A H Danser

Summary

Affiliation: Erasmus University
Country: The Netherlands

Publications

  1. ncbi Local renin-angiotensin systems: the unanswered questions
    A H Jan Danser
    Department of Pharmacology, Room EE1418b, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Int J Biochem Cell Biol 35:759-68. 2003
  2. ncbi Prorenin, renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts. Evidence for renin binding
    A H Danser
    Department of Pharmacology, Cardiovasculair Onderzoeksinstituut Erasmus Universiteit Rotterdam, Netherlands
    Circulation 96:220-6. 1997
  3. ncbi Prorenin uptake in the heart: a prerequisite for local angiotensin generation?
    A H Jan Danser
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    J Mol Cell Cardiol 34:1463-72. 2002
  4. ncbi Renin-angiotensin system gene polymorphisms: potential mechanisms for their association with cardiovascular diseases
    A H Danser
    Room EE1418b Department of Pharmacology, Erasmus University Rotterdam, Dr Molewaterplein 50, 3015 GE, Rotterdam, Netherlands
    Eur J Pharmacol 410:303-316. 2000
  5. pmc L-NAME-resistant bradykinin-induced relaxation in porcine coronary arteries is NO-dependent: effect of ACE inhibition
    A H Danser
    Department of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Br J Pharmacol 131:195-202. 2000
  6. ncbi Angiotensin I to angiotensin II conversion in the human forearm and leg. Effect of the angiotensin converting enzyme gene insertion/deletion polymorphism
    A H Danser
    Cardiovasculair Onderzoeksinstituut Erasmus Universiteit Rotterdam, The Netherlands
    J Hypertens 17:1867-72. 1999
  7. ncbi Is there a local renin-angiotensin system in the heart?
    A H Danser
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    Cardiovasc Res 44:252-65. 1999
  8. ncbi Angiotensin I-to-II conversion in the human renal vascular bed
    A H Danser
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    J Hypertens 16:2051-6. 1998
  9. ncbi Angiotensinogen (M235T) and angiotensin-converting enzyme (I/D) polymorphisms in association with plasma renin and prorenin levels
    A H Danser
    Cardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    J Hypertens 16:1879-83. 1998
  10. ncbi Bradykinin-induced release of nitric oxide by the isolated perfused rat heart: importance of preformed pools of nitric oxide-containing factors
    A H Danser
    Department of Pharmacology, Cardiovasculair Onderzoeksinstituut Erasmus Universiteit Rotterdam, The Netherlands
    J Hypertens 16:239-44. 1998

Collaborators

Detail Information

Publications57

  1. ncbi Local renin-angiotensin systems: the unanswered questions
    A H Jan Danser
    Department of Pharmacology, Room EE1418b, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Int J Biochem Cell Biol 35:759-68. 2003
    ..with the local generation or effects of angiotensin II), and (5) to what degree do differences in tissue angiotensin generation underlie the association between cardiovascular diseases and renin-angiotensin system gene polymorphisms?..
  2. ncbi Prorenin, renin, angiotensinogen, and angiotensin-converting enzyme in normal and failing human hearts. Evidence for renin binding
    A H Danser
    Department of Pharmacology, Cardiovasculair Onderzoeksinstituut Erasmus Universiteit Rotterdam, Netherlands
    Circulation 96:220-6. 1997
    ..A local renin-angiotensin system in the heart is often invoked to explain the beneficial effects of ACE inhibitors in heart failure. The heart, however, produces little or no renin under normal conditions...
  3. ncbi Prorenin uptake in the heart: a prerequisite for local angiotensin generation?
    A H Jan Danser
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    J Mol Cell Cardiol 34:1463-72. 2002
    ..e., immediate binding of angiotensin II to its receptors with minimal loss into the extracellular space...
  4. ncbi Renin-angiotensin system gene polymorphisms: potential mechanisms for their association with cardiovascular diseases
    A H Danser
    Room EE1418b Department of Pharmacology, Erasmus University Rotterdam, Dr Molewaterplein 50, 3015 GE, Rotterdam, Netherlands
    Eur J Pharmacol 410:303-316. 2000
    ....
  5. pmc L-NAME-resistant bradykinin-induced relaxation in porcine coronary arteries is NO-dependent: effect of ACE inhibition
    A H Danser
    Department of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Br J Pharmacol 131:195-202. 2000
    ..ACE inhibitors potentiate BK independent of their effect on BK metabolism...
  6. ncbi Angiotensin I to angiotensin II conversion in the human forearm and leg. Effect of the angiotensin converting enzyme gene insertion/deletion polymorphism
    A H Danser
    Cardiovasculair Onderzoeksinstituut Erasmus Universiteit Rotterdam, The Netherlands
    J Hypertens 17:1867-72. 1999
    ..Here we quantify ACE genotype-related Ang I to Ang II conversion in the human forearm and leg using non-pressor 125I-Ang I infusions...
  7. ncbi Is there a local renin-angiotensin system in the heart?
    A H Danser
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    Cardiovasc Res 44:252-65. 1999
    ..In addition, the role of alternative angiotensin-generating enzymes (cathepsin, chymase) and the possibility of (pro)renin uptake from the circulation is evaluated...
  8. ncbi Angiotensin I-to-II conversion in the human renal vascular bed
    A H Danser
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    J Hypertens 16:2051-6. 1998
    ..To overcome this problem, we now infused 125I-angiotensin I directly into the renal artery...
  9. ncbi Angiotensinogen (M235T) and angiotensin-converting enzyme (I/D) polymorphisms in association with plasma renin and prorenin levels
    A H Danser
    Cardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    J Hypertens 16:1879-83. 1998
    ....
  10. ncbi Bradykinin-induced release of nitric oxide by the isolated perfused rat heart: importance of preformed pools of nitric oxide-containing factors
    A H Danser
    Department of Pharmacology, Cardiovasculair Onderzoeksinstituut Erasmus Universiteit Rotterdam, The Netherlands
    J Hypertens 16:239-44. 1998
    ..To study whether the vasorelaxant effect of bradykinin in the coronary vascular bed depends on the release of NO from preformed pools and/or de-novo synthesis of NO resulting from bradykinin-induced stimulation of NO synthase...
  11. ncbi Determinants of interindividual variation of renin and prorenin concentrations: evidence for a sexual dimorphism of (pro)renin levels in humans
    A H Danser
    Department of Pharmacology, Cardiovasculaire Onderzoeksinstituut Erasmus Universiteit Rotterdam, The Netherlands
    J Hypertens 16:853-62. 1998
    ..Plasma renin concentrations are an important factor in cardiovascular risk profiling...
  12. ncbi AT(2) receptor-mediated vasodilation in the heart: effect of myocardial infarction
    M P Schuijt
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    Am J Physiol Heart Circ Physiol 281:H2590-6. 2001
    ..RVC, at baseline or with ANG II, was not affected by PD123319 in infarcted and sham animals. In conclusion, coronary but not renal AT(2) receptor stimulation results in vasodilation, and this effect is enhanced in infarcted rats...
  13. ncbi Cardiomyocytes bind and activate native human prorenin : role of soluble mannose 6-phosphate receptors
    J J Saris
    Cardiovascular Research Institute COEUR, Department of Pharmacology, Internal Medicine, Erasmus University Rotterdam, The Netherlands
    Hypertension 37:710-5. 2001
    ....
  14. ncbi Angiotensin converting enzyme is the main contributor to angiotensin I-II conversion in the interstitium of the isolated perfused rat heart
    L M de Lannoy
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    J Hypertens 19:959-65. 2001
    ..CONCLUSIONS: In the intact rat heart, ACE is the main contributor to angiotensin I to angiotensin II conversion, both in the coronary vascular bed and the interstitium. Cardiac ACE is not limited to the coronary vascular endothelium...
  15. ncbi Bradykinin potentiation by angiotensin-(1-7) and ACE inhibitors correlates with ACE C- and N-domain blockade
    B Tom
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    Hypertension 38:95-9. 2001
    ..The inhibitory effects of Ang-(1-7) are limited to the ACE C-domain, raising the possibility that Ang-(1-7) synergistically increases the blood pressure-lowering effects of N-domain-specific ACE inhibitors...
  16. ncbi Negative inotropic effect of bradykinin in porcine isolated atrial trabeculae: role of nitric oxide
    B Tom
    Department of Pharmacology, Erasmus University Rotterdam, The Netherlands
    J Hypertens 19:1289-93. 2001
    ..The inconsistent results obtained with L-NAME suggest that it depends on NO synthesized de novo and/or NO from storage sites...
  17. ncbi Prorenin accumulation and activation in human endothelial cells: importance of mannose 6-phosphate receptors
    M M van den Eijnden
    Cardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 21:911-6. 2001
    ..Most likely, therefore, in the absence of angiotensinogen synthesis or endocytosis, M6P receptor-mediated prorenin internalization by endothelial cells represents prorenin clearance...
  18. ncbi Intrarenal angiotensin II: interstitial and cellular levels and site of production
    J P van Kats
    Cardiovascular Research Institute Erasmus University Rotterdam (COEUR, Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    Kidney Int 60:2311-7. 2001
    ..We propose the existence of a low-Ang II vascular system-related interstitial compartment that is separate from tubular fluid, where, according to micropuncture studies, Ang II levels might be high...
  19. ncbi Angiotensin II type 2 receptors and cardiac hypertrophy in women with hypertrophic cardiomyopathy
    J Deinum
    Cardiovascular Research Institute of the Erasmus University Rotterdam COEUR, Department of Internal Medicine, Erasmus University Rotterdam, Rotterdam, The Netherlands
    Hypertension 38:1278-81. 2001
    ..In conclusion, AT(2)-Rs modulate cardiac hypertrophy in women with HCM, independently of the circulating renin-angiotensin system. These data support the contention that AT(2)-Rs mediate antitrophic effects in humans...
  20. ncbi Superoxide does not mediate the acute vasoconstrictor effects of angiotensin II: a study in human and porcine arteries
    Martin P Schuijt
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 21:2335-44. 2003
    ..To investigate whether superoxide mediates angiotensin (Ang) II-induced vasoconstriction...
  21. ncbi The (pro)renin receptor: therapeutic consequences
    Genevieve Nguyen
    Expert Opin Investig Drugs 15:1131-5. 2006
    ..Ultimately, this could lead to the development of (pro)renin receptor blockers (i.e., drugs that not only prevent tissue angiotensin generation but also inhibit renin- or prorenin-induced effects)...
  22. ncbi Prorenin: back into the arena
    A H Jan Danser
    Hypertension 47:824-6. 2006
  23. doi Pharmacogenetics of ACE inhibition in stable coronary artery disease: steps towards tailored drug therapy
    Jasper J Brugts
    Department of Cardiology, Erasmus Medical Center, Rotterdam, The Netherlands
    Curr Opin Cardiol 23:296-301. 2008
    ..This review discusses several approaches to guide angiotensin-converting enzyme-inhibition therapy to more specific groups of patients that are most likely to benefit...
  24. ncbi Renin, prorenin and the putative (pro)renin receptor
    A H Jan Danser
    Department of Pharmacology, Erasums MC, Rotterdam, The Netherlands
    J Renin Angiotensin Aldosterone Syst 6:163-5. 2005
  25. ncbi ACE phenotyping as a first step toward personalized medicine for ACE inhibitors. Why does ACE genotyping not predict the therapeutic efficacy of ACE inhibition?
    A H Jan Danser
    Department of Pharmacology, Erasmus MC, University Medical Center Rotterdam, P O Box 1738, 3000 DR Rotterdam, The Netherlands
    Pharmacol Ther 113:607-18. 2007
    ....
  26. ncbi Letter by Krop et al regarding article, "Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium"
    Manne Krop
    Circulation 114:e556; author reply e557. 2006
  27. ncbi Angiotensinogen M235T polymorphism and the risk of myocardial infarction and stroke among hypertensive patients on ACE-inhibitors or beta-blockers
    Hedi Schelleman
    Department of Epidemiology and Biostatistics, Erasmus MC, Rotterdam, The Netherlands
    Eur J Hum Genet 15:478-84. 2007
    ..ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke...
  28. ncbi Novel drugs targeting hypertension: renin inhibitors
    A H Jan Danser
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    J Cardiovasc Pharmacol 50:105-11. 2007
    ..The review ends with a brief overview of the available (pre)clinical aliskiren data and a description of its safety profile...
  29. ncbi Prorenin is the endogenous agonist of the (pro)renin receptor. Binding kinetics of renin and prorenin in rat vascular smooth muscle cells overexpressing the human (pro)renin receptor
    Wendy W Batenburg
    Erasmus MC, Rotterdam, The Netherlands
    J Hypertens 25:2441-53. 2007
    ..Here, we evaluated the kinetics of renin/prorenin binding to the recently discovered human (pro)renin receptor (h(P)RR), and the idea that such binding underlies tissue angiotensin generation...
  30. doi Renin academy in focus
    A H Jan Danser
    Department of Internal Medicine, room E1418b, Erasmus MC, s Gravendijkwal 230, Rotterdam, The Netherlands
    J Renin Angiotensin Aldosterone Syst 8:212. 2007
  31. pmc Prorenin anno 2008
    A H Jan Danser
    Division of Vascular Pharmacology and Metabolism, Department of Internal Medicine, Erasmus MC, Dr Molewaterplein 50, Rotterdam, The Netherlands
    J Mol Med (Berl) 86:655-8. 2008
    ..The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation...
  32. doi Aliskiren-binding increases the half life of renin and prorenin in rat aortic vascular smooth muscle cells
    Wendy W Batenburg
    Erasmus MC, 3015 GE Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 28:1151-7. 2008
    ..We also investigated whether aliskiren affects (pro)renin binding to its receptors, using rat aortic vascular smooth muscle cells (VSMCs) overexpressing the h(P)RR...
  33. ncbi Circulating versus tissue renin-angiotensin system: on the origin of (pro)renin
    Manne Krop
    Division of Vascular Pharmacology and Metabolism, Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
    Curr Hypertens Rep 10:112-8. 2008
    ..This review provides an update on the sources of (pro)renin in the body, lists the known stimulants and inhibitors of its production, and discusses the concept that prorenin rather than renin determines tissue angiotensin generation...
  34. ncbi Renin, prorenin and the putative (pro)renin receptor
    A H Jan Danser
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    Hypertension 46:1069-76. 2005
  35. ncbi Transendothelial transport of renin-angiotensin system components
    Mark M E D van den Eijnden
    Department of Pharmacology, Cardiovascular Research Institute COEUR, Erasmus Medical Center, Rotterdam, The Netherlands
    J Hypertens 20:2029-37. 2002
    ....
  36. ncbi The role of locally expressed angiotensin converting enzyme in cardiac remodeling after myocardial infarction in mice
    Wendy M Aartsen
    Department of Pharmacology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, P O Box 616, 6200 MD, Maastricht, The Netherlands
    Cardiovasc Res 56:205-13. 2002
    ..In the present study, mice lacking tissue-bound angiotensin converting enzyme (t-ACE -/-) were used to investigate the importance of t-ACE during cardiac remodeling after myocardial infarction...
  37. ncbi Prorenin-induced myocyte proliferation: no role for intracellular angiotensin II
    Jasper J Saris
    Cardiovascular Research Institute COEUR, Department of Pharmacology, Erasmus University Medical Center Rotterdam, The Netherlands
    Hypertension 39:573-7. 2002
    ..Taken together, our results do not support the concept of Ang II generation in cardiomyocytes following intracellular prorenin activation...
  38. doi A twofold genetic increase of ACE expression has no effect on the development of spontaneous hypertension
    Ibrahim Nassar
    Institute of Clinical Pharmacology and Toxicology, Charité Centrum für Thearapieforschung, Charite Universitatsmedizin Berlin, Berlin, Germany
    Am J Hypertens 21:200-5. 2008
    ..e., the Ace allele of the normotensive Wistar-Kyoto (WKY) rat, in the hypertensive background of stroke-prone spontaneously hypertensive (SHRSP) rats...
  39. ncbi Selective angiotensin-converting enzyme C-domain inhibition is sufficient to prevent angiotensin I-induced vasoconstriction
    Joep H M van Esch
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    Hypertension 45:120-5. 2005
    ....
  40. ncbi Endothelin-1 and blood pressure in women
    A H Jan Danser
    J Hypertens 22:675-6. 2004
  41. ncbi Adrenal angiotensin: origin and site of generation
    Jorge P van Kats
    Department of Pharmacology, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Hypertens 18:1104-10. 2005
    ..Here we investigated what percentage of adrenal Ang II originates at adrenal tissue sites, and whether intracellular renin contributes to adrenal angiotensin production...
  42. doi The renin rise with aliskiren: it's simply stoichiometry
    A H Jan Danser
    Hypertension 51:e27-8; author reply e29. 2008
  43. ncbi No net effect of angiotensin II on blood pressure?
    Martin P Schuijt
    Hypertension 39:E27-8. 2002
  44. pmc Vasoconstriction is determined by interstitial rather than circulating angiotensin II
    Martin P Schuijt
    Department of Pharmacology, Erasmus University Medical Centre Rotterdam, Rotterdam, The Netherlands
    Br J Pharmacol 135:275-83. 2002
    ..5. Interstitial, rather than circulating Ang II determines vasoconstriction. Arterial Ang I, resulting in high interstitial Ang II levels via its local conversion by ACE, may be of greater physiological importance than arterial Ang II...
  45. doi Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors
    Florian Gembardt
    Department of Cardiology, Charite Berlin, Campus Benjamin Franklin, Berlin, Germany
    FASEB J 22:3068-77. 2008
    ....
  46. ncbi Cardiac angiotensin II: an intracrine hormone?
    Martin P Schuijt
    Department of Pharmacology, Erasmus Medical Centre, Rotterdam, The Netherlands
    Am J Hypertens 15:1109-16. 2002
    ..Intracellular angiotensin II generation is unlikely to occur, in particular because angiotensinogen is not available in the cytosol...
  47. ncbi The impact of angiotensin-converting enzyme inhibitor therapy on the extracellular collagen matrix during left ventricular assist device support in patients with end-stage heart failure
    Stefan Klotz
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York, USA
    J Am Coll Cardiol 49:1166-74. 2007
    ..We hypothesized that angiotensin-converting enzyme inhibition (ACE-I) during left ventricular assist device (LVAD) support in patients with end-stage heart failure prevents potentially deleterious effects on the extracellular matrix...
  48. ncbi Cardiac aldosterone in subjects with hypertrophic cardiomyopathy
    Wenxia Chai
    Department of Pharmacology, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    J Renin Angiotensin Aldosterone Syst 7:225-30. 2006
    ..This finding raises the need for studies determining the benefit of aldosterone blockade in HCM...
  49. ncbi Nongenomic effects of aldosterone in the human heart: interaction with angiotensin II
    Wenxia Chai
    Department of Pharmacology, Erasmus MC, 3015 GE Rotterdam, The Netherlands
    Hypertension 46:701-6. 2005
    ..These effects are specific and involve PKC and ERK 1/2, respectively. Furthermore, they occur in a nongenomic manner, and require pathological aldosterone concentrations...
  50. ncbi Mechanical unloading during left ventricular assist device support increases left ventricular collagen cross-linking and myocardial stiffness
    Stefan Klotz
    Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY, USA
    Circulation 112:364-74. 2005
    ....
  51. ncbi Cardioprotective effects of eplerenone in the rat heart: interaction with locally synthesized or blood-derived aldosterone?
    Wenxia Chai
    Department of Pharmacology, Erasmus MC, Rotterdam, The Netherlands
    Hypertension 47:665-70. 2006
    ..The rapid, mineralocorticoid receptor-independent kinetics of aldosterone suggest that its accumulation in the heart involves cell surface binding rather than internalization...
  52. pmc Genomic and nongenomic effects of aldosterone in the rat heart: why is spironolactone cardioprotective?
    Wenxia Chai
    Department of Pharmacology, Room EE1418b, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Br J Pharmacol 145:664-71. 2005
    ..MR blockade reduces infarct size and increases LVP recovery following coronary artery occlusion. The MR-related phenomena may underlie, at least in part, the beneficial actions of spironolactone in heart failure...
  53. ncbi 77th Scientific Sessions of the American Heart Association
    A H Jan Danser
    Erasmus MC, Department of Pharmacology, Room EE1418b, Dr Molewaterplein 50, 3015GE Rotterdam, The Netherlands
    Expert Opin Investig Drugs 14:203-7. 2005
    ..The sessions were divided into basic, clinical and population science. The abstracts have been published in a supplement to Circulation (2004) 110(7)...
  54. ncbi Is angiotensin II made inside or outside of the cell?
    Wenxia Chai
    Department of Pharmacology, Room EE1418b, Erasmus MC, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Curr Hypertens Rep 7:124-7. 2005
    ..It is eventually concluded that angiotensin generation at tissue sites occurs extracellularly, most likely on the cell surface...
  55. ncbi Bradykinin, angiotensin-(1-7), and ACE inhibitors: how do they interact?
    Beril Tom
    Department of Pharmacology, Room EE1418b, Erasmus Medical Centre, Dr Molewaterplein 50, 3015 GE Rotterdam, The Netherlands
    Int J Biochem Cell Biol 35:792-801. 2003
    ..The levels of angiotensin-(1-7) are increased during ACE inhibition, and most studies suggest that its hypotensive effects are mediated in a bradykinin-dependent manner...
  56. ncbi ACE-versus chymase-dependent angiotensin II generation in human coronary arteries: a matter of efficiency?
    Beril Tom
    Department of Pharmacology, Thoracic Surgery and Heart Valve Bank, Erasmus MC, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 23:251-6. 2003
    ..The objective of this study was to investigate ACE- and chymase-dependent angiotensin I-to-II conversion in human coronary arteries (HCAs)...
  57. pmc Why are mineralocorticoid receptor antagonists cardioprotective?
    Wenxia Chai
    Department of Pharmacology, Room EE1418b, Erasmus MC, Dr Molewaterplein 50, 3015 GE, Rotterdam, The Netherlands
    Naunyn Schmiedebergs Arch Pharmacol 374:153-62. 2006
    ..Some of these effects occur via or in synergy with angiotensin II, and involve a non-MR-mediated mechanism. This raises the possibility that aldosterone synthase inhibitors might exert beneficial effects on top of MR blockade...