Abbas Dehghan

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study)
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Am J Cardiol 113:1-6. 2014
  2. pmc Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med 6:30. 2008
  3. doi Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
  4. pmc Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
  5. doi SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
  6. pmc Serum uric acid and chronic kidney disease: the role of hypertension
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e76827. 2013
  7. ncbi Risk of type 2 diabetes attributable to C-reactive protein and other risk factors
    Abbas Dehghan
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Diabetes Care 30:2695-9. 2007
  8. pmc Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet 372:1953-61. 2008
  9. doi Kidney function and microstructural integrity of brain white matter
    Sanaz Sedaghat
    From the Departments of Epidemiology S S, L G M C, M D G, A H, O H F, M W V, A D, M A I, Radiology L G M C, M D G, A v d L, M W V, M A I, Medical informatics M d G, Internal Medicine E J H, and Neurology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Neurology 85:154-61. 2015
  10. ncbi High serum uric acid as a novel risk factor for type 2 diabetes
    Abbas Dehghan
    Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Diabetes Care 31:361-2. 2008

Detail Information

Publications29

  1. doi Comparison of prognosis in unrecognized versus recognized myocardial infarction in men versus women >55 years of age (from the Rotterdam Study)
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, University Medical Center Rotterdam, Rotterdam, The Netherlands Electronic address
    Am J Cardiol 113:1-6. 2014
    ..In men, the prognosis is as unfavorable as that of patients with recognized MIs. ..
  2. pmc Lack of association of two common polymorphisms on 9p21 with risk of coronary heart disease and myocardial infarction; results from a prospective cohort study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    BMC Med 6:30. 2008
    ..We examined the SNPs in relation to the risk of CHD and MI in a large population based study of elderly population...
  3. doi Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease
    Aaron Isaacs
    Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 33:2233-9. 2013
    ..We tested the hypothesis that the cumulative effects of common genetic variants for lipids are collectively associated with subclinical atherosclerosis and incident coronary heart disease...
  4. pmc Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study
    Mandy van Hoek
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Diabetes 57:3122-8. 2008
    ..Genome-wide association (GWA) studies identified multiple new genetic variants that associate with type 2 diabetes. The predictive value of genetic testing for prediction of type 2 diabetes in the general population is unclear...
  5. doi SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin
    M Carola Zillikens
    Department of Internal Medicine, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Free Radic Biol Med 46:836-41. 2009
    ..Correction of niacin deficiency and SIRT1 modulators may prolong the life span of patients with diabetes...
  6. pmc Serum uric acid and chronic kidney disease: the role of hypertension
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 8:e76827. 2013
    ..In this population-based study we investigated the association between serum uric acid and decline in renal function and tested whether hypertension moderates this association...
  7. ncbi Risk of type 2 diabetes attributable to C-reactive protein and other risk factors
    Abbas Dehghan
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Diabetes Care 30:2695-9. 2007
    ..To calculate the population-attributable risk (PAR) of C-reactive protein (CRP) and other risk factors for type 2 diabetes...
  8. pmc Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Centre, Rotterdam, Netherlands
    Lancet 372:1953-61. 2008
    ..Hyperuricaemia, a highly heritable trait, is a key risk factor for gout. We aimed to identify novel genes associated with serum uric acid concentration and gout...
  9. doi Kidney function and microstructural integrity of brain white matter
    Sanaz Sedaghat
    From the Departments of Epidemiology S S, L G M C, M D G, A H, O H F, M W V, A D, M A I, Radiology L G M C, M D G, A v d L, M W V, M A I, Medical informatics M d G, Internal Medicine E J H, and Neurology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Neurology 85:154-61. 2015
    ..To investigate the association of kidney function with white matter microstructural integrity...
  10. ncbi High serum uric acid as a novel risk factor for type 2 diabetes
    Abbas Dehghan
    Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, P O Box 2040, 3000 CA Rotterdam, Netherlands
    Diabetes Care 31:361-2. 2008
    ..To investigate the association between serum uric acid level and risk of type 2 diabetes...
  11. doi Association of renal function with vascular stiffness in older adults: the Rotterdam study
    Sanaz Sedaghat
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Age Ageing 43:827-33. 2014
    ..A potential mechanism linking cardiovascular disease to chronic kidney disease might be the change in arterial elasticity. We aim to determine the association between renal function and arterial stiffness in older subjects...
  12. pmc Thyroid function and age-related macular degeneration: a prospective population-based cohort study--the Rotterdam Study
    Layal Chaker
    Rotterdam Thyroid Center, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Med 13:94. 2015
    ..The association between thyroid function and age-related macular degeneration (AMD) has not been investigated in the general population...
  13. pmc Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels
    Abbas Dehghan
    Erasmus Medical Center, Dr Molewaterplein 50, Rotterdam, Netherlands
    Circulation 123:731-8. 2011
    ..C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We sought to identify genetic variants that are associated with CRP levels...
  14. pmc Pleiotropy among common genetic loci identified for cardiometabolic disorders and C-reactive protein
    Symen Ligthart
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
    PLoS ONE 10:e0118859. 2015
    ..In addition to reverse causation, our data suggests that pleiotropic genetic variants partially underlie the association between CRP and cardiometabolic phenotypes. ..
  15. doi Association of uric acid genetic risk score with blood pressure: the Rotterdam study
    Sanaz Sedaghat
    Departments of Epidemiology S S, R P, A G U, A H, B H Ch S, O H F, A D, M A I, Internal Medicine A G U, Radiology M A I, and Neurology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Hypertension 64:1061-6. 2014
    ..Our study suggests that genome wide association study's findings can be associated with an intermediate factor or have a pleiotropic role and, therefore, should be applied for Mendelian Randomization with caution. ..
  16. ncbi Genetic variation, C-reactive protein levels, and incidence of diabetes
    Abbas Dehghan
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands
    Diabetes 56:872-8. 2007
    ..45, 95% CI 1.08-1.96). These findings support the hypothesis that serum CRP enhances the development of diabetes...
  17. doi The association of common polymorphisms in miR-196a2 with waist to hip ratio and miR-1908 with serum lipid and glucose
    Mohsen Ghanbari
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Obesity (Silver Spring) 23:495-503. 2015
    ..Given the crucial role of miRNAs in gene expression, genetic variation within miRNA genes is expected to affect miRNA function and substantially contribute to disease risk...
  18. doi EN-RAGE: a novel inflammatory marker for incident coronary heart disease
    Symen Ligthart
    From the Department of Epidemiology S L, S S, M A I, A H, O H F, A D, Department of Neurology M A I, and Department of Radiology M A I, Erasmus University Medical Center, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 34:2695-9. 2014
    ..Inflammation plays a key role in atherosclerosis. We hypothesized that novel inflammatory markers may predict the risk of coronary heart disease (CHD)...
  19. pmc Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease
    Joyce B J van Meurs
    Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Am J Clin Nutr 98:668-76. 2013
    ....
  20. doi The relation of uric acid to brain atrophy and cognition: the Rotterdam Scan Study
    Benjamin F J Verhaaren
    Department of Epidemiology, Erasmus MC University Medical Center, NL 3000 CA Rotterdam, The Netherlands
    Neuroepidemiology 41:29-34. 2013
    ..However, it is unknown whether uric acid also relates to global brain changes such as brain atrophy. We therefore studied the relation of uric acid to brain atrophy and whether this is accompanied by worse cognitive function...
  21. pmc Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts
    Abbas Dehghan
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Circ Cardiovasc Genet 2:125-33. 2009
    ..Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels...
  22. doi Subclinical thyroid dysfunction and the risk of stroke: a systematic review and meta-analysis
    Layal Chaker
    Department of Internal Medicine, Thyroid Center, Erasmus University Medical Center, Room Ee502, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    Eur J Epidemiol 29:791-800. 2014
    ..Also, there were insufficient events to exclude clinically significant risk from subclinical hyperthyroidism, and more data are required for subgroup analyses...
  23. pmc Low-risk susceptibility alleles in 40 human breast cancer cell lines
    Muhammad Riaz
    Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Cancer 9:236. 2009
    ..The mechanism by which the low-risk SNPs confer breast cancer risks is currently unclear. The breast cancer association consortium BCAC has hypothesized that the low-risk SNPs modulate expression levels of nearby located genes...
  24. doi Blood pressure parameters and carotid intraplaque hemorrhage as measured by magnetic resonance imaging: The Rotterdam Study
    Mariana Selwaness
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Hypertension 61:76-81. 2013
    ..The association between pulsatile flow and IPH may provide novel insights in the development of the vulnerable plaque...
  25. pmc High bone mineral density and fracture risk in type 2 diabetes as skeletal complications of inadequate glucose control: the Rotterdam Study
    Ling Oei
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Diabetes Care 36:1619-28. 2013
    ..Individuals with type 2 diabetes have increased fracture risk despite higher bone mineral density (BMD). Our aim was to examine the influence of glucose control on skeletal complications...
  26. pmc Renal function is related to severity of coronary artery calcification in elderly persons: the Rotterdam study
    Abdelilah El Barzouhi
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
    PLoS ONE 6:e16738. 2011
    ..Since renal function diminishes with aging we examined the association between GFR and CAC in the Rotterdam Study, a population-based study of elderly individuals...
  27. pmc Identifying genetic risk variants for coronary heart disease in familial hypercholesterolemia: an extreme genetics approach
    Jorie Versmissen
    Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Eur J Hum Genet 23:381-7. 2015
    ..Most likely, this method is not as effective in leveraging effect size as anticipated, and may, therefore, not lead to significant gains in statistical power...
  28. doi A genetic variant in the seed region of miR-4513 shows pleiotropic effects on lipid and glucose homeostasis, blood pressure, and coronary artery disease
    Mohsen Ghanbari
    Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands Department of Genetics, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
    Hum Mutat 35:1524-31. 2014
    ..Our findings indicate a pleiotropic effect of miR-4513 on cardiometabolic phenotypes and may improve our understanding of the pathophysiology of cardiometabolic diseases. ..
  29. pmc Variance heterogeneity analysis for detection of potentially interacting genetic loci: method and its limitations
    Maksim V Struchalin
    Department of Epidemiology, Erasmus MC, Rotterdam, 3000 CA, The Netherlands
    BMC Genet 11:92. 2010
    ..In this work, we evaluated statistical properties of variance heterogeneity analysis in respect to the detection of potentially interacting SNPs in a case when an interaction variable is unknown...