Research Topics
Species | R L de SwartSummaryAffiliation: Erasmus MC Country: The Netherlands Publications
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Detail Information
Publications
Differences in expression of junctional adhesion molecule-A and beta-catenin in multiple sclerosis brain tissue: increasing evidence for the role of tight junction pathologyMaureen Padden
Conway Institute, School of Biomolecular and Biomedical Research, UCD, Dublin, Ireland
Acta Neuropathol 113:177-86. 2007..Conversely, the adherens junction component of the TJ, as indicated by beta-catenin expression is normally expressed in all MS and control tissue categories...
Relative contributions of measles virus hemagglutinin- and fusion protein-specific serum antibodies to virus neutralizationRik L De Swart
Department of Virology, Erasmus MC, Rotterdam, The Netherlands
J Virol 79:11547-51. 2005..These results demonstrate that measles virus neutralizing antibodies are mainly directed to the H protein...- Aerosol measles vaccination in macaques: preclinical studies of immune responses and safetyRik L De Swart
Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
Vaccine 24:6424-36. 2006..No evidence for a safety hazard associated with the route of vaccination was detected. The results of this study support further clinical evaluation of aerosol vaccination for measles... - Measles vaccination of macaques by dry powder inhalationRik L De Swart
Department of Virology, Erasmus MC, Postgraduate School of Molecular Medicine, Rotterdam, The Netherlands
Vaccine 25:1183-90. 2007..These studies provide proof of principle that dry powder inhalation is a possible route for measles vaccination, but suggest that either the vaccine formulation or the method of delivery need to be improved for a better immune response... - Immunization of macaques with formalin-inactivated human metapneumovirus induces hypersensitivity to hMPV infectionRik L De Swart
Department of Virology, Erasmus MC, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Vaccine 25:8518-28. 2007..This study indicates that formalin-inactivated hMPV vaccines have the same propensity to predispose for immune-mediated disease as inactivated RSV and MV vaccines... - Predominant infection of CD150+ lymphocytes and dendritic cells during measles virus infection of macaquesRik L De Swart
Department of Virology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
PLoS Pathog 3:e178. 2007..Fluorescent imaging of MV infection in non-human primates demonstrated a crucial role for lymphocytes and dendritic cells in the pathogenesis of measles and measles-associated immunosuppression... 
The pathogenesis of measles revisitedRik L De Swart
Department of Virology, Erasmus MC, Rotterdam, The Netherlands
Pediatr Infect Dis J 27:S84-8. 2008..These antigen-presenting cells may traffic the virus to the regional lymph nodes where they can transmit the virus to lymphocytes, which during viremia disseminate the virus throughout the body...- Measles studies in the macaque modelR L de Swart
Department of Virology, Erasmus MC, University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
Curr Top Microbiol Immunol 330:55-72. 2009.... - Depletion of measles virus glycoprotein-specific antibodies from human sera reveals genotype-specific neutralizing antibodiesRik L De Swart
Department of Virology, Erasmus MC, PO Box 2040, 3000 CA Rotterdam, The Netherlands
J Gen Virol 90:2982-9. 2009..In addition, it was shown that, in sera from naturally immune donors, the majority of VN antibodies are specific for MV H protein, but up to 10 % of neutralizing antibodies are specific for MV F protein... - Measles virus protein-specific IgM, IgA, and IgG subclass responses during the acute and convalescent phase of infectionH S El Mubarak
Department of Virology, Erasmus MC, Rotterdam, The Netherlands
J Med Virol 72:290-8. 2004..Interestingly, acute phase IgG(3) and IgA responses were associated, and were only detected in samples with high IgG. This study provides a comprehensive perspective on the antibody response to wild-type measles virus infection... - Prevention of measles in Sudan: a prospective study on vaccination, diagnosis and epidemiologyR L de Swart
Institute of Virology, Erasmus Medical Centre Rotterdam, PO Box 1738, 3000, Rotterdam, The Netherlands
Vaccine 19:2254-7. 2001..The studies intended to provide a rational basis for improvement of measles vaccination strategies, and strengthen measles research infrastructure in Khartoum... - Surveillance of measles in the Sudan using filter paper blood samplesH S El Mubarak
Department of Virology, Erasmus MC, Rotterdam, The Netherlands
J Med Virol 73:624-30. 2004..The results also demonstrate that measles continues to be endemic in the Sudan... - Measles virus fusion protein- and hemagglutinin-transfected cell lines are a sensitive tool for the detection of specific antibodies by a FACS-measured immunofluorescence assayR L de Swart
Institute of Virology, Erasmus University, Rotterdam, The Netherlands
J Virol Methods 71:35-44. 1998.... - Development of a semi-quantitative real-time RT-PCR for the detection of measles virusH S El Mubarak
Department of Virology, Erasmus MC, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands
J Clin Virol 32:313-7. 2005..In conclusion, the TaqMan assay developed is specific, sensitive, rapid and reproducible, and can be of use for diagnostic purposes or for studies on the pathogenesis of measles... - Identification of a common HLA-DP4-restricted T-cell epitope in the conserved region of the respiratory syncytial virus G proteinL de Waal
Department of Virology, Erasmus MC, Rotterdam, The Netherlands
J Virol 78:1775-81. 2004..Its putative role in protection and/or immunopathogenesis remains to be determined... - Genetic characterization of wild-type measles viruses circulating in suburban Khartoum, 1997-2000H S El Mubarak
Institute of Virology, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands
J Gen Virol 83:1437-43. 2002..Our study demonstrates a remarkable genetic stability of an endemically circulating MV strain... - Morbillivirus infections of aquatic mammals: newly identified members of the genusA D Osterhaus
Department of Virology, Erasmus University, Rotterdam, Netherlands
Vet Microbiol 44:219-27. 1995..Finally experimental evidence that environmental pollution may have contributed to the severity and extent of these infections in recent years is presented... - Retrospective identification of three undiagnosed cases of measles encephalitisY A Nur
Institute of Virology, Erasmus MC, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
Eur J Clin Microbiol Infect Dis 21:900-1. 2002 - Moderate local and systemic respiratory syncytial virus-specific T-cell responses upon mild or subclinical RSV infectionL de Waal
Institute of Virology, Erasmus MC, Rotterdam, The Netherlands
J Med Virol 70:309-18. 2003.... - In vivo tropism of attenuated and pathogenic measles virus expressing green fluorescent protein in macaquesRory D de Vries
Department of Virology, Erasmus MC, P O Box 2040, 3000 CA, Rotterdam, Netherlands
J Virol 84:4714-24. 2010..This study shows that despite in vitro differences, attenuated and pathogenic MV show highly similar in vivo tropism in the lungs. However, systemic spread of attenuated MV is restricted... - Streptococcus pneumoniae exposure is associated with human metapneumovirus seroconversion and increased susceptibility to in vitro HMPV infectionN J Verkaik
Department of Medical Microbiology and Infectious Diseases, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
Clin Microbiol Infect 17:1840-4. 2011..This was not the case for cells pre-incubated with H. influenzae, M. catarrhalis on S. aureus. We conclude that exposure to S. pneumoniae can modulate HMPV infection... - An immunohistochemical study of the distribution of the measles virus receptors, CD46 and SLAM, in normal human tissues and subacute sclerosing panencephalitisStephen McQuaid
Neuropathology Laboratory, Royal Victoria Hospital, Queen s University Belfast, Northern Ireland
Lab Invest 82:403-9. 2002..In the case of wild-type stains, which are unable to use CD46, a further as yet unknown receptor(s) would be necessary to fully explain the pathology of MV infection... - Measles virus superinfection immunity and receptor redistribution in persistently infected NT2 cellsMartin Ludlow
School of Biology and Biochemistry, The Queen's University of Belfast, Belfast BT9 7BL, Northern Ireland, UK
J Gen Virol 86:2291-303. 2005..Only small numbers of non-fusing green fluorescent piNT2-MVDsRed1 cells (1 : 300 000) were identified in which superinfecting MVeGFP entered, replicated and expressed its genes... - The F gene of rodent brain-adapted mumps virus is a major determinant of neurovirulenceKen Lemon
School of Biomedical Sciences, The Queen s University of Belfast, Belfast, BT9 7BL, Northern Ireland, United Kingdom
J Virol 81:8293-302. 2007..Expression of the F gene of the neurovirulent strain alone was sufficient to induce significant levels of hydrocephalus. Coexpression of the homologous HN gene led to a marginal increase in the level of hydrocephalus... - Increased expression of endoplasmic reticulum stress-related signaling pathway molecules in multiple sclerosis lesionsAoife Ní Mháille
National University of Ireland, Galway, Ireland
J Neuropathol Exp Neurol 67:200-11. 2008..A possible link between a perturbed ER and lesion development in MS suggests a signaling pathway that may represent a new therapeutic target in MS... - Rinderpest and peste des petits ruminants viruses exhibit neurovirulence in miceSareen E Galbraith
School of Biology and Biochemistry, The Queen's University of Belfast, Belfast, Northern Ireland, United Kingdom
J Neurovirol 8:45-52. 2002..Transient infection of the CNS of cattle and goats with RPV and PPRV, respectively, remains a possibility, which could provide relevant models for the initial stages of MV infection in humans... - Infection of human oligodendroglioma cells by a recombinant measles virus expressing enhanced green fluorescent proteinJonnie Plumb
Neuropathology Laboratory, Royal Group of Hospitals Trust, Belfast, Northern Ireland, United Kingdom
J Neurovirol 8:24-34. 2002.... - Tight junctional abnormality in multiple sclerosis white matter affects all calibres of vessel and is associated with blood-brain barrier leakage and active demyelinationJohn Kirk
School of Medicine Inflammation Research Centre, Queen's University of Belfast, Northern Ireland, UK
J Pathol 201:319-27. 2003..In NAWM, it suggests either pre-lesional change or secondary damage. Clinically inapparent TJ pathology has prognostic implications and should be considered when planning disease-modifying therapy... - Abnormal endothelial tight junctions in active lesions and normal-appearing white matter in multiple sclerosisJonnie Plumb
Neuropathology Laboratory, Royal Group of Hospitals Trust, Belfast, Northern Ireland, United Kingdom
Brain Pathol 12:154-69. 2002..BBB disruption due to tight junctional pathology should be regarded as a significant form of tissue injury in MS, alongside demyelination and axonopathy...