Heleen M den Hertog

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Cooling therapy for acute stroke
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Postbus 2040, Rotterdam, Netherlands, 3000 CA
    Cochrane Database Syst Rev . 2009
  2. doi request reprint Effects of high-dose paracetamol on blood pressure in acute stroke
    H M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Acta Neurol Scand 125:265-71. 2012
  3. ncbi request reprint Therapeutic hypothermia in acute ischemic stroke
    Heleen den Hertog
    Deparment of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Expert Rev Neurother 7:155-64. 2007
  4. ncbi request reprint [Rhombencephalitis due to Listeria monocytogenes]
    M H den Hertog
    Erasmus MC Centrum, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 151:1885-90. 2007
  5. pmc Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480]
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    BMC Cardiovasc Disord 8:29. 2008
  6. doi request reprint The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Centre, Rotterdam, Netherlands
    Lancet Neurol 8:434-40. 2009
  7. pmc C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death
    H M den Hertog
    Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol 256:2003-8. 2009
  8. pmc An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurol 258:302-7. 2011
  9. pmc Metformin and sitAgliptin in patients with impAired glucose tolerance and a recent TIA or minor ischemic Stroke (MAAS): study protocol for a randomized controlled trial
    Elizabeth Osei
    Department of Neurology, Medisch Spectrum Twente, PO Box 50 000, Enschede, 7500, KA, The Netherlands
    Trials 16:332. 2015
  10. doi request reprint γ'/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke
    Evita G van den Herik
    Erasmus MC University Medical Center, Department of Neurology, Rotterdam, The Netherlands
    Thromb Haemost 105:430-4. 2011

Collaborators

Detail Information

Publications19

  1. doi request reprint Cooling therapy for acute stroke
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Postbus 2040, Rotterdam, Netherlands, 3000 CA
    Cochrane Database Syst Rev . 2009
    ..In patients with acute stroke, lowering temperature may therefore improve outcome. This is an update of a Cochrane review first published in 1999...
  2. doi request reprint Effects of high-dose paracetamol on blood pressure in acute stroke
    H M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Acta Neurol Scand 125:265-71. 2012
    ..Besides its antipyretic effects, paracetamol may affect blood pressure through cyclooxygenase-2 inhibition. We therefore aimed to assess the effect of high-dose paracetamol on blood pressure in patients with acute stroke...
  3. ncbi request reprint Therapeutic hypothermia in acute ischemic stroke
    Heleen den Hertog
    Deparment of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Expert Rev Neurother 7:155-64. 2007
    ..Large randomized clinical trials are needed to study the effect of both physical and medical cooling on functional outcome after stroke...
  4. ncbi request reprint [Rhombencephalitis due to Listeria monocytogenes]
    M H den Hertog
    Erasmus MC Centrum, Postbus 2040, 3000 CA Rotterdam
    Ned Tijdschr Geneeskd 151:1885-90. 2007
    ..Early diagnosis and treatment improve the prognosis...
  5. pmc Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480]
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    BMC Cardiovasc Disord 8:29. 2008
    ..Therefore, the planned primary analysis of the PAIS study has been changed from fixed dichotomization of the mRS to a sliding dichotomy analysis...
  6. doi request reprint The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Centre, Rotterdam, Netherlands
    Lancet Neurol 8:434-40. 2009
    ..The Paracetamol (Acetaminophen) In Stroke (PAIS) trial aimed to assess whether early treatment with paracetamol improves functional outcome in patients with acute stroke by reducing body temperature and preventing fever...
  7. pmc C-reactive protein in the very early phase of acute ischemic stroke: association with poor outcome and death
    H M den Hertog
    Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Neurol 256:2003-8. 2009
    ..7, 95% CI 1.0–2.9) at 3 months. In addition, the risk of poor outcome or death at 3 months increased with higher levels of CRP. CRP within 12 h of ischemic stroke is an independent prognostic factor of poor outcome at 3 months...
  8. pmc An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurol 258:302-7. 2011
    ..30; 95% CI 1.05-1.63) and death (aOR 1.51; 95% CI 1.15-1.98). An early rise in body temperature rather than high body temperature on admission is a risk factor for unfavorable outcome in patients with acute stroke...
  9. pmc Metformin and sitAgliptin in patients with impAired glucose tolerance and a recent TIA or minor ischemic Stroke (MAAS): study protocol for a randomized controlled trial
    Elizabeth Osei
    Department of Neurology, Medisch Spectrum Twente, PO Box 50 000, Enschede, 7500, KA, The Netherlands
    Trials 16:332. 2015
    ..We will also assess whether a slow increase in metformin dose and better support and information on this treatment will reduce the incidence of side effects in these patients...
  10. doi request reprint γ'/total fibrinogen ratio is associated with short-term outcome in ischaemic stroke
    Evita G van den Herik
    Erasmus MC University Medical Center, Department of Neurology, Rotterdam, The Netherlands
    Thromb Haemost 105:430-4. 2011
    ..Increased fibrinogen γ' relative to total fibrinogen levels are associated with unfavourable outcome in the early phase after stroke...
  11. ncbi request reprint Nonfocal Symptoms in Patients with Transient Ischemic Attack or Ischemic Stroke: Occurrence, Clinical Determinants, and Association with Cardiac History
    Gerben J J Plas
    Department of Neurology, Medisch Spectrum Twente, Enschede, The Netherlands
    Cerebrovasc Dis 42:439-445. 2016
    ..We assessed the occurrence of nonfocal symptoms in patients with TIA or minor ischemic stroke in a neurological outpatient clinic in terms of clinical determinants, cardiac history, and atrial fibrillation (AF)...
  12. doi request reprint Safety and feasibiLIty of Metformin in patients with Impaired glucose Tolerance and a recent TIA or minor ischemic stroke (LIMIT) trial - a multicenter, randomized, open-label phase II trial
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Int J Stroke 10:105-9. 2015
    ..We aimed to assess the safety, feasibility, and effects on glucose metabolism of treatment with metformin in patients with TIA or minor ischemic stroke and impaired glucose tolerance...
  13. doi request reprint Prediabetes in patients with stroke or transient ischemic attack: prevalence, risk and clinical management
    Susanne Fonville
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Cerebrovasc Dis 37:393-400. 2014
    ..Prediabetes is highly prevalent in nondiabetic patients with transient ischemic attack (TIA) or ischemic stroke and nearly doubles their risk of stroke. This offers new options for secondary stroke prevention...
  14. doi request reprint Prevalence of prediabetes and newly diagnosed diabetes in patients with a transient ischemic attack or stroke
    Susanne Fonville
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Cerebrovasc Dis 36:283-9. 2013
    ....
  15. doi request reprint Occurrence and predictors of persistent impaired glucose tolerance after acute ischemic stroke or transient ischemic attack
    Susanne Fonville
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands Electronic address
    J Stroke Cerebrovasc Dis 23:1669-75. 2014
    ..We aimed to assess the occurrence of persistent impaired glucose tolerance after a stroke or TIA and to develop a prediction model to identify patients at risk of persistent impaired glucose tolerance...
  16. doi request reprint Variation in the C-reactive protein gene is associated with serum levels of CRP in patients with acute ischemic stroke
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands m denhertog erasmusmc nl
    Cerebrovasc Dis 29:372-5. 2010
    ..We investigated whether haplotypes representing common variations in the CRP gene are associated with levels of CRP in patients with acute ischemic stroke...
  17. doi request reprint Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 °
    Inger R de Ridder
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Int J Stroke 10:457-62. 2015
    ..43; 95% confidence interval: 1.02-1.97). This relation was also found in the patients with a body temperature of 36.5 °C or higher (odds ratio 1.31; 95% confidence interval 1.01-1.68). These findings need confirmation...
  18. doi request reprint Health education in patients with a recent stroke or transient ischaemic attack: a comprehensive review
    Lisette Maasland
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Int J Stroke 6:67-74. 2011
    ..Future trials should be large, have a long follow-up, should use an intensive and repetitive approach and involve patients' relatives to induce and maintain a healthy lifestyle...
  19. ncbi request reprint Does prior antiplatelet treatment improve functional outcome after intra-arterial treatment for acute ischemic stroke?
    Maxim Jhl Mulder
    Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Stroke . 2016
    ..Our aim was to study whether intra-arterial treatment in patients with prior antiplatelet treatment is safe and whether prior antiplatelet treatment modifies treatment effect...