P J D Delhanty

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity
    Patric J D Delhanty
    Departments of Internal Medicine and Pediatric Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Mol Biol Rep 41:7967-72. 2014
  2. doi request reprint Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis
    Patric J D Delhanty
    Dept of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    FASEB J 27:1690-700. 2013
  3. doi request reprint Ghrelin and glucose homeostasis
    P J D Delhanty
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Peptides 32:2309-18. 2011
  4. ncbi request reprint Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway
    P J D Delhanty
    Department of Internal Medicine, Rm Ee542, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 293:E302-9. 2007
  5. doi request reprint Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization
    Patric J D Delhanty
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 299:E497-505. 2010
  6. pmc Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice
    Patric J D Delhanty
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 5:e11749. 2010
  7. ncbi request reprint Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity
    C Gauna
    Department of Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:5035-42. 2004
  8. ncbi request reprint Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a
    P J D Delhanty
    Department of Internal Medicine, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GD Rotterdam, The Netherlands
    J Endocrinol 188:37-47. 2006
  9. doi request reprint Desacyl ghrelin is influenced by changes in insulin concentration during an insulin tolerance test
    K Blijdorp
    Department of Medicine section Endocrinology, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Growth Horm IGF Res 23:193-5. 2013

Collaborators

Detail Information

Publications9

  1. doi request reprint Functional characterization of a new human melanocortin-4 receptor homozygous mutation (N72K) that is associated with early-onset obesity
    Patric J D Delhanty
    Departments of Internal Medicine and Pediatric Endocrinology, Erasmus MC, Rotterdam, The Netherlands
    Mol Biol Rep 41:7967-72. 2014
    ..Our data describe a rare homozygous inactivating mutation in the first intra-cellular loop of MC4R that markedly impairs its function and is associated with early-onset obesity and hyperphagia. ..
  2. doi request reprint Des-acyl ghrelin analogs prevent high-fat-diet-induced dysregulation of glucose homeostasis
    Patric J D Delhanty
    Dept of Internal Medicine, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    FASEB J 27:1690-700. 2013
    ..AZP531 also prevented a HFD-induced increase in acyl ghrelin levels. Our data indicate DAG analogs as potential treatment for the prevention of metabolic syndrome...
  3. doi request reprint Ghrelin and glucose homeostasis
    P J D Delhanty
    Department of Internal Medicine, Erasmus MC, 3000 CA Rotterdam, The Netherlands
    Peptides 32:2309-18. 2011
    ..A promising recently developed approach appears to be through the blockade of GOAT activity, although the longer term effects of this treatment remain to be investigated...
  4. ncbi request reprint Ghrelin and its unacylated isoform stimulate the growth of adrenocortical tumor cells via an anti-apoptotic pathway
    P J D Delhanty
    Department of Internal Medicine, Rm Ee542, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 293:E302-9. 2007
    ....
  5. doi request reprint Unsaturated fatty acids prevent desensitization of the human growth hormone secretagogue receptor by blocking its internalization
    Patric J D Delhanty
    Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Physiol Endocrinol Metab 299:E497-505. 2010
    ....
  6. pmc Unacylated ghrelin rapidly modulates lipogenic and insulin signaling pathway gene expression in metabolically active tissues of GHSR deleted mice
    Patric J D Delhanty
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    PLoS ONE 5:e11749. 2010
    ..There is increasing evidence that unacylated ghrelin (UAG) improves insulin sensitivity and glucose homeostasis; however, the mechanism for this activity is not fully understood since a UAG receptor has not been discovered...
  7. ncbi request reprint Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity
    C Gauna
    Department of Medicine, Erasmus Medical Center, 3015 GE Rotterdam, The Netherlands
    J Clin Endocrinol Metab 89:5035-42. 2004
    ....
  8. ncbi request reprint Ghrelin and unacylated ghrelin stimulate human osteoblast growth via mitogen-activated protein kinase (MAPK)/phosphoinositide 3-kinase (PI3K) pathways in the absence of GHS-R1a
    P J D Delhanty
    Department of Internal Medicine, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GD Rotterdam, The Netherlands
    J Endocrinol 188:37-47. 2006
    ..Overall, our data suggest new roles for ghrelin and UAG in modulating human osteoblast proliferation via a novel signal transduction pathway...
  9. doi request reprint Desacyl ghrelin is influenced by changes in insulin concentration during an insulin tolerance test
    K Blijdorp
    Department of Medicine section Endocrinology, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Growth Horm IGF Res 23:193-5. 2013
    ..We aimed to assess changes in DAG in response to the rapid increase in insulin concentration during an insulin tolerance test (ITT) in normal weight and obese subjects...