Robert J de Knegt

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. doi request reprint Randomised clinical trial: escitalopram for the prevention of psychiatric adverse events during treatment with peginterferon-alfa-2a and ribavirin for chronic hepatitis C
    R J de Knegt
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 34:1306-17. 2011
  2. doi request reprint Risk factors for infection during treatment with peginterferon alfa and ribavirin for chronic hepatitis C
    Robert Roomer
    Department of Gastroenterology and Hepatology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hepatology 52:1225-31. 2010
  3. doi request reprint Evaluation of transient elastography for fibrosis assessment compared with large biopsies in chronic hepatitis B and C
    Claudia Verveer
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
    Liver Int 32:622-8. 2012
  4. doi request reprint Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients
    Joep de Bruijne
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 52:1590-9. 2010
  5. doi request reprint Continuous interferon-α2b infusion in combination with ribavirin for chronic hepatitis C in treatment-experienced patients
    Robert Roomer
    Department of Gastroenterology and Hepatology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Antivir Ther 17:509-17. 2012
  6. doi request reprint Discordance between HCV RNA assays for week 24 HCV RNA determination during pegylated interferon-α/ribavirin treatment for chronic hepatitis C
    Robert Roomer
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antivir Ther 16:771-4. 2011
  7. pmc Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life. An international, multicenter, randomized, controlled study
    Geert Bezemer
    Dpt, Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Gastroenterol 12:11. 2012
  8. doi request reprint Thrombocytopenia and the risk of bleeding during treatment with peginterferon alfa and ribavirin for chronic hepatitis C
    Robert Roomer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Hepatol 53:455-9. 2010
  9. pmc Negative regulation of hepatitis C virus specific immunity is highly heterogeneous and modulated by pegylated interferon-alpha/ribavirin therapy
    Mark A A Claassen
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 7:e49389. 2012
  10. doi request reprint Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7
    Andre Boonstra
    Department of Gastroenterology and Hepatology, Erasmus Medical Center University Hospital, Rotterdam, The Netherlands
    Antivir Ther 17:657-67. 2012

Collaborators

Detail Information

Publications26

  1. doi request reprint Randomised clinical trial: escitalopram for the prevention of psychiatric adverse events during treatment with peginterferon-alfa-2a and ribavirin for chronic hepatitis C
    R J de Knegt
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Aliment Pharmacol Ther 34:1306-17. 2011
    ..35.9% in the placebo-group (P = 0.015, Chi-squared test). CONCLUSIONS  Prophylactic treatment with escitalopram is effective in the prevention of psychiatric side-effects during interferon-based treatment of hepatitis C...
  2. doi request reprint Risk factors for infection during treatment with peginterferon alfa and ribavirin for chronic hepatitis C
    Robert Roomer
    Department of Gastroenterology and Hepatology, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Hepatology 52:1225-31. 2010
    ..Older patients and patients with poorly controlled diabetes mellitus have a greater risk of developing infections during HCV treatment...
  3. doi request reprint Evaluation of transient elastography for fibrosis assessment compared with large biopsies in chronic hepatitis B and C
    Claudia Verveer
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
    Liver Int 32:622-8. 2012
    ..We prospectively studied the performance of TE compared to histology and also whether there are differences between CHB and CHC. Only large biopsies (≥ 25 mm) were used...
  4. doi request reprint Antiviral activity of narlaprevir combined with ritonavir and pegylated interferon in chronic hepatitis C patients
    Joep de Bruijne
    Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 52:1590-9. 2010
    ..Narlaprevir (with or without ritonavir) alone or in combination with PEG-IFN-α-2b was safe and well tolerated...
  5. doi request reprint Continuous interferon-α2b infusion in combination with ribavirin for chronic hepatitis C in treatment-experienced patients
    Robert Roomer
    Department of Gastroenterology and Hepatology, Erasmus Medical Center University Medical Center, Rotterdam, The Netherlands
    Antivir Ther 17:509-17. 2012
    ..The aims of the study were to assess safety, tolerability and virological response in patients who were previous PEG-IFN-α/ribavirin non-responders...
  6. doi request reprint Discordance between HCV RNA assays for week 24 HCV RNA determination during pegylated interferon-α/ribavirin treatment for chronic hepatitis C
    Robert Roomer
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Antivir Ther 16:771-4. 2011
    ..The aim of this study was to assess discordance between the week 24 HCV RNA test results of two PCR-based assays (Amplicor and TaqMan) and the transcription-mediated amplification (TMA) HCV RNA qualitative assay...
  7. pmc Long-term effects of treatment and response in patients with chronic hepatitis C on quality of life. An international, multicenter, randomized, controlled study
    Geert Bezemer
    Dpt, Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    BMC Gastroenterol 12:11. 2012
    ..HRQL improves after successful treatment. This trial explores the course of and factors associated with HRQL in patients given individualized or standard treatment based on early treatment response (Ditto-study)...
  8. doi request reprint Thrombocytopenia and the risk of bleeding during treatment with peginterferon alfa and ribavirin for chronic hepatitis C
    Robert Roomer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Hepatol 53:455-9. 2010
    ..The aim of this study was to investigate the correlation between thrombocytopenia and the occurrence of bleedings during antiviral treatment for HCV infection...
  9. pmc Negative regulation of hepatitis C virus specific immunity is highly heterogeneous and modulated by pegylated interferon-alpha/ribavirin therapy
    Mark A A Claassen
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    PLoS ONE 7:e49389. 2012
    ..Our findings emphasize the importance of negative regulation for the dysfunctional HCV-specific immunity, which should be considered in the design of future immunomodulatory therapies...
  10. doi request reprint Potent immune activation in chronic hepatitis C patients upon administration of an oral inducer of endogenous interferons that acts via Toll-like receptor 7
    Andre Boonstra
    Department of Gastroenterology and Hepatology, Erasmus Medical Center University Hospital, Rotterdam, The Netherlands
    Antivir Ther 17:657-67. 2012
    ..ANA773, an oral prodrug of a small-molecule Toll-like receptor (TLR)7 agonist, induces a dose-related decrease in serum HCV RNA levels in chronic hepatitis C patients...
  11. pmc Retention of CD4+ CD25+ FoxP3+ regulatory T cells in the liver after therapy-induced hepatitis C virus eradication in humans
    Mark A A Claassen
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Virol 85:5323-30. 2011
    ..These findings provide important insight into the dynamics of the immune response to HCV, as well as the effect of therapy on intrahepatic immunity...
  12. doi request reprint Comparison of non-invasive assessment to diagnose liver fibrosis in chronic hepatitis B and C patients
    Krista J M Stibbe
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Scand J Gastroenterol 46:962-72. 2011
    ..We compared seven non-invasive tests, separately and in combination, in chronic hepatitis patients to detect early stages of fibrosis according to the Metavir score in liver biopsy...
  13. doi request reprint Natural killer cell activity and function in chronic HCV-infected patients during peg interferon and ribavirin: early effects of active substance use
    Daphne M Hotho
    Liver Unit, Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Antiviral Res 97:347-55. 2013
    ....
  14. doi request reprint Association between sustained virological response and all-cause mortality among patients with chronic hepatitis C and advanced hepatic fibrosis
    Adriaan J van der Meer
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    JAMA 308:2584-93. 2012
    ..Chronic hepatitis C virus (HCV) infection outcomes include liver failure, hepatocellular carcinoma (HCC), and liver-related death...
  15. doi request reprint Abundant numbers of regulatory T cells localize to the liver of chronic hepatitis C infected patients and limit the extent of fibrosis
    Mark A A Claassen
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center Rotterdam, s Gravendijkwal 230, Rotterdam, The Netherlands
    J Hepatol 52:315-21. 2010
    ..However, little is known about Treg present in livers of HCV-infected patients, their association with clinical parameters, and immunopathology resulting in disease progression...
  16. doi request reprint Erythropoietin administration suppresses human monocyte function in vitro and during therapy-induced anemia in HCV patients
    Michelle Spaan
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, The Netherlands
    Antiviral Res 98:469-75. 2013
    ..Our findings demonstrate an inhibitory effect of EPO on the secretion of effector molecules by monocytes and a stimulatory effect on the phagocytic activity by monocytes...
  17. ncbi request reprint Gamma-glutamyltransferase and rapid virological response as predictors of successful treatment with experimental or standard peginterferon-alpha-2b in chronic hepatitis C non-responders
    Jilling F Bergmann
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Liver Int 27:1217-25. 2007
    ....
  18. doi request reprint Safety and antiviral activity of JTK-652: a novel HCV infection inhibitor
    Joep de Bruijne
    Department of Gastroenterology and Hepatology, Academic Medical Center, University of Amsterdam, The Netherlands
    Antivir Ther 15:765-73. 2010
    ..This study describes the in vitro and in vivo development of JTK-652, a novel pyrrolopyridazin-derived HCV infection inhibitor...
  19. doi request reprint Increased risk of hepatocellular carcinoma among patients with hepatitis C cirrhosis and diabetes mellitus
    Bart J Veldt
    Erasmus MC University Medical Center, Department of Gastroenterology and Hepatology, Rotterdam, The Netherlands
    Hepatology 47:1856-62. 2008
    ..013). Multivariate Cox regression analysis of patients with Ishak 6 cirrhosis showed that diabetes mellitus was independently associated with the development of HCC (hazard ratio, 3.28; 95% CI, 1.35-7.97; P = 0.009)...
  20. doi request reprint Pharmacokinetics and antiviral activity of PHX1766, a novel HCV protease inhibitor, using an accelerated Phase I study design
    Daphne M Hotho
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
    Antivir Ther 17:365-75. 2012
    ..Two clinical trials investigated the safety, tolerability, pharmacokinetics and antiviral activity of PHX1766 in healthy volunteers (HV) and chronic hepatitis C patients, by use of a dose-adaptive overlapping clinical trial design...
  21. doi request reprint The response to TLR ligation of human CD16⁺CD14⁻ monocytes is weakly modulated as a consequence of persistent infection with the hepatitis C virus
    Cheng Peng
    Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Mol Immunol 48:1505-11. 2011
    ....
  22. doi request reprint Epidemiology and management of chronic hepatitis E infection in solid organ transplantation: a comprehensive literature review
    Xinying Zhou
    Department of Gastroenterology and Hepatology, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Rev Med Virol 23:295-304. 2013
    ..In addition, an in-depth emphasis of this clinical issue and a discussion of future development are also presented. Copyright © 2013 John Wiley & Sons, Ltd. ..
  23. doi request reprint Clinical implications of chronic hepatitis E virus infection in heart transplant recipients
    Ludi Koning
    Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands
    J Heart Lung Transplant 32:78-85. 2013
    ....
  24. pmc Telaprevir/boceprevir era: from bench to bed and back
    Qiuwei Pan
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 3015 CE Rotterdam, The Netherlands
    World J Gastroenterol 18:6183-8. 2012
    ..We further emphasized some emerging concerns with perspective of further development in this field...
  25. pmc Serum markers and intestinal mucosal injury in chronic gastrointestinal ischemia
    Désirée van Noord
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Dig Dis Sci 56:506-12. 2011
    ..Diagnosing chronic gastrointestinal ischemia (CGI) is a challenging problem in clinical practice. Serum markers for CGI would be of great diagnostic value as a non-invasive test method...
  26. ncbi request reprint Randomized placebo controlled phase I/II trial of alpha-galactosylceramide for the treatment of chronic hepatitis C
    Bart J Veldt
    Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center Rotterdam, Room Ca 326a, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Hepatol 47:356-65. 2007
    ..The aim of this study was to investigate the safety and the antiviral activity of alpha-galactosylceramide as a novel class of treatment for chronic hepatitis C patients...