R L de Swart

Summary

Affiliation: Erasmus MC
Country: The Netherlands

Publications

  1. ncbi request reprint Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology
    Maureen Padden
    Conway Institute, School of Biomolecular and Biomedical Research, UCD, Dublin, Ireland
    Acta Neuropathol 113:177-86. 2007
  2. ncbi request reprint Measles studies in the macaque model
    R L de Swart
    Department of Virology, Erasmus MC, University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Top Microbiol Immunol 330:55-72. 2009
  3. pmc The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation
    D Tien Nguyen
    Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    PLoS Pathog 6:e1001049. 2010
  4. pmc Relative contributions of measles virus hemagglutinin- and fusion protein-specific serum antibodies to virus neutralization
    Rik L De Swart
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Virol 79:11547-51. 2005
  5. ncbi request reprint Measles vaccination of macaques by dry powder inhalation
    Rik L De Swart
    Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Rotterdam, The Netherlands
    Vaccine 25:1183-90. 2007
  6. ncbi request reprint Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection
    Rik L De Swart
    Department of Virology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Vaccine 25:8518-28. 2007
  7. ncbi request reprint Aerosol measles vaccination in macaques: preclinical studies of immune responses and safety
    Rik L De Swart
    Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Vaccine 24:6424-36. 2006
  8. pmc Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques
    Rik L De Swart
    Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    PLoS Pathog 3:e178. 2007
  9. doi request reprint The pathogenesis of measles revisited
    Rik L De Swart
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    Pediatr Infect Dis J 27:S84-8. 2008
  10. doi request reprint Depletion of measles virus glycoprotein-specific antibodies from human sera reveals genotype-specific neutralizing antibodies
    Rik L De Swart
    Department of Virology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Gen Virol 90:2982-9. 2009

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathology
    Maureen Padden
    Conway Institute, School of Biomolecular and Biomedical Research, UCD, Dublin, Ireland
    Acta Neuropathol 113:177-86. 2007
    ..Conversely, the adherens junction component of the TJ, as indicated by beta-catenin expression is normally expressed in all MS and control tissue categories...
  2. ncbi request reprint Measles studies in the macaque model
    R L de Swart
    Department of Virology, Erasmus MC, University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Curr Top Microbiol Immunol 330:55-72. 2009
    ....
  3. pmc The synthetic bacterial lipopeptide Pam3CSK4 modulates respiratory syncytial virus infection independent of TLR activation
    D Tien Nguyen
    Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    PLoS Pathog 6:e1001049. 2010
    ..Moreover, our results also suggest a potential application for these synthetic lipopeptides as adjuvants for live-attenuated viral vaccines...
  4. pmc Relative contributions of measles virus hemagglutinin- and fusion protein-specific serum antibodies to virus neutralization
    Rik L De Swart
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Virol 79:11547-51. 2005
    ..These results demonstrate that measles virus neutralizing antibodies are mainly directed to the H protein...
  5. ncbi request reprint Measles vaccination of macaques by dry powder inhalation
    Rik L De Swart
    Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Rotterdam, The Netherlands
    Vaccine 25:1183-90. 2007
    ..These studies provide proof of principle that dry powder inhalation is a possible route for measles vaccination, but suggest that either the vaccine formulation or the method of delivery need to be improved for a better immune response...
  6. ncbi request reprint Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infection
    Rik L De Swart
    Department of Virology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Vaccine 25:8518-28. 2007
    ..This study indicates that formalin-inactivated hMPV vaccines have the same propensity to predispose for immune-mediated disease as inactivated RSV and MV vaccines...
  7. ncbi request reprint Aerosol measles vaccination in macaques: preclinical studies of immune responses and safety
    Rik L De Swart
    Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Vaccine 24:6424-36. 2006
    ..No evidence for a safety hazard associated with the route of vaccination was detected. The results of this study support further clinical evaluation of aerosol vaccination for measles...
  8. pmc Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaques
    Rik L De Swart
    Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    PLoS Pathog 3:e178. 2007
    ..Fluorescent imaging of MV infection in non-human primates demonstrated a crucial role for lymphocytes and dendritic cells in the pathogenesis of measles and measles-associated immunosuppression...
  9. doi request reprint The pathogenesis of measles revisited
    Rik L De Swart
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    Pediatr Infect Dis J 27:S84-8. 2008
    ..These antigen-presenting cells may traffic the virus to the regional lymph nodes where they can transmit the virus to lymphocytes, which during viremia disseminate the virus throughout the body...
  10. doi request reprint Depletion of measles virus glycoprotein-specific antibodies from human sera reveals genotype-specific neutralizing antibodies
    Rik L De Swart
    Department of Virology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
    J Gen Virol 90:2982-9. 2009
    ..In addition, it was shown that, in sera from naturally immune donors, the majority of VN antibodies are specific for MV H protein, but up to 10 % of neutralizing antibodies are specific for MV F protein...
  11. ncbi request reprint Measles virus protein-specific IgM, IgA, and IgG subclass responses during the acute and convalescent phase of infection
    H S El Mubarak
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Med Virol 72:290-8. 2004
    ..Interestingly, acute phase IgG(3) and IgA responses were associated, and were only detected in samples with high IgG. This study provides a comprehensive perspective on the antibody response to wild-type measles virus infection...
  12. ncbi request reprint Prevention of measles in Sudan: a prospective study on vaccination, diagnosis and epidemiology
    R L de Swart
    Institute of Virology, Erasmus Medical Centre Rotterdam, PO Box 1738, 3000, Rotterdam, The Netherlands
    Vaccine 19:2254-7. 2001
    ..The studies intended to provide a rational basis for improvement of measles vaccination strategies, and strengthen measles research infrastructure in Khartoum...
  13. ncbi request reprint Surveillance of measles in the Sudan using filter paper blood samples
    H S El Mubarak
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Med Virol 73:624-30. 2004
    ..The results also demonstrate that measles continues to be endemic in the Sudan...
  14. ncbi request reprint Measles virus fusion protein- and hemagglutinin-transfected cell lines are a sensitive tool for the detection of specific antibodies by a FACS-measured immunofluorescence assay
    R L de Swart
    Institute of Virology, Erasmus University, Rotterdam, The Netherlands
    J Virol Methods 71:35-44. 1998
    ....
  15. ncbi request reprint Development of a semi-quantitative real-time RT-PCR for the detection of measles virus
    H S El Mubarak
    Department of Virology, Erasmus MC, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    J Clin Virol 32:313-7. 2005
    ..In conclusion, the TaqMan assay developed is specific, sensitive, rapid and reproducible, and can be of use for diagnostic purposes or for studies on the pathogenesis of measles...
  16. pmc Identification of a common HLA-DP4-restricted T-cell epitope in the conserved region of the respiratory syncytial virus G protein
    L de Waal
    Department of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Virol 78:1775-81. 2004
    ..Its putative role in protection and/or immunopathogenesis remains to be determined...
  17. ncbi request reprint Genetic characterization of wild-type measles viruses circulating in suburban Khartoum, 1997-2000
    H S El Mubarak
    Institute of Virology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
    J Gen Virol 83:1437-43. 2002
    ..Our study demonstrates a remarkable genetic stability of an endemically circulating MV strain...
  18. ncbi request reprint Moderate local and systemic respiratory syncytial virus-specific T-cell responses upon mild or subclinical RSV infection
    L de Waal
    Institute of Virology, Erasmus MC, Rotterdam, The Netherlands
    J Med Virol 70:309-18. 2003
    ....
  19. ncbi request reprint Morbillivirus infections of aquatic mammals: newly identified members of the genus
    A D Osterhaus
    Department of Virology, Erasmus University, Rotterdam, Netherlands
    Vet Microbiol 44:219-27. 1995
    ..Finally experimental evidence that environmental pollution may have contributed to the severity and extent of these infections in recent years is presented...
  20. ncbi request reprint Retrospective identification of three undiagnosed cases of measles encephalitis
    Y A Nur
    Institute of Virology, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur J Clin Microbiol Infect Dis 21:900-1. 2002
  21. pmc In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaques
    Rory D de Vries
    Department of Virology, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, Netherlands
    J Virol 84:4714-24. 2010
    ..This study shows that despite in vitro differences, attenuated and pathogenic MV show highly similar in vivo tropism in the lungs. However, systemic spread of attenuated MV is restricted...
  22. doi request reprint Streptococcus pneumoniae exposure is associated with human metapneumovirus seroconversion and increased susceptibility to in vitro HMPV infection
    N J Verkaik
    Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Clin Microbiol Infect 17:1840-4. 2011
    ..This was not the case for cells pre-incubated with H. influenzae, M. catarrhalis on S. aureus. We conclude that exposure to S. pneumoniae can modulate HMPV infection...
  23. ncbi request reprint Measles virus superinfection immunity and receptor redistribution in persistently infected NT2 cells
    Martin Ludlow
    School of Biology and Biochemistry, The Queen s University of Belfast, Belfast BT9 7BL, Northern Ireland, UK
    J Gen Virol 86:2291-303. 2005
    ..Only small numbers of non-fusing green fluorescent piNT2-MVDsRed1 cells (1 : 300 000) were identified in which superinfecting MVeGFP entered, replicated and expressed its genes...
  24. ncbi request reprint An immunohistochemical study of the distribution of the measles virus receptors, CD46 and SLAM, in normal human tissues and subacute sclerosing panencephalitis
    Stephen McQuaid
    Neuropathology Laboratory, Royal Victoria Hospital, Queen s University Belfast, Northern Ireland
    Lab Invest 82:403-9. 2002
    ..In the case of wild-type stains, which are unable to use CD46, a further as yet unknown receptor(s) would be necessary to fully explain the pathology of MV infection...
  25. ncbi request reprint Infection of human oligodendroglioma cells by a recombinant measles virus expressing enhanced green fluorescent protein
    Jonnie Plumb
    Neuropathology Laboratory, Royal Group of Hospitals Trust, Belfast, Northern Ireland, United Kingdom
    J Neurovirol 8:24-34. 2002
    ....
  26. ncbi request reprint Rinderpest and peste des petits ruminants viruses exhibit neurovirulence in mice
    Sareen E Galbraith
    School of Biology and Biochemistry, The Queen s University of Belfast, Belfast, Northern Ireland, United Kingdom
    J Neurovirol 8:45-52. 2002
    ..Transient infection of the CNS of cattle and goats with RPV and PPRV, respectively, remains a possibility, which could provide relevant models for the initial stages of MV infection in humans...
  27. ncbi request reprint Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosis
    Jonnie Plumb
    Neuropathology Laboratory, Royal Group of Hospitals Trust, Belfast, Northern Ireland, United Kingdom
    Brain Pathol 12:154-69. 2002
    ..BBB disruption due to tight junctional pathology should be regarded as a significant form of tissue injury in MS, alongside demyelination and axonopathy...
  28. doi request reprint Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesions
    Aoife Ní Mháille
    National University of Ireland, Galway, Ireland
    J Neuropathol Exp Neurol 67:200-11. 2008
    ..A possible link between a perturbed ER and lesion development in MS suggests a signaling pathway that may represent a new therapeutic target in MS...
  29. ncbi request reprint Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelination
    John Kirk
    School of Medicine Inflammation Research Centre, Queen s University of Belfast, Northern Ireland, UK
    J Pathol 201:319-27. 2003
    ..In NAWM, it suggests either pre-lesional change or secondary damage. Clinically inapparent TJ pathology has prognostic implications and should be considered when planning disease-modifying therapy...
  30. pmc The F gene of rodent brain-adapted mumps virus is a major determinant of neurovirulence
    Ken Lemon
    School of Biomedical Sciences, The Queen s University of Belfast, Belfast, BT9 7BL, Northern Ireland, United Kingdom
    J Virol 81:8293-302. 2007
    ..Expression of the F gene of the neurovirulent strain alone was sufficient to induce significant levels of hydrocephalus. Coexpression of the homologous HN gene led to a marginal increase in the level of hydrocephalus...