. 2006
    ..The aim of this study was to assess the expression of bile acid receptors in the esophagus (normal, esophagitis, Barrett's esophagus and adenocarcinoma) and to investigate their possible function...
  5. pmc Chemotherapy followed by surgery versus surgery alone in patients with resectable oesophageal squamous cell carcinoma: long-term results of a randomized controlled trial
    Jurjen J Boonstra
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    BMC Cancer 11:181. 2011
    ..Initial results reported only in abstract form in 1997, demonstrated an advantage for overall survival in the CS group. The results of this trial have been updated and discussed in the timeframe in which this study was performed...
  6. ncbi request reprint Clinical importance of molecular determinations in gynecologic patients with multiple tumors
    Winand N M Dinjens
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Cancer 97:1766-74. 2003
    ..The authors investigated whether the detection of molecular aberrations in multiple gynecologic tumors in individual patients provided clinically useful information on the correlation between the tumors...
  7. ncbi request reprint Identification of a 7.1-mega base pairs minimal deletion at 14q31.1-32.11 in adenocarcinomas of the gastroesophageal junction
    Winand N M Dinjens
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Hum Pathol 37:534-41. 2006
    ..The identification of this minimal deletion and the data base information on the genes present in this region facilitate the search for the candidate tumor suppressor gene(s)...
  8. pmc MGMT promoter methylation is prognostic but not predictive for outcome to adjuvant PCV chemotherapy in anaplastic oligodendroglial tumors: a report from EORTC Brain Tumor Group Study 26951
    Martin J van den Bent
    Department of Neuro Oncology and Pathology, Daniel den Hoed Cancer Center and Erasmus University Medical Center, Rotterdam, The Netherlands
    J Clin Oncol 27:5881-6. 2009
    ..It is unknown if MGMT promoter methylation is also predictive to outcome to RT followed by adjuvant procarbazine, lomustine, and vincristine (PCV) chemotherapy in patients with anaplastic oligodendroglial tumors (AOT)...
  9. doi request reprint Frequent loss of 17p, but no p53 mutations or protein overexpression in benign and malignant pheochromocytomas
    Bart Jeroen Petri
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Mod Pathol 21:407-13. 2008
    ..We conclude that, although there is frequent loss of the p53 locus on 17p, the p53 gene does not appear to play a major role in pheochromocytoma tumorigenesis...
  10. ncbi request reprint Candidate gene mutation analysis in bilateral adrenal pheochromocytoma and sympathetic paraganglioma
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, JNI room 222, PO Box 2040, 3000 CR Rotterdam, The Netherlands
    Endocr Relat Cancer 14:453-62. 2007
    ..We suggest that sequential mutation analysis should be directed first at RET, followed by VHL and SDHD for patients with bilateral adrenal PCC at diagnosis, and at SDHB and SDHD for patients with sPGL...
  11. doi request reprint Barrett's oesophageal adenocarcinoma encompasses tumour-initiating cells that do not express common cancer stem cell markers
    Brechtje A Grotenhuis
    Department of Surgery, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Pathol 221:379-89. 2010
    ..However, antibodies directed against novel surface antigens are needed to detect subpopulations enriched for CSCs in EA by transplantation assays...
  12. pmc First-line temozolomide chemotherapy in progressive low-grade astrocytomas after radiotherapy: molecular characteristics in relation to response
    Walter Taal
    Department of Neuro Oncology Neurology, Erasmus MC, Daniel den Hoed Cancer Center, Groene Hilledijk 301, 3075 EA, Rotterdam, The Netherlands
    Neuro Oncol 13:235-41. 2011
    ..01) and a methylated MGMT promoter (P = .02). We conclude that MGMT promoter methylation and IDH1 mutations seem to predict survival from the time of diagnosis, but not PFS to TMZ...
  13. ncbi request reprint Chromosomal and microsatellite instability of adenocarcinomas and dysplastic lesions (DALM) in ulcerative colitis
    Jolanda M van Dieren
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
    Diagn Mol Pathol 15:216-22. 2006
    ..Further, we found a low percentage of MSI. Thus, DALM/UCCs display profound chromosomal instability, but this is not associated with concurrent MSI...
  14. ncbi request reprint The molecular biology of esophageal adenocarcinoma
    Linetta B Koppert
    Department of Surgery, Erasmus MC, University Medical Center, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Surg Oncol 92:169-90. 2005
    ..Carcinomas that arise in the setting of Barrett's esophagus are thought to develop as part of the metaplasia-dysplasia-carcinoma sequence...
  15. doi request reprint Array comparative genomic hybridization, expression array, and protein analysis of critical regions on chromosome arms 1q, 7q, and 8p in adenocarcinomas of the gastroesophageal junction
    Herman van Dekken
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Cancer Genet Cytogenet 189:37-42. 2009
    ..2 (92.1 Mb; P<0.01); other genes showed less stringent associations. In conclusion, using a straightforward approach we constructed a targeted gene profile for GEJ adenocarcinomas...
  16. doi request reprint Array-comparative genomic hybridization in sporadic benign pheochromocytomas
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Endocr Relat Cancer 16:505-13. 2009
    ..In addition, genes on 21q and 22q might play a more important role in PCC pathogenesis than had been assumed thus far...
  17. doi request reprint Yield of routine molecular analyses in colorectal cancer patients ≤70 years to detect underlying Lynch syndrome
    Margot G F Van Lier
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    J Pathol 226:764-74. 2012
    ..Routine use of MSI testing may be considered in CRC patients up to the age of 70 years, with a central role for the pathologist in the selection of patients...
  18. doi request reprint Deletion of exons 1a-2 of BRCA1: a rather frequent pathogenic abnormality
    Ans M W van den Ouweland
    Department of Clinical Genetics, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Genet Test Mol Biomarkers 13:399-406. 2009
    ..This observation, together with the previously described families with exon 1a-2 deletions of BRCA1, demonstrates that this type of deletions is relatively frequent in breast/ovarian cancer families...
  19. doi request reprint Lymphatic micrometastases in patients with early esophageal adenocarcinoma
    Brechtje A Grotenhuis
    Department of Surgery, Erasmus Medical Center, Rotterdam, The Netherlands
    J Surg Oncol 102:863-7. 2010
    ..The study aim was to investigate whether the presence of occult tumor cells in lymph nodes could explain this variation...
  20. ncbi request reprint Reduced p120ctn expression correlates with poor survival in patients with adenocarcinoma of the gastroesophageal junction
    Bas P L Wijnhoven
    Department of Surgery, Erasmus MC, Rotterdam, The Netherlands
    J Surg Oncol 92:116-23. 2005
    ..The role of p120ctn in malignancy is not clear yet. We studied the in vivo expression and cellular localization of p120ctn in adenocarcinomas of the gastroesophageal junction...
  21. ncbi request reprint Neuroendocrine in Barrett's mucosa and adenocarcinomas of the gastroesophageal junction
    Linetta B Koppert
    Department of Surgery, Josephine Nefkens Institute, University Medical Center Rotterdam, The Netherlands
    Int J Surg Pathol 12:117-25. 2004
    ..In multi-variate analysis, CGA in Barrett was an independent prognostic factor for survival after surgery. Therefore CGA in Barrett adjacent to GEJ adenocarcinoma might be helpful in the assessment of patient outcome...
  22. doi request reprint IDH1 and IDH2 mutations are prognostic but not predictive for outcome in anaplastic oligodendroglial tumors: a report of the European Organization for Research and Treatment of Cancer Brain Tumor Group
    Martin J van den Bent
    Dept Neuro Oncology and Pathology, Daniel den Hoed Cancer Center and Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Clin Cancer Res 16:1597-604. 2010
    ....
  23. doi request reprint Non-pheochromocytoma (PCC)/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis
    Thomas G Papathomas
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    Eur J Endocrinol 170:1-12. 2014
    ..Absence of SDHB expression in tumors derived from tissues susceptible to SDH deficiency is not fully elucidated...
  24. doi request reprint Trp53 inactivation leads to earlier phaeochromocytoma formation in pten knockout mice
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Centre, CA Rotterdam, The Netherlands
    Endocr Relat Cancer 19:731-40. 2012
    ..Therefore, the present model appears to be a suitable model that might allow the preclinical study of new therapeutics for these tumours...
  25. doi request reprint SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors
    Lindsey Oudijk
    Department of Pathology, Erasmus MC, University Medical Center Rotterdam, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Mod Pathol 26:456-63. 2013
    ..Identifying GISTs with deficient SDH activity warrants additional genetic testing, evaluation and follow-up for inherited disorders and paragangliomas...
  26. ncbi request reprint An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, Netherlands
    Lancet Oncol 10:764-71. 2009
    ..We investigated whether SDHB immunohistochemistry could effectively discriminate between SDH-related and non-SDH-related phaeochromocytomas and paragangliomas in large retrospective and prospective tumour series...
  27. doi request reprint SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas
    Esther Korpershoek
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 96:E1472-6. 2011
    ..A recent report described a patient with an abdominal paraganglioma, immunohistochemically negative for SDHA, and identified a causal germline mutation in SDHA...
  28. ncbi request reprint Microarray-based CGH of sporadic and syndrome-related pheochromocytomas using a 0.1-0.2 Mb bacterial artificial chromosome array spanning chromosome arm 1p
    Marieke Aarts
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    Genes Chromosomes Cancer 45:83-93. 2006
    ..3, and 1p34.3-1p36.33. In conclusion, these data strongly suggest that chromosome arm 1p is the site for multiple tumor suppressor genes, although the potential candidate genes CDKN2C and PTPRF/LAR are not included in these regions...
  29. ncbi request reprint Clinical characteristics of pheochromocytoma patients with germline mutations in SDHD
    Hilde Dannenberg
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Oncol 23:1894-901. 2005
    ..We examined the value of SDHD mutation screening in patients presenting with apparently sporadic and familial pheochromocytoma for the identification of SDHD-related pheochromocytomas...
  30. doi request reprint Parasympathetic paragangliomas are part of the Von Hippel-Lindau syndrome
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 94:4367-71. 2009
    ..However, in parasympathetic paragangliomas occurring in VHL disease, biallelic inactivation of the VHL gene has not been demonstrated to date...
  31. ncbi request reprint Genomic analysis of Barrett's esophagus after ablative therapy: persistence of genetic alterations at tumor suppressor loci
    Mariska Hage
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    Int J Cancer 118:155-60. 2006
    ..Therefore, the goal of treatment should be the complete elimination of Barrett's mucosa...
  32. pmc Mismatch repair and treatment resistance in ovarian cancer
    Jozien Helleman
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    BMC Cancer 6:201. 2006
    ..The aim of this study is to determine the frequency of mismatch repair (MMR) inactivation in ovarian cancer and its association with resistance to platinum-based chemotherapy...
  33. ncbi request reprint Biallelic germline mutations of mismatch-repair genes: a possible cause for multiple pediatric malignancies
    Jan Werner Poley
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Cancer 109:2349-56. 2007
    ..Therefore, the authors studied the role of homozygosity or compound heterozygosity (CZ) for MMR gene defects in children with multiple primary tumors...
  34. doi request reprint Intra-tumoral molecular heterogeneity in benign and malignant pheochromocytomas and extra-adrenal sympathetic paragangliomas
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, 3000 CA Rotterdam, The Netherlands
    Endocr Relat Cancer 17:653-62. 2010
    ..We demonstrate that malignant PCC and sPGL have more intra-tumoral molecular heterogeneity than benign tumors, which suggests that benign and malignant PCC and sPGL have a different pathogenesis...
  35. pmc Functional polymorphisms associated with disease-free survival in resected carcinoma of the esophagus
    Jurjen J Boonstra
    Department of Surgery, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Gastrointest Surg 15:48-56. 2011
    ....
  36. doi request reprint Isocitrate dehydrogenase mutations are rare in pheochromocytomas and paragangliomas
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Room Ae304, Erasmus MC, University Medical Center Rotterdam, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    J Clin Endocrinol Metab 95:1274-8. 2010
    ..Conclusion: IDH mutations are very rare in paragangliomas and pheochromocytomas and do not appear to play an important role in oncogenic HIF activation known to be present in these tumors...
  37. doi request reprint A review on the molecular diagnostics of Lynch syndrome: a central role for the pathology laboratory
    Margot G F Van Lier
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, The Netherlands
    J Cell Mol Med 14:181-97. 2010
    ..In this review we address these molecular analyses, the central role for the pathologist in the selection of patients for germline diagnostics of LS, as well as the molecular basis of LS...
  38. doi request reprint The pathogenesis of Barrett's metaplasia and the progression to esophageal adenocarcinoma
    Brechtje A Grotenhuis
    Department of Surgery, Erasmus MC, University Medical Center, 2040, 3000 CA, Rotterdam, The Netherlands
    Recent Results Cancer Res 182:39-63. 2010
    ..This review outlines the process of pathogenesis of Barrett's metaplasia and its progression to esophageal adenocarcinoma...
  39. ncbi request reprint New developments in the detection of the clinical behavior of pheochromocytomas and paragangliomas
    Ronald R de Krijger
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Endocr Pathol 17:137-41. 2006
    ..In this article, recent attempts at marker detection, such as those mentioned above, as well as emerging knowledge on the molecular abnormalities in benign and malignant PCC and PGL will be presented...
  40. ncbi request reprint Mistaken identity of widely used esophageal adenocarcinoma cell line TE-7
    Jurjen J Boonstra
    Department of Surgery, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Cancer Res 67:7996-8001. 2007
    ..Furthermore, the cell lines TE-2, TE-3, TE-7, TE-12, and TE-13 should be regarded as one single squamous cell carcinoma cell line...
  41. ncbi request reprint p53 alterations and their relationship to SDHD mutations in parasympathetic paragangliomas
    Francien H van Nederveen
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Mod Pathol 16:849-56. 2003
    ..Given the fact that hypoxia induces p53 expression and regarding the absence of p53 mutations, these results suggest that p53 inactivation does not play a major role in the tumorigenesis of hereditary and sporadic paragangliomas...
  42. ncbi request reprint Von Hippel-Lindau gene alterations in sporadic benign and malignant pheochromocytomas
    Hilde Dannenberg
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands
    Int J Cancer 105:190-5. 2003
    ..We report novel VHL mutations in sporadic pheochromocytomas, which are slightly correlated with malignancy. VHL mutations may have some impact on the malignant transformation of pheochromocytomas...
  43. doi request reprint Mapping of homozygous deletions in verified esophageal adenocarcinoma cell lines and xenografts
    Jurjen J Boonstra
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Genes Chromosomes Cancer 51:272-82. 2012
    ..In summary, in this report we describe the identification of HDs in a series of verified EAC cell lines and xenografts. The deletions documented here are a step forward identifying the key genes involved in EAC development...
  44. ncbi request reprint Molecular genetic alterations in adrenal and extra-adrenal pheochromocytomas and paragangliomas
    Hilde Dannenberg
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC Rotterdam, The Netherlands
    Endocr Pathol 14:329-50. 2003
    ..This review presents an overview of our current understanding of the molecular pathogenesis of pheochromocytoma and paraganglioma...
  45. ncbi request reprint Allelic imbalance on distal 7q (7q36.1-q36.3) in gastric cardia and oesophageal (Barrett's) adenocarcinoma
    Kees J Vissers
    Department of Pathology, Josephine Nefkens Institute, Rotterdam, The Netherlands
    Anticancer Res 25:913-6. 2005
    ..Oesophageal (Barrett's) and gastric cardia adenocarcinomas are cancers arising at and around the gastro-oesophageal junction. The prognosis is poor, since detection is usually at a late stage and metastatic spread occurs early...
  46. ncbi request reprint TP53 mutation analysis of malignant peripheral nerve sheath tumors
    Robert M Verdijk
    Department of Pathology, Erasmus MC, University, Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 69:16-26. 2010
    ..These results indicate that TP53 mutations are relatively rare in human MPNST and that they are not positively correlated with the presence of NF1...
  47. doi request reprint Underutilization of microsatellite instability analysis in colorectal cancer patients at high risk for Lynch syndrome
    Margot G F Van Lier
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Scand J Gastroenterol 44:600-4. 2009
    ..The aim of this study was to evaluate whether MSI analysis was performed in colorectal cancer patients at risk for LS according to the revised Bethesda Guidelines...
  48. ncbi request reprint The occurrence of SDHB gene mutations in pheochromocytoma
    Francien H van Nederveen
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Room Be 232, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Ann N Y Acad Sci 1073:177-82. 2006
    ..Also, a link has been established between malignant behavior and inactivating mutations of SDHB. In this article we review the published SDHB gene mutations, as well as the location and behavior of the resulting PCCs...
  49. pmc Verification and unmasking of widely used human esophageal adenocarcinoma cell lines
    Jurjen J Boonstra
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Natl Cancer Inst 102:271-4. 2010
    ..Widespread use of contaminated cell lines threatens the development of treatment strategies for EAC...
  50. ncbi request reprint Frequent genetic changes in childhood pheochromocytomas
    Ronald R de Krijger
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Ann N Y Acad Sci 1073:166-76. 2006
    ..From our findings we conclude that (a) a large proportion (40%) of pediatric PCC patients is diagnosed in the context of inherited cancer syndromes, and (b) candidate gene analysis appears to be indicated to detect germline mutations...
  51. pmc SDHB immunohistochemistry: a useful tool in the diagnosis of Carney-Stratakis and Carney triad gastrointestinal stromal tumors
    José Gaal
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Mod Pathol 24:147-51. 2011
    ..In case of negative SDHB staining in GISTs, Carney-Stratakis syndrome or Carney triad should be considered and appropriate clinical surveillance should be instituted...
  52. ncbi request reprint Genetic aberrations in gliomatosis cerebri support monoclonal tumorigenesis
    Johan M Kros
    Department of Pathology, University Hospital Rotterdam, The Netherlands
    J Neuropathol Exp Neurol 61:806-14. 2002
    ..The wide distribution of a particular set of genetic aberrations in this case supports the concept of monoclonal tumor proliferation. The results point to involvement of TP53 mutation in the tumorigenesis of gliomatosis cerebri...
  53. doi request reprint Identification of Familial Adenomatous Polyposis carriers among children with desmoid tumours
    Anna A Kattentidt Mouravieva
    Department of Clinical Genetics, Erasmus MC, University Medical Centre, Rotterdam, The Netherlands
    Eur J Cancer 48:1867-74. 2012
    ..The aim of this study is to form guidelines for the identification of possible APC germline mutation carriers among children with desmoid tumours, based on CTNNB1 mutation analysis and immunohistochemical analysis (IHC) for β-catenin...
  54. ncbi request reprint Genomic analysis of a case of multifocal adenocarcinoma in ulcerative colitis
    Herman van Dekken
    Department of Pathology, Erasmus Medical Center, Josephine Nefkens Institute, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Virchows Arch 449:716-21. 2006
    ..We conclude that these three multifocal tumors must have originated from the same preneoplastic lineage...
  55. doi request reprint Conditional Pten knock-out mice: a model for metastatic phaeochromocytoma
    Esther Korpershoek
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    J Pathol 217:597-604. 2009
    ..The mouse model should allow further studies into the pathogenesis of human malignant PCCs and into therapeutic strategies for these tumours...
  56. ncbi request reprint Frequent germ-line succinate dehydrogenase subunit D gene mutations in patients with apparently sporadic parasympathetic paraganglioma
    Hilde Dannenberg
    Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, 1738 Rotterdam, The Netherlands
    Clin Cancer Res 8:2061-6. 2002
    ..We used conformation-dependent gel electrophoresis and sequence determination analysis of germ-line and tumor DNA to identify SDHD mutations. We compared the clinical and molecular characteristics of sporadic and hereditary PGLs...
  57. doi request reprint Successive B-cell lymphomas mostly reflect recurrences rather than unrelated primary lymphomas
    Willemina R R Geurts-Giele
    Dept of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Am J Clin Pathol 140:114-26. 2013
    ..To address whether successive B-cell lymphomas, diagnosed within a 5- to 15-year interval, are recurrences or unrelated primary lymphomas...
  58. doi request reprint Prospective evaluation of molecular screening for Lynch syndrome in patients with endometrial cancer ≤ 70 years
    Celine H M Leenen
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Gynecol Oncol 125:414-20. 2012
    ....
  59. doi request reprint Distinct gene mutation profiles among luminal-type and basal-type breast cancer cell lines
    Antoinette Hollestelle
    Department of Medical Oncology, Josephine Nefkens Institute, Erasmus, The Netherlands
    Breast Cancer Res Treat 121:53-64. 2010
    ....
  60. pmc Prevalence of c-KIT mutations in gonadoblastoma and dysgerminomas of patients with disorders of sex development (DSD) and ovarian dysgerminomas
    Remko Hersmus
    Department of Pathology, Erasmus MC University Medical Center Rotterdam, Josephine Nefkens Institute, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    PLoS ONE 7:e43952. 2012
    ..This data supports the existence of two distinct but parallel pathways in the development of dysgerminoma, in which mutational status of c-KIT might parallel the presence of TSPY...
  61. ncbi request reprint Analysis of immunoglobulin H gene rearrangement by polymerase chain reaction in primary central nervous system lymphoma
    Johan M Kros
    Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Neurosurg 97:1390-6. 2002
    ..In the present study, the contribution of both FR3 single and FR2 seminested PCR procedures for confirming the diagnosis of PCNSL was estimated retrospectively in 30 cases of PCNSL and in three cases of epidural lymphoma...
  62. ncbi request reprint A metastasis of an adenocarcinoma in a BRCA1 mutation carrier, a diagnostic problem not solved by morphology alone
    Vibeke Kuenen-Boumeester
    Department of Pathology, Erasmus Medical Center, Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Hum Pathol 35:629-32. 2004
    ..Surprisingly, at that time an occult breast carcinoma was identified to be the origin of the 2 metastatic locations as confirmed by molecular analysis. Eventually the patient could be treated accordingly...
  63. ncbi request reprint Allelic imbalance of 7q32.3-q36.1 during tumorigenesis in Barrett's esophagus
    Peter H J Riegman
    Departments of Pathology, Josephine Nefkens Institute, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands
    Cancer Res 62:1531-3. 2002
    ..1. These data suggest that markers from this area can be used as a diagnostic tool in Barrett's esophagus, i.e., to distinguish between watchful waiting and active treatment...
  64. doi request reprint Molecular diagnostics of a single multifocal non-small cell lung cancer case using targeted next generation sequencing
    Willemina R R Geurts-Giele
    Department of Pathology, Josephine Nefkens Institute, Erasmus MC, University Medical Center, P O Box 2040, 3000 CA, Rotterdam, The Netherlands
    Virchows Arch 462:249-54. 2013
    ..However, the application of the PGM in routine pathology molecular diagnostics needs validation in larger series of cases...
  65. ncbi request reprint Spectrum of genetic changes in gastro-esophageal cancer cell lines determined by an integrated molecular cytogenetic approach
    Carla Rosenberg
    Laboratory of Cytochemistry and Cytometry, Department Molecular Cell Biology, Leiden University Medical Center LUMC, Leiden, The Netherlands
    Cancer Genet Cytogenet 135:35-41. 2002
    ....
  66. ncbi request reprint Breast cancer in an MSH2 gene mutation carrier
    Pieter J Westenend
    Laboratory for Pathology Dordrecht, 3317 NL Dordrecht, The Netherlands
    Hum Pathol 36:1322-6. 2005
    ..We tested the tumor for loss of heterozygosity of the MSH2 gene and found loss of the wild-type MSH2 allele. These data strongly suggest that the MSH2 gene was involved in the development of this breast tumor...
  67. ncbi request reprint Increased sensitivity of B-cell clonality analysis in formalin-fixed and paraffin-embedded B-cell lymphoma samples using an enzyme blend with both 5'-->3' DNA polymerase and 3'-->5' exonuclease activity
    Timea P Gurbity
    Hematology Unit, 2nd Department of Internal Medicine, University of Szeged, Szeged, Hungary
    Virchows Arch 443:643-8. 2003
    ..In conclusion, the r Tth DNA polymerase greatly improves sensitivity of FR3/JH PCR in FFPE biopsies of mature B-cell lymphomas, most probably by increasing the primer matches during PCR amplification...
  68. ncbi request reprint Determination of the molecular relationship between multiple tumors within one patient is of clinical importance
    Joost R M van der Sijp
    Department of Surgical Oncology, Dr Daniel den Hoed Clinic, University Hospital Dijkzigt, The Netherlands
    J Clin Oncol 20:1105-14. 2002
    ..To determine the molecular relationship between multiple tumors within one patient and to evaluate the impact of this knowledge on clinical management...
  69. ncbi request reprint Somatic SDHB mutation in an extraadrenal pheochromocytoma
    Francien H van Nederveen
    N Engl J Med 357:306-8. 2007
  70. ncbi request reprint A subset of head and neck squamous cell carcinomas exhibits integration of HPV 16/18 DNA and overexpression of p16INK4A and p53 in the absence of mutations in p53 exons 5-8
    Harriet C Hafkamp
    Research Institute GROW, Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Maastricht, Maastricht, The Netherlands
    Int J Cancer 107:394-400. 2003
    ..Evaluation of clinical data revealed a significant inverse relation between tobacco use with or without alcohol consumption, and HPV positivity of the tumors...