Marieke C J Dekker
Affiliation: Erasmus MC
Country: The Netherlands
- Parkinson's disease: piecing together a genetic jigsawM C J Dekker
Genetic Epidemiologic Unit, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Brain 126:1722-33. 2003..We review advances in the genetics of Parkinson's disease, focusing on the monogenic forms and their clinical and population-genetic consequences...
- Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonismMarieke C J Dekker
Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Neurosci Lett 348:117-9. 2003..009, P=0.006, respectively). Our data are hampered by small numbers, yet suggest that the C282Y mutation increases the risk of PD and non-PD PS. The rarity of this genotype requires a large series of patients to prove our hypothesis...
- Evidence for novel loci for late-onset Parkinson's disease in a genetic isolate from the NetherlandsAida M Bertoli-Avella
Genetic Epidemiologic Unit, Department of Clinical Genetics and Department of Epidemiology and Biostatistics, Erasmus MC Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands
Hum Genet 119:51-60. 2006..7-6.1, P < 0.001). Moreover, a common haplotype with excess of sharing among late-onset PD cases was observed on both regions. Our results suggest the existence of two loci influencing PD susceptibility on chromosome 9q and 14q...
- A deletion in DJ-1 and the risk of dementia--a population-based surveyAlejandro Arias Vasquez
Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
Neurosci Lett 372:196-9. 2004..All subjects were heterozygous for the deletion and related to a common ancestor within eight generations. Our results suggest it is unlikely that haploinsufficiency in the DJ-1 gene imparts an increased risk for dementia...
- Loss of nuclear activity of the FBXO7 protein in patients with parkinsonian-pyramidal syndrome (PARK15)Tianna Zhao
Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
PLoS ONE 6:e16983. 2011..The activity of FBXO7 in the nucleus appears therefore crucial for the maintenance of brain neurons and the pathogenesis of PARK15...
- Prospects of genetic epidemiology in the 21st centuryMarieke C J Dekker
Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
Eur J Epidemiol 18:607-16. 2003....
- Phenotypic subtypes in attention deficit hyperactivity disorder in an isolated populationEsther A Croes
Genetic Epidemiology Unit, Department of Epidemiology and Biostatistics, Erasmus Medical Centre, PO Box 1738, 3000 DR Rotterdam, The Netherlands
Eur J Epidemiol 20:789-94. 2005..01). Our data suggests that using two informants in diagnosing ADHD helps identify a phenotype with a strong genetic component. The inattentive phenotype showed strong familial clustering and evidence of a recessive origin...
- Attention-deficit/hyperactivity disorder (ADHD): parents' judgment about school, teachers' judgment about homePieter F A de Nijs
Outpatients Department of Child and Adolescent Psychiatry, Erasmus MC Sophia Children s Hospital, 3000 CB Rotterdam, The Netherlands
Eur Child Adolesc Psychiatry 13:315-20. 2004..The aim of this study was to separate sources of observer and situational variance in reporting attention-deficit/hyperactivity disorder (ADHD) symptomatology...
- Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonismVincenzo Bonifati
Genetic Epidemiologic Unit, Department of Clinical Genetics, Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, Post Office Box 1738, 3000 DR Rotterdam, Netherlands
Science 299:256-9. 2003..Elucidating the physiological role of DJ-1 protein may promote understanding of the mechanisms of brain neuronal maintenance and pathogenesis of Parkinson's disease...
- Brachydactyly and short stature in a kindred with early-onset parkinsonismMarieke C J Dekker
Am J Med Genet A 130:102-4. 2004..Since the bone length reduction was more pronounced in the homozygous parkinsonism patients than in their heterozygous relatives, however, the PARK7 region may contain a modifier gene for growth...